Clinical trials: Deep Venous Insufficiency
Renal Insufficiency
Venous Thromboembolism in Renally Impaired Patients and Direct Oral Anticoagulants
In renally impaired patients with acute venous thromboembolism (VTE), standard-of-care (SOC) anticoagulation, i.e. heparins-vitamin K antagonists (VKA), at therapeutic dosage is associated with an increased risk of thromboembolic…
- Trial name
- VERDICT (NCT02664155)
- Testing
- Apixaban, Rivaroxaban, Heparin
- Where
- 31 sites in France
- Volunteers
- 203 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Deep Vein Thrombosis, Postthrombotic Syndrome
Rivaroxaban With Diosmin in Long-term Treatment of Deep Vein Thrombosis
The randomized clinical study aimed to assess the efficacy and safety of standard anticoagulation with rivaroxaban in combination with diosmin compared to the isolated use of standard rivaroxaban for prolonged therapy of acute…
- Trial name
- RIDILOTT-DVT (NCT03413618)
- Testing
- Rivaroxaban, Diosmin, compression stockings
- Where
- Russia
- Volunteers
- 90 people
- Sponsor
- Pirogov Russian National Research Medical University
Post-Thrombotic Syndrome
The MUFFIN-PTS Trial
In this randomized controlled trial (RCT), the investigators will determine whether a 6-month course of oral Micronized Purified Flavonoid Fraction (MPFF 1000 mg daily), compared with placebo, improves the symptoms and signs of…
- Trial name
- MUFFIN-PTS (NCT03833024)
- Testing
- Micronized Purified Flavonoid Fraction
- Where
- 7 sites in Canada
- Volunteers
- 88 people
- Sponsor
- Sir Mortimer B. Davis - Jewish General Hospital
Venous Thrombosis, Venous Insufficiency
Evaluating the Relationship Between Blood Clotting Disorders, Inflammation, and Obesity in Individuals With Venous Disorders and Post-Thrombotic Syndrome
Venous thrombosis is the development of a blood clot in a vein. Post-thrombotic syndrome (PTS) is a painful condition that can develop following a venous thrombosis in one of the deep veins of the leg.
- Trial name
- NCT00395265
- Where
- United States
- Volunteers
- 2,211 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Post Thrombotic Syndrome, Deep Vein Thrombosis
Post Thrombotic Syndrome Prevention Study
This is a two arm, prospective, single center, randomized clinical trial. Subjects will be randomly assigned into one of two groups using block randomization technique in a 1:1 ratio.
- Trial name
- NCT03039517
- Testing
- ACTitouch, Compression garments (stockings)
- Where
- United States
- Sponsor
- NYU Langone Health
May-Thurner Syndrome, Deep Vein Thrombosis
Venous Stent for the Iliofemoral Vein Investigational Clinical Trial Using the DUO Venous Stent System
This is a prospective, multi-center, single-arm, non-blinded clinical trial designed to investigate the safety and efficacy of the Vesper DUO Venous Stent System as compared to a pre-defined performance goal (PG) established from…
- Conditions
- May-Thurner Syndrome, Deep Vein Thrombosis, Chronic Venous Insufficiency
- Trial name
- VIVID (NCT04580160)
- Testing
- Duo Venous Stent System
- Where
- 30 sites in United States, Poland
- Volunteers
- 162 people
- Sponsor
- Vesper Medical, Inc.
Venous Thromboses, Venous Disease
The GORE® VIABAHN® FORTEGRA Venous Stent Post-Approval Study
This study is a prospective, multicenter, single-arm post-market clinical study to evaluate the GORE® VIABAHN® FORTEGRA Venous Stent in real-world use.
- Conditions
- Venous Thromboses, Venous Disease, Venous Leg Ulcer, Venous Stasis
- Trial name
- NCT07538609
- Testing
- GORE® VIABAHN® FORTEGRA Venous Stent
- Where
- 4 sites in United States
- Volunteers
- 150 people
- Sponsor
- W.L.Gore & Associates
Postphlebitic Syndrome, Post-Thrombotic Syndrome
The 36-month Extension to Follow up Sub Study
The purpose of this study is to evaluate leg health for one additional year in patients with symptomatic proximal deep venous thrombosis who did not already develop Post-Thrombotic Syndrome (PTS) during the 2 years of follow up…
- Conditions
- Postphlebitic Syndrome, Post-Thrombotic Syndrome, Deep Vein Thrombosis
- Trial name
- NCT01615692
- Where
- 20 sites in Canada
- Sponsor
- Sir Mortimer B. Davis - Jewish General Hospital
Atrial Fibrillation, Deep Vein Thrombosis
A Genomic Approach to Warfarin Dose Prescription in Admixed Caribbean Hispanics
Caribbean Hispanics are a population with a disproportionately high prevalence of cardio-metabolic disorders but with a limited expectation of benefits from current pharmacogenetic algorithms derived mainly in subjects of…
- Conditions
- Atrial Fibrillation, Deep Vein Thrombosis, Cardiac Valvular Insufficiency, Coagulopathies
- Trial name
- NCT02345356
- Testing
- Genotype-guided, Standard-of-Care
- Where
- 3 sites in United States, Puerto Rico
- Volunteers
- 200 people
- Sponsor
- University of Puerto Rico
Venous Recanalisation
Clinical and Hemodynamic Evaluation After Venous Recanalization of Post-thrombotic Iliofemoral Syndromes
Post-thrombotic syndrome (PTS) is the most common chronic complication of deep vein thrombosis (DVT). The endovascular recanalization and stenting technique has become the gold standard treatment for medically resistant and…
- Trial name
- CHEVROPIS (NCT05954663)
- Testing
- Basic demographic information
- Where
- France
- Volunteers
- 24 people
- Sponsor
- Hospices Civils de Lyon
Post Thrombotic Syndrome
Long-Term Post Thrombotic Syndrome Assessment (CELEST Long Term).
The CELEST Long term is a prospective study, assessing the very long term risk of post thrombotic syndrome (PTS) in patients enrolled in the CELEST double-blind RCT.
- Trial name
- CELEST-LT (NCT06046807)
- Testing
- Phone call
- Where
- France
- Volunteers
- 288 people
- Sponsor
- Laboratoires Innothera
Renal Insufficiency
Dalteparin's Influence on Renally Compromised: Anti-Ten-A Study (DIRECT)
The investigators' primary research objective is: To determine the safety of dalteparin prophylaxis, 5,000 IU once-daily, in Intensive Care Unit (ICU) patients based on: the proportion of patients with trough anti-Xa > 0.40 IU/mL…
- Trial name
- NCT00138099
- Testing
- Fragmin (dalteparin sodium)
- Where
- 14 sites in Canada
- Volunteers
- 140 people
- Sponsor
- Hamilton Health Sciences Corporation
Venous Thromboses, Venous Disease
The GORE® VIABAHN® FORTEGRA Venous Stent Iliofemoral Study
This study is a prospective, non-randomized, multicenter, single-arm, clinical study to evaluate the performance, safety and efficacy of the GORE® VIABAHN® FORTEGRA Venous Stent (formerly known as GORE® VIAFORT Vascular Stent)…
- Conditions
- Venous Thromboses, Venous Disease, Venous Leg Ulcer, Venous Stasis
- Trial name
- NCT05489588
- Testing
- GORE® VIAFORT Vascular Stent
- Where
- 24 sites in United States
- Volunteers
- 165 people
- Sponsor
- W.L.Gore & Associates
Renal Failure Chronic Requiring Hemodialysis, Central Venous Catheterization
Duration and Adverse Events of Non-cuffed Catheter in Patients With Hemodialysis
The duration and adverse events of non-cuffed catheter in patients with hemodialysis will be investigated by multicenter prospective cohort.
- Conditions
- Renal Failure Chronic Requiring Hemodialysis, Central Venous Catheterization, Inadequate Hemodialysis Blood Flow, Venous Stenosis
- Trial name
- DACAPO (NCT02264964)
- Testing
- GamCath®, Arteriovenous fistula creation
- Volunteers
- 1,400 people
- Sponsor
- Shanghai Changzheng Hospital
Deep Vein Thrombosis, Deep Vein Thrombosis Leg
Compression Hosiery to Avoid Post-Thrombotic Syndrome
Patients with a deep vein thrombosis (DVT) may develop long-term symptoms, e.g. lifelong leg pain, skin changes and occasionally ulceration, known as post-thrombotic syndrome (PTS).
- Conditions
- Deep Vein Thrombosis, Deep Vein Thrombosis Leg, Post Thrombotic Syndrome
- Trial name
- CHAPS (NCT04103112)
- Testing
- Graduated compression stocking
- Where
- 12 sites in United Kingdom
- Volunteers
- 152 people
- Sponsor
- Imperial College London
Venous Leg Ulcers
Study Investigating the Safety and Efficacy of HP802-247 in the Treatment of Venous Leg Ulcers >12 cm2 to ≤ 36 cm2
This study is being done to find out if an investigational product called HP802-247 can help people with venous leg ulcers. Investigational means that HP802-247 has not been approved by the U.S.
- Trial name
- NCT01737762
- Testing
- HP802-247, Vehicle
- Where
- 43 sites in United States, Canada and 1 more
- Volunteers
- 155 people
- Sponsor
- Healthpoint
Postthrombotic Syndrome
The Ideal Deep Venous Thrombosis (DVT) Study
In the Netherlands, 25.000 patients each year are diagnosed with Deep Venous Thrombosis (DVT). Elastic compression stocking (ECS) therapy reduces the incidence of post thrombotic syndrome (PTS) following DVT from 50% without ECS…
- Trial name
- IDEAL (NCT01429714)
- Testing
- Individually tailored duration of elastic compression therapy, Elastic compression therapy with a standard duration of 24 months
- Where
- 14 sites in Italy, Netherlands
- Volunteers
- 865 people
- Sponsor
- Maastricht University Medical Center
Hemorrhage
Safety Study of Enoxaparin Prophylaxis in Critically Ill Adults With Severe Renal Insufficiency
The investigators study is the first step (a pilot study) in determining whether the manufacturer's recommended dose of a blood thinner called enoxaparin, in adults who are patients in an intensive care unit and have severely…
- Trial name
- NCT02690090
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Ottawa Hospital Research Institute
Venous Thrombosis Deep (Limbs), Venous Insufficiency (Chronic)(Peripheral)
Apixaban vs Rivaroxaban vs No Anticoagulant to Prevent EHIT After Great Saphenous Vein Laser Ablation
Endothermal heat-induced thrombosis (EHIT) is a thrombotic complication specific to endovenous thermal ablation of the great saphenous vein (GSV), for which no prophylactic regimen is standardized.
- Conditions
- Venous Thrombosis Deep (Limbs), Venous Insufficiency (Chronic)(Peripheral), Varicose Veins Leg, Venous Thrombosis
- Trial name
- NCT07699796
- Testing
- Apixaban, Rivaroxaban
- Where
- United States
- Volunteers
- 564 people
- Sponsor
- Heart, Artery, and Vein Center of Fresno
Acute Kidney Injury, Deep Venous Thrombosis
Norwegian Intensive Care Unit Dalteparin Effect Study
The main purpose of the NORIDES study is to investigate the effect of pharmacological thromboprophylaxis with low molecular weight heparins (LMWHs) in critically ill patients, and how it is affected by presence of acute kidney…
- Trial name
- NORIDES (NCT01721928)
- Testing
- Continuous venovenous hemodialysis
- Where
- Norway
- Volunteers
- 70 people
- Sponsor
- Oslo University Hospital