Clinical trials: Deficiency Disease
Anemia, Iron-deficiency
Effectiveness of Selling Micronutrient Sprinkles in Rural Kenya
The purpose of the study is to evaluate the effectiveness of household-based distribution of evidence-based health products and to measure the health impact of these combined interventions on a population basis.
- Trial name
- NICHE (NCT01088958)
- Testing
- Micronutrient powders (Sprinkles)
- Where
- Kenya
- Volunteers
- 7,200 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Hypercholesterolemia, Vitamin D Deficiency
Effects of Vitamin D on Lipids
The purpose of this study is to examine whether oral vitamin D supplementation in people with inadequate vitamin D concentrations will lower LDL-cholesterol and total cholesterol concentrations.
- Trial name
- NCT00723385
- Testing
- Vitamin D (1000 or 2000 IU/day)
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Marasmus
Effectiveness of Safe Drinking Water in Treatment of Severe Acute Malnutrition (Pakistan)
This study builds evidence on the importance of using safe drinking water during the nutritional treatment of children affected by Severe Acute Malnutrition (SAM).
- Trial name
- NCT02751476
- Testing
- Point of Use (PoU) water treatment flocculent disinfectant., Point of Use (PoU) water treatment chlorine disinfectant, Point of Use (PoU) ceramic water filter
- Volunteers
- 820 people
- Sponsor
- Action Contre la Faim
Cytomegalovirus Infections, HIV Infections
A Randomized, Phase I/II Trial to Assess the Safety and Antiviral Effects of Escalating Doses of A Human Anti-Cytomegalovirus Monoclonal Antibody (SDZ MSL-109) in Patients With the Acquired Immunodeficiency Syndrome and CMV Viremia and/or Viruria
To determine the safety, tolerance, and potential in vivo antiviral effects of five dosage levels and a dose to be determined of human anti-cytomegalovirus (CMV) monoclonal antibody (SDZ MSL-109; formerly SDZ 89-109) when…
- Trial name
- NCT00002268
- Testing
- Sevirumab
- Where
- 2 sites in United States
- Sponsor
- Sandoz
Human Immunodeficiency Virus
Using Social Media to Improve ART Retention and Treatment Outcomes Among YLHIV in Nigeria
A randomized control trial to test the effectiveness of a structured online support group, SMART (Social Media to improve ART Retention in Treatment) Connections, to improve retention in HIV care services among youth living with…
- Trial name
- Y-SMART (NCT03516318)
- Testing
- SMART Connections
- Where
- Nigeria
- Volunteers
- 355 people, healthy volunteers welcome
- Sponsor
- FHI 360
Acute Myeloid Leukemia, Chronic Myelomonocytic Leukemia
A Study to Evaluate S241656 Alone or in Combination in Participants With Selected Myeloid Malignancies
The objective of this study is to evaluate the safety, tolerability, and pharmacokinetics (PK) of S241656 and to determine the recommended dose for expansion (RDE) of S241656 in participants with relapsed/refractory (R/R) acute…
- Conditions
- Acute Myeloid Leukemia, Chronic Myelomonocytic Leukemia, Myelodysplastic Syndrome Acute Myeloid Leukemia
- Trial name
- NCT07719348
- Testing
- S241656, Posaconazole
- Volunteers
- 64 people
- Sponsor
- Servier
Vitamin D Deficiency, Respiratory Tract Infections
Vitamin D Supplementation for the Prevention of Acute Respiratory Infections: a RCT in Young Finnish Men
Vitamin D intervention effects on the prevention of acute respiratory tract infections among Young Finnish Men
- Trial name
- NCT05014048
- Testing
- Vitamin D3
- Where
- Finland
- Volunteers
- 231 people, healthy volunteers welcome
- Sponsor
- Tampere University
Diabetes Mellitus, Type 2, Kidney Diseases
Effect of Weekly High-dose Vitamin D3 Supplementation on the Association Between Circulatory FGF-23 and A1c Levels
Among Jordanians, there is a high prevalence of T2DM. VDD has also spread rapidly in the past decade. Preliminary results of recent studies have shown that VD3 has a potential role in reducing FBG.
- Trial name
- NCT04682626
- Testing
- Soft gelatin capsules each contains 50 000 IU VD3 (cholecalciferol) equivalents to 1.25 mg.
- Where
- Jordan
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Applied Science Private University
Refractory Iron Deficiency Anemia
Endoscopy in Anemic Children
Assess the role of Upper and lower gastrointestinal endoscopy in evaluation of refractory iron deficiency anemia in children
- Trial name
- NCT06729489
- Testing
- Upper Endoscopy
- Where
- Egypt
- Volunteers
- 25 people
- Sponsor
- Sohag University
N-Acetylneuraminic Acid Storage Disease
Sialic Acid Supplementation in N-Acetylneuraminic Acid Synthase (NANS) Deficiency
This study is aimed at assessing the impact of short-term (3 days) exogenous sialic acid supplementation on endogenous biomarkers of sialic acid metabolism in NANS deficient patients.
- Trial name
- NCT03545568
- Testing
- Neu5Ac supplementation
- Where
- 2 sites in Italy, Switzerland
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Lausanne
Pneumonia, Pneumocystis Carinii, HIV Infections
A Study of Three Drugs Plus Zidovudine in the Prevention of Infections in HIV-Infected Patients
To evaluate and compare 3 anti-pneumocystis regimens plus zidovudine (AZT) in persons with HIV infection and T4 cell count less than 200 cells/mm3.
- Trial name
- NCT00000991
- Testing
- Pentamidine isethionate, Sulfamethoxazole-Trimethoprim, Dapsone
- Where
- 21 sites in United States, Tanzania
- Volunteers
- 600 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV, HIV Infections
T-cell Responses to Concurrent HIV and Herpesvirus Infections
This is a research study in which we are trying to discover new information about how HIV and herpes viruses interact with the immune system.
- Trial name
- NCT03996018
- Testing
- T-cell lymphocyte responses
- Where
- United States
- Volunteers
- 135 people
- Sponsor
- St. Jude Children's Research Hospital
Limbal Stem Cell Deficiency
Multi-Center, Prospective, Non-Interventional Study in Subjects With Limbal Stem Cell Deficiency
The goal of this non-interventional, observational study is to describe the natural history, clinical course, and management patterns of subjects with limbal stem cell deficiency (LSCD).
- Trial name
- NCT07636590
- Testing
- Non-interventional
- Where
- 8 sites in United States
- Volunteers
- 500 people
- Sponsor
- Claris Biotherapeutics, Inc.
Cardiovascular Diseases, Vitamin D Deficiency
The Effect of Vitamin D Statues on Endothelial Function
In the United States, cardiovascular disease causes over one-third of all deaths and vitamin D deficiency is an epidemic. An increasing body of data suggests that low vitamin D status adversely impacts the cardiovascular system.
- Trial name
- CVD Cookie (NCT01049048)
- Testing
- Vitamin D3
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Alpha-Mannosidosis
Evaluation of Long-term Efficacy of Treatment With Lamazym
The overall objective is to evaluate the long-term efficacy of Lamazym i.v. treatment in patients with alpha-Mannosidosis previously enrolled in Lamazym trials and currently receiving the treatment according to the AfterCare…
- Trial name
- rhLAMAN-10 (NCT02478840)
- Testing
- Lamazym
- Where
- Denmark
- Volunteers
- 18 people
- Sponsor
- Zymenex A/S
Liver Post-transplant Patients
Assessement of the Prevalence of Lysosomal Acid Lipase Deficiency in Liver Post-transplant Patients
Lysosomal Acid Lipase (LAL) deficiency is a rare, autosomal recessive storage disease linked to decrease enzymatic activity of LAL, responsible for intracellular accumulation of cholesterol esters and triglycerides.
- Trial name
- LALTH-2 (NCT02851550)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Hospices Civils de Lyon
Severe Combined Immunodeficiency, Atypical
Generalized Neonatal Screening of Severe Combined Immunodeficiencies
Severe combined Immunodeficiencies ( SCID ) are a group of inherited diseases of the immune system by characterised profound abnormalities of T cell development .
- Trial name
- DEPISTREC (NCT02244450)
- Testing
- SCID screening
- Where
- 51 sites in France
- Volunteers
- 190,539 people, healthy volunteers welcome
- Sponsor
- Nantes University Hospital
HIV Infections
Proof-of-Concept Clinical Pharmacology Trial for HIV Antigen Presentation Therapeutic Biologic Mix
Conducting an initial small, controlled clinical pharmacology trial to assess for therapeutic biologics activity (proof-of-concept) that suggests the potential for clinical benefit of HIV (+) patients 1.
- Trial name
- HIVGP-BCG (NCT07182838)
- Testing
- HIV Therapeutic Biologic Mix - HIV GP160 plus BCG Vaccine Mix for percutaneous use
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Han Xu, M.D., Ph.D., FAPCR, Medical Director, IRB Chair
HIV Infections
Resistance to HIV Infection
The immune systems of some individuals may be capable of resisting HIV infection. These individuals do not appear to be infected with HIV despite multiple sexual encounters with HIV infected partners.
- Trial name
- NCT00069485
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Hiv
Welcoming by Design Pilot: Reducing Structural Stigma by Changing Clinic Systems and Architectural Design
The purpose of this study is to test the feasibility and acceptability of implementing clinic system changes and physical structures in Uganda to improve aesthetics, welcome, and privacy to reduce HIV stigma, improve…
- Trial name
- NCT05642676
- Testing
- Clinics remodeling
- Where
- United States
- Sponsor
- University of Minnesota
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