Clinical trials: Deep Brain Stimulation
Dystonia
Alteration of Deep Brain Stimulation Parameters for Dystonia
Deep brain stimulation (DBS) involves placing electrodes into the brain. Through these electrodes, artificial electrical signals are chronically delivered into deep brain regions in order to alter abnormal brain activity.
- Trial name
- NCT00971854
- Testing
- Alteration of deep brain stimulator settings
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Sleep Disorder, Hyperphagia
Effect of Deep Propioceptive Stimulation in Prader-Willi Syndrome
The main objective is to study the effect of deep propioceptive stimulation with a heavy blanket for 2 weeks compared with a placebo blanket on sleep quality and behavior in patients with PWS
- Conditions
- Sleep Disorder, Hyperphagia, Behavior Disorders
- Trial name
- NCT05044000
- Testing
- Deep propioceptive stimulation
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Corporacion Parc Tauli
Healthy Volunteers
Temporal Interference Methods for Non-invasive Deep Brain Stimulation, Study 1.3
This grant aims to develop a line of research using temporal interference (TI) electrical neurostimulation technology to understand the causal role of deep brain structures in cognition.
- Trial name
- NCT07594795
- Testing
- Temporal Interference (TI) Electrical Stimulation - dACC 20 Hz TI Active, Temporal Interference (TI) Electrical Stimulation - dACC Comparison Frequency TI Active
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Indiana University
Parkinson's Disease (PD), Essential Tremor
LIFUS For Neurological Disorders
Low intensity focused ultrasound (LIFUS) has the potential to be used as a means of non-invasive neuro-modulation. To this day, the use of LIFUS is under investigation.
- Conditions
- Parkinson's Disease (PD), Essential Tremor, Orthostatic Tremor, Dystonia
- Trial name
- NCT07417280
- Testing
- LIFUS
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Refractory Epilepsy
Deep Brain Stimulation of the Anterior Nucleus of the Thalamus in Intractable Epilepsy
Deep Brain Stimulation (DBS) of the anterior nucleus of the thalamus (ANT) has been proposed in patients with severe intractable epilepsy.
- Trial name
- NCT04771065
- Where
- France
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Visual Attention in Parkinson's Disease
Visual Selective Attention in Parkinson's Disease
Parkinson's disease (PD), which is generally considered to be a motor disorder, is now known to be accompanied in many instances by a variety of cognitive defects.
- Trial name
- VSA-PD (NCT01135407)
- Testing
- Recording during computerized tests
- Where
- France
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Obsessive Compulsive Disorder
Deep Brain Stimulation of NAc/ALIC to Prevent Treatment-Refractory Obsessive Compulsive Disorder
Nucleus accumbens/anterior limb of internal capsule play important roles in the process of treatment-refractory obsessive compulsive disorder, deep brain stimulation of nucleus accumbens/anterior limb of internal capsule will…
- Trial name
- NCT02601677
- Testing
- Deep brain stimulation, Fluoxetine
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Tang-Du Hospital
Essential Tremor, Parkinson's Disease (PD)
Attention and Eye Movement in Parkinson's Disease
The goal of this observational and interventional study is to understand how therapeutic deep brain stimulation (DBS) affects attention, perception and cognition in participants with Parkinson's disease (PD) and non-PD movement…
- Conditions
- Essential Tremor, Parkinson's Disease (PD), Dystonias
- Trial name
- NCT06899022
- Testing
- Normal therapeutic DBS, Reduced current DBS, Reduced frequency DBS
- Where
- United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Parkinson's Disease
Effect of Deep Brain Stimulation on Gait of Patients With Parkinson's Disease Depending on Electrode Location in Subthalamic Area
Deep brain stimulation of STN (subthalamic nucleus) at high frequencies generally improved gait in parkinsonian patients. However, sometimes the investigators observed a gait aggravation either with using high voltage and high…
- Trial name
- NCT01782638
- Testing
- deep brain stimulation
- Where
- France
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Parkinson Disease
Frequency Effect of STN-DBS Through the Dual System on FOG in PD
We aim to confirm the effect for FOG by changing the frequency through the dual-system approach in PD patients after STN-DBS.
- Trial name
- NCT04285099
- Testing
- Application of dual system in frequency A, Application of dual system in frequency B
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Parkinson's Disease
Motor Performance in Parkinson's Disease After High Intensive Exercise or Deep Brain Stimulation
The purpose of this study is (1) to provide quantitative information of the motor manifestations of Parkinson's disease and (2) to quantify the effect of high intensive antigravity locomotor exercise or Deep Brain Stimulation…
- Trial name
- NCT01446549
- Testing
- High intensive antigravity locomotor exercise, Deep Brain Stimulation
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Nicotine Use Disorder, Substance Use Disorders
Temporal Interference Neurostimulation and Addiction
This project aims to develop a line of research using new non-invasive neurostimulation technology to treat adults with opioid use disorders (OUDs).
- Trial name
- NCT04432064
- Testing
- Active TI-NDBS, tDCS
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Indiana University
Parkinson's Disease
Hub and Spoke, Comparative Outcomes for Parkinson's Disease Treated With Deep Brain Stimulation
Outcomes study to test the hypothesis that patients first identified by community-based neurologists, implanted by a networked movement disorders center, and then managed by the same community-based neurologist will have clinical…
- Trial name
- Hub&Spoke (NCT02541617)
- Testing
- Programming by community Neurologist, Standard of care
- Volunteers
- healthy volunteers welcome
- Sponsor
- Vanderbilt University
Parkinson Disease, Movement Disorders
Cognitive Decline Following Deep Brain Stimulation
This research study aims to identify MRI-based brain biomarkers that predict an individual's response to Deep Brain Stimulation (DBS). In particular, this study will focus on changes in cognition associated with DBS.
- Trial name
- NCT05822388
- Testing
- Deep Brain Stimulation Surgical Procedures as Part of Routine Clinical Care
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
DYT-1, DYT1
Can Short Latency Afferent Inhibition Give us Clues to Better DYT 1 Dystonia Treatments?
This is a research study using transcranial magnetic stimulation (TMS) to investigate interactions between the sensory system and the motor cortex in primary generalized dystonia (DYT1 dystonia) subjects who undergo deep brain…
- Conditions
- DYT-1, DYT1, DYT 1, Dystonia
- Trial name
- NCT01435681
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Florida
Parkinson Disease, OCD
Role of Basal Ganglia and Thalamus in Perceptual Consciousness and Metacognition
The term perceptual awareness refers to subjective experience... or the phenomenology associated with the processing of a sensory stimulus.
- Conditions
- Parkinson Disease, OCD, Dystonia
- Trial name
- METACTION (NCT04461730)
- Testing
- deep brain stimulation
- Volunteers
- healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Deep Brain Stimulation, PARKINSON DISEASE (Disorder)
Cortical Network Modulation by Subthalamic Nucleus DBS
Deep brain stimulation of the subthalamic nucleus (STN DBS) in Parkinson's disease (PD) can provide substantial motor benefit yet can also produce unwanted mood and cognitive side effects.
- Trial name
- NCT04922411
- Testing
- Deep Brain Stimulation
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Cervical Dystonia
Insights Into Deep Brain Stimulation (DBS) for Cervical Dystonia
The purpose of this research study is to determine the physical brain changes in people with cervical dystonia after deep brain stimulation (DBS) surgery and as compared to healthy controls.
- Trial name
- NCT01671527
- Testing
- Transcranial magnetic stimulation (TMS)
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Florida
Essential Tremor
Functional Brain Network Changes in Patients Undergoing Deep Brain Stimulation for Essential Tremor
The purpose of this study is to collect electrophysiological data related to functional brain network changes in patients undergoing deep brain stimulation for the treatment of essential tremor.
- Trial name
- TRaNCE (NCT06293638)
- Testing
- Alcohol, Alprazolam, Cold Therapy
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Treatment-Resistant Depression
Early Identification of TRD and Construction and Clinical Validation of NTBS Precision Technology
The goal of this clinical trial is to learn about the characteristics, identify early and intervene effectively in time in Treatment-Resistant Depression.
- Trial name
- NCT05777876
- Testing
- non-invasive transcranial deep brain stimulation, Motor cortex stimulation, non-invasive transcranial deep brain stimulation with closed-loop
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University