Clinical trials: Deep Carious Lesions
Indirect Pulp Cap
A Study Comparing Eggshell Based and Gold Standard Materials to Heal Deep Tooth Damage in Adult Molars
This clinical trial will evaluate the effectiveness of eggshell-derived calcium hydroxyapatite compared to calcium hydroxide as indirect pulp capping agent in permanent teeth.
- Trial name
- NCT07183514
- Testing
- eggshell-derived calcium hydroxyapatite, Calcium hydroxide
- Where
- Pakistan
- Volunteers
- 54 people
- Sponsor
- University of Health Sciences Lahore
Caries,Dental, Crown of Tooth With Poor Contour
Clinical and Radiographical Evaluation of CAD-CAM Crowns With and Without Deep Margin Elevation
Deep margin elevation (DME) is a non-invasive restorative technique to relocate the deep cervical margin to a supragingival position using resin composite.
- Conditions
- Caries,Dental, Crown of Tooth With Poor Contour, Broken Teeth, Survival, Prosthesis
- Trial name
- NCT06114030
- Testing
- Deep margin elevation with composite resin and Lithium disilicate glass-ceramic crowns
- Where
- United Arab Emirates
- Volunteers
- 560 people
- Sponsor
- University of Sharjah
Dental Caries
Selective or Stepwise Removal of Deep Caries
Background: For treating deep caries lesions, selective or stepwise, i. e. one- and two-step incomplete excavation seems advantageous compared with complete caries removal.
- Trial name
- NCT02232828
- Testing
- Selective removal, Stepwise removal
- Where
- 4 sites in Germany
- Volunteers
- 300 people
- Sponsor
- Charite University, Berlin, Germany
Dental Caries
A Clinical Study of KH001 for Pulp Preservation and Safety in Deep Dentin Caries
The Purpose of this Study is to Evaluate Pulp Preservation and Safety of KH001 in the Administration of Deep Dentin Caries.
- Trial name
- NCT07751016
- Testing
- KH001
- Where
- South Korea
- Volunteers
- 36 people
- Sponsor
- Seoul National University Dental Hospital
Deep Caries, Carious Exposure of Pulp
Outcome of Selective & Nonselective Caries Removal in Permanent Teeth
Patients presenting with deep decay within permanent teeth presents a common clinical challenge to dentists. The aim of this trial is to compare the success rate of the non-selective caries removal (NSCR) and selective caries…
- Trial name
- RCT-SNCR (NCT06378814)
- Testing
- Selective Caries Removal (No Pulp Exposure), Non-Selective Caries Removal (No Pulp exposure), Partial Pulpotomy (Pulp Exposed)
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- King's College London
Pulpitis - Irreversible
Pulpotomy vs Root Canal Treatment for Teeth With Symptomatic Irreversible Pulpitis
This study is a randomised controlled trial for complete pulpotomy as an alternative to root canal treatment for teeth with clinical diagnosis of symptomatic irreversible pulpitis (i.e.
- Trial name
- NCT05964933
- Testing
- Complete Pulpotomy, Pulpectomy and Root Canal Treatment
- Where
- Singapore
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Deep Carious Lesions, Caries Class I
A Comparative Study of Different Traditional and Bioactive Indirect Pulp Capping Materials
The protection of the dentin-pulp complex consists of the application of one or more layers of specific material between the restorative material and dental tissue to avoid additional challenge to the pulp tissue caused by…
- Conditions
- Deep Carious Lesions, Caries Class I, Caries Class II
- Trial name
- NCT06707311
- Testing
- patients received calcium hydroxide with glass ionomer restorative material, patients received TheraCal LC with glass ionomer restorative material, patients received bioactive bonding with glass ionomer restorative material
- Where
- Egypt
- Volunteers
- 72 people
- Sponsor
- Cairo University
Pulp Exposure, Dental, Deep Dental Caries
Effects of Total and Selective Caries Removal - Requiring or Avoiding Vital Pulp Therapy - on Pulp Vitality and Postoperative Pain in Deep Carious Mature Permanent Teeth: A Split-Mouth Clinical Study
The effect of selective caries cleaning and total caries cleaning on pulp health and post operative pain in teeth with deep caries will be investigated.
- Trial name
- NCT07041905
- Testing
- Total Caries Removal, Selective Caries Removal
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people
- Sponsor
- Cukurova University
Patients With Deep Carious Lesions
Comparative Study Between Biodentine and Mineral Trioxide Aggregate in Direct Pulp Capping
Comparative study between Biodentine and MTA in direct pulp capping of deeply carious teeth.
- Trial name
- NCT02803528
- Testing
- Biodentine, MTA
- Where
- Syria
- Volunteers
- 30 people
- Sponsor
- Damascus University
Ozone, Caries
Effectiveness of the Ozone Application in Two-Visit Indirect Pulp Therapy of Permanent Molars With Deep Carious Lesion
The aim of this study was to evaluate the clinical and microbiological effectiveness of the ozone application in two-visit indirect pulp therapy.
- Trial name
- ozone (NCT03693066)
- Testing
- Ozone, chlorhexidine digluconate, Control
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Izmir Katip Celebi University
Deep Caries
Evaluation of the Remineralizing Effect of Aloe Vera Versus Diode Laser for Management of Deep Carious Lesions.
The present study will be performed to evaluate: The remineralizing effect of Aloe Vera versus Diode laser on deep carious dentin after selective caries removal.
- Trial name
- NCT05327049
- Testing
- no intervention, diode laser, Aloe Vera
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Caries, Dental
Effect of Pulpotomy Using TheraCal Versus MTA on Survival Rate of Cariously-Exposed Vital Permanent Molars
Objective: To assess which is the most efficient pulpotomy medicament on tooth survival in patients with a cariously-exposed vital young permanent molar regarding: absence of postoperative pain, sinus or swelling, internal/…
- Trial name
- NCT03119779
- Testing
- MTA-Anglus, TheraCal
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Cairo University
Deep Caries
Evaluation of Biodentine Versus Glass Ionomer Cement in Treatment of Very Deep Carious Lesions
The aim of this study is to compare the effect of new bioactive dentine substitute (Biodentine) versus glass ionomer cement in very deep carious lesions clinically and radiographically using digital radiography in the terms of…
- Trial name
- NCT02868918
- Testing
- biodentine, glass ionomer cement, DigoraH optium
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Cairo University
Vital Pulp Therapy
Diagnostic Biomarkers to Correlate Molecular Changes and Inflammatory Cascade in the Dental Pulp.
This study aimed to evaluate the molecular changes that occur within the pulp tissue during inflammation and its correlation with vital pulp therapy with its different treatment modalities (Direct pulp capping, Partial Pulpotomy…
- Trial name
- NCT05464797
- Testing
- Pulp therapy, Cytokines level in pulpal blood.
- Where
- Egypt
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Dental Caries in Children
Partial or Complete Excavation of Deep Caries in Primary Molars
Background: The traditional approach of carious lesions with risk for progression has has been to excavate all infected and demineralised tissue before placement of the restoration.
- Trial name
- PBRN (NCT04614285)
- Testing
- Partial excavation
- Where
- Sweden
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Dental Caries in Children, Tooth Diseases
Hall Technique or Modified Hall Technique of Deep Carious Lesions in Primary Molars
The purpose of this randomized clinical trial is to compare the clinical/radiographic success of Hall technique and modified Hall technique in the treatment of primary molars with deep dentine carious lesions in children…
- Conditions
- Dental Caries in Children, Tooth Diseases, Tooth Demineralization, Stomatognathic Diseases
- Trial name
- NCT05220865
- Testing
- Hall Technique, Modified Hall Technique
- Where
- Turkey (Türkiye)
- Volunteers
- 268 people, healthy volunteers welcome
- Sponsor
- Ankara Yildirim Beyazıt University
Gingivitis
Cervical Carious Lesions Restored With Calcium Silicate Based Cement (Biodentine) Compared With Glass-ionomer Cement
This study will test if applying calcium silicate cements (Biodentine) to restore cervical carious lesions might adversely affect the gingival health in comparison with conventionally used tooth colored material (GIC)
- Trial name
- NCT03418246
- Testing
- GIC, Biodentine
- Volunteers
- 28 people
- Sponsor
- Jordan University of Science and Technology
Dental Caries
Pulp Protection in Selective Carious Tissue Removal
Although selective removal of carious tissue to soft dentin (SRCT-S) has been proposed as the standard of care for the management of deep dentin caries, it is unclear whether a cavity liner is necessary.
- Trial name
- PULPROTECT (NCT04250142)
- Testing
- Self-etching Adhesive, Glass Ionomer
- Where
- Chile
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- University of Talca
Dental Caries, Dental Pulp Exposure
Stepwise and One Step Techniques In Deep Dentin Lesion
This double blind, randomized, controlled clinical trial aimed to observe the success of stepwise (SW) and one step (OneS) excavation techniques in the management of deep dentin caries.
- Trial name
- NCT04351048
- Testing
- Stepwise Excavation, One Step Excavation
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- TIJEN PAMIR
Dental Caries in Children
Experimental Research on Deep Carious Lesion Treatment of Molars
Maintaining dental pulp vitality is crucial for tooth preservation and functionality. Untreated dental caries may lead to pulp necrosis and infection, affecting children's growth and well-being.
- Trial name
- VITAPULP (NCT03626740)
- Testing
- TheraCal, MTA
- Where
- Romania
- Volunteers
- 40 people
- Sponsor
- Carol Davila University of Medicine and Pharmacy