Clinical trials: Defects
PTA (Percutaneous Transluminal Angioplasty ), Femoropopliteal Artery Disease
Clinical Outcomes of GENOSS PCB for Femoropopliteal Artery Disease
The GENOSS PCB study aims to evaluate the safety and efficacy of a Paclitaxel-coated PTA Balloon Catheter(GENOSS® PCB) in patients with the femoropopliteal artery disease.
- Trial name
- GENOSS PCB (NCT07399080)
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Genoss Co., Ltd.
Spina Bifida
QUALAS Validation in Dutch
Rationale Patients with spina bifida often experience a decreased quality of life compared to patients without spina bifida. The Quality of Life Assessment for Spina Bifida (QUALAS) is a validated questionnaire to assess the…
- Trial name
- NCT06723951
- Testing
- QUALAS survey
- Where
- 2 sites in Netherlands
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Erasmus Medical Center
Hypoplastic Left Heart Syndrome, Single Ventricle
Transcoronary Infusion of Cardiac Progenitor Cells in Patients With Single Ventricle Physiology
Hypoplastic left heart syndrome (HLHS) and related anomalies involved a single ventricle are characterized by hypoplasia of the left heart and the aorta with compromised systemic cardiac output.
- Conditions
- Hypoplastic Left Heart Syndrome, Single Ventricle, Heart Failure
- Trial name
- TICAP (NCT01273857)
- Testing
- Autologous cardiac progenitor cell transplantation, staged shunt procedure
- Where
- Japan
- Volunteers
- 14 people
- Sponsor
- Okayama University
Congenital Heart Defects
Outcomes in Patients and Their Closest Relatives Treated for Congenital Heart Disease With Catheter Based or Surgical Techniques
This study compares clinical, self- reported and cost outcomes in children and adolescents treated with pulmonary valve implantation, percutaneous versus open surgical technique.
- Trial name
- MEQC (NCT01421030)
- Testing
- Percutaneous pulmonary valve implantation or open heart surgery
- Where
- Norway
- Volunteers
- 40 people
- Sponsor
- Oslo University Hospital
Articular Cartilage Lesion of the Femoral Condyle
RCT of ChondroCelect® (in an ACI Procedure) vs Microfracture in the Repair of Cartilage Defects of the Knee
This is a phase III, multicenter, open-label, randomized controlled trial of ChondroCelect® in an Autologous Chondrocyte Implantation (ACI) procedure compared to the procedure of microfracture (MF) in the repair of symptomatic…
- Trial name
- TIGACT01 (NCT00414700)
- Testing
- ChondroCelect implantation, Microfracture
- Where
- 12 sites in Belgium, Croatia and 2 more
- Volunteers
- 118 people
- Sponsor
- TiGenix n.v.
Heart Defects, Congenital, Pediatrics
CHAMP App Cardiac Study and Repository
This is a multi-site research study with an optional research repository that will consist of clinically derived data and photographic or video images of patients in the home setting with complex health conditions to evaluate the…
- Trial name
- CHAMP (NCT06034392)
- Testing
- CHAMP App
- Where
- 9 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Lori Erickson
Channelopathies, Brugada Syndrome
Safety of Local Dental Anesthesia in Patients With Cardiac Channelopathies
Patients with cardiac channelopathies needing restorative dental treatment will be included in two sessions of the study, using local dental anesthetic: lidocaine 2% with epinephrine and lidocaine 2% without vasoconstrictor.
- Conditions
- Channelopathies, Brugada Syndrome, Long QT Syndrome, Ventricular, Tachycardia
- Trial name
- SLDAPCC (NCT03182777)
- Testing
- Dental restorative procedure
- Where
- Brazil
- Volunteers
- 31 people
- Sponsor
- University of Sao Paulo General Hospital
Marfan Syndrome, Marfan Related Disorders
Development of a Blood Test for Marfan Syndrome
The objective of this study is to determine whether a simple blood test can be a useful clinical tool for monitoring aortic disease in Marfan syndrome and Marfan-related disorders.
- Conditions
- Marfan Syndrome, Marfan Related Disorders, Control Subjects
- Trial name
- NCT02148900
- Where
- 5 sites in United States
- Volunteers
- 336 people, healthy volunteers welcome
- Sponsor
- Shriners Hospitals for Children
Pulmonary Arterial Hypertension, Congenital Heart Disease
Iloprost for the Treatment of Pulmonary Hypertension in Adults With Congenital Heart Disease
Pulmonary arterial hypertension (PAH), or high blood pressure in the lungs, is common in patients with congenital heart disease.
- Conditions
- Pulmonary Arterial Hypertension, Congenital Heart Disease, Eisenmenger's Syndrome
- Trial name
- NCT01319045
- Testing
- Iloprost
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of California, Los Angeles
Congenital Heart Disease
Exercise Training in Grown-up Congenital Heart Disease
Rationale: Regular physical activity and aerobic exercise training are related to decreased cardiovascular mortality in healthy individuals, as well as in individuals with cardiovascular risk factors and cardiac patients.
- Trial name
- ExTra-GUCH (NCT02825472)
- Testing
- exercise training
- Where
- 2 sites in Italy, Netherlands
- Volunteers
- 100 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Congenital Heart Disease (CHD), Complex Congenital Heart Disease
Community-Based Remote Cardiac Rehabilitation Program for Pediatric Patients With Complex Congenital Heart Disease
This study is to develop a 12-week community-based remote cardiac rehabilitation program for pediatric patients with complex congenital heart disease and to assess its validity and safety.
- Conditions
- Congenital Heart Disease (CHD), Complex Congenital Heart Disease, Congenital Heart Disease in Children
- Trial name
- NCT06912412
- Testing
- Community-based supervised remote cardiac rehabilitation, Home-based cardiac rehabilitation program
- Where
- South Korea
- Volunteers
- 10 people
- Sponsor
- Seoul National University Hospital
Dental Fluorosis
Clinical Evaluation of Dental Fluororsis Treatment Modalities
Background: Various treatment modalities are available to improve esthetics of fluorosed teeth based on its severity. Aim: evaluate the clinical performance of different minimal invasive treatment protocols on mild to moderate…
- Trial name
- NCT05204277
- Testing
- Opalescence™ boost™ PF 40%, Opalustre™, MI-Paste Plus®
- Where
- Egypt
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Suez Canal University
Heterotaxy Syndrome
Heterotaxy Syndrome and Intestinal Rotation Abnormalities - A Prospective Study
Infants with heterotaxy syndrome (HS) are born with an abnormal arrangement of organs along the right-left body axis. Abnormalities of intestinal rotation and fixation are commonly associated with HS.
- Trial name
- NCT01591928
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Alberta
Concentrated Growth Factor, Bone Substitute
Effect of Concentrated Growth Factors on Healing of Apicomarginal Defects: a Prospective Study
The persistent and chronic apical periodontitis has caused great difficulties for clinical physicians. Ensuring rapid and successful healing of the extensively damaged periapical region is a pressing issue that needs to be…
- Trial name
- NCT05938907
- Testing
- concentrated growth factor, bone substitute, concentrated growth factor + bone substitute
- Where
- China
- Volunteers
- 72 people
- Sponsor
- West China Hospital
White Spot Lesions, White Spot Lesions [Initial Caries] on Smooth Surface of Tooth
Assessing the Effects of Resin Infiltration and Resin Modified Glass Ionomer on the Color Changes of White Spot Lesions in a Clinical and Laboratory Setting
The goal of this clinical trial is to assess the efficacy of "Icon® resin infiltration" and "VanishTM XT varnish" in restoring the appearance of white spot lesions WSLs in healthy children affected with anterior white spot…
- Conditions
- White Spot Lesions, White Spot Lesions [Initial Caries] on Smooth Surface of Tooth, Enamel Hypomineralization
- Trial name
- RI (NCT06696105)
- Testing
- Resin infiltration, Vanish XT varnish (resin modified glass ionomer restoration)
- Where
- 2 sites in Saudi Arabia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- King Abdulaziz University
Articular Cartilage of the Femoral Condyle Between 2-6cm2
NOVOCART®3D for Treatment of Articular Cartilage of the Knee
This study is to compare NOVOCART 3D relative to Microfracture for the treatment of knee cartilage defects. Efficacy will be evaluated by both pain and function. Safety will also be evaluated.
- Trial name
- N3D (NCT01957722)
- Testing
- Microfracture, NOVOCART 3D
- Where
- 35 sites in United States, Canada
- Volunteers
- 233 people
- Sponsor
- Aesculap Biologics, LLC
Meningioma, Tumor, Brain
MiDura-Study (Neuro-Patch in Duraplasty)
The aim of this study is to collect systematically and proactively data regarding the performance of Neuro-Patch, like complications and handling, under daily clinical practice when used as intended by the manufacturer
- Conditions
- Meningioma, Tumor, Brain, Chiari Malformation, Vascular Malformation
- Trial name
- MiDura (NCT04189172)
- Where
- 4 sites in France, Germany
- Volunteers
- 328 people
- Sponsor
- Aesculap AG
Prematurity, Neonatal Sepsis
Defects in Opsonophagocytosis in Premature Infants
The purpose of the study is to characterize innate immune function of premature infants, and identify defects that may be responsible for the development of bacterial sepsis.
- Trial name
- NCT00866567
- Where
- Switzerland
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Acute Knee Cartilage Injury, Tear of Articular Cartilage of Knee, Current
EAGLE European Post Market Study
Prospective, multi-center, non-randomized, historical controlled, post-market study of patients requiring surgical repair of a focal articular cartilage lesion or osteochondral defect in the knee.
- Trial name
- EAGLE (NCT02309957)
- Testing
- BioMatrix CRD
- Where
- 6 sites in Germany, Italy and 2 more
- Volunteers
- 33 people
- Sponsor
- Kensey Nash Corporation
PFO - Patent Foramen Ovale
Amplatzer PFO Occluder Post-marketing Surveillance Study
The purpose of the Amplatzer PFO Occluder post-marketing clinical use surveillance study is to observe the frequency, type and degree of adverse device effects and adverse events in order to assure the safety of the new medical…
- Trial name
- PFO PMS Jpn (NCT04349995)
- Testing
- Amplatzer PFO Occluder
- Where
- Japan
- Volunteers
- 500 people
- Sponsor
- Abbott Medical Devices
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.