Clinical trials: Defecation Disorder, open to volunteers
Spinal Cord Injuries, Gut Microbiome
Impact of Gut Microbiome on Metabolic and Bowel Function During the First Year After Spinal Cord Injury
The Investigators will recruit 35 participants with acute SCI (within 6 weeks of injury) Fasting blood collection and bowel function survey will be conducted 3 times: at baseline [within 6 weeks of injury], 6, and 12 months after…
- Trial name
- NCT05670288
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Alabama at Birmingham
Spinal Cord Injuries, Autonomic Dysreflexia
NO AD: Use of Nitric Oxide (NO) Donors for the Prevention of Autonomic Dysreflexia (AD) During Bowel Care Following SCI
This project aims to evaluate the safety and efficacy of using a short-acting drug to reduce the maximal blood pressure during dangerous blood pressure spikes that happen during bowel care in individuals with spinal cord injury.
- Trial name
- NO AD (NCT05635851)
- Testing
- Glyceryl Trinitrate Only Product in Oromucosal Dose Form
- Volunteers
- 26 people
- Sponsor
- Simon Fraser University
Dyssynergia, Constipation
Fecobionics in Biofeedback Therapy in Dyssynergia Patients
Constipation affects 12-19% of Americans. Pelvic floor dyssynergia is considered to play an important role in constipation but the underlying mechanisms are not well understood in individual patients.
- Trial name
- NCT05807321
- Testing
- Fecobionics
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- The California Medical Innovations Institute, Inc.
Normal Subjects, Fecal Incontinence
Trial to Evaluate Fecobionics in Fecal Incontinence (FI) (NORMAL and ABNORMAL-FI)
The objective is to determine the length-tension properties of the anal sphincters using Fecobionics in normal subjects and FI patients during anal distension and during simulated evacuation.
- Trial name
- NCT05412069
- Testing
- Fecobionics
- Where
- 2 sites in United States
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- The California Medical Innovations Institute, Inc.
Hirschsprung Disease
Urinary and Sexual Symptoms in Patients With Hirschsprung Disease
Hirschsprung disease is a rare congenital disorder affecting the gastrointestinal tract of newborns. It is caused by the absence of enteric ganglion cells in a segment of the large intestine, preventing normal bowel function and…
- Trial name
- UroSexH (NCT07742436)
- Testing
- Type of pull-through procedure performed as part of routine clinical care (Swenson, Duhamel, or Soave).
- Where
- 5 sites in France
- Volunteers
- 556 people
- Sponsor
- University Hospital, Grenoble
Defecation Disorder, Gastrointestinal Motility Disorder
"The Effect of Abdominal Massage on Gastrointestinal Functions in Mechanically Ventilated Patients Receiving Enteral Nutrition in Intensive Care"
This study aims to evaluate the effects of abdominal massage on gastrointestinal functions in mechanically ventilated patients receiving enteral nutrition in intensive care units.
- Conditions
- Defecation Disorder, Gastrointestinal Motility Disorder, Gastrointestinal Motility and Defecation Conditions
- Trial name
- AMGF-ICU (NCT06631001)
- Testing
- Abdominal Massage
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Mersin University
Chronic Spinal Cord Injury
Abdominal Electrical Stimulation for Bowel Dysfunction in SCI
Many people with spinal cord injury (SCI) have bowel problems resulting in constipation and need a long time to empty the bowel. Some people spend an hour or more to empty their bowel.
- Trial name
- NCT06948175
- Testing
- Abdominal transcutaneous electrical stimulation (TES)
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- University of Alberta
Post Operative Patients
The Food Network Effect
The goal of this clinical trial is to learn if exposure to food related visual stimuli during the postoperative period can improve gastrointestinal recovery after abdominal surgery in adult patients.The main questions it aims to…
- Trial name
- NCT07618559
- Testing
- Food Related Visual Stimuli Exposure
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Casey Morehouse, DO
Fecal Incontinence, Dyssynergic Defecation
Home Biofeedback Therapy for Dyssynergic Defecation, Fecal Incontinence and Urinary Incontinence
Biofeedback therapy is an effective treatment for the management of patients with dyssynergic defecation and constipation, urinary incontinence (UI), and fecal incontinence (FI).
- Conditions
- Fecal Incontinence, Dyssynergic Defecation, Urinary Incontinence
- Trial name
- Bioanatoner (NCT05771597)
- Testing
- Home Biofeedback therapy, Office biofeedback therapy
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Augusta University
Spinal Cord Injuries, Neurogenic Bowel
Abdominal Functional Electrical Stimulation to Improve Bowel Function in Spinal Cord Injury
The primary objective of this study is to gather information about the effectiveness of abdominal FES to improve bowel management time (BMT) for people with chronic SCI.
- Trial name
- NCT06345781
- Testing
- Abdominal Functional Electrical Stimulation
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Craig Hospital
Morbid Obesity, Anorectal Diseases
GLP-1 Receptor Agonists and Early Proctologic Effects in Morbid Obesity
Prospective observational cohort study evaluating the early proctologic effects of GLP-1 receptor agonist therapy in morbidly obese patients.
- Conditions
- Morbid Obesity, Anorectal Diseases, Drug-Related Side Effects and Adverse Reactions, Constipation
- Trial name
- GLP-PROCT (NCT07668765)
- Testing
- GLP-1 receptor agonist therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Gazi University
Rectal Prolapse
FOAM: Functional Outcome After Ventral Mesh Rectopexy
Rectal prolapse is a protrusion of rectal wall through the anus. A surgical technique called Ventral mesh rectopexy has become a standard procedure for this condition in many centers.
- Trial name
- NCT06455501
- Testing
- Ventral mesh rectopexy
- Volunteers
- 70 people
- Sponsor
- Uppsala University
Dyssynergic Defecation
Effects of Connective Tissue Massage Plus Biofeedback for Dyssynergic Defecation
The goal of this randomized controlled clinical trial is to evaluate the effects of connective tissue massage (CTM) added to electromyographic biofeedback (EMG-BF) in adults with dyssynergic defecation (DD).
- Trial name
- NCT07890727
- Testing
- Electromyographic Biofeedback (EMG-BF), Connective Tissue Massage (CTM)
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people
- Sponsor
- Selcuk University
Pelvic Floor Prolapse, Functional Constipation
Efficacy of Conservative Treatment of Functional Defecatory Disorders in Females With Pelvic Organ Prolapse
This study is planned to evaluate the efficacy of complex conservative treatment (including tibial neuromodulation, biofeedback therapy, special pelvic floor training and diet modification) in women with pelvic organ prolapse
- Conditions
- Pelvic Floor Prolapse, Functional Constipation, Rectocele
- Trial name
- NCT04547816
- Testing
- Biofeedback therapy, Tibial neuromodulation, Pelvic floor muscles training
- Where
- 2 sites in Russia
- Volunteers
- 100 people
- Sponsor
- Federal State Budgetary Scientific Institution
Defecation Disorder
Electromyographic Biofeedback Therapy in Patients With Dyssynergic Defecation
This study aimed to investigate the effects of game-based electromyographic (EMG) biofeedback therapy on the quality of life and sleep quality of individuals diagnosed with dyssynergic defecation.
- Trial name
- NCT07482696
- Testing
- Game-Based Electromyographic (EMG) Biofeedback Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Kocaeli University
Anxiety, Bowel Habits
Test Anxiety on Bowel Health and Constipation in Students
This observational cross-sectional study aims to examine the relationship between test anxiety, bowel health, and constipation in university students.
- Conditions
- Anxiety, Bowel Habits, Constipation
- Trial name
- NCT07654959
- Testing
- Observational assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Lokman Hekim University
Chronic Ischemic-Hypoxic Enteropathy
Gut Oxygen Therapy for Ischemic-Hypoxic Bowel Disease
This single-center, double-blind, randomized, intra-individual crossover controlled study aims to investigate the efficacy and safety of intestinal oxygen therapy via a deep intestinal catheter as a targeted route for intestinal…
- Trial name
- NCT07621367
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The Second Hospital of Nanjing Medical University
Ileal Pouch
Study of EXE-346 Live Biotherapeutic to Reduce High Bowel Movement Frequency in Subjects With an IPAA (PROF)
The aim of this study is to assess the safety and preliminary efficacy of treatment with EXE-346, a live biotherapeutic, which may reduce bowel movement frequency in patients with an ileal pouch-anal anastomosis (IPAA) and lead…
- Trial name
- PROF (NCT05938465)
- Testing
- EXE-346
- Where
- 8 sites in United States
- Volunteers
- 50 people
- Sponsor
- Exegi Pharma, LLC
Colorectal Cancer (CRC)
Transcutaneous Electrical Acustimulation on Postoperative Bowel Function Recovery in Elderly Patients
The goal of this clinical trial is to clarify the efficacy and safety of transcutaneous electrical acustimulation (TEA) in elderly patients with colorectal cancer, and to evaluate its clinical value in promoting postoperative…
- Trial name
- NCT07574502
- Testing
- TEA
- Where
- 2 sites in China
- Volunteers
- 190 people
- Sponsor
- Sir Run Run Shaw Hospital
Menopause, Perimenopausal Disorder
Pelvic Floor Symptoms Across Menopausel Stages
The menopausal transition is associated with substantial hormonal alterations that may adversely affect lower urinary tract function, bowel function, and sexual health.
- Trial name
- NCT07690137
- Testing
- Assessment for Lower Urinary Tract Symptoms, Assessment for Bowel Symptoms, Constipation Severity Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 180 people
- Sponsor
- Bezmialem Vakif University