Clinical trials: Degenerative; Dementia
Frontotemporal Dementia, Frontotemporal Lobar Degeneration
Neurofilament Surveillance Project (NSP)
This is a biomarker study designed to collect and analyze blood specimens from individuals carrying known familial frontotemporal lobar degeneration (f-FTLD) mutations compared to a control group of individuals without known…
- Conditions
- Frontotemporal Dementia, Frontotemporal Lobar Degeneration, FTD-GRN, FTD
- Trial name
- NCT04516499
- Where
- 8 sites in United States
- Volunteers
- 342 people, healthy volunteers welcome
- Sponsor
- The Bluefield Project to Cure Frontotemporal Dementia
Frontotemporal Dementia, Family Members
Genetic Frontotemporal Dementia Initiative for Neurodevelopment
This is an international multi-centre cohort study of first and second degree family members of individuals who carry Frontotemporal Dementia (FTD) mutations in MAPT, GRN or C9ORF72 repeat expansions for youths between the ages…
- Trial name
- GENFI-NeuroDev (NCT05779813)
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Western University
Dementia, Neurodegenerative Diseases
Retinal Hyperspectral Imaging in Neurodegenerative Diseases
Hyperspectral retinal imaging is a non-invasive imaging modality in which a series of images of the retina are captured using light of different wavelengths.
- Conditions
- Dementia, Neurodegenerative Diseases, Alzheimer Disease, Parkinson Disease
- Trial name
- NCT07545473
- Testing
- Hyperspectral camera
- Where
- Australia
- Volunteers
- 930 people, healthy volunteers welcome
- Sponsor
- Center for Eye Research Australia
Frontotemporal Lobar Degeneration
DAPHNE Scale Validation in Frontotemporal Lobar Degeneration
Psycho-behavioral disorders assessment is crucial for the diagnosis and follow-up of patients with frontotemporal degeneration (FTD).
- Trial name
- DAPHNE (NCT02889601)
- Testing
- Psycho-behavioural assessment
- Where
- France
- Volunteers
- 89 people
- Sponsor
- Nantes University Hospital
Parkinsonism
Proactive and Integrated Management and Empowerment in Parkinson's Disease (PRIME-UK): A New Model of Care (PRIME-RCT)
People living with Parkinson's disease experience progressive motor and non-motor symptoms, which negatively impact on health-related quality of life. Symptoms emerge and evolve as the disease progresses.
- Trial name
- PRIME-RCT (NCT05127057)
- Testing
- PRIME Parkinson Care, Usual Care
- Where
- United Kingdom
- Volunteers
- 214 people
- Sponsor
- University of Bristol
Parkinson Disease, Parkinson's Disease and Parkinsonism
Complex Eye Movements in Parkinson's Disease and Related Movement Disorders
Diagnosing Parkinson's disease (PD) depends on the clinical history of the patient and the patient's response to specific treatments such as levodopa.
- Conditions
- Parkinson Disease, Parkinson's Disease and Parkinsonism, Progressive Supranuclear Palsy, Corticobasal Degeneration
- Trial name
- NCT04925622
- Testing
- Complex eye movement exam
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Saccadous, Inc.
Dementia, Cognitive Impairment
Evaluation of Blood-Based Biomarkers and Remote Cognitive Assessment for Dementia Triage (SANDBOX)
Dementia is a leading cause of death in the UK, and long waits for diagnosis can delay access to care and treatment. The SANDBOX study is a research study in NHS Memory Clinics investigating whether providing clinicians with…
- Trial name
- SANDBOX (NCT07842029)
- Where
- 12 sites in United Kingdom
- Volunteers
- 1,000 people
- Sponsor
- Prima Mente
Dementia
Far Infrared Radiation Treatment of Dementia and Other Mental Illness
This trial is a preliminary study to determine the use of far infrared radiation for the treatment of dementia and other mental sickness.
- Trial name
- NCT00574054
- Testing
- Far Infrared
- Where
- Canada
- Volunteers
- 4 people
- Sponsor
- GAAD Medical Research Institute Inc.
Alzheimers Disease
Identifying Potential Effects of Liraglutide on Degenerative Changes
Today Alzheimers disease can not be cured. Animal experiments have shown that the hormone GLP-1 can improve memory in Alzheimer-prone mice.
- Trial name
- NCT01469351
- Testing
- Liraglutide, non-active study drug
- Where
- Denmark
- Volunteers
- 34 people
- Sponsor
- University of Aarhus
Primary Progressive Aphasia, Dementia
Cognitive Reserve and Response to Speech-Language Intervention in Bilingual Speakers With Primary Progressive Aphasia
Difficulties with speech and language are the first and most notable symptoms of primary progressive aphasia (PPA). While there is evidence that demonstrates positive effects of speech-language treatment for individuals with PPA…
- Conditions
- Primary Progressive Aphasia, Dementia, Dementia, Frontotemporal, Alzheimer Disease
- Trial name
- NCT05741853
- Testing
- Video-Implemented Script Training for Aphasia (VISTA), Lexical Retrieval Training (LRT)
- Where
- 3 sites in United States, Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Stephanie Grasso
Cognitive Impairment, Alzheimer Disease
Impact of Hypno-analgesia on Pain During a Lumbar Puncture for Diagnosis of Alzheimer's Disease
One of the missions of the Memory of Resources and Research Center (CMRR) is to establish a diagnosis of expertise in patients with amestic, language or behavioral cognitive complaint.
- Trial name
- PLHYMANEDE (NCT03352024)
- Testing
- Relational care, Hypno-analgesia
- Sponsor
- University Hospital, Montpellier
Frontotemporal Dementia
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of DNL593 in Healthy Participants and Participants With Frontotemporal Dementia (FTD-GRN)
This is a Phase 1/2, multicenter, randomized, placebo-controlled, double-blind study to evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of single and multiple doses of DNL593 in two parts…
- Trial name
- NCT05262023
- Testing
- DNL593
- Where
- 26 sites in United States, Belgium and 10 more
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Denali Therapeutics Inc.
Nonfluent Aphasia, Progressive, Primary Progressive Nonfluent Aphasia
tDCS and Speech Therapy for Motor Speech Disorders Caused by FTLD Syndromes: a Feasibility Study
The investigators will test the feasibility of using transcranial direct current stimulation (tDCS) and speech therapy to treat participants with motor speech disorders caused by Frontotemporal Lobar Degeneration Pathology…
- Conditions
- Nonfluent Aphasia, Progressive, Primary Progressive Nonfluent Aphasia, Primary Progressive Non Fluent Aphasia, Progressive Supranuclear Palsy
- Trial name
- NCT04883229
- Testing
- Halo Neuroscience Neurostimulator
- Sponsor
- University of California, San Francisco
Frontotemporal Dementia
GENetic Fronto Temporal Dementia Initiative in Lille
GENFI Lille is a French cohort that belongs to the international initiative GENFI2, a five year longitudinal biomarker cohort study of genetic FTD and its associated disorders (including MND/ALS) investigating members of families…
- Trial name
- GENFI-LILLE (NCT04639622)
- Testing
- Investigation procedures
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Frontotemporal Dementia
Flortaucipir PET Imaging in Subjects With FTD
This study is designed to assess the usefulness of flortaucipir in Positron Emission Tomography (PET) imaging for subjects diagnosed with Frontotemporal Dementia (FTD).
- Trial name
- NCT03040713
- Testing
- Flortaucipir F18, Brain PET scan
- Where
- 3 sites in United States
- Volunteers
- 16 people
- Sponsor
- Avid Radiopharmaceuticals
Dementia
Corticolimbic Degeneration and Treatment of Dementia
The overall purpose of this research is to determine if there is a relationship between your symptoms of Dementia of the Alzheimers type and changes in the size and shape of certain brain structures during combined Donepezil…
- Trial name
- NCT00768261
- Testing
- Memantine (Namenda®), Donepezil (Aricept®)
- Volunteers
- 39 people
- Sponsor
- Washington University School of Medicine
Major Depressive Disorder
Pathophysiology of Neurodegeneration in Late-life Depression (AV45+THK)
Late-life depression has been frequently associated with cognitive impairment. Several meta-analyses consistently suggested that a history of depression approximately doubles an individual's risk for developing dementia later in…
- Trial name
- NCT03430869
- Testing
- F-18 AV-45, F-18-THK-5351
- Where
- Taiwan
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Alzheimer's Disease
Alzheimer's Disease: Clinical Investigation and Neuroimage Studies Including 18F-PM-PBB3 and 18F-florbetapir (AV-45) PET Examination
Dementia is a common neurodegenerative syndrome in aged population. Alzheimer's disease (AD) is the most common disease. The main pathological findings in AD include senile plaques (SP) and neurofibrillary tangles (NFT).
- Trial name
- PMPBB3/AV45 (NCT04305210)
- Testing
- F-18 PMPBB3, 18F-florbetapir
- Where
- Taiwan
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Alzheimer Disease, Dementia With Lewy Bodies
Cerebro Spinal Fluid Collection (CSF)
Cognitive neurodegenerative diseases are a major public health issue. At present, the diagnosis of certainty is still based on anatomopathological analyses.
- Conditions
- Alzheimer Disease, Dementia With Lewy Bodies, Frontotemporal Dementia, Parkinson's Disease Dementia
- Trial name
- Analzheimer (NCT04844060)
- Testing
- Lumbar punction
- Where
- France
- Volunteers
- 10,000 people
- Sponsor
- University Hospital, Strasbourg, France
Primary Progressive Aphasia, PPA
Rehabilitating and Decelerating Language Loss in Primary Progressive Aphasia With tDCS Plus Language Therapy
People with Primary Progressive Aphasia (PPA) are is a debilitating disorder characterized by the gradual loss of language functioning, even though cognitive functioning is relatively well preserved until the advanced stages of…
- Trial name
- NCT03728582
- Testing
- Active tDCS plus Speech-Language Therapy
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Johns Hopkins University