Clinical trials: Deep Infiltrating Endometriosis
Endometriosis
A Study of the Potential Risk Factors Linked to the Development of Severe Forms of Endometriosis
This study will aim to identify genetic, medical, dietary and environmental factors associated with the development of endometrioma and/or deep infiltrating endometriosis in order to move towards early diagnosis and…
- Trial name
- FEELING (NCT01351051)
- Where
- 7 sites in China, France and 1 more
- Volunteers
- 1,008 people
- Sponsor
- Ipsen
Endometriosis, Endometriosis-related Pain
Intraoperative Sono-assessment In Deep Endometriosis
Deep infiltrating endometriosis (DIE) involving the bowel, particularly the rectosigmoid region, is associated with significant gastrointestinal symptoms and impaired quality of life.
- Conditions
- Endometriosis, Endometriosis-related Pain, Pelvic Pain Syndrome, Endometriosis, Rectum
- Trial name
- INSIDE (NCT07517081)
- Volunteers
- 57 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Endometriosis
Laparoscopic Segmental Bowel Resection for Deep Infiltrating Colorectal Endometriosis
This study is executed to evaluate the outcome on quality of life, pain, sexuality, pregnancy rate and recurrence rate after a fertility sparing multidisciplinary CO2 laser laparoscopic radical excision of deep infiltrating…
- Trial name
- NCT00462176
- Testing
- multidisciplinary laparoscopy, Questionnaires
- Where
- Belgium
- Volunteers
- 45 people
- Sponsor
- University Hospital, Gasthuisberg
Deep Endometriosis, Surgery
Imaging Comparison for the Preoperative Planning and Diagnosis of DIE: a Multicenter Retrospective Study.
Several centers in Belgium use both transvaginal ultrasound (TVS) and magnetic resonance imaging (MRI) for the preoperative diagnosis of deep infiltrating endometriosis (DIE), while other centers rely almost exclusively on TVS.
- Conditions
- Deep Endometriosis, Surgery, Transvaginal Ultrasound, MRI
- Trial name
- NCT06994091
- Where
- Belgium
- Volunteers
- 200 people
- Sponsor
- Ziekenhuis Oost-Limburg
Endometriosis
Physiotherapy of the Pelvic Floor in Women With Deep Infiltrating Endometriosis
The aim of our study is to evaluate the impact of pelvic floor physiotherapy in symptomatic patients affected by deep infiltrating endometriosis, using 3D/4D transperineal ultrasound for evaluation of pelvic floor morphometry…
- Trial name
- endofisio-01 (NCT03572075)
- Testing
- assessment of symptoms at the first medical examination, pelvic floor physiotherapy, standard care protocol
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Endometriosis
Functional Outcome in Patients That Underwent Laparoscopic Sigmoid and/or Rectum Resection
Questionnaire To assess the functional outcome in patients that underwent laparoscopic sigmoid and/or rectum resection.
- Trial name
- NCT01953250
- Where
- Belgium
- Volunteers
- 143 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Endometriosis, Endometriosis of Colon
Intraoperative vs Transvaginal Ultrasound in Rectosigmoid Endometriosis
Deep infiltrating endometriosis (DIE) of the rectum and rectosigmoid colon represents one of the most severe forms of endometriosis and often requires surgical management when symptomatic and unresponsive to medical therapy.
- Conditions
- Endometriosis, Endometriosis of Colon, Endometriosis; Bowel, Endometriosis, Rectum
- Trial name
- INTREND (NCT07517055)
- Volunteers
- 98 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Pelvic Endometriosis, Endometriosis Outside Pelvis
Near-infrared Fluorescence Imaging as a Supportive Tool for Localisation of Deep Infiltrating Endometriosis During Laparoscopy
The aim of the study is to establish a new and more accurate method to visualize the peritoneal changes caused by endometriosis using Indocyanine Green mediated fluorescence imaging.
- Trial name
- NCT03332004
- Testing
- Indocyanine Green
- Where
- Italy
- Volunteers
- 27 people
- Sponsor
- Catholic University of the Sacred Heart
Adenomyosis of Uterus
Association of Ultrasound Features of the Myometrium Suggestive of Adenomyosis and Clinical Symptoms
The goal of this study/research is to assess the relationship between ultrasound features of the myometrium suggestive of adenomyosis and clinical symptoms of adenomyosis and to establish a reporting system for adenomyosis…
- Trial name
- MUSA3 (NCT07397715)
- Where
- 5 sites in Belgium, Poland and 2 more
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Swiss GO Trial Group
Endometriosis, Endometriosis (Diagnosis)
Deep Endometriosis Affecting the Urogenital Tract: Long-term Outcomes and Impact on Renal Function
Endometriosis is a chronic estrogen-dependent disease characterized by the presence and growth of endometrium-like tissue outside the uterine cavity.
- Conditions
- Endometriosis, Endometriosis (Diagnosis), Urinary Tract Diseases
- Trial name
- RENDO (NCT07776574)
- Where
- Czechia
- Volunteers
- 20 people
- Sponsor
- Charles University, Czech Republic
Deep Infiltrating Endometriosis, Pelvic Pain, Dysmenorrhea Dyspareunia
Nerve Fiber Density in DIE Nodules & Pelvic Pain
Deep infiltrating endometriosis (DIE) is a highly symptomatic form of endometriosis linked to severe dysmenorrhea, dyspareunia, dyschezia, dysuria, and chronic pelvic pain.
- Trial name
- DIENerveDens (NCT07274956)
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 65 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Endometriosis
Evaluation of New Biomarkers in Stage 3 and 4 Endometriosis
The diagnostic value of Annexin V, sVCAM-1, sICAM-1, vascular endothelial growth factor and Proinflammatory cytokines (TNF-a and interleukin-6) in ovarian endometriosis and deep infiltrating endometriosis, their levels in…
- Trial name
- NCT05312528
- Testing
- endometriosis surgery, other benign condition surgeries
- Where
- Turkey (Türkiye)
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Bagcilar Training and Research Hospital
Pelvic Endometriosis, Endometriosis Outside Pelvis
Prospective Evaluation of Near-infrared Fluorescence Imaging Use as a Supportive Tool in Deep Infiltrating Endometriosis Surgery
The aim of the study is to establish a new and more accurate method to visualize the peritoneal changes caused by endometriosis using Indocyanine Green mediated fluorescence imaging.
- Trial name
- GRE-Endo-2 (NCT03935165)
- Testing
- Indocyanine Green
- Where
- Italy
- Volunteers
- 51 people
- Sponsor
- Catholic University of the Sacred Heart
Deep Infiltrating Endometriosis (DIE), Infertility
Ultra-Long GnRH-a Pretreatment for FET Outcomes in Patients With Deep Infiltrating Endometriosis
Deep infiltrating endometriosis is a severe form of endometriosis that may reduce fertility and negatively affect pregnancy outcomes after assisted reproductive treatment.
- Trial name
- DIE-GnRHa-FET (NCT07696351)
- Testing
- Triptorelin (GnRH agonists), Hormone Replacement Therapy (HRT)
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Li-jun Ding
Endometriosis
Improvement in Quality of Life and Pain Scores After Laparoscopic Management of Deep Infiltrating Endometriosis
This is a retrospective cohort study that evaluates the postoperative pain findings of a consecutive series of laparoscopic surgeries for deep infiltrating endometriosis (DIE).
- Trial name
- NCT04062916
- Testing
- BSGE pelvic pain questionnaire and VAS scores
- Where
- Turkey (Türkiye)
- Volunteers
- 65 people
- Sponsor
- Acibadem Fulya Hastanesi
Deep Infiltrating Endometriosis With or Without Bowel Involvement
Intraoperative Ultrasound in Bowel Deep Endometriosis
This study investigates the use of intraoperative transvaginal (IOTVUS) and/or endorectal ultrasound (IOERUS) in the surgical treatment of bowel deep infiltrating endometriosis (DIE).
- Trial name
- NCT06876376
- Testing
- intraoperative ultrasound for the assessment of bowel deep infiltrating endometriosis
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- Fundacion Dexeus
Endometriosis
Quality of Life in Patients Undergoing Colorectal Resection for Deep Infiltrating Endometriosis
The aim of this study is to evaluate the quality of life of patients undergoing colorectal resection for deep infiltrating endometriosis of the bowel.
- Trial name
- ENDO-RESECT (NCT03824054)
- Testing
- colorectal resection
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Catholic University of the Sacred Heart
Endometriosis
Quinagolide Vaginal Ring on Lesion Reduction Assessed by MRI in Women With Endometriosis/Adenomyosis
This will be a randomized, double-blind, placebo-controlled, proof-of-mechanism phase 2 trial investigating the effect of quinagolide extended-release vaginal ring on reduction of lesions assessed by high-resolution magnetic…
- Trial name
- QLARITY (NCT03749109)
- Testing
- Quinagolide 1080 µg
- Where
- 11 sites in Denmark, Germany and 2 more
- Volunteers
- 67 people
- Sponsor
- Ferring Pharmaceuticals
Endometriosis
Treatment by HIFU With Focal One® of Posterior Deep Infiltrating Endometriosis Lesions With Intestinal Involvement.
Deep invasive endometriosis (DIE) includes lesions of the rectosigmoid. Theses lesions are associated with painful symptoms that can alter quality of life.
- Trial name
- NCT03613298
- Testing
- HIFU (Focal One®)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- EDAP TMS S.A.
Deep Endometriosis, Infertility, Female
Impact of Operation on Fertility for Women With Severe Endometriosis
The EFFORT study compares the impact on fertility of operation or fertility treatment (IVF, in vitro fertilization) in a multicenter randomized controlled trial.
- Trial name
- EFFORT (NCT04610710)
- Testing
- Operation, Fertility treatment
- Where
- 3 sites in Denmark, France
- Volunteers
- 38 people
- Sponsor
- Horsens Hospital