Clinical trials: Defect, Congenital Heart
Congenital Heart Disease, Arrhythmia
Catheter Ablation in Congenital Heart Disease: French National Prospective Registry
Arrhythmias represent one of the main late complications in patients with congenital heart disease. Atrial arrhythmias are associated with a significant morbidity and are the first cause of urgent hospitalization, and sudden…
- Trial name
- CATCH-Registry (NCT04202796)
- Testing
- Catheter ablation
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Paris Cardiovascular Research Center (Inserm U970)
Congenital Heart Disease
Calprotectin and Gut Disease Study
Necrotising enterocolitis (NEC) is a serious gut disease that can develop in infants born with cardiac defects. It causes inflammation and injury to the gut mucosa and may be life-threatening.1 The aetiology of NEC in cardiac…
- Trial name
- SAFE NEC (NCT07112794)
- Volunteers
- 300 people
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Patent Foramen Ovale, Obstructive Sleep Apnea
PFO Closure for Obstructive Sleep Apnoea
Obstructive sleep apnoea (OSA) is a condition which involves episodes of interrupted breathing during sleep due to repetitive narrowing or collapse of the throat.
- Trial name
- PCOSA-1 (NCT02771561)
- Testing
- Patent Foramen Ovale Closure
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Papworth Hospital NHS Foundation Trust
HCM, Noonan Syndrome and Other Rasopathy
Clinical Trial of a MEK Inhibitor for RASopathy-Associated Severe Infantile Hypertrophic Cardiomyopathy: Baby MERIT
This project seeks to perform a Phase 3 clinical trial to test whether an FDA-approved cancer drug called trametinib is effective in treating young infants with genetic conditions called RASopathies and a severe, life-threatening…
- Conditions
- HCM, Noonan Syndrome and Other Rasopathy, Heart Failure (Pediatric)
- Trial name
- Baby MERIT (NCT07817186)
- Testing
- Trametinib
- Volunteers
- 25 people
- Sponsor
- Carelon Research
Isolated Noncompaction of the Ventricular Myocardium
Risk Stratification and Early Prevention Strategies for Non-compaction of Ventricular Myocardium (CAPTAIN)
This study intends to retrospectively-prospectively enroll NVM patients from multiple centers to establish a natural population cohort of NVM patients.
- Trial name
- NCT06504056
- Testing
- Diagnosis of NVM
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Sudden Cardiac Arrest, Sudden Arrhythmic Death Syndrome
Hearts in Rhythm Organization (HiRO)National Registry and Bio Bank
The Hearts in Rhythm Organization (HiRO) is a national network of Canadian researchers/clinicians, working towards a better understanding of the rare genetic causes of sudden cardiac death (SCD).
- Conditions
- Sudden Cardiac Arrest, Sudden Arrhythmic Death Syndrome, Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC), Long QT Syndrome (LQTS)
- Trial name
- HiRO (NCT04189822)
- Where
- Canada
- Volunteers
- 10,000 people
- Sponsor
- University of British Columbia
Turner Syndrome, Renal Insufficiency, Chronic
Study to Define Optimal IGF-1 Monitoring in Children Treated With NutropinAq
The main purpose of this study is to establish an optimal monitoring regimen in NutropinAq treated children, using newly developed capillary blood spot IGF-1 measurement technology.
- Conditions
- Turner Syndrome, Renal Insufficiency, Chronic, Pituitary Diseases, Dwarfism
- Trial name
- OPTIMA (NCT00234533)
- Testing
- Somatropin (rDNA origin)
- Where
- 45 sites in Belgium, Czechia and 12 more
- Volunteers
- 251 people
- Sponsor
- Ipsen
Prader-Willi Syndrome, PWS-like Syndrome
GROWing Up With Rare GENEtic Syndromes
Introduction Rare complex syndromes Patients with complex genetic syndromes, by definition, have combined medical problems affecting multiple organ systems, and intellectual disability is often part of the syndrome.
- Conditions
- Prader-Willi Syndrome, PWS-like Syndrome, Silver Russel Syndrome, Congenital Hypopituitarism
- Trial name
- GROW UR GENES (NCT04463316)
- Testing
- Retrospective file studies
- Where
- Netherlands
- Volunteers
- 600 people
- Sponsor
- dr. Laura C. G. de Graaff-Herder
Congenital Heart Disease
Theophylline Effects in the Fontan Circulation
A single group treatment phase 2 single-arm no-masking study to assess safety and efficacy of a short-term oral treatment with theophylline (ATC-no.
- Trial name
- THIEF (NCT05717049)
- Testing
- Theophylline Tablets
- Where
- Norway
- Volunteers
- 10 people
- Sponsor
- Oslo University Hospital
Coronary Arteriosclerosis, Hypoalphalipoproteinemias
High-Density Lipoprotein (HDL) Treatment Study
A low level of plasma high-density lipoprotein (HDL) cholesterol, "the good cholesterol", is the most common lipid abnormality observed in patients with a premature atherosclerotic cardiovascular disease.
- Conditions
- Coronary Arteriosclerosis, Hypoalphalipoproteinemias, Genetic Diseases, Inborn
- Trial name
- NCT00458055
- Testing
- Atorvastatin; Fenofibrate; Niacin
- Where
- Canada
- Volunteers
- 19 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Tetralogy of Fallot (TOF), Ventricular Tachycardia
Validation of ECG-Based Ventricular Arrhythmia Localization Algorithms in Patients With Repaired Tetralogy of Fallot
Doctors use patterns on heart rhythm tracings (ECGs) to predict where abnormal heart rhythms originate, but these prediction methods were developed in people with normal heart structure.
- Trial name
- NCT07607821
- Testing
- RV and LV pace mapping
- Volunteers
- 30 people
- Sponsor
- Boston Children's Hospital
Wolf Parkinson White Syndrome, Arrythmias
Wolf-Parkinson-White Syndrome and Asymptomatic Pre-excitation in Africa (a Multicenter WPW African Registry)
The purpose of this prospective observational study is to characterize the clinical profile of patients with WPW syndrome and patients with asymptomatic WPW pattern on ECG in different African countries and how these patients are…
- Trial name
- NCT06260384
- Testing
- electrocardiogram
- Where
- Egypt
- Volunteers
- 500 people
- Sponsor
- Ain Shams University
Down Syndrome (Trisomy 21), Edwards Syndrome (Trisomy 18)
Non-Invasive Screening for Fetal Aneuploidy: A New Maternal Plasma Marker
Validate that circulating cell free fetal nucleic acid can be used to identify a direct marker for fetal aneuploidy, particularly fetal Down Syndrome (DS), that is better than surrogate markers.
- Conditions
- Down Syndrome (Trisomy 21), Edwards Syndrome (Trisomy 18), Patau Syndrome (Trisomy 13), Turner Syndrome
- Trial name
- NCT00770458
- Where
- 7 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Sequenom, Inc.
Univentricular Heart, Microvascular Dysfunction
Cardiac Magnetic Resonance Stress-perfusion Study in Patinets with Fontan Circulation
Univentricular heart (UVH) is a severe congenital heart disease. Accurate advanced non-invasive diagnostic methods is limited. Cardiovascular magnetic resonance (CMR) imaging has evolved as a particularly useful tool for the…
- Conditions
- Univentricular Heart, Microvascular Dysfunction, Heart Failure, Magnetic Resonance
- Trial name
- CMR_TCPC (NCT06735521)
- Testing
- Cardiac magnetic resonance stress-perfusion
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Karolinska Institutet
Heart Diseases
Development of an Screening System in Children With Congenital Heart Disease Based on Cloud Computing and Big Data
This study intends to establish an automatic system for screening on children with congenital heart disease, the system include the auscultation of cardiac murmur and the test of oxygen saturation, the data was analyzed based on…
- Trial name
- NCT03929133
- Testing
- automatic screening machine on congenital heart disease
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Myocardial Bridge of Coronary Artery, Myocardial Bridge
Myocardialbridge Bypass Graft Surgery Efficacy Verification
Myocardial Bridge Bypass Graft surgery is introduced to relieve the unmedical symptoms of patients with long-segment or deep myocardial bridge, clinical outcomes will be collected to verify the effectiveness of the surgery.
- Conditions
- Myocardial Bridge of Coronary Artery, Myocardial Bridge, Myocardial Bridging, Myocardial Infarction
- Trial name
- NCT06857838
- Testing
- MBBG, MB CABG, MB unroof
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Xi'an International Medical Center Hospital
Genetic Disorder, Turner Syndrome
Use of Somatropin in Turner Syndrome
This trial is conducted in Europe. The aim of this trial is to study the dose-response relationship and effect of somatropin (Norditropin®) on final height in girls with Turner Syndrome.
- Trial name
- NCT01518036
- Testing
- somatropin
- Where
- United Kingdom
- Volunteers
- 57 people
- Sponsor
- Novo Nordisk A/S
ST Elevation Myocardial Infarction, Colchicine
Effect of Colchicine on MMP-9, NOX2, and TGF-β1 in Myocardial Infarct
Reducing NOX-2, MMP-9, and TGF-β1 Expression in Preventing Ventricular Remodelling Post Acute ST-Segment Elevation Myocardial Infarction using Colchicine (Post Late Reperfusion Percutaneous Coronary Intervention and…
- Conditions
- ST Elevation Myocardial Infarction, Colchicine, Cardiac Remodeling, Ventricular
- Trial name
- NCT05709509
- Testing
- Colchicine, Percutaneous Coronary Intervention, Optimal medical treatment including statin, aspirin, P2Y12 inhibitor, and nitrate.
- Where
- Indonesia
- Volunteers
- 148 people
- Sponsor
- RSD dr. Soebandi
Sudden Cardiac Death
CIQTP Prolongation : Role and Mechanism in Sudden Cardiac Death
Despite major progress in molecular and phenotypic characterization of primary electrical disorders, many (aborted) sudden cardiac deaths (SCD) occur in young victims without identifiable abnormalities.
- Trial name
- IQARE-SCD (NCT03387072)
- Testing
- Non interventional study
- Where
- 4 sites in France
- Volunteers
- 394 people
- Sponsor
- Nantes University Hospital
Cardiomyopathy, Dilated
Prognostic Value of Myocardial Fibrosis Quantified Using CMR in Patient With Dilated Cardiomyopathy
: Fibrosis, in general, is a scarring process, which is characterized by fibroblast accumulation and excess deposition of extracellular matrix (ECM) proteins, which leads to distorted organ architecture and function.
- Trial name
- NCT02352129
- Testing
- CMR using T1 mapping technique
- Where
- France
- Volunteers
- 262 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
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