Clinical trials: Deficiency Disease
Hiv, Sexually Transmitted Infections (Not HIV or Hepatitis)
Improving Perinatal Outcomes Among Kenyan Pregnant Women With an Integrated STI Testing Model
The investigators will conduct a 3-arm individual-level RCT in Kisumu and Siaya, Kenya to compare perinatal outcomes associated with 3 models of STI testing and management in antenatal care.
- Trial name
- PrIMI (NCT06203951)
- Testing
- Xpert® CT/NG and TV testing
- Where
- 8 sites in Kenya
- Volunteers
- 3,132 people, healthy volunteers welcome
- Sponsor
- University of Washington
Acquired Immune Deficiency Syndrome
A Post Marketing Survey Study to Evaluate the Safety and Effectiveness of Prezista
The purpose of this study is to assess the safety data of darunavir in a natural clinical practice.
- Trial name
- NCT01741831
- Testing
- No intervention
- Where
- South Korea
- Volunteers
- 225 people
- Sponsor
- Janssen Korea, Ltd., Korea
HIV/AIDS, Nicotine Dependence
Optimizing Tobacco Use Treatment for PLWHA
The advent of anti-retroviral therapy (ART) for people living with HIV/AIDS (PLWHA) substantially improved life expectancy but has also led to the critical need to address modifiable risk factors associated with cancer and…
- Trial name
- HTO (NCT04176172)
- Testing
- Varenicline, Nicotine patch, Standard treatment
- Where
- 2 sites in United States
- Volunteers
- 340 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
GVHD, Bone Marrow Transplant Failure
α1-antitrypsin (AAT) Levels and Functions in Allogeneic Bone Marrow Transplantation and Throughout Progression Into GVHD
Create a personalized time and context curve of patient circulating α1-antitrypsin (AAT) levels and functions before hematopoietic stem cell transplantation and throughout progression into GVHD. PRIMARY ENDPOINT 1.
- Conditions
- GVHD, Bone Marrow Transplant Failure, Alpha 1-Antitrypsin
- Trial name
- AATGVHD-MARK (NCT03188601)
- Where
- 4 sites in Israel
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Sarcopenia, Chronic Kidney Diseases
Sarcopenia, Fall and Osteoporosis in Chronic Kidney Disease
This study is a cross-sectional study that wishes to investigate whether there is an increased incidence of sarcopenia in patients with chronic kidney disease compared to the Danish background population.
- Conditions
- Sarcopenia, Chronic Kidney Diseases, Osteoporosis
- Trial name
- NCT04515342
- Testing
- DXA, Muscle strength and function assessment, Blood samples
- Where
- 2 sites in Denmark
- Volunteers
- 140 people
- Sponsor
- Herlev Hospital
Tuberculosis, Pulmonary, HIV Coinfection
Pharmacist-Led Intervention to Improve TB Treatment Adherence
The goal of this clinical trial is to compare the adherence of co-morbid patients in control and experimental group The main question[s]it aims to answer are: 1.
- Trial name
- RA-15041995 (NCT06608069)
- Testing
- Educational counselling
- Where
- 2 sites in Malaysia
- Volunteers
- 383 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Wiskott-Aldrich Syndrome
A Clinical Study to Evaluate the Use of a Cryopreserved Formulation of OTL-103 in Subjects With Wiskott-Aldrich Syndrome
This is an open-label, single arm study to evaluate the cryopreserved formulation of OTL-103 Gene Therapy. OTL-103 consists of autologous CD34+ hematopoietic stem cells in which the gene encoding for the Wiskott-Aldrich Syndrome…
- Trial name
- NCT03837483
- Testing
- OTL-103
- Where
- 2 sites in United States, Italy
- Volunteers
- 10 people
- Sponsor
- Fondazione Telethon
Depression, Chronic Liver Disease
Vitamin D Improves Depression in Liver Patients
This study evaluates the efficacy of vitamin D replacement therapy in reducing depressive symptoms in patients with chronic liver disease and vitamin D deficiency.
- Trial name
- CLDVitD (NCT02359266)
- Testing
- Vitamin D
- Where
- Germany
- Volunteers
- 111 people
- Sponsor
- Universität des Saarlandes
Pregnant HIV Positive Women
A Prospective, Observational Study of HIV-Infected Pregnant Women and Their Infants at Clinical Sites in Latin American and Caribbean Countries
By the end of 1999, it was estimated that 1.2 million children were living with HIV infection. During 1999 alone, 600,000 children were newly infected with HIV, mostly in less-developed countries.
- Trial name
- NCT00341302
- Where
- 12 sites in Argentina, Brazil and 1 more
- Volunteers
- 3,554 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
HIV Infections
Pharmacokinetic Study of Two Generic Co-formulations of Lopinavir/Ritonavir for HIV Infected Children (SURF)
This pilot pharmacokinetic study is designed to exclude a large difference (>40%) in pharmacokinetics (esp. AUC) between two new Lopimune formulations and the branded formulation.
- Trial name
- SURF (NCT00665951)
- Testing
- Lopinavir/ritonavir
- Where
- Netherlands
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Chronic Insomnia
Shiwei Anshen Granules for Chronic Insomnia
This is a multi-center, randomized, controlled clinical study inlcuding 240 subjects with chronic insomnia. The purpose of this study is to evaluate the efficacy and safety of Shiwei Anshen Granules (an Chinese herbal…
- Trial name
- Shiwei-Anshen (NCT07895329)
- Testing
- Shiwei Anshen granules
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Dongzhimen Hospital, Beijing
HIV Infection
Evaluating a Microfinance Intervention for High Risk Women in Mongolia
The proposed study aims to test the feasibility and preliminary efficacy of a combined 4-session HIV sexual risk reduction (HIVSRR) and microfinance intervention (including 34 training session and matched savings) to reduce…
- Trial name
- NCT01861431
- Testing
- HIV Sexual Risk reduction, HIV Sexual Risk reduction plus Microfinance
- Where
- Mongolia
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- Columbia University
HIV-1 Infections, HIV Infections
Pre-Exposure Prophylaxis to Prevent HIV-1 Acquisition Within HIV-1 Discordant Couples
Randomized, blinded, placebo-controlled trial to demonstrate if pre-exposure prophylaxis decreases HIV-1 acquisition among HIV-1 uninfected individuals within HIV-1 discordant couples.
- Trial name
- Partners PrEP (NCT00557245)
- Testing
- Tenofovir Disoproxil Fumarate (TDF), Emtricitabine/Tenofovir Disoproxil Fumarate (FTC/TDF)
- Where
- 9 sites in Kenya, Uganda
- Volunteers
- 4,758 people, healthy volunteers welcome
- Sponsor
- University of Washington
Common Variable Immunodeficiency, Agammaglobulinemia
Specific IgG Antibody in Patients With Primary Antibody Deficiencies Treated With Subcutaneous Immunoglobulin
Objective: Measure serum IgG antibody to Streptococcus pneumoniae serotypes 1, 3, 5, 6B, 9V e 14, Haemophilus influenzae type b and tetanus toxoid in patients with primary antibody deficiencies who were treated with subcutaneous…
- Trial name
- NCT00661401
- Testing
- gammaglobulin
- Where
- Brazil
- Volunteers
- 5 people
- Sponsor
- Federal University of São Paulo
Malignant Neoplasm of Breast, Breast Cancer
Comprehensive Analysis of Predictors of the Treatment With Pembrolizumab and Olaparib in Patients With Unresectable or Metastatic HER2 Negative Breast Cancer and a Deleterious Germline Mutation or a Homologous Recombination Deficiency (COMPRENDO
This study will examine the combination of pembrolizumab and olaparib in three populations. Cohort 1: aBC patients with a germline mutation in BRCA1 or BRCA2, cohort 2: aBC patients with a germline mutation in one of the moderate…
- Trial name
- COMPRENDO (NCT05033756)
- Testing
- Pembrolizumab Injection [Keytruda], Olaparib Oral Tablet [Lynparza]
- Where
- 6 sites in Germany
- Volunteers
- 11 people
- Sponsor
- Institut fuer Frauengesundheit
Birth Weight, Small for Gestational Age at Delivery
Improving Birth Outcomes in Bangladesh
Maternal undernutrition is a global public health problem with far-reaching effects for both mothers and infants. Poor maternal nutrition negatively affects fetal growth and development.
- Conditions
- Birth Weight, Small for Gestational Age at Delivery, Diet; Deficiency, Gestational Weight Gain
- Trial name
- NCT05855551
- Testing
- Base cash transfer, Behavior change communication (BCC), Food basket
- Where
- Bangladesh
- Volunteers
- 4,620 people, healthy volunteers welcome
- Sponsor
- International Food Policy Research Institute
HIV Infections
A Clinical Trial to Evaluate the Safety and Immunogenicity of Recombinant HIV-1 Envelope Protein BG505 SOSIP.GT1.1 Gp140 Vaccine, Adjuvanted in Healthy, HIV-uninfected Adults
This is a phase 1 clinical trial to evaluate the safety, tolerability, and immunogenicity of HIV-1 envelope protein BG505 SOSIP.GT1.1 gp140 trimer Vaccine, Adjuvanted, in up to 48 healthy HIV-uninfected adult volunteers.
- Trial name
- NCT04224701
- Testing
- BG505 SOSIP GT1.1 gp140 Vaccine, Adjuvanted
- Where
- 3 sites in United States, Netherlands
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- International AIDS Vaccine Initiative
Meningitis, Cryptococcal, HIV Infections
Safety and Efficacy of Amphotericin B Lipid Complex in the Treatment of Cryptococcal Meningitis in Patients With the Acquired Immunodeficiency Syndrome
To evaluate the safety, tolerance and efficacy of three different dosage regimens of Amphotericin B Lipid Complex (ABLC) compared to Fungizone (Amphotericin B) in patients with AIDS and cryptococcal meningitis.
- Trial name
- NCT00002019
- Testing
- Amphotericin B, Lipid-based, Amphotericin B
- Where
- 19 sites in United States
- Sponsor
- Liposome
HIV Infections
Pediatric Expanded Access Program-Oral Solution (0831-908)
Monitor the safety and tolerability of efavirenz oral solution in combination with Antiretroviral Therapy for the treatment of patients age 3 to 16 years who have failed therapy or who are intolerant to their current therapy.
- Trial name
- NCT00543530
- Testing
- MK0831
- Sponsor
- Merck Sharp & Dohme LLC
Neurotrophic Keratitis
Nerve Growth Factor for the Treatment of Cornea Disease
To determine the efficacy and safety of nerve growth factor in the treatment of limbal stem cell deficiency (LSCD) associated with neurotrophic cornea.
- Trial name
- NCT04552730
- Testing
- Cenegermin-Bkbj
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Stanford University
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