Clinical trials: Deformity of Spine
Scoliosis, Quality of Life
Assessing the Quality of Life in Adults With Spinal Deformity
Spinal deformities, such as scoliosis, can have a significant impact on the physical and psychological health of patients. Over time, specific tools for this condition have been developed to investigate the extent of this impact…
- Trial name
- NCT05333757
- Testing
- Questionnaire
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Istituto Scientifico Italiano Colonna Vertebrale
Age-Related Osteoporosis
Genetic Regulators of Bone Health That Are Unique to Vertebral Bone
Osteoporosis is an age related disease in which a person's bone slowly becomes weaker with time. The bones may become so weak that they break easily such as a fall from standing height.
- Trial name
- NCT05946278
- Testing
- Sample collection for gene expression
- Where
- United States
- Volunteers
- 550 people
- Sponsor
- University of Colorado, Denver
MDC1A, SELENON-related Myopathy
The Natural History of Patients With Mutations in SEPN1 (SELENON) or LAMA2
SEPN1 (SELENON) is a rare congenital myopathy due to mutations in the SELENON gene. MDC1A is a rare congenital muscle dystrophy due to mutations in the LAMA2 gene.
- Trial name
- NCT04478981
- Testing
- No intervention
- Where
- Netherlands
- Volunteers
- 38 people
- Sponsor
- Radboud University Medical Center
Degenerative Disc Disease, Craniocervical Injuries
Posterior Cervical Fixation Study
The objective of this study is to evaluate the safety and performance of occipito-cervico-thoracic spine surgery using posterior fixation as measured by reported complications, radiographic outcomes, and patients reported…
- Conditions
- Degenerative Disc Disease, Craniocervical Injuries, Cervical Radiculopathy, Cervical Disc Disease
- Trial name
- NCT04770571
- Testing
- observational study
- Where
- 7 sites in United States
- Volunteers
- 150 people
- Sponsor
- NuVasive
Adult Spinal Deformity, Sagittal Deformity
A Novel Classification of Sagittal Spinal Alignment to Aid Surgical Planning for Adult Spinal Deformity
Surgical outcomes, including radiographic outcomes, patient-reported outcomes, postoperative complications, and revision surgery rates, were compared in patients with adult spinal deformity who underwent correction surgery with…
- Conditions
- Adult Spinal Deformity, Sagittal Deformity, Sagittal Alignment, Sagittal Imbalance
- Trial name
- CSSAASD (NCT06470152)
- Testing
- Correction strategy in reference to our PI-dependent clustering of sagittal alignment, Correction strategy in reference to the SAAS score
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Xuanwu Hospital, Beijing
Low Back Pain, Muscle Strength
Back Squat Exercise Treatment for Low Back Pain: Clinical Trial
Summary: Low back pain is the leading cause of deficiency and loss of productivity worldwide. No evidence of any particular exercise was more effective than another for treating nonspecific low back pain.
- Conditions
- Low Back Pain, Muscle Strength, Visceral Obesity, Spine Disease
- Trial name
- NCT04691258
- Testing
- Experimental: Complete Group, Active Comparator: Restricted Group
- Where
- 3 sites in Brazil
- Volunteers
- 32 people
- Sponsor
- Universidade Federal de Goias
Hyperkyphosis, Adolescent, Muscle Activation
Schroth and Scapular Muscle Activation in Hyperkyphosis
This randomized controlled trial aims to investigate the effects of Schroth exercises on scapular muscle activation in children with thoracic hyperkyphosis.
- Conditions
- Hyperkyphosis, Adolescent, Muscle Activation, Scapula; Deformity, Acquired, Exercise Therapy
- Trial name
- NCT06907914
- Testing
- Schroth
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people
- Sponsor
- Istanbul University - Cerrahpasa
Proximal Junctional Kyphosis, Adult Spinal Deformity Surgery
Post-Operative Thoracolumosacral Orthosis for PJK
Proximal junctional kyphosis (PJK) is a common post-operative radiographic finding after surgery for adult spinal deformity (ASD) patients.
- Conditions
- Proximal Junctional Kyphosis, Adult Spinal Deformity Surgery, Thoracolumbosacral Orthosis
- Trial name
- NCT06491030
- Testing
- Align PJK™ TLSO brace, Standard of Care
- Where
- 6 sites in United States
- Volunteers
- 84 people
- Sponsor
- Hospital for Special Surgery, New York
Spinal Deformity, Bone Graft
Prospective i-FactorTM Analysis Fusion Rate and Quality of Life
Adult spinal deformity surgery is a complex procedure that involves many risks and complications. Bone grafts and bone substitutes are essential to achieve fusion and manage stability in spinal surgery.
- Conditions
- Spinal Deformity, Bone Graft, Fusion Rate, Quality of Life
- Trial name
- NCT04610021
- Testing
- i-FactorTM Bone graft
- Where
- Spain
- Volunteers
- 128 people
- Sponsor
- Complejo Asistencial Universitario de León Urgencias
Adult Spinal Deformity Surgery
SALVAGE Trial (Safety And cLinical Value of AutoloGous rEinfusion)
The investigator hypothesizes intraoperative salvaged red blood cells are a poor substitute for allogenic packed red blood cell transfusions.
- Trial name
- SALVAGE (NCT07712666)
- Testing
- Cell Saver
- Volunteers
- 146 people
- Sponsor
- Mayo Clinic
Adult Spinal Deformity
Neurologic Complications in Spinal Deformity Surgery - Extension
272 subjects with "high risk" adult spinal deformity requiring surgical correction were enrolled in the previous prospective multi-center international Scoli-RISK-1 study.
- Trial name
- NCT02949245
- Testing
- Interventions
- Where
- 11 sites in United States, Canada and 4 more
- Volunteers
- 77 people
- Sponsor
- AO Foundation, AO Spine
Down Syndrome, Cervical Spine Instability in Down Syndrome
Cervical Spine Abnormalities in Down Syndrome
The study aims to determine the prevalence,clinical presentations and radiographic cervical spine abnormalities associated Down syndrome in children at sohag university hospital
- Trial name
- NCT07260136
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Sohag University
Post-operative Pain, Spine, Open
The Effect of Press Needle in the Combination of Ear and Body Acupuncture Points on Visual Analog Scale in Post-Operative Patients of Open Spine Surgery
Postoperative pain is pain that arises after a surgical procedure, resulting from trauma during the surgical incision process. It is generally acute in nature and is accompanied by an inflammatory response.
- Trial name
- NCT06165575
- Testing
- Press needle
- Where
- 3 sites in Indonesia
- Volunteers
- 54 people
- Sponsor
- Universitas Indonesia
Postural Kyphosis, Spine
Reliability of PHAS in Postural Hyperkyphosis
This observational, cross-sectional study aims to evaluate the reliability of the Postural Habits and Awareness Scale (PHAS) in patients with postural hyperkyphosis.
- Conditions
- Postural Kyphosis, Spine, Assessment, Self
- Trial name
- NCT06907901
- Testing
- PHAS Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people
- Sponsor
- Istanbul University - Cerrahpasa
Low Back Pain, Lumbosacral Radiculopathy
A Prospective Study to Compare Bupivacaine and Exparel Versus Bupivacaine or Exparel Alone for Postoperative Pain Relief
The purpose of this study is to collect information about how patients feel when doctors manage their pain after lumbar spine surgery using a combination of EXPAREL® and bupivacaine injected into the lumbar spine at the end of…
- Conditions
- Low Back Pain, Lumbosacral Radiculopathy, Lumbar Disc Degeneration, Lumbar Disc Herniation
- Trial name
- NCT03514277
- Testing
- Exparel, Bupivacaine
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Virtua Health, Inc.
Adult Spinal Deformity, Degenerative Scoliosis
Gait and Paraspinal sEMG in Degenerative Spinal Diseases
This cross-sectional observational study aims to quantitatively compare three-dimensional gait parameters, surface electromyography (EMG) patterns, and radiological parameters among patients with different degenerative spinal…
- Conditions
- Adult Spinal Deformity, Degenerative Scoliosis, Sagittal Deformity, Sagittal Imbalance
- Trial name
- TDGKSEPDSD (NCT07309926)
- Testing
- Gait analysis and surface electromyography analysis
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Disc Degenerative Disease, Spondylolisthesis
A Clinical Study of a Spine Fusion System in Vertebral Body Fusion Surgery
The primary objective of this study is to demonstrate that the efficacy and safety of Spine fusion system manufactured in China is no inferior than imported product.
- Conditions
- Disc Degenerative Disease, Spondylolisthesis, Spinal Fracture, Spinal Deformity
- Trial name
- NCT02252185
- Testing
- Johnson&Johnson Medical Suzhou made Spine Fusion System, Imported EXPEDIUM screws and OPAL cage
- Where
- 8 sites in China
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Medical (Suzhou) Ltd.
Aortic Coarctation
Levosimendan Versus Combination With Magnesium Sulphate on Spine Protection by NIRS in Infants Undergoing Coarctectomy
In pediatric patients ,undergoing elective surgical correction of aortic coarcatation one of our main concern is spinal cord protection .Our aim to study the protective effect of levosimendan versus its combination with magnesium…
- Trial name
- NCT04330755
- Testing
- Saline Solution, Levosimendan, Magnesium Sulfate
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Dalia Saad Abd-El Kader
Idiopathic Scoliosis, Spinal Curvatures
UNiD Rods Register
Retro-prospective study allowing inclusion of patients with spinal deformities treated by patient-specific rods (UNiD). This study aims to assess performance, clinical outcomes and safety
- Conditions
- Idiopathic Scoliosis, Spinal Curvatures, Spondylolisthesis, Degenerative Scoliosis
- Trial name
- NCT02926404
- Testing
- UNiD Rods
- Where
- 13 sites in Belgium, France and 1 more
- Volunteers
- 743 people
- Sponsor
- Medicrea International
Hemostatics, Hemostasis
Efficacy of ARISTA-AH for Restoring Hemostasis Following Posterior Long-segment Spinal Fusion.
The aim of this study is to assess the efficacy of the ARISTA AH for restoring hemostasis following a long segment posterior spinal fusion.
- Conditions
- Hemostatics, Hemostasis, Spinal Deformity, Spinal Fusion
- Trial name
- NCT05323448
- Testing
- Control Group, ARISTA
- Where
- France
- Volunteers
- 91 people
- Sponsor
- Polyclinique Bordeaux Nord Aquitaine