Clinical trials: Defect, Congenital
Congenital Heart Disease, Heart Diseases
IPSC Repository of Pediatric Cardiovascular Disease
Obtain blood samples for generation and maintenance of induced pluripotent stem cells (iPSCs) and genomic/DNA sequencing for biomedical research that will improve the understanding and treatment of pediatric cardiovascular disease
- Trial name
- NCT05550324
- Testing
- Blood draw
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Mingtao Zhao
Congenital Heart Disease (CHD), Artificial Intelligence (AI)
A Multicenter Study of Artificial Intelligence Model for Fetal Congenital Heart Disease
This study addresses congenital heart disease in fetuses, a specific birth defect, by collaborating with multicenter medical institutions across China.
- Trial name
- NCT06796127
- Where
- China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Beijing Anzhen Hospital
Congenital Heart Disease
A Comparison of Multidetector CT and TE in the Diagnosis of Congenital Cyanotic Heart Diseases
Multi-detector computed tomography angiography (MDCTA) provides high-resolution images of the heart and its vasculature, allowing for accurate anatomical assessment, detection of complex cardiac morphology,
- Trial name
- NCT06749548
- Testing
- Group 1
- Where
- Pakistan
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Superior University
Age Related Macular Degeneration, Retinitis Pigmentosa
Visual Activity Evoked by Infrared in Humans After Dark Adaptation
This pilot study will evaluate the visual response to infrared (IR) in humans after dark adaptation. The investigators plan to determine which wavelength and intensity the human eye is most sensitive to in healthy and color-blind…
- Conditions
- Age Related Macular Degeneration, Retinitis Pigmentosa, Congenital Stationary Night Blindness, Colorblindness
- Trial name
- NCT02909985
- Testing
- Tungsten halogen light with narrow bandpass filters
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Congenital Heart Defect, Cardiac Function
Automated Fetal Cardiac Function in Babies Affected by Heart Diseases
The goal of this international multicentre prospective observational cohort study with a nested case-control study is to test some automated fetal heart functional parameters in healthy babies compared to those affected by a…
- Trial name
- NCT05698277
- Testing
- Automated fetal cardiac function evaluation
- Where
- 7 sites in Australia, Israel and 3 more
- Volunteers
- 495 people, healthy volunteers welcome
- Sponsor
- Anna Erenbourg
Congenital Heart Defect, Congenital Heart Disease
Microvascular Dysfunction in Adults With Congenital Heart Disease and the Effect of Exercise Training
The goal of this prospective cohort study is to deepen the understanding of the pathophysiology in adults with congenital heart disease (CHD).
- Conditions
- Congenital Heart Defect, Congenital Heart Disease, Microvascular Dysfunction, Exercise Training
- Trial name
- MICONEX (NCT06715137)
- Testing
- Exercise training
- Where
- Belgium
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Coronary Artery Disease, Myocarditis
A 10-Minute Cardiovascular Magnetic Resonance Protocol for Cardiac Disease
This study aims to identify and assess new CMR techniques that can improve current CMR protocols.
- Conditions
- Coronary Artery Disease, Myocarditis, Infiltrative Cardiomyopathy, Dilated Cardiomyopathy
- Trial name
- NCT04464655
- Where
- Canada
- Volunteers
- 2,130 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Congenital Heart Disease
A Comprehensive Registry Study of the Whole Life Cycle of Patients With CHD
This observational study aims to collect data on the prevalence, intervention, and prognosis of congenital heart disease (CHD) in Chinese patients across their entire lifecycle.
- Trial name
- NCT06611787
- Where
- China
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Beijing Anzhen Hospital
Coagulopathy, Congenital Heart Disease
FFP Usage in Pediatric CV Surgery
When small children undergo heart surgery with the heart-lung machine, in the past, blood products to help the blood clot such as Fresh Frozen Plasma (FFP) was routinely used in children under 10kg.
- Trial name
- NCT05819788
- Where
- Canada
- Volunteers
- 431 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Respiratory Muscle Weakness
Inspiratory Training in Children After Fontan
This study will assess physical and respiratory capacity, diaphragmatic mobility and quality of life. Healthy children and children who have undergone Fontan surgery will participate.
- Trial name
- NCT06580808
- Testing
- Fontan Training Group
- Where
- Brazil
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Congenital Heart Disease
Fetal Heart Ultrasound Suspicious Radiographic Finding Identification - Reader Study
Clinical performance of the device will be evaluated in a fully-crossed, multiple-reader multiple-case (MRMC) study. This study will be used to determine the impact of the device on reader performance in identifying suspicious…
- Trial name
- NCT06392555
- Testing
- Device-Aided performances, Device-Unaided performances
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- BrightHeart
Prone posıtıon
Extruded the effectıveness of Prone posıtıon ın ınfants evaluatıon
The aim of this study was to determine the effect of prone position on vital signs, arterial blood gases and blood values in 0-1 year old infants extubated after congenital heart surgery.
- Trial name
- NCT06493058
- Testing
- Prone positioning
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Cardiovascular Diseases, Arrythmia
iPSC Biobank of Biomarkers Diversity in Cardiovascular Disease
The Investigators will create a clinical database and a Biobank of stem cells derived from the blood of participants with cardiovascular disease.
- Conditions
- Cardiovascular Diseases, Arrythmia, Cardiomyopathies, Heart Failure
- Trial name
- INFERENCE (NCT06371937)
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Environmental Exposure, Pregnancy Outcome
The Ma'Anshan Birth Cohort (MABC)
The Ma'anshan Birth Cohort (MABC) is a population-based prospective pregnancy and birth cohort study that aims to explore the early environmental and genetic determinants of maternal and child health, with a focus on health…
- Conditions
- Environmental Exposure, Pregnancy Outcome, Birth Defects, Child Development
- Trial name
- NCT03215368
- Where
- China
- Volunteers
- 3,474 people, healthy volunteers welcome
- Sponsor
- Anhui Medical University
Congenital Heart Disease
Utility of MRI With Doppler Ultrasound Gating for Advanced Fetal Monitoring
We will test an ultrasound device that uses sound waves to detect the fetal heart beat, and use this device to tell the MRI scanner when to collect pictures of the fetal heart.
- Trial name
- NCT03541291
- Testing
- SMART-SYNC LM03
- Where
- Canada
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Patient Participation, Heart Defects, Congenital
Liver Disease, Myocardial Fibrosis and Collaterals in the Adult Fontan Patient a Metabolomics and Proteomics Approach
Out objective is to identify the mechanisms that promote hepatic and myocardial fibrosis, and collateral vessel formation in patients with complex congenital heart disease and Fontan circulation.
- Conditions
- Patient Participation, Heart Defects, Congenital, Liver Diseases, Collateral Circulation, Any Site
- Trial name
- NCT04764305
- Where
- Austria
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Medical University Innsbruck
Acute Kidney Injury, Congenital Heart Disease
Acute Kidney Injury After Cardiac Surgery on CPB
The purpose of this retrospective study is to determine the incidence and severity of acute kidney injuries (AKI) after heart surgery on cardiopulmonary bypass (CPB) in the pediatric intensive care unit (PICU) in Lausanne…
- Conditions
- Acute Kidney Injury, Congenital Heart Disease, Surgery, CBP
- Trial name
- NCT03513718
- Where
- Switzerland
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Down Syndrome, Congenital Heart Disease
Congenital Heart Disease: Impact on Learning and Development in Down Syndrome (CHILD-DS)
The study objective is to compare neurodevelopmental (ND) and behavioral outcomes between children with Down syndrome (DS) who had complete atrioventricular septal defect (CAVSD) repair and children from the same clinical sites…
- Trial name
- CHILD-DS (NCT05312177)
- Testing
- Stanford Binet Intelligence Scales, Fifth Edition, Vineland Adaptive Behavior Scales Third Edition, Peabody Picture Vocabulary Test, Fifth Edition
- Where
- 14 sites in United States, Canada
- Volunteers
- 273 people, healthy volunteers welcome
- Sponsor
- Carelon Research
Rheumatoid Arthritis, Ankylosing Spondylitis
PatientSpot Formerly Known as ArthritisPower
Patient Power is a patient research network and database (registry) to collect prospective information about demographics, self-reported diagnoses and medications, and willingness to participate in research from participants with…
- Conditions
- Rheumatoid Arthritis, Ankylosing Spondylitis, Fibromyalgia, Gout
- Trial name
- NCT03840928
- Where
- United States
- Volunteers
- 40,000 people, healthy volunteers welcome
- Sponsor
- Global Healthy Living Foundation
Mothers, Quality of Life
The Effect of Web-based Training Given to Mothers of Babies With Congenital Heart Disease
This study was assessed the impact of a web-based education program provided to mothers of infants with congenital heart diseases on their quality of life and self-efficacy levels.
- Conditions
- Mothers, Quality of Life, Self Efficacy, Training
- Trial name
- NCT06168344
- Testing
- Web-Based Education Program
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi