Clinical trials: Defect, Congenital Heart
Hypoplastic Left Heart Syndrome
Fetal Aortic Valvuloplasty for Evolving Hypoplastic Left Heart Syndrome
The purpose of this research is to investigate the best way to manage evolving hypoplastic left heart syndrome (HLHS).
- Trial name
- NCT06342999
- Testing
- Fetal Aortic Valvuloplasty Procedure, Emerge Monorail and Over-The-Wire PTCA Dilatation Catheter, Trek RX and Mini Trek RX Coronary Dilatation Catheter
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Mauro H. Schenone
Congenital Heart Disease, Neurodevelopment
Improving Neurodevelopment in Adolescents With Congenital Heart Disease
Executive dysfunction can profoundly impact all dimensions of a child's development. Impairments in executive function are a central component of the neurodevelopmental phenotype associated with CHD, and manifest as behavioral…
- Conditions
- Congenital Heart Disease, Neurodevelopment, Executive Function, Working Memory Training
- Trial name
- NCT02759263
- Testing
- Cogmed Working Memory Training
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Boston Children's Hospital
Hypothyroidism, CHD
Hypothyroidism With Congenital Heart Disease (CHD)
Congenital hypothyroidism is one of the most preventable causes of neurocognitive impairment because early treatment is possible in neonates. The thyroid hormone is important for normal growth and development in infancy.
- Trial name
- NCT03496363
- Testing
- TSH , T4
- Volunteers
- 50 people
- Sponsor
- Assiut University
Congenital Heart Disease (CHD)
Assessment of Flow With the New Four-dimensional Velocity-encoded Magnetic Resonance Imaging Technique
The purpose of our study is to validate the accuracy of 4D PC flow method in quantification of thoracic and upper abdominal blood flow volumes in children.
- Trial name
- 4D Flow (NCT02952287)
- Testing
- 4D PC MRI acquisition
- Volunteers
- 100 people
- Sponsor
- The Hospital for Sick Children
Turner Syndrome
Cardiopulmonary Exercise Testing in Girls (8-18y) with Turner Sydrome.
The goal of this clinical trial is to have a beter insight in the exercise tolerance in girls with Turner Syndrome aged 8-18 years .
- Trial name
- NCT06780514
- Testing
- Cardiopulmonary exercise test
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- University Hospital, Ghent
Heart Disease Congenital
The Swiss Registry for Heart Diseases in Children Living in Switzerland. SPHC
The Swiss Pediatric Heart Cohort aims to collect representative longitudinal data on all children diagnosed with a clinically relevant heart disease in Switzerland.
- Trial name
- SPHC (NCT04442685)
- Where
- Switzerland
- Volunteers
- 590 people
- Sponsor
- University Children's Hospital, Zurich
Refractory Epilepsy, Arrhythmia
Cardiac Rhythm Abnormalities in Patients With Refractory Epilepsy at High Risk for Sudden Death
People with epilepsy are at a higher risk for sudden unexpected death than the general population. Sudden unexpected death in epilepsy (SUDEP) is a major cause of death in this population, accounting for 10-50% of deaths for…
- Conditions
- Refractory Epilepsy, Arrhythmia, Sudden Death
- Trial name
- NCT00203333
- Testing
- Medtronic REVEAL
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Thomas Jefferson University
Rare Diseases, Marfan Syndrome
Marfan Syndrome (MFS) and Facial Dysmorphism: Non-invasive 3D Assessment
The goal of this study observational prospective study is to define the facial morphological features associated with Marfan syndrome (MFS). The main qustion it aims to answer are: 1.
- Trial name
- FACE (NCT05702476)
- Where
- Italy
- Volunteers
- 140 people
- Sponsor
- IRCCS Policlinico S. Donato
Arrhythmogenic Cardiomyopathy, Arrhythmogenic Right Ventricular Cardiomyopathy
Targeted Therapy With Glycogen Synthase Kinase-3 Inhibition for Arrhythmogenic Cardiomyopathy
The TaRGET study is a multi-centre, prospective, randomized, double-blind, placebo-controlled trial designed to evaluate the potential therapeutic efficacy of tideglusib, a glycogen synthase kinase-3 β inhibitor, in genotype…
- Trial name
- TaRGET (NCT06174220)
- Testing
- Tideglusib
- Where
- 17 sites in Canada
- Volunteers
- 120 people
- Sponsor
- Hamilton Health Sciences Corporation
Aortic Valve Stenosis, Bicuspid Aortic Valve
Bicuspid Aortic Valve Stenosis and the Effect of vItamin K2 on Calciummetabolism on 18F-NaF PET/MRI
Early development of calcified aortic valve disease (CAVD) is a commonly occurring complication in patients with a bicuspid aortic valve (BAV, an aortic valve consisting of two leaflets instead of three).
- Trial name
- BASIK2 (NCT02917525)
- Testing
- Vitamin K2
- Where
- Netherlands
- Volunteers
- 44 people
- Sponsor
- Maastricht University Medical Center
Heart Failure
SGLT2 for Heart Failure in CHD Patients
Heart failure (HF) in adult patients with congenital heart disease is a major cause of morbidity and mortality. Approximately 30% of patients with significant congenital heart disease will develop signs of heart failure.
- Trial name
- GACH (NCT05897489)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Parent Mental Health
Preparing Heart and Mind™: A Patient Engagement Pathway for Parents and Their Caregiving Partners After a Major Fetal Anomaly Diagnosis
The purpose of this study is to test and evaluate the Preparing Heart and Mind™ (PHM™) patient engagement pathway as a nurse-guided intervention to lower psychological distress and enhance caregiving competencies among…
- Trial name
- NCT05282368
- Testing
- PHM™ Pathway
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- University of Minnesota
Growth Hormone Deficiency, Turner's Syndrome
Evaluation of the Adherence and the Patient Acceptability of Zomacton® Treatment With the Zomajet® Vision X Device
The study is performed to collect long-term data on the treatment adherence and patient's acceptability when Zomacton®10 mg is administered with the Zomajet® Vision X device in patients with a growth hormone deficiency or…
- Trial name
- ZOMAXEPT (NCT02018172)
- Testing
- somatropin
- Where
- France
- Volunteers
- 3 people
- Sponsor
- Ferring Pharmaceuticals
Congenital Heart Disease in Pregnancy, Prenatal Diagnosis
The National Program for the Improvement of Management of Fetal Congenital Heart Disease in China
To investigate and evaluate the capacity of prenatal screening, diagnosis and counseling of congenital heart disease in medical institutions in China, in order to understand the current status and existing problems of prenatal…
- Conditions
- Congenital Heart Disease in Pregnancy, Prenatal Diagnosis, Fetal Echocardiography
- Trial name
- NCT05940363
- Testing
- Improvement on Prenatal Screening and Treatment Capabilities for Congenital Heart Disease with a Comprehensive Diagnosis and Treatment Program Incorporating New Technologies
- Volunteers
- 9,000 people
- Sponsor
- Beijing Anzhen Hospital
Cardiomyopathy, Dilated
Early Treatment With Candesartan vs Placebo in Genetic Carriers of Dilated Cardiomyopathy (EARLY-GENE Trial)
Prospective, multicenter, randomized, placebo-controlled, double-blind clinical trial to evaluate safety and efficacy of candesartan in the prevention of the development of Dilated Cardiomyopathy (DCM) in genetic carriers of a…
- Trial name
- EARLY-GENE (NCT05321875)
- Testing
- Candesartan
- Where
- Spain
- Volunteers
- 320 people
- Sponsor
- Cristina Avendaño Solá
Stable Angina Pectoris, Periodontitis
Effect of Periodontal Therapy on Asprosin in Stable Angina
This study aims to evaluate the effect of non-surgical periodontal therapy on serum asprosin levels in patients with stable angina and periodontitis.
- Trial name
- NCT07591844
- Testing
- Non-surgical periodontal therapy (scaling and root planing), Non-surgical periodontal therapy (Professional dental cleaning)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Cardiomyopathy, Dilated
Registry of Cell Therapy in Non-Ischemic Dilated Cardiomyopathy
Although several studies have demonstrated beneficial effects of stem cell therapy in patients with non-ischemic dilated cardiomyopathy, the long term benefits and predictors of response to therapy remain undefined.
- Trial name
- RECORD (NCT02445534)
- Testing
- Autologous stem cell therapy
- Where
- Slovenia
- Volunteers
- 250 people
- Sponsor
- University Medical Centre Ljubljana
Tetralogy of Fallot, Congenital Heart Disease
Tetralogy of Fallot for Life
The aim is to conduct a prospective multi-centre international inception cohort study with an enrollment goal of 3,000 TOF patients and 2 year follow-up post-repair.
- Conditions
- Tetralogy of Fallot, Congenital Heart Disease, Congenital Heart Defect
- Trial name
- TOF-LIFE (NCT02968264)
- Where
- 20 sites in United States, Australia and 10 more
- Volunteers
- 1,108 people
- Sponsor
- Population Health Research Institute
Cardiovascular Diseases, Defect, Congenital Heart
Family Study of Congenital Cardiovascular Malformations
To determine genetic mechanisms responsible for congenital cardiovascular malformations.
- Conditions
- Cardiovascular Diseases, Defect, Congenital Heart, Heart Diseases
- Trial name
- NCT00005258
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Total Anomalous Pulmonary Venous Connection
Sutureless Technique and Conventional Repairs for Total Anomalous Pulmonary Venous Connection
The purpose of this study is to evaluate the efficacy of conventional repair and sutureless surgical repair of total anomalous pulmonary venous connection.
- Trial name
- NCT04234711
- Testing
- Surgical strategy
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Guangdong Provincial People's Hospital
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.