Clinical trials: Decreased Vascular Flow
Burns, Pain
Effects of Virtual Reality Application on Pain Reduction and Cerebral Blood Flow in Robot Training in Burn Patients
The purpose of this study is to determine whether the application of virtual reality (VR) is effective in reducing training pain in robot-assisted gait training (RAGT) in patients with lower extremity burn.
- Conditions
- Burns, Pain, Virtual Reality
- Trial name
- NCT05004766
- Testing
- Robot assisted gait training with virtual reality
- Volunteers
- 10 people
- Sponsor
- Hangang Sacred Heart Hospital
PreDiabetes
Study: Diet and Exercise Study to Improve Brain Blood Flow: Blood Flow Improvement Trial
Project Summary Metabolic syndrome (MetS) is associated with the development of diabetes and cardiovascular disease; however it is also linked with cognitive decline and dementia.
- Trial name
- BFIT (NCT03117829)
- Testing
- Diet and Exercise
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Coronary Artery Disease, Atherosclerosis
The CHORAL Flow Study
CHORAL Flow is a randomised, double blinded, placebo-controlled trial of the effects of evolocumab on coronary flow at 12 weeks.
- Conditions
- Coronary Artery Disease, Atherosclerosis, Hyperlipidemias
- Trial name
- CHORAL (NCT04073134)
- Testing
- Evolocumab
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- Imperial College London
Coronary Artery Disease
Multislice Computed Tomography Assessment of PCSK9 Inhibition on Coronary Perfusion
The MARKOV study is an investigator-sponsored single arm, prospective study to assess the effect of evolocumab on the improvement in coronary flow (FFRCT) after 18 and 36 months of treatment in patients with coronary…
- Trial name
- MARKOV (NCT03851263)
- Testing
- Evolocumab
- Sponsor
- ECRI bv
Heart Failure, Ventricular Function, Left
Resistance Exercise With Blood Flow Restriction by Vascular Occlusion on Myocardial Function in Heart Failure With Reduced Ejection Fraction
Exercise is essential in cardiac rehabilitation for heart failure patients.Aerobic training and resistance training are both recommended.
- Trial name
- ERFOCARD (NCT07118410)
- Testing
- Application of a vascular restriction device during resistance training
- Where
- France
- Volunteers
- 38 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Borderline High LDL-cholesterol
Effects of Ubiquinol and Ubiquinone on Vascular Function in Healthy Adults With Borderline High LDL-Cholesterol
This randomized, double-blind, placebo-controlled clinical trial will evaluate the effects of Ubiquinol and Ubiquinone on vascular endothelial function in generally healthy adults with borderline high LDL-cholesterol.
- Trial name
- NCT07881601
- Testing
- Ubiquinol, Ubiquinone
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- SF Research Institute, Inc.
Type 2 Diabetes
Effect of Angiotensin Converting Enzyme Inhibitor, Lisinopril, on Renal Blood Flow and Its Correlation With Proteinuria Reduction in Subjects With Type 2 Diabetes and Kidney Disease
The purpose of the study is to investigate the effect of a blood pressure medication, Lisinopril, or similar drugs in that class, on the flow of blood to the kidneys.
- Trial name
- NCT01101269
- Testing
- ACEI or ARB, Lisinopril
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Anastomotic Leak
Quantification of Anastomostic Blood Flow With Fluorescence Imaging in Low Anterior Resection for Rectal Cancer
A serious and life-threatening complication to rectal surgery is anastomotic leakage, AL. In Denmark, approximately 800 patients every year, are operated for rectal cancer, 50% of these with resection and anastomosis.
- Trial name
- FILAR (NCT05627934)
- Testing
- qICG
- Where
- Denmark
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Decreased Vascular Flow
Interferential Electrical Stimulation and Vasodilatation in Healthy Individuals
Interferential electrical stimulation (IES) increases local blood flow. It is not known whether increases in blood flow may be caused by inhibition of sympathetic activity, mediated by muscle metaboreflex activity.
- Trial name
- InterM (NCT01450371)
- Testing
- Interferential
- Where
- 3 sites in Brazil
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Refractory Angina Pectoris, Ischemic Heart Disease
Cardiac Shock Wave Treatment in Patients With Reduced Coronary Flow Reserve
The purpose of the study is to assess the feasibility of Cardiac Shock Wave Treatment in patients with anginal chest pain and evidence of abnormal myocardial perfusion under stress in the absence of significant stenoses of the…
- Conditions
- Refractory Angina Pectoris, Ischemic Heart Disease, Coronary Artery Disease
- Trial name
- NCT03438500
- Testing
- Cardiac Extracorporeal Shockwave Therapy (Modulith SLC)
- Where
- Germany
- Sponsor
- Storz Medical AG
Improve Endothelial Function and Decrease Vascular Stenosis
Phosphodiesterase Type 5 Inhibition to Improve Endothelial Function and Vascular Remodeling in Chronic Kidney Disease and End Stage Renal Disease Patients Requiring New Arteriovenous Fistula
Patients with stage IV and V chronic kidney disease and end stage renal disease requiring hemodialysis at University of Alabama at Birmingham (UAB) Dialysis Clinics will be recruited from the UAB Vascular Access Clinic, which has…
- Trial name
- NCT02414204
- Testing
- Sildenafil
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Alabama at Birmingham
Physiology, Ocular, Microcirculation
Role of Nitrogen Oxide (NO) in the Control of Choroidal Blood Flow During a Decrease in Ocular Perfusion Pressure
Autoregulation is the ability of a vascular bed to maintain blood flow despite changes in perfusion pressure. For a long time it had been assumed that the choroid is a strictly passive vascular bed, which shows no autoregulation.
- Conditions
- Physiology, Ocular, Microcirculation, Regional Blood Flow, Autoregulation
- Trial name
- NCT00810927
- Testing
- Suction cup application, Laser Doppler flowmetry, Measurement of intraocular pressure
- Where
- Austria
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Citrulline, Blood Flow
Effect of L-Citrulline on Vascular Function
The objective of this project is to determine the importance of peripheral vascular function on gait performance in older adults.
- Conditions
- Citrulline, Blood Flow, Aging
- Trial name
- NCT03127917
- Testing
- L-citrulline
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Texas Tech University
Arteriovenous Fistula
The Effectiveness of FRAME FR for AVF Repair in High-Flow Reduction & Stabilization, A Prospective Trial
Patients with end-stage renal disease require permanent vascular access to enable safe and effective hemodialysis. An arteriovenous fistula (AVF), where a vein is mobilized and connected to an artery in the arm, is considered the…
- Trial name
- FRAME (NCT04795401)
- Testing
- FRAME FR IFU
- Where
- France
- Volunteers
- 21 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Intracerebral Hemorrhage
Intracerebral Hemorrhage Acutely Decreasing Arterial Pressure Trial
Rationale: Management of blood pressure (BP) in the acute phase of intracerebral hemorrhage (ICH) remains controversial. Although it has been established that there is a transient moderate reduction of perihematoma cerebral blood…
- Trial name
- ICH ADAPT (NCT00963976)
- Testing
- labetalol/hydralazine/enalapril
- Where
- 4 sites in Canada
- Volunteers
- 74 people
- Sponsor
- University of Alberta
Decreased Vascular Flow
Optic Nerve Head Autoregulation During Changes in Arterial Blood Pressure
Constant despite changes in perfusion pressure. It is observed in many vascular beds of the human body to prevent that variations in perfusion pressure are directly transmitted into changes in blood flow.
- Trial name
- NCT01663883
- Testing
- Isometric exercise
- Where
- Austria
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Ischemic Stroke
Augmenting Cerebral Blood Flow to Preserve the Penumbra Trial
The primary objective of the study is to demonstrate that SPG (Sphenopalatine Ganglion) stimulation started within 6 hours from stroke onset slows the expansion of the infarct core volume in acute ischemic stroke.
- Trial name
- ImpACT-P (NCT04014621)
- Testing
- SPG stimulation
- Where
- 4 sites in Georgia
- Volunteers
- 100 people
- Sponsor
- BrainsGate
Periferal Arterial Occlusive Disease, PAOD
Effect on Blood Flow Using the FlowOx™ Device in Patients With Reduced Peripheral Circulation in the Lower Leg
A study to assess the effect of negative pulsating pressure therapy on patients with impaired blood flow to the leg caused by arterial disease, to see if the FlowOx device will increase the blood flow to the leg in these patients.
- Trial name
- NCT01893840
- Testing
- FlowOx
- Where
- Norway
- Volunteers
- 20 people
- Sponsor
- Otivio AS
Heart Failure
Study to Evaluate the Effects of AZD3427 in Patients With Heart Failure
The primary purpose of this mechanistic study is to evaluate the vasodilatory effects of AZD3427 in adult patients with heart failure and will be performed at approximately 2 study sites in the United Kingdom.
- Trial name
- NCT04890548
- Testing
- AZD3427
- Sponsor
- AstraZeneca
Brain Aneurysm
Reduction in Volume and Prolonged Shrinkage of Brain Aneurysms After Combined Endovascular Interventions
The goal of this observational study is to learn about the long-term effects of combined endovascular interventions in participants over the age of 18 who take endovascular interventions employing endoluminal flow diverter…
- Trial name
- NCT06541275
- Testing
- brain MRI and CT
- Where
- Kazakhstan
- Volunteers
- 102 people
- Sponsor
- National Centre for Neurosurgery, Republic of Kazakhstan