Clinical trials: Deep Sedation
Deep Sedations, Conscious Sedation
Comparison of Safety and Efficacy for Different Sedation Regimens During Colonoscopy
This is a randomized, double-blinded, prospective study which will be conducted at the Department of Gastroenterology, King Saud Hospital, Unaizah, Qassim, Saudi Arabia.
- Conditions
- Deep Sedations, Conscious Sedation, Colonoscopy
- Trial name
- NCT06763705
- Testing
- Midazolam, Propofol, Fentanyl
- Where
- Saudi Arabia
- Volunteers
- 183 people
- Sponsor
- Qassim Health Cluster
Pulsed-field Ablation, Deep Sedation
Safety And FEasibility of a Simplified Deep Sedation Protocol for Pulsed-Field Ablation
The aim of the SAFE-PFA study is to demonstrate the feasibility and safety of a simplified deep-sedation protocol for pulsed-field ablation of atrial fibrillation, with a specific focus on patient-reported outcomes.
- Conditions
- Pulsed-field Ablation, Deep Sedation, Atrial Fibrillation (AF)
- Trial name
- SAFE-PFA (NCT07633548)
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Caen
Deep Sedation, High Flow Nasal Canula
HFNO Flow Rates and Cerebral Oxygenation During Deep Sedation for Cystoscopy
For Patients and Families This study aims to investigate how high-flow oxygen therapy affects oxygen levels, especially brain oxygenation, during cystoscopy procedures performed under sedation.
- Conditions
- Deep Sedation, High Flow Nasal Canula, Cerebral Oxygenation, PSI
- Trial name
- NCT07630038
- Testing
- High-Flow Nasal Oxygen 40 L/min (HF40), High-Flow Nasal Oxygen 55 L/min (HF55), High-Flow Nasal Oxygen 70 L/min (HF70)
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Firat University
Atrial Fibrillation, Electric Countershock
BIS-Guided Sedation Versus Standard Clinical Sedation During Elective Electrical Cardioversion for Atrial Fibrillation
Electrical cardioversion (ECV) is a standard procedure used to restore normal heart rhythm in patients with atrial fibrillation (AF) by delivering a brief electrical shock to the heart.
- Conditions
- Atrial Fibrillation, Electric Countershock, Deep Sedation
- Trial name
- BIS-ECV-RCT (NCT07569016)
- Testing
- BIS-guided propofol sedation, Clinical-guided propofol sedation
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Istanbul University - Cerrahpasa
Deep Sedation
Airway Management During Deep Sedation in Hysteroscopy
Hysteroscopy is used to examine and treat uterine diseases. Because of severe pain due to uterine distention and cervical dilatation, deep sedation usually be provided during this procedure.
- Trial name
- NCT05701839
- Testing
- face mask ventilation, nasopharyngeal tube ventilation, oxygen saturation monitoring
- Where
- China
- Volunteers
- 400 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Deep Sedation, Non-invasive Ventilation Support
Comparison of Nasal Continuous Positive Airway Pressure (CPAP) Mask and Nasal Airway in Molar Tooth Extraction Under Deep Sedation
In patients with high levels of fear and anxiety, it is recommended to perform dental procedures under sedation or general anesthesia depending on the nature of the procedure.
- Conditions
- Deep Sedation, Non-invasive Ventilation Support, Nasal Airway, Nasal CPAP Mask
- Trial name
- NCT06436638
- Testing
- Non-invasive ventilation support equipment
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Gözde Nur Erkan
Atrial Fibrillation (AF), PFA
Electrophysiologist-led Deep Sedation Protocols for Pulsed Field Ablation for Atrial Fibrillation Using a Bipolar Tip-Catheter: The DEEP-PFA Randomized Controlled Trial
The DEEP-PFA trial is an investigator-initiated, prospective, single-center, three-arm (1: 1: 1), randomized controlled study comparing three anesthesia regimens-midazolam + fentanyl (DS1), flurbiprofen + midazolam + fentanyl…
- Conditions
- Atrial Fibrillation (AF), PFA, Deep Sedation
- Trial name
- NCT07149545
- Testing
- Arm A (Fentanyl + Midazolam), Arm B (Flurbiprofen axetil + Fentanyl + Midazolam), Arm C (Fentanyl + Dexmedetomidine)
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Beijing Anzhen Hospital
Deep Sedation
Clinical Performance of the Automated Closed-loop Minimum Viable Prototype
The goal of this clinical trial is to evaluate a minimum viable prototype for automated closed-loop administration of propofol in deep sedated patients under invasive mechanical ventilation in the ICU.
- Trial name
- NCT06187545
- Testing
- Minimum viable prototype, Usual care
- Where
- 3 sites in Chile
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Chile
Deep Sedation
Prospective Validation of the Eleveld Model of Propofol for Procedural Sedation in Adults.
The goal of this prospective observational study is to identify effect site concentrations (CET) of propofol using the Eleveld model for different levels of procedural sedation.
- Trial name
- NCT06325033
- Where
- Netherlands
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Atrial Fibrillation, Atrial Fibrillation, Paroxysmal or Persistent
Deep Sedation in Catheter Ablation of Atrial Fibrillation
The current practice of anesthesia for atrial fibrillation catheter ablation （CA） procedure is inconsistent, including general anesthesia, deep sedation, and conscious sedation.Due to the nature of deep sedation, it has been…
- Conditions
- Atrial Fibrillation, Atrial Fibrillation, Paroxysmal or Persistent, Deep Sedations, Conscious Sedation
- Trial name
- PRIORI-AF (NCT06836999)
- Testing
- deep sedation, Conscious sedation
- Where
- 16 sites in China
- Volunteers
- 1,334 people
- Sponsor
- The First Affiliated Hospital of Dalian Medical University
Deep Sedation, Oxygen Therapy
HFNC Vs LFNC in Patients with AF Undergoing RFCA Under Deep Sedation.
Oxygen supplementation through high flow nasal cannula (HFNC) may reduce the incidence of desaturation and hypoxemia during deep sedation at radiofrequency catheter ablation (RFCA procedures).This study is designed to test the…
- Conditions
- Deep Sedation, Oxygen Therapy, Radiofrequency Ablation
- Trial name
- NCT04842253
- Testing
- High flow nasal cannula
- Where
- Netherlands
- Volunteers
- 141 people
- Sponsor
- Maastricht University Medical Center
Anesthesia, Deep Sedation
Comparison of Two Electroencephalograms (EEG) Monitors in Patients Undergoing General Anesthesia
Hypothesis: There is a statistically measurable correlation between qNOX and rough clinical signs of insufficient anti-nociception such as movements during Laryngeal Mask Airway (LMA) insertion, skin Incision, LMA removal.
- Trial name
- NCT02928172
- Testing
- qCON-qNOX, BIS
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Cedars-Sinai Medical Center
RASS-score, Deep Sedation
Comparison of 2 Depth of Sedation Indices in the Intensive Care Unit
In the intensive care unit of the Free University hospital of Brussels, sedated patients are standardly monitored with the Masimo SEDline device to see how deeply a patient is asleep.
- Conditions
- RASS-score, Deep Sedation, Post-cardiac Surgery
- Trial name
- PSIWAV (NCT05587803)
- Testing
- Neurowave and Sedline indices in view
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Universitair Ziekenhuis Brussel
Burn Unspecified Degree, Deep Sedation
Effects Of Different Anesthesia Applications On Mood, Depression, And Anxiety Levels In Burn Patients
Adequate and effective pain management and prevention of depression are essential in burn patients. This study aims to investigate the effects of ketamine sedation in burn patients in terms of mood disorders, depression, anxiety…
- Trial name
- NCT06165848
- Where
- Turkey (Türkiye)
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- T.C. Sağlık Bakanlığı Ankara Bilkent Şehir Hastanesi
Deep Sedation, Dental Treatment
High-flow Nasal Oxygenation During Deep Sedation in Pediatric Dental Patients
It is important to choose an appropriate oxygenation technique during intravenous deep sedation in pediatric dental treatment. The study is to evaluate the efficacy and safety of high-flow nasal oxygenation in intravenous deep…
- Conditions
- Deep Sedation, Dental Treatment, Pediatric Patients
- Trial name
- NCT05762692
- Testing
- High-flow nasal oxygenation device
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Peking University
Trauma, Fractures, Closed
Intranasal Versus Intravenous Ketamine for Procedural Sedation in Children With Non-operative Fractures
This a randomized clinical trial involving children with non-operative fractures presenting the emergency department randomized either to intranasal or intravenous ketamine.
- Conditions
- Trauma, Fractures, Closed, Children, Only, Deep Sedation
- Trial name
- NCT03781817
- Testing
- Intravenous Ketamine, Intranasal Ketamine
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Alabama at Birmingham
Deep Sedation, Dexmedetomidine
Intranasal Dexmedetomidine for Deep-sedated Pediatric Dental Patients
It is important to choose an appropriate analgesia/sedation technique in pediatric dental treatment. Premedication combined with intravenous anesthesia is often used in deep sedation technique for pediatric dental treatment and…
- Trial name
- NCT04509414
- Testing
- Dexmedetomidine, Midazolam
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University
Deep Sedation, Ambulatory Surgery
Effects Of Propofol-Dexmedetomıdıne And Propofol- Remıfentanıl In Hysteroscopıc Operations.
In our study, the investigators aimed to compare the effects of dexmedetomidine-propofol and remifentanil-propofol combinations on perioperative spontaneous respiration, hemodynamics, recovery, participants, surgeon and…
- Conditions
- Deep Sedation, Ambulatory Surgery, Ambulatory Surgical Procedure
- Trial name
- NCT05674201
- Testing
- Propofol-Dexmedetomidine
- Where
- Turkey (Türkiye)
- Volunteers
- 2 people
- Sponsor
- Siirt Training and Research Hospital
Deep Sedation, Mechanical Ventilation
Spectral Edge Frequency From Spectral EEG Analysis to Guide Deep Sedation in the Critical Care Setting (Pilot)
Critically ill patients under mechanical ventilation (MV) have pain, anxiety, sleep deprivation and agitation. The use of analgesics and sedatives drugs (sedoanalgesia) is a common practice to produce pain relief and comfort…
- Trial name
- SEFICU (NCT04026451)
- Testing
- Sedation guided by SEF95 (10-13 Hz) from SedLine® monitor, Sedation guided by SAS scale (1-2), Deep sedation with propofol andfentanyl
- Where
- 2 sites in Chile
- Sponsor
- University of Chile
Critically Ill, Deep Sedation
Efficacy and Safety of Remimazolam Besylate Versus Propofol for Sedation in Critically Ill Patients With Deep Sedation
The purpose of this study is to evaluate the efficacy and safety of remimazolam besylate compared to propofol for sedation in critically ill patients with deep sedation.
- Trial name
- NCT05539521
- Testing
- Remimazolam Besylate, Propofol
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology