Clinical trials: Defibrillation
Atrial Fibrillation
Single vs. Dual-DCCV in Obese Patients
Currently, the usual initial strategy for direct current cardioversion (DCCV) typically involves delivering 200J of electricity between two pads placed in the anterior and posterior positions (i.e., one on the chest and one on…
- Trial name
- NCT04539158
- Testing
- Direct Current Cardioversion
- Where
- 3 sites in United States
- Volunteers
- 200 people
- Sponsor
- Dr. Daniel P Morin, MD MPH FHRS
Atrial Fibrillation, Atrial Flutter
Anteroposterior Versus Anterolateral Electrode Position for Electrical Cardioversion of Atrial Fibrillation
Atrial fibrillation is the most common heart rhythm disorder (arrhythmia) worldwide. Nearly 40 million people are affected by atrial fibrillation worldwide, and this number is expected to increase by over 50% by 2050.
- Trial name
- SHOCK-VECTOR (NCT05511389)
- Testing
- Anterolateral electrode position, Anteroposterior electrode position, Manual pressure
- Where
- 4 sites in Canada
- Volunteers
- 1,750 people
- Sponsor
- McMaster University
Atrial Fibrillation
Shock Energy for Electrical Cardioversion of Persistent Atrial Fibrillation
The goal of this clinical trial is to compare the efficacy of a maximum output shock for cardioverting atrial fibrillation between two commonly used defibrillators in New Zealand .
- Trial name
- NCT05903170
- Testing
- 360J LifePak Monitor/Defibrillator, 200J Philips HeartStart MRx Monitor/Defibrillator
- Where
- New Zealand
- Volunteers
- 100 people
- Sponsor
- Wellington Hospital
Atrial Fibrillation
Stepwise Strategy for Treatment of Atrialfibrillation Substrate Study
Electrical/pharmacological cardioversion improves structural remodeling of left atrium. We hypothesized that radiofrequency ablation surgery for atrial fibrillation has a higher success rate and a lower recurrence rate of atrial…
- Trial name
- SAFE (NCT07129564)
- Testing
- treatment react
- Where
- China
- Volunteers
- 480 people
- Sponsor
- Yuehui Yin
Emergency Medical Services, Electric Countershock
A Feasibility Study for Elective Cardioversion of Atrial Fibrillation at Home
The goal of this pilot, non-controlled, non-randomised, single centre, prospective intervention feasibility study is to assess the feasibility of a home DC-ECV in the treatment of recurrent symptomatic AF performed by APP in 25…
- Trial name
- Electra-1 (NCT06322836)
- Testing
- Duble current electro cardioversion
- Where
- Netherlands
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- RAV Brabant MWN
Ventricular Arrhythmias
Study of Defibrillation Testing In Patients Undergoing Initial ICD Implantation
The primary objective of this study is to compare the composite outcome of total mortality and operative complications in patients who do not undergo defibrillation testing to those who do undergo defibrillation testing at the…
- Trial name
- TNT-ICD (NCT01905007)
- Testing
- Defibrillation testing
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- The Cooper Health System
Monomorphic Ventricular Tachycardia
Evaluation of Inducible Monomorphic Ventricular Tachycardia (MMVT) in Patients With St. Jude Medical (SJM) Implantable Cardioverter Defibrillator (ICD) Systems or Cardiac Resynchronization Therapy Defibrillation (CRT-D) Systems.
The intent of this observational study is to understand the role of non-invasive programmed stimulation (NIPS) to induce substrate based MMVT (Monomorphic Ventricular Tachycardia) in patients receiving new St.
- Trial name
- EPIC (NCT02584595)
- Testing
- ICD/CRT-D with NIPS or EP Study
- Sponsor
- Abbott Medical Devices
Cardiac Pacing, Electric Countershock
Follow-up of Patients With Implantable Cardioverter Defibrillators by Home Monitoring (ANVITE)
Patients with implantable cardioverter defibrillators (ICDs) should undergo regular device follow-ups every 3 months, to verify proper ICD function.
- Conditions
- Cardiac Pacing, Electric Countershock, Ventricular Tachyarrhythmia
- Trial name
- ANVITE (NCT00858559)
- Testing
- Implantable cardioverter defibrillator with Home Monitoring function, Standard implantable cardioverter defibrillator
- Where
- Germany
- Volunteers
- 110 people
- Sponsor
- Biotronik SE & Co. KG
Tachycardia, Ventricular Arrhythmias
Acute Study to Collect Electrical Signals From the Heart Using a Special Lead
The main purpose of this clinical study is to collect electrograms from an investigational lead placed in an extravascular space, for development of a future Implantable Cardioverter Defibrillator (ICD) system.
- Trial name
- NCT02772380
- Testing
- Defibrillation following induction of VT/VF
- Where
- 36 sites in United States, Australia and 10 more
- Volunteers
- 87 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Atrial Fibrillation (AF)
Exercise-induced Cardioversion in Persistent Atrial Fibrillation
This study aims to to evaluate the feasibility of conducting a larger randomized controlled trial (RCT) to assess whether an exercise stress test on an ergometer bicycle could induce sinus rhythm in patients with persistent AF…
- Trial name
- ExPAF (NCT07008066)
- Testing
- Bicycle ergometer excercise, Standard care with electrical cardioversion
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Uppsala University
Ventricular Arrhythmias
Acute Defibrillation Study
The proposed study is designed to characterize defibrillation efficacy in humans for the potential development of a new extravascular implantable cardioverter defibrillator (ICD) system.
- Trial name
- NCT02227121
- Testing
- Defibrillation following induction of VT/VF
- Where
- 7 sites in Hong Kong, Netherlands and 2 more
- Volunteers
- 16 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Atrial Fibrillation, Electric Countershock
BIS-Guided Sedation Versus Standard Clinical Sedation During Elective Electrical Cardioversion for Atrial Fibrillation
Electrical cardioversion (ECV) is a standard procedure used to restore normal heart rhythm in patients with atrial fibrillation (AF) by delivering a brief electrical shock to the heart.
- Conditions
- Atrial Fibrillation, Electric Countershock, Deep Sedation
- Trial name
- BIS-ECV-RCT (NCT07569016)
- Testing
- BIS-guided propofol sedation, Clinical-guided propofol sedation
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Istanbul University - Cerrahpasa
Atrial Fibrillation
Impact of New Biomarkers on Maintenance of Sinus Rhythm After Cardioversion or Ablation of Atrial Fibrillation
The Biorhythm study aims to investigate the utility of new biomarkers (e.g. MR proANP, ST2) measured pre-procedure for the prediction of procedural success in patients with atrial fibrillation undergoing cardioversion or ablation.
- Trial name
- Biorhythm (NCT03351816)
- Testing
- Ablation of atrial fibrillation, Cardioversion
- Where
- 3 sites in France
- Volunteers
- 106 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Defibrillator, Tricuspid Valve Regurgitation
Early Feasibility Study of 3930M Defibrillation Lead Implantation Via the Middle Cardiac Vein in Patients With Tricuspid Valve Regurgitation
Prospective, single center, early feasibility study designed to evaluate the initial safety and device performance of the Medtronic 3930M Lead when implanted via the Middle Cardiac Vein in patients with Tricuspid Valve…
- Trial name
- MCV3930 EFS (NCT07811609)
- Testing
- Defibrillator
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Minneapolis Heart Institute Foundation
Atrial Fibrillation
Inflammation as a Predictor in Cardioversion of Atrial Fibrillation
The laboratory test, C-Reactive Protein (CRP), has become well established as a marker of inflammation. Recently a high CRP level (indicating an increase in inflammation) was identified as a risk factor for atrial fibrillation.
- Trial name
- NCT00590525
- Testing
- Cardioversion
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Creighton University
Cardiac Arrest, Ventricular Fibrillation
VectOr ChAnge defibriLlatIon in Refractory Shockable rhyThms
Management of cardiac arrest according to published guidelines has remained largely unchanged for a decade. Thames Valley Air Ambulance provide Critical Care Paramedic and Physician teams who respond to cardiac arrests and offer…
- Conditions
- Cardiac Arrest, Ventricular Fibrillation, Ventricular Tachycardia
- Trial name
- VOCALIST (NCT05926973)
- Testing
- Enhanced cardiac arrest bundle
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Thames Valley Air Ambulance
Atrial Fibrillation
Intravenous Cardioversion of Atrial Fibrillation (AF) With AZD1305
This study is being carried out to see which dose of AZD1305 is safe and effective in cardioverting atrial fibrillation into normal heart rhythm.
- Trial name
- NCT00915356
- Testing
- AZD1305
- Where
- 31 sites in Czechia, Denmark and 6 more
- Volunteers
- 228 people
- Sponsor
- AstraZeneca
Defibrillation Capacity of Defibrilators After Replacement
Cardioverter Defibrillator Replacement With Induction of Ventricular Fibrillation and Defibrillation Testing
The SIMPLE study was a large one, and lasted quite a few years due to its design as a randomized controlled trial and the follow up needed to reach an endpoint.
- Trial name
- SIMPLER (NCT02513030)
- Testing
- Defibrillation testing during ICD replacement
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Sheba Medical Center
Atrial Fibrillation
A Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacokinetics of HSY244 in Participants With Atrial Fibrillation
This was a randomized, placebo-controlled, investigator- and participant-blinded study to evaluate the efficacy, safety, tolerability, and pharmacokinetics (PK) of HSY244 in participants with atrial fibrillation (AF), with and…
- Trial name
- NCT04582409
- Testing
- HSY244
- Where
- 4 sites in United States, Germany
- Volunteers
- 13 people
- Sponsor
- Novartis Pharmaceuticals
Cardiomyopathy, Heart Failure
Evaluating Myocardial Injury for Defibrillation Threshold Testing Methods for ICD Implantation
The objective of this study is to evaluate myocardial injury, if any, as quantified by cardiac markers (Troponin-T) in defibrillation threshold (DFT) testing during implantation of implantable cardioverter defibrillators (ICDs)…
- Conditions
- Cardiomyopathy, Heart Failure, Cardiac Arrhythmia
- Trial name
- ULV (NCT02111993)
- Testing
- Standard Defibrillation Testing, Upper Limit of Vulnerability Testing
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of California, San Diego