Clinical trials: Deficiency Disease
HIV Infections
Stigma, Social Support and Quality of Life
The primary goal of this observational study is to investigate the relationship between perceived stigma and social support in HIV+ patients.
- Trial name
- 4826 (NCT05781204)
- Testing
- Survey
- Where
- Italy
- Volunteers
- 96 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
HIV Infection
Interleukin-2 Plus Antiretroviral Therapy for HIV-Infected Patients With Low CD4+ Counts (SILCAAT Study)
This study will examine whether interleukin-2 (IL-2) plus antiretroviral therapy (ART) slows HIV disease progression in patients with low CD4+ T cell counts compared with patients taking ART alone.
- Trial name
- SILCAAT (NCT00013611)
- Testing
- Proleukin
- Where
- United States
- Volunteers
- 1,695 people
- Sponsor
- University of Minnesota
Chronic Kidney Failure, AIDS-Associated Nephropathy
Prevalence of Proteinuria and Chronic Kidney Disease in Pediatric HIV-Infected Patients
Among adults with Human Immunodeficiency Virus (HIV) and Acquired Immunodeficiency Syndrome (AIDS), Chronic Kidney Disease (CKD) has previously been reported to occur in approximately 10% of children with HIV-infection.
- Conditions
- Chronic Kidney Failure, AIDS-Associated Nephropathy, HIV Infections
- Trial name
- NCT00153621
- Where
- United States
- Volunteers
- 320 people
- Sponsor
- Children's National Research Institute
HIV, Sexually Transmitted Diseases
Safer Choices 2 - HIV, STD, & Pregnancy Prevention Program
The purpose of the study is to adapt, implement, and evaluate an effective theoretically-based, high school HIV prevention program,Safer Choices, for higher risk youth in alternative schools. Primary Research Question 1.
- Conditions
- HIV, Sexually Transmitted Diseases, Pregnancy, HIV Infections
- Trial name
- NCT00223314
- Testing
- HIV, STD, Pregnancy Prevention Curriculum
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- The University of Texas Health Science Center, Houston
Hereditary Angioedema (HAE)
A Study of Lanadelumab in Children With Hereditary Angioedema (HAE) in Multiple Countries
HAE is a rare condition. It causes sudden swelling under the skin and inside the body, like in the belly, throat, or genitals. This swelling happens because of a temporary leak in blood vessels but does not cause itching or…
- Trial name
- NCT07251933
- Testing
- No intervention
- Where
- 24 sites in Argentina, France and 4 more
- Volunteers
- 37 people
- Sponsor
- Takeda
HIV Infections
A Study of Nevirapine Used Alone or in Combination With AZT in HIV-1-Infected Children
Monotherapy phase: To evaluate and compare the safety, tolerance, pharmacokinetics, and preliminary activity of nevirapine administered alone in mildly to moderately symptomatic HIV-infected children ages 2 months to less than 18…
- Trial name
- NCT00001111
- Testing
- Nevirapine, Zidovudine
- Where
- 7 sites in United States
- Volunteers
- 35 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Limbal Stem Cell Deficiency
ABCB5 as a Prognostic Marker in Survival of Cultivated Limbal Stem Cell Transplantation
In this study the prognostic value of ABCB5 in survival of the limbal stem cell transplantation expanded in vitro on amniotic membrane for corneal surface reconstruction in patients with limbal stem cell deficiency will be…
- Trial name
- NCT02579993
- Testing
- Pannus and conjunctival dissection, Human cultivated limbal stem cell transplantation
- Where
- Mexico
- Volunteers
- 10 people
- Sponsor
- Instituto de Oftalmología Fundación Conde de Valenciana
HIV Infections, Lipodystrophy
Exercise for Patients With HIV Infections
The investigators will evaluate the effects of an endurance exercise program on the physical performance, the well being, and indicators of metabolic function in patients with an HIV infection.
- Conditions
- HIV Infections, Lipodystrophy, Inflammation
- Trial name
- NCT00910936
- Testing
- Exercise
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Charite University, Berlin, Germany
HIV Infections
Study Evaluating Vaccine in Adults With HIV
The purpose of this study is to learn whether the study vaccine and adjuvants (drugs that are used to help improve immune responses) have an acceptable safety profile in treating individuals with HIV.
- Trial name
- NCT00195234
- Testing
- HIV CTL MEP 1000 micrograms, 19 months per subject
- Where
- 10 sites in United States
- Volunteers
- 60 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
HIV Infections
AmbassADDOrs for Health Study
The goal of the study is to evaluate Malkia Klabu ("Queen Club") in Tanzania, a loyalty program intervention that creates adolescent girls and young women (AGYW)-friendly drug shops where AGYW can access HIV prevention services…
- Trial name
- ADDO (NCT05357144)
- Testing
- Loyalty card program at drug shops & supply of HIVST and SRH products, Comparison drug shops
- Where
- 2 sites in Tanzania
- Volunteers
- 157 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Antithrombin III Deficiency, Covid19
Antithrombin III in Infectious Disease Caused by COVID-19
The purpose of this research study is to see if participants who have SARS-CoV-2 and low levels of AT3 in the blood will benefit by being given AT3.
- Trial name
- NCT04899232
- Testing
- Antithrombin III
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Enrique Ginzburg
CDKL5 Deficiency Disorder
The Association Between Fever and CDKL5 Deficiency Disorder: a Nationwide Survey
The primary objective of this research is to study the effects of fever on seizure activity in patients with CDKL5 deficiency disorder
- Trial name
- NCT06663163
- Testing
- Observation
- Where
- China
- Volunteers
- 131 people
- Sponsor
- Xuanwu Hospital, Beijing
Genetic Syndrome
NGLY1 Deficiency: A Prospective Natural History Study
NGLY1 deficiency is a rare genetic disorder that is characterized by: global developmental delay and/or intellectual disability, hypo- or alacrima, transient elevation of transaminases, and a hyperkinetic movement disorder.
- Trial name
- NCT03834987
- Testing
- Neurodevelopmental Assessment
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Stanford University
Hiv, Aids
Reducing Time to Spaced-out Appointments for Newly-diagnosed People Living With HIV
The objectives of this study are to pilot test the effect of reducing time to spaced-out appointments from 18 to 6 months for newly-diagnosed people living with HIV (PLWH) in Rwanda who have initiated antiretroviral therapy…
- Trial name
- NCT04567693
- Testing
- Early spaced-out appointments
- Where
- Rwanda
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Colorectal Neoplasms, Hereditary Nonpolyposis, Endometrial Neoplasms
Study of Universal Screening for Lynch Syndrome in Chinese Patients of Endometrial Cancer
In patients diagnosed as endometrial cancer by thorough pathologic examinations, Lynch syndromes are screened by (1)immunohistochemical staining (for MLH1, MSH2, MSH6 and PMS2), (2) tests of microsatellite instability and (3)…
- Trial name
- NCT03291106
- Testing
- immunohistochemical staining, tests of microsatellite instability, clinical criteria of Lynch syndromes
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Lei Li
Growth Hormone Deficiency, Adult Growth Hormone Deficiency
BELux Children OutcoME During A(@)Dulthood With GHD
Our objective is to evaluate the outcome in adulthood of Belgian and Luxembourgish patients treated with rhGH during childhood for CO-GHD.
- Trial name
- BELCOME@GHD (NCT06694506)
- Testing
- Biological Sample
- Where
- Belgium
- Volunteers
- 200 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Deficiency, Vitamin D
Vitamin D Status After Single Oral Dose of Cholecalciferol in Low Fat Meal Compared to High-fat Meal
The purpose of this study is to evaluate the absorption of dietary supplement of vitamin D3 (cholecalciferol), through the variation of 25 (OH) D levels, as the fat content of the meal associated with the administration of the…
- Trial name
- VITDAB_08606 (NCT00968734)
- Testing
- colecalciferol
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Federal University of Rio Grande do Sul
Nutritional Rickets
Vitamin D and Genetics in Nutritional Rickets
The purpose of this study is: 1. To compare the response of rickets to calcium with and without vitamin D. 2. To assess whether vitamin D increases calcium absorption in calcium deficiency rickets. 3.
- Trial name
- NCT00949832
- Testing
- Vitamin D + Calcium, Calcium, Vitamin D2
- Where
- Nigeria
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Dry Eye, Sjogren's Syndrome
Pilot Study for Testing Safety of Repetitive Magnetic Stimulation for Treatment of Dry Eye
The study aims to test the safety of Repetitive Magnetic Stimulation (RMS) treatment for dry eye disease. Patients are asked to undergo a one-time treatment with Epitech Ocular Magnetic Stimulation Device on one eye in the first…
- Conditions
- Dry Eye, Sjogren's Syndrome, Aqueous Tear Deficiency, Meibomian Gland Dysfunction
- Trial name
- NCT03012698
- Testing
- Ocular Repetitive Magnetic Stimulation (RMS) treatment
- Where
- 3 sites in Israel
- Volunteers
- 29 people
- Sponsor
- Epitech Mag Ltd.
HIV Infection, Erythrocyte Glutathione Deficiency
Role of HIV on Glutathione Synthesis and Oxidative Stress
HIV infection is associated the development of increased oxidative stress and deficiency of glutathione (GSH), the dominant endogenous antioxidant protein, but the underlying mechanisms contributing to GSH deficiency are hitherto…
- Trial name
- NCT01355198
- Testing
- Cysteine (as n-acetylcysteine) and glycine, Cysteine/glycine
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Baylor College of Medicine
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