Clinical trials: Deficiency; Fibrinogen, Acquired
Acquired Fibrinogen Deficiency
Phase 3 Study of Fibrinogen Concentrate (CSL511) in Subjects With Pseudomyxoma Peritonei Undergoing Cytoreductive Surgery
This study is a phase 3, prospective, single center, randomized, open label, controlled, parallel arm, interventional study to investigate the efficacy and safety of CSL511, in participants undergoing cytoreductive surgery (CRS)…
- Trial name
- NCT06617897
- Testing
- CSL511 Fibrinogen concentrate (human), Cryoprecipitate
- Where
- United Kingdom
- Volunteers
- 90 people
- Sponsor
- CSL Behring
Trauma Induced Coagulopathy, Trauma Coagulopathy
Point of Care Fibrinogen Measurement in Trauma Patients in the Emergency Department
Background: Why This Study Matters When someone suffers a severe injury (like from a car crash), they can bleed heavily. One complication doctors often face is something called Trauma-Induced Coagulopathy (TIC).
- Conditions
- Trauma Induced Coagulopathy, Trauma Coagulopathy, Fibrinogen Deficiency, Fibrinogen; Deficiency, Acquired
- Trial name
- POCFIB (NCT07097337)
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- Erasmus Medical Center
Fibrinogen; Deficiency, Acquired, PHARMACOKINETICS
Pharmacokinetic Model of Fibrinogen Plasma Levels After Fibrinogen Administration
characterize the fibrinogen PK in patients with acquired -chronic (cirrhotic patients) or acute- hypofibrinogenemia (severe trauma or critical haermorrhage), showing endogenous production.
- Trial name
- PKMF (NCT05503498)
- Testing
- DATA RECORDING
- Where
- 2 sites in Spain
- Volunteers
- 200 people
- Sponsor
- Hospital Clinic of Barcelona
Post Partum Hemorrhage, Fibrinogenolysis; Hemorrhage
Patient Blood Management for Massive Obstetric Hemorrhage
Obstetric Hemorrhage continues to be the first cause of maternal morbidity and mortality around the world especially in middle to low income countriesThe blood components are high value resources; however, its use has been shown…
- Conditions
- Post Partum Hemorrhage, Fibrinogenolysis; Hemorrhage, Fibrinogen; Deficiency, Acquired, Massive Hemorrhage
- Trial name
- NCT03784794
- Testing
- Thromboelastometry, Standard Coagulation Test, Fibrinogen Concentrate Human
- Where
- Mexico
- Volunteers
- 100 people
- Sponsor
- Angel Augusto Perez Calatayud
Deficiency; Fibrinogen, Acquired
FIBrinogen REplenishment in Surgery
This is a pragmatic, prospective, multi-center, randomized, active-control, single-blinded, non-inferiority phase 3 trial in adult cardiac surgical patients.
- Trial name
- FIBRES (NCT03037424)
- Testing
- Octafibrin, Cryoprecipitate
- Where
- 11 sites in Canada
- Volunteers
- 827 people
- Sponsor
- University Health Network, Toronto
Trauma, Bleeding Disorder
Early Administration of Fibrinogen in Polytraumatized Patients With Hypofibrinogenemia: a Randomized Feasibility Trial
This is a randomized feasibility trial conducted with severe trauma patients. At admission patients presented hypofibrinogenemia, hypotension and tachycardia.
- Conditions
- Trauma, Bleeding Disorder, Fibrinogen; Deficiency, Acquired
- Trial name
- NCT02864875
- Testing
- Fibrinogen concentrate
- Where
- Brazil
- Volunteers
- 32 people
- Sponsor
- University of Sao Paulo General Hospital