Clinical trials: Defects
Congenital Heart Disease
High-exchange ULTrafiltration to Enhance Recovery After Pediatric Cardiac Surgery
Malformations of the heart are common; 1.35 million infants are born each year with congenital heart disease. Many of these defects carry a considerable threat to the individual's quality of life as well as survival.
- Trial name
- ULTRA (NCT04920643)
- Testing
- Ultrafiltration
- Where
- Canada
- Volunteers
- 104 people
- Sponsor
- IWK Health Centre
Stroke, Brain Diseases
VIrtual Reality Glasses Use to Improve Lateropulsion and the Post-stroke Postural Vertical
VIRGIL is a monocentric interventional study aiming to investigate the effect of immersion in a virtual tilted room on modulation of the verticality representation (postural vertical [PV] and visual vertical [VV]), which in turn…
- Conditions
- Stroke, Brain Diseases, Cerebrovascular Disorders, Postural; Defect
- Trial name
- VIRGIL (NCT04911738)
- Testing
- Virtual Reality , immersion in a virtual titlted room
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Cesarean Scar Defect
Hysteroscopic "360°" Surgery for Improvement of Symptoms in Cesarean Scar Defects
Patients with symptomatic Cesarean Scar Defect (CSD) who are expected to undergo hysteroscopic surgery will be randomly divided into the traditional hysteroscopic "channelization" treatment group and the hysteroscopic "360 °"…
- Trial name
- NCT06917014
- Testing
- 360°, traditional
- Volunteers
- 88 people
- Sponsor
- Fu Xing Hospital, Capital Medical University
Adult Congenital Heart Disease
Real-World Data on the Effects of Cardiac Resynchronization Therapy in Adult Patients With Congenital Heart Disease
This study aims to evaluate the real-world effects of cardiac resynchronization therapy (CRT) in adult patients with congenital heart disease (ACHD).
- Trial name
- RECORD-CHD (NCT06969924)
- Testing
- Cardiac resynchronization therapy
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Leiden University Medical Center
Post Traumatic Soft Tissue Defects That Could be Reached by Pedicled Anterolateral Thigh Flap, Post Tumor Excision Soft Tissue Defects
Reliability and Versatility of Pedicled Anterolateral Thigh Flap in Reconstruction of Soft Tissue Defects
a prospective case series study for evaluation of the reliability and versatility of pedicled anterolateral thigh flap in the reconstruction of soft tissue defects as regards flap survival and complications, donor site morbidity…
- Conditions
- Post Traumatic Soft Tissue Defects That Could be Reached by Pedicled Anterolateral Thigh Flap, Post Tumor Excision Soft Tissue Defects, Post Debridement Soft Tissue Defects
- Trial name
- NCT06841419
- Testing
- surgical reconstruction of a soft tissue defects by a pedicled flap
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Sohag University
Congenital Heart Disease, Emotional Regulation
Efficacy of a Web-Based Emotion Regulation Intervention for Patients With Congenital Heart Disease
Congenital heart disease (CHD) is associated with daily stressors and functional impairments that can cause negative emotions. Emotion regulation abilities may determine whether people with CHD develop psychopathology or adapt to…
- Trial name
- NCT05862909
- Testing
- CHD-specific web-based emotion regulation intervention, General web-based emotion regulation intervention
- Where
- Germany
- Volunteers
- 524 people
- Sponsor
- Heidelberg University
Ventricular Septal Defect, Papillary Muscle Rupture
Mechanical Complications of Acute Myocardial Infarction: a Multicenter Prospective Study
In 2019, the international study titled "CAUTION Study - 1" (MeChanical complicAtions of acUte myocardial infarcTion: an InternatiOnal multiceNter cohort study), a retrospective multicenter study, was launched and registered on…
- Conditions
- Ventricular Septal Defect, Papillary Muscle Rupture, Cardiac Rupture, Pseudoaneurysm
- Trial name
- CAUTION 2 (NCT06676345)
- Testing
- Surgical treatment, Percutaneous treatment
- Where
- Italy
- Volunteers
- 800 people
- Sponsor
- Maastricht University Medical Center
Heart Septal Defect, Heart Septal Defects, Atrial
Safety and Efficacy Study of reSept ASD Occluder for Treating Secundum ASD
Evaluation of the safety and efficacy of the reSept ASD Occluder to treat patients with clinically significant secundum atrial septal defect
- Conditions
- Heart Septal Defect, Heart Septal Defects, Atrial, Heart Defects, Congenital, Cardiovascular Abnormalities
- Trial name
- ASCENT ASD (NCT04591392)
- Testing
- reSept ASD Occluder
- Where
- 32 sites in United States, Canada and 2 more
- Volunteers
- 250 people
- Sponsor
- atHeart Medical
Fetal Congenital Abnormalities, Fetoscopy
Fetoscopic Robotic Open Spina Bifida Treatment
Fetal spina bifida is a common birth defect that results in hydrocephalus, motor-, bowel-, bladder- and sexual dysfunction in the child. The condition is progressive in utero.
- Conditions
- Fetal Congenital Abnormalities, Fetoscopy, Fetal Surgery, Robotic Surgical Procedure
- Trial name
- FROST (NCT06907732)
- Testing
- Fetoscopic robotic open spina bifida closure
- Volunteers
- 15 people
- Sponsor
- Mount Sinai Hospital, Canada
Bone Defects of the Limbs
Evaluation of the Safety and Efficacy of Artificial Bone Repair Materials for Repair of Long Bone Defects in the Extremities
Evaluation of the Safety and Efficacy of Artificial Bone Repair Materials for Repair of Long Bone Defects in the Extremities: A Prospective, Randomized Controlled, Single-Blind, Non-Inferiority Clinical Trial
- Trial name
- NCT06959459
- Testing
- Intervention Group:Use of artificial bone repair materials produced by Changzhou Bone-Renewal Medical Technologies LLC., Control group: Use of β-tricalcium phosphate bioceramics produced by Shanghai Biolu Biomaterials Co., Ltd.
- Where
- China
- Volunteers
- 156 people
- Sponsor
- Chinese PLA General Hospital
Neural Tube Defects, Spina Bifida
Fetoscopic Neural Tube Defect Repair
This is a single-arm prospective study to record maternal and neonatal outcomes on subjects who undergo fetoscopic repair of Neural Tube Defects (NTD) at Oregon Health \& Science University (OHSU).
- Trial name
- NTD (NCT06946563)
- Testing
- Fetoscopic Neural Tube Defect Repair Devices
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Oregon Health and Science University
Intrabony Defect, Periodontal Diseases
RGD With Minimally Invasive Non-Surgical Technique in Treatment of Periodontal Intrabony Defect
Periodontal regeneration is a complex process that involves coordinated activities and interactions of many cell types, extracellular matrix, cytokines, and specific growth factors to restore tissue integrity.
- Conditions
- Intrabony Defect, Periodontal Diseases, Alveolar Bone Loss
- Trial name
- MINST + RGD (NCT06936605)
- Testing
- RGD Peptide
- Volunteers
- 45 people
- Sponsor
- Minia University
Infant of Diabetic Mother, Sacral Agenesis
Screening for Sacral Agenesis in Offspring of Mothers With Diabetes in Pregnancy
Babies born to mothers with pregestational diabetes will be screened with parental consent for sacral agenesis
- Trial name
- NCT05033275
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Missouri-Columbia
Septic Shock, Platelet Signal Processing Defect
PLatelets Acetyl-CoA Carboxylase Phosphorylation State in SEPtic Shock
Knowing the dramatic increase in thrombin generation during sepsis, our research hypothesis is that AMPK-induced ACC phosphorylation in platelets is increased and that this might modulate platelets metabolism and more…
- Conditions
- Septic Shock, Platelet Signal Processing Defect, Inflammatory Response, Disseminated Intravascular Coagulation
- Trial name
- PLACCSEPS (NCT04107402)
- Testing
- Assessment of coagulopathy, Platelets activation and Platelets-Neutrophils interplay
- Where
- Belgium
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Meta-diaphyseal Bone Defect In Long Bone
Treatment Of Meta-diaphyseal Bone Defect In Long Bone With Titanium Mesh Cage
Meta-diaphyseal bone defects in long bones pose a significant challenge in orthopedic surgery. Traditional treatment methods include autologous bone grafts, allografts, and distraction osteogenesis.
- Trial name
- NCT06923579
- Testing
- Titanium Mesh Cage
- Volunteers
- 20 people
- Sponsor
- Assiut University
Bone Substitutes, Bone Defect
Pre-market Study to Evaluate Safety and Performance of GreenBone Implant (Long Bone Study)
Multi-center, international, prospective, open-label, single-arm, first-in-human clinical investigation. The Patients enrolled in this clinical investigation will undergo a scheduled surgery for the treatment of long bone defects…
- Trial name
- NCT03884790
- Testing
- surgical repair of long bone defects
- Where
- 8 sites in Bosnia and Herzegovina, Israel and 4 more
- Volunteers
- 16 people
- Sponsor
- GreenBone Ortho S.p.A.
Congenital Heart Disease
Antenatal Investigation of Fetuses With Complex Congenital Heart Defects Using multiOMICS
This study will use multiOMICS study on fetuses with complexe congenital heart defects (CHD) to identify etiological epigenetic factors of these cardiac malformations, related to environmental factors during pregnancy.
- Trial name
- CARDIOMICS (NCT06705543)
- Testing
- multi-omics genetic analyses included exome, multi-omics genetic analyses
- Where
- 2 sites in France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Transition to Adult Care, Congenital Heart Disease
Development and Polit Study of Get Ready With my Heart Program
The goal of this clinical trial is to learn if the Get Ready with my Heart Program developed based on SMART theory is applicable for AYAs with CHD to enhance their Transition Readiness.
- Trial name
- NCT06418373
- Testing
- Get Ready with My Heart Program, Conventional intervention
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Children's Hospital of Fudan University
Visual Field Defects, Visual Field Loss
Study on the Effectiveness and Safety of VRT in Patients With Visual Field Defects
The goal of this clinical trial is to learn if visual restoration therapy (VRT) (a type of treatment that aims to improve vision) works to the visual rehabilitation of patients with visual field defects.
- Trial name
- NCT06914505
- Testing
- visual restoration therapy
- Volunteers
- 58 people
- Sponsor
- Xuanwu Hospital, Beijing
Congenital Heart Disease (CHD), Complex Congenital Heart Disease
Community-Based Remote Cardiac Rehabilitation Program for Pediatric Patients With Complex Congenital Heart Disease
This study is to develop a 12-week community-based remote cardiac rehabilitation program for pediatric patients with complex congenital heart disease and to assess its validity and safety.
- Conditions
- Congenital Heart Disease (CHD), Complex Congenital Heart Disease, Congenital Heart Disease in Children
- Trial name
- NCT06912412
- Testing
- Community-based supervised remote cardiac rehabilitation, Home-based cardiac rehabilitation program
- Where
- South Korea
- Volunteers
- 10 people
- Sponsor
- Seoul National University Hospital