Clinical trials: Deep Inferior Epigastric Perforator
Breast Reconstruction, Abdominal Wall Morbidity
Changes To The Abdominal Wall After DIEP Flap Breast Reconstruction
The purpose of this study was to perform an evaluation of the structural changes in the abdominal wall after harvesting a DIEP flap in breast reconstruction.
- Trial name
- NCT02563977
- Testing
- 2 year postop CT scan of the abdomen
- Where
- Norway
- Volunteers
- 14 people
- Sponsor
- Oslo University Hospital
Perioperative Tissue Oxygenation
Improving Tissue Oxygenation in Breast Reconstruction Surgery
Breast reconstruction is an integral part of breast cancer care. There are two main types of breast reconstruction: alloplastic (using implants), and autologous (using patient's tissue).
- Trial name
- NCT04020172
- Testing
- Dobutamine
- Where
- 2 sites in Canada
- Volunteers
- 40 people
- Sponsor
- Dr. Glenio Mizubuti (MD, PhD)
Breast Neoplasms, Mammaplasty
ARTISS a Single-centre Randomised Control Study
The Influence of ARTISS on post-operative abdominal drainage and seroma formation in DIEP/MS-TRAM free flap breast reconstruction patients.
- Trial name
- ARTISS (NCT04931615)
- Testing
- ARTISS 4mL Fibrin Sealant Topical Solution (Frozen), no ARTISS
- Where
- United Kingdom
- Volunteers
- 135 people
- Sponsor
- Mid and South Essex NHS Foundation Trust
Mammaplasty, Microsurgery
Perioperative Management of DIEP Flaps
By comparison of two different protocols with diverse fluid/ catecholamine administration limits (fluid restriction vs. catecholamine restriction with target systolic blood pressure > 100 mmHg) the investigators would like to…
- Conditions
- Mammaplasty, Microsurgery, Free Tissue Flaps
- Trial name
- NCT03118024
- Testing
- Crystalloid Solutions, Catecholamines
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Regensburg
Breast Cancer
Outcomes of a Deep Inferior Epigastric Perforator Flap Program
The purpose of this study is to analyze an institution's experience with starting a subspecialized DIEP flap program.
- Trial name
- NCT00543907
- Where
- United States
- Volunteers
- 977 people
- Sponsor
- Beth Israel Deaconess Medical Center
Deep Inferior Epigastric Artery Perforator Flap Breast Reconstruction
The Effect of Volatile Anesthesia and Total Intravenous Anesthesia on Shedding of the Endothelial Glycocalyx in Patients Undergoing Mastectomy and Breast Reconstruction Using Deep Inferior Epigastric Artery Perforator Free Flap
The aim of this study was to investigate the effects of total intravenous and inhalation anesthesia on the damage of endothelial glucocorticoids by comparing the concentration of syndecan-1 in patients undergoing mastectomy and…
- Trial name
- NCT05136508
- Testing
- Propofol, Sevoflurane
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Yonsei University
Breast Cancer
CT-Angiography Prior to DIEP Flap Breast Reconstruction
This study will Investigate whether or not preoperative computed tomography (CT) angiography will lower operative times and post operative complications for breast reconstruction performed with a deep inferior epigastric artery…
- Trial name
- NCT02883387
- Testing
- Preoperative CT angiography, No Preoperative Imaging
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- University of Colorado, Denver
Breast Neoplasms, Ischemia-Reperfusion Injury
DIEP Flap Breast Reconstruction: Perioperative Biomarkers and Outcomes
Brief Summary This observational study will follow patients who undergo DIEP flap breast reconstruction to better understand a common surgical challenge called ischemia-reperfusion (I/R) injury.
- Conditions
- Breast Neoplasms, Ischemia-Reperfusion Injury, Postoperative Complications, Wound Healing
- Trial name
- NCT07263347
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Hubei Cancer Hospital
Mammaplasty
Accuracy of Deep Inferior Epigastric Artery Perforator Mapping - Color Doppler Ultrasound Versus CT Angiography
The goal of this clinical trial is to compare the accuracy and contribution of Color Doppler Ultrasound (CDU) guided Deep Inferior Epigastric Artery (DIEA) perforator mapping with or without mapping using Computer Tomography…
- Trial name
- CDUxCTA (NCT05687006)
- Testing
- Colour Doppler Ultrasound
- Where
- Czechia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- St. Anne's University Hospital Brno, Czech Republic
Breast Reconstruction, Deep Inferior Epigastric Perforator
Synthetic Electrospun Fiber Matrix in Abdominal Wall Donor Sites for Breast Reconstruction
This prospective single-arm pilot study will evaluate the application of meshed 5 × 7 cm Restrata® sheets to the abdominal wall donor site following deep inferior epigastric perforator (DIEP) or abdominal wall autologous free…
- Conditions
- Breast Reconstruction, Deep Inferior Epigastric Perforator, Breast Reconstruction After Mastectomy
- Trial name
- NCT07851415
- Testing
- Restrata®
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Washington University School of Medicine
Arterial Hypotension
Effect of Phenylephrine Versus Norepinephrine on Venous Return
Induction of general anesthesia often induces a decrease in the mean arterial blood pressure (MAP) caused by arterial and venous dilatation.
- Trial name
- NCT03872570
- Testing
- Phenylephrine, Norepinephrine
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- Algemeen Ziekenhuis Maria Middelares
Hypotension During Surgery
Goal-directed Fluid Therapy During Deep Inferior Epigastric Perforator (DIEP) Free Flap Breast Reconstruction
Adequate free flap perfusion during Deep Inferior Epigastric Perforator (DIEP) flap breast reconstruction surgery requires maintaining blood pressure above 100 mmHg and avoiding excessive fluid administration.
- Trial name
- GDFT DIEP-flap (NCT06080178)
- Testing
- Plasma-lyte (static group), Norepinephrine (static group), Plasma-lyte (dynamic group)
- Where
- Belgium
- Volunteers
- 82 people
- Sponsor
- Algemeen Ziekenhuis Maria Middelares
Mammary Reconstruction
Use of the Venous Coupler in Breast Reconstruction by Means of a Deep Inferior Epigastric Perforator: Reduction of Surgery Length and Venous Thromboses ?
This is a retrospective study performed on medical records, in order to compare the number of venous thromboses, the surgery duration, the complications rate and the duration of anastomosis in breast reconstructive surgeries by…
- Trial name
- NCT03340623
- Testing
- Venous coupler
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- Brugmann University Hospital
Breast Cancer
BENEFIT OF MECHANICAL ISCHEMIC PRECONDITIONING ON TOLERANCE OF ADIPOSE TISSUE TO ISCHEMIA REPERFUSION OF TYPE DIEP (DEEP INFERIOR EPIGASTRIC PERFORATOR) FREE FLAPS.
Breast cancer is the most common cancer amongst women in terms of frequency, with more than 50 000 newly diagnosed cases per year in France. The average 5-year survival rate for women with breast cancer is around 85%.
- Trial name
- PRIMIDIEP (NCT05373069)
- Testing
- Mechanical ischemic preconditioning of diep-type flap
- Where
- France
- Volunteers
- 18 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sensitisation
DIEP (Deep Inferior Epigastric Artery Perforator) Flap Sensory Recovery Following Neurotization
The purpose of this study is to compare the sensory return of DIEP flaps with nerve connection to DIEP flaps with no nerve connection to see which is better.
- Trial name
- NCT04818190
- Testing
- Sensory neurotization
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of Manitoba
Deep Inferior Epigastric Perforator Flap Reconstruction
Case Series Comparing Drains to TissuGlu® in a Donor Site DIEP Flap Breast Reconstruction Procedure
To evaluate the safety and effectiveness of a lysine-derived urethane adhesive (TissuGlu® Surgical Adhesive) as a less invasive alternative to surgical drains in the abdominal donor site for deep inferior epigastric perforator…
- Trial name
- NCT03481140
- Testing
- TissuGlu Surgical Adhesive
- Volunteers
- 58 people
- Sponsor
- Cohera Medical, Inc.
Breast Reconstruction
Impact of Drainless Donor Abdominal Site in Deep Inferior Epigastric Perforator (DIEP) Flap on Complications and Duration of Hospital Stay.
Inserting surgical drains is an ancient approach used across different specialties because of its many advantages such as discharge of fluid accumulation, appraising and qualifying drain capacities, lowering infection…
- Trial name
- NCT06468488
- Testing
- DIEP flap surgery without drain, DIEP flap surgery with drains
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Breast Cancer
The Effects of Indocyanine Green Angiography (IGA) on Deep Inferior Epigastric Artery Perforator (DIEP) Flap Design and Post-Operative Fat Necrosis
The aim of this study is to prospectively evaluate the effect of intra-operative Indocyanine green angiography (IGA) on both flap design and rate of post-operative fat necrosis in patients undergoing autologous breast…
- Trial name
- SPY (NCT02144961)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Washington
Breast Cancer, Perforator Flap
Deep Inferior Epigastric Artery Flap for Breast Reconstruction
Background: There is no consensus on the duration of prophylactic antibiotics for autologous breast reconstruction after mastectomy.
- Conditions
- Breast Cancer, Perforator Flap, Anti-Infectives Adverse Reaction, Infections
- Trial name
- NCT05088239
- Testing
- prophylactic antibiotics duration
- Volunteers
- 108 people
- Sponsor
- Chiayi Christian Hospital
Breast Cancer, Exercise
The Effect of a Post-operative Exercise Programme Versus Standard Care on Physical Fitness of Patients With Breast Cancer Undergoing Deep Inferior Epigastric Perforator (DIEP) Flap Reconstruction Surgery
All patients undergoing mastectomy for breast cancer should be offered the option of reconstructive surgery. The Deep Inferior Epigastric Perforator Flap or DIEP reconstruction as it is commonly referred to, is becoming the…
- Trial name
- EXERCISE DIEP (NCT07672392)
- Testing
- Structured individualised 12-week post operative exercise programme
- Where
- Ireland
- Volunteers
- 78 people
- Sponsor
- Royal College of Surgeons, Ireland