Clinical trials: Deep Sedation
Surgery, Hypoventilation
A Comparison of the Detection of Hypoventilation During Deep Sedation Utilizing Nasal End Title CO@ Versus Transcutaneous CO2 Measurement Techniques
The estimation of the partial pressure of carbon dioxide (PCO2) in the arterial blood is used to judge the adequacy of ventilation during spontaneous and controlled ventilation.
- Trial name
- NCT00954733
- Testing
- Arterial blood draw
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Northwestern University
Hypercarbia
The Effect of Ketamine in the Prevention of Hypoventilation in Patients Undergoing Deep Sedation Using Propofol and Fentanyl
Procedures performed under sedation have the same severity in regards to morbidity and mortality as procedures performed under general anesthesia1.
- Trial name
- NCT01825083
- Testing
- Ketamine
- Where
- United States
- Sponsor
- Northwestern University
Deep Sedation
Clinical Performance of the Automated Closed-loop Minimum Viable Prototype
The goal of this clinical trial is to evaluate a minimum viable prototype for automated closed-loop administration of propofol in deep sedated patients under invasive mechanical ventilation in the ICU.
- Trial name
- NCT06187545
- Testing
- Minimum viable prototype, Usual care
- Where
- 3 sites in Chile
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Chile
Intensive Care Unit Syndrome
Different Volatile Anaesthetics and the Depth of Long Term ICU Sedation
The MIRUS system (TIM, Andernach, Germany) as well as the AnaConDa uses a reflector to conserve volatile anaesthetics (VA). Both systems can be paired with ICU ventilators, but MIRUS features an automated control of end-tidal VA…
- Trial name
- NCT03860129
- Testing
- Isoflurane, Sevoflurane, Desflurane
- Volunteers
- 30 people
- Sponsor
- Ruhr University of Bochum
Hypoxia
Comparison of Hypoxia Between HFNC and SNC in Patient Undergoing UGI Endoscopic Procedures in Deep Sedation
Hypoxia frequently occurs as a complication during upper gastrointestinal endoscopic procedures performed under deep sedation. Traditional oxygen delivery methods, such as the simple nasal cannula, are commonly used to prevent…
- Trial name
- NCT06482879
- Testing
- Oxygen delivery
- Where
- Nepal
- Volunteers
- 122 people
- Sponsor
- National Academy of Medical Sciences, Nepal
Light, Anesthesia
Light and Anesthesia
The objective of this clinical trial is to investigate the effect of light exposure on sedation depth during general anesthesia.The primary research questions this study aims to address include: Does light condition affect the…
- Conditions
- Light, Anesthesia, Sedation
- Trial name
- NCT07517484
- Testing
- eye mask
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Peking University People's Hospital
Sedation During Lower Extremity Surgery Under Spinal Anesthesia
Remimazolam Concentration and Sedation Depth During Lower Extremity Surgery Under Spinal Anesthesia
This study will examine how the amount of remimazolam predicted to reach its site of action relates to the depth of sedation during lower extremity surgery under spinal anesthesia.
- Trial name
- NCT07863063
- Testing
- Remimazolam
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Seoul National University Hospital
Deep Sedation, Ventilators, Mechanical
Pain, Agitation and Delirium (PAD) Protocol in the Duke CICU
This study aims to examine the use of protocol directed sedation using the Duke PAD protocol with the current sedation medications of propofol or dexmedetomidine compared to the PAD protocol with midazolam, per cardiac intensive…
- Conditions
- Deep Sedation, Ventilators, Mechanical, Critical Illness
- Trial name
- NCT02903407
- Testing
- Midazolam, Propofol, Dexmedetomidine
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Duke University
Loss of Consciousness at End of Life
Measuring Depth of Unconsciousness at the End of Life Using Bispectral Index (BIS)
The purpose of this study is to use the BIS monitor to assess the degree of consciousness in pre-terminal palliative patients admitted to our palliative care unit and to ascertain if this tool provides a more accurate assessment…
- Trial name
- BISSOPS (NCT01768416)
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- University Hospital, Ghent
Critically Ill, Deep Sedation
Efficacy and Safety of Remimazolam Besylate Versus Propofol for Sedation in Critically Ill Patients With Deep Sedation
The purpose of this study is to evaluate the efficacy and safety of remimazolam besylate compared to propofol for sedation in critically ill patients with deep sedation.
- Trial name
- NCT05539521
- Testing
- Remimazolam Besylate, Propofol
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Pain
Moderate Versus Deep Procedural Sedation With Propofol in the Emergency Department
This study is a clinical trial of moderate sedation versus deep sedation with propofol for procedural sedation in the Emergency Department.
- Trial name
- NCT02404610
- Testing
- Moderate Procedural Sedation with a sedative medication., Deep Procedural Sedation with a sedative medication., propofol
- Where
- United States
- Volunteers
- 107 people
- Sponsor
- Hennepin Healthcare Research Institute
Sedation Complication, High Flow Nasal Oxygen Therapy
Impact of Sedation With HFNOT on tcPCO2, mitoPO2 and mitoVO2.
Deep procedural sedation has seen an increased use indication over the last couple of years aided by the introduction of high flow nasal oxygen therapy (HFNOT) during these procedures.
- Trial name
- NCT06124027
- Testing
- Monitoring tcPCO2 and mitoPO2
- Where
- Netherlands
- Volunteers
- 35 people
- Sponsor
- Calvin de Wijs, MSc
Movement Disorders, Parkinson Disease
Sedation During Microelectrode Recordings Before Deep Brain Stimulation for Movement Disorders.
The purpose of this study is to detect possible changes in the electrical activity of the Basal Ganglia related to sedation during deep brain stimulation surgery.
- Conditions
- Movement Disorders, Parkinson Disease, Parkinsonian Disorders, Dystonia
- Trial name
- NCT00355927
- Testing
- Sedation with IV propofol
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Hadassah Medical Organization
The Effect of BIS Closed-loop Target Control on Postoperative Operation
Effects of BIS Closed Loop Target Controlled Infusion on Perioperative Inflammatory Response and Prognosis of Elderly Patients Undergoing Laparoscopic Radical Gastrectomy for Gastric Cancer
The purpose of this study is to find the elderly patients with laparoscopic gastric cancer radical is suitable the BIS closed round target control level of anesthesia depth of sedation, can decrease the elderly laparoscopic…
- Trial name
- NCT05173909
- Testing
- BIS closed-loop target controlled infusion
- Where
- China
- Volunteers
- 73 people
- Sponsor
- Zhonghua Chen,MD
RASS-score, Deep Sedation
Comparison of 2 Depth of Sedation Indices in the Intensive Care Unit
In the intensive care unit of the Free University hospital of Brussels, sedated patients are standardly monitored with the Masimo SEDline device to see how deeply a patient is asleep.
- Conditions
- RASS-score, Deep Sedation, Post-cardiac Surgery
- Trial name
- PSIWAV (NCT05587803)
- Testing
- Neurowave and Sedline indices in view
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Universitair Ziekenhuis Brussel
Endoscopic Surgical Procedure
Sedation for Endoscopic Procedures
Endoscopic procedures for biliary strictures, stenting or drainage (ERCP) and ultrasonic imaging or biopsies (EUS) are performed under sedation or anesthesia.
- Trial name
- SEEUPP (NCT05038917)
- Where
- Sweden
- Volunteers
- 500 people
- Sponsor
- Ostergotland County Council, Sweden
Oxygen Administration During Deep Sedation
Nasopharyngeal Versus Nasal Cannula Oxygen Supplementation in Surgery Patients
The investigators plan to conduct a randomized, controlled trial comparing nasopharyngeal oxygen supplementation to traditional nasal cannula in patients undergoing oral surgery under moderate sedation.
- Trial name
- NCT02219464
- Testing
- Nasopharyngeal catheter, Nasal Cannula, Oxygen Supplementation
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Vanderbilt University
Biliary Tract Diseases, Pancreatic Diseases
Comparison Between Continuous Infusion and Intermittent Bolus Injection of Propofol for Deep Sedation During ERCP
The aim of this study is to compare sedation efficiency, safety and satisfaction by both endoscopist, assistants, and the patients between continuous infusion and intermittent bolus injection of propofol for deep sedation during…
- Trial name
- NCT01900938
- Testing
- Continuous infusion of propofol, Intermittent bolus injection of propofol, Midazolam
- Where
- South Korea
- Volunteers
- 210 people
- Sponsor
- Hanyang University
Critical Illness
Efficacy and Safety of Fospropofol Disodium Versus Propofol for Deep Sedation in Critically Ill Patients
The purpose of this study is to evaluate the efficacy and safety of fospropofol disodium for injection compared to propofol for deep sedation in mechanically ventilated ICU patients.
- Trial name
- NCT05870514
- Testing
- Fospropofol disodium for injection, Propofol
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xiaobo Yang, MD
Procedural Sedation
Propofol vs. Midazolam-based Balanced Propofol for Nonanesthesiologist Moderate Sedation in Colonoscopy
Nonanesthesiologist administration of propofol for sedation is actually a field of growing interest for endoscopists, as demonstrated by recent American and European guidelines on this issue.
- Trial name
- MIDAPROP (NCT01428882)
- Testing
- Midazolam, Propofol
- Where
- Spain
- Volunteers
- 135 people
- Sponsor
- Infante, Javier Molina, M.D.