Clinical trials: Deformity of Limb
Metacarpal Fracture
Syndactyly Versus Closed Reduction in 5th Metacarpal Neck Fracture
This study aims to compare the functional results of two different therapeutic approaches in patients that present with a 5th metacarpal neck fracture.
- Trial name
- NCT03434587
- Testing
- Syndactyly, Reduction and inmobilization
- Where
- Spain
- Volunteers
- 72 people
- Sponsor
- Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
Pes Planus
Effectiveness of Manuel Therapy Methods in Pes Planus
The aim of this study is to compare the immediate effects of joint-oriented manual therapy and soft tissue-oriented manual therapy on dorsiflexion angle, static and dynamic balance, muscle-tendon mechanical properties, and…
- Trial name
- NCT07326020
- Testing
- joint mobilization, myofascial release
- Where
- Turkey (Türkiye)
- Volunteers
- 33 people
- Sponsor
- Hande Guney Deniz
Arthritis, Rheumatoid, Activities of Daily Living
Adaptation of EDAQ Into Turkish, Examining The Reliability and Validity For People With RA
The aim of the study is to adapt the Evaluation of Daily Activity Questionnaire into Turkish language, and to examine the reliability and validity for people with rheumatoid arthritis.
- Trial name
- NCT05244824
- Testing
- Adaptation into Turkish, Examining The Reliability and Validity for People with RA
- Where
- Turkey (Türkiye)
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Duchenne Muscular Dystrophy
Upper Limb Assessment in Duchenne Muscular Dystrophy
The literature on outcome measures assessing upper limbs in Duchenne muscular dystrophy (DMD) is quite scanty. While there have been considerable advances for ambulant DMD boys, no prospective study has so far been devoted to…
- Trial name
- PUL in DMD (NCT02436720)
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Catholic University of the Sacred Heart
Duchenne Muscular Dystrophy, Becker Muscular Dystrophy
Clinical Trial of Coenzyme Q10 and Lisinopril in Muscular Dystrophies
The study will include 120 participants aged 8 and up with Duchenne, Becker, or autosomal recessive limb-girdle (specifically: LGMD 2C-2F and 2I) muscular dystrophies that have no clinical cardiac symptoms.
- Conditions
- Duchenne Muscular Dystrophy, Becker Muscular Dystrophy, Limb Girdle Muscular Dystrophy
- Trial name
- NCT01126697
- Testing
- Coenzyme Q10 and Lisinopril
- Where
- 7 sites in United States, Canada and 1 more
- Volunteers
- 63 people
- Sponsor
- Cooperative International Neuromuscular Research Group
Foot Deformities, Flatfoot
Translation, Cross-cultural Adaptation, and Validation of the FPI-6 in Spain
The objective of this study is to translate, cross-culturally adapt, and validate the Spanish version of the Foot Posture Index (FPI-6).
- Trial name
- FPI-6-ES (NCT07590297)
- Testing
- Spanish version of the Foot Posture Index (FPI-6)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Paloma López Ros
Restless Legs Syndrome, Sleep Quality
Restless Legs Syndrome and Sleep Quality in Pes Planus
Pes planus, also known as flatfoot, is a common foot deformity that can affect the biomechanics of the lower limbs. However, its relationship with neurological conditions has not been studied extensively.
- Conditions
- Restless Legs Syndrome, Sleep Quality, Pain, Quality of Life
- Trial name
- FLAT-RLS (NCT07117591)
- Where
- Turkey (Türkiye)
- Volunteers
- 242 people, healthy volunteers welcome
- Sponsor
- Bozok University
Ataxia, Spinocerebellar, Ataxias, Hereditary
Functional Trunk Training in Ataxia Patients
The study is to examine the effect of functional trunk training on trunk control and upper extremity functions in patients with autosomal recessive ataxia.
- Trial name
- NCT04740359
- Testing
- Functional training, Routine training
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Hasan Kalyoncu University
Duchenne Muscular Dystrophy
Use of Dynamic Arm Supports to Promote Activities of Daily Living in Individuals With DMD
This study is a longitudinal, randomized control trial evaluating the use of two commercially available dynamic arm support devices (1) Armon Ayura-Kinova and 2) JAECO WREX) to promote participation in activities of daily living…
- Trial name
- NCT03531788
- Testing
- Armon Ayura (Kinova), JAECO Wrex
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Roxanna Marie Bendixen
Flat Foot
Effect of Biodex Balance Training and Short Foot Exercise on Myoelectric Activity of Paraspinal Muscles in Subjects with Flexible Flatfoot
The goal of this study is to see the effect of the combination of biodex balance system and short foot exercise in the treatment of subjects with flexible flat foot.
- Trial name
- NCT06606392
- Testing
- Biodex balance system, Short Foot Exercise
- Where
- 2 sites in Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Femoral Anteversion, Pes Planovalgus
Describing the Effects of Insoles in Children With Increased Femoral Anteversion and Pes Planovalgus
Increased Femoral Anteversion is a transverse plan problem that affects lower body alignment, walking and standing characteristics and also pes planovalgus mostly accompanies with IFA.
- Conditions
- Femoral Anteversion, Pes Planovalgus, Flat Foot
- Trial name
- NCT03812822
- Testing
- Insole
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Istanbul Kültür University
Hypothyroidism, Primary Hypothyroidism
Serum Adipokines and Metabolic Parameters With Hormone Replacement in Newly Diagnosed Hypothyroidism
Primary hypothyroidism is associated with significant metabolic disturbances, including dyslipidemia, insulin resistance, adipose tissue dysfunction, and altered adipokine secretion.
- Conditions
- Hypothyroidism, Primary Hypothyroidism, Metabolic Syndrome
- Trial name
- NCT07616570
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Clubfoot Deformity, Forefoot Adductus
Outcomes of Eight-Plate Epiphysiodesis for Residual Clubfoot Deformities
Purpose: The purpose of this prospective clinical study is to evaluate the radiographic outcomes, effectiveness, and safety of lateral calcaneocuboid guided growth using an extra-periosteal tension-band plate (eight-plate) to…
- Trial name
- clubfoot (NCT07621328)
- Testing
- Lateral Calcaneocuboid Guided Growth (Eight-Plating)
- Where
- Egypt
- Volunteers
- 15 people
- Sponsor
- Cairo University
Marfan Syndrome
Clinical Variability in Marfan Syndrome
Marfan syndrome is an autosomal dominant connective tissue disorder caused by mutations in the fibrillin-1 gene (FBN1). Penetrance of FBN1 mutations is complete but intra and inter familial clinical expressivity is extremely…
- Trial name
- Variarfan (NCT01707563)
- Testing
- skin punch biopsy and molecular biology, fibroblast culture and molecular biology
- Where
- France
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Flat Feet, Surgery
Return To Sport Activities in Patients Surgically Treated For Flat Foot in Paeditric Age
The SURGERY of arthrosis of the subtalar joint, carried out between 9 and 12 years of age, the aim is to restore and maintain the physiological alignment between the talus and the calcaneus during bone maturation.
- Conditions
- Flat Feet, Surgery, Sports Physical Therapy
- Trial name
- CSSPORT (NCT04269421)
- Testing
- calcaneo-stop: arthrosis of the subtalar joint
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Istituto Ortopedico Rizzoli
Clubfoot
Exploring the Causes of Clubfoot Using Magnetic Resonance Imaging, MRI
The purpose of this study is to: 1. compare structural variations observed in the calf and foot of the clubfoot mouse model(pma)with human clubfoot patients antenatally and postnatally; 2.
- Trial name
- NCT01088828
- Testing
- Magnetic Resonance Imaging (MRI) of calf and foot
- Where
- United Kingdom
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen
Neoplasm
A Study to Evaluate the Clinical Efficacy of JNJ-42756493 (Erdafitinib), A Pan-Fibroblast Growth Factor Receptor (FGFR) Tyrosine Kinase Inhibitor, In Asian Participants With Advanced Non-Small-Cell Lung Cancer, Urothelial Cancer, Esophageal Cancer Or Cholangiocarcinoma
The primary purpose of this study is to evaluate objective response rate (ORR) as per Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 of erdafitinib in a molecularly-defined subset of Asian participants with…
- Trial name
- NCT02699606
- Testing
- Erdafitinib
- Where
- 6 sites in China, South Korea and 1 more
- Volunteers
- 35 people
- Sponsor
- Janssen Research & Development, LLC
Pes Planus, Diaphragm Issues
The Relationship Between Pes Planus, Diaphragm, Postural Control, and Plantar Pressure
Our primary aim is to compare diaphragm function (resting thickness, activity/resting thickness ratio indicating contractility), postural control, and plantar pressure between individuals with pes planus and healthy controls…
- Conditions
- Pes Planus, Diaphragm Issues, Plantar Pressure, Postural Control
- Trial name
- NCT06491212
- Testing
- Determination of Foot Deformity Level, Foot Function Index, UFAA-International Physical Activity Questionnaire
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Alanya Alaaddin Keykubat University
Pes Planus
Effect of Different Exercise Approaches on Balance and Proprioception in Individuals With Pes Planus
Pes planus; It can be defined as the valgus of the hindfoot while loading the foot, the disappearance of the medial longitudinal arch in the midfoot, and the supination of the forefoot relative to the hindfoot.
- Trial name
- NCT05549063
- Testing
- Mobility and Stability Exercise, Stretching Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Recurrent Congenital Talipes Equinovarus
SPLATT to Peroneus Brevis vs TATT to Lateral Cuneiform
Congenital talipes equinovarus, is a common congenital foot deformity involving hindfoot equinus and varus, along with mid-/forefoot adduction and cavus.
- Trial name
- Recurrent CTEV (NCT06300645)
- Testing
- SPLATT
- Where
- Egypt
- Volunteers
- 25 people
- Sponsor
- Assiut University