Clinical trials: Degenerative Arthritis
Articular Cartilage Lesion of Knee
Study to Assess the Safety of Treatment of Articular Cartilage Lesions With CartiLife®
The purpose of this study is to assess the safety and efficacy of implanting bead-type autologous chondrocytes (CartiLife®) obtained by culturing expanded costal chondrocytes of the patient with a chondral defect in the knee.
- Trial name
- NCT03517046
- Testing
- CartiLife
- Volunteers
- 6 people
- Sponsor
- Biosolution Co., Ltd.
Osteoarthritis
Chronic Pain Master Protocol (CPMP): A Study of LY3556050 in Participants With Osteoarthritis
This study is being done to test the safety and efficacy of LY3556050 for the treatment of osteoarthritis pain. This trial is part of the chronic pain master protocol, H0P-MC-CPMP (NCT05986292), which is a protocol to accelerate…
- Trial name
- NCT04627038
- Testing
- LY3556050
- Where
- 40 sites in United States, Puerto Rico
- Volunteers
- 202 people
- Sponsor
- Eli Lilly and Company
Osteoarthritis
Fixed Bearing Versus Mobile Bearing Patient Satisfaction and Clinical Outcome Study
The purpose of this study is to determine if there is a patient satisfaction preference of Fixed Bearing versus Mobile Bearing Unicompartmental Knee Arthroplasty (UKA) in patients who are at a minimum two years post operative.
- Trial name
- NCT02633085
- Testing
- Fixed Bearing or Mobile Bearing UKA
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medacta USA
Osteoarthritis, Knee
Calypso Knee System Clinical Study, OUS
A study to evaluate the safety and effectiveness of the Calypso Knee System when used in subjects with symptomatic osteoarthritis of the medial compartment of the knee.
- Trial name
- NCT03838978
- Testing
- Calypso Knee System (Implantable Shock Absorber)
- Where
- 5 sites in Belgium, Poland
- Volunteers
- 81 people
- Sponsor
- Moximed
Osteoarthrosis
E1K Intra Articular(IA) Treatment for Knee Osteoarthritis
The objective of this study is to evaluate the efficacy and safety of pain relief treatment on knee osteoarthritis when administered E1K or placebo in patients with knee osteoarthritis aged 40 to 70 to determine the optimal dose.
- Trial name
- NCT05697952
- Testing
- E1K 1,200 ㎍/joint, E1K 2,400 ㎍/joint
- Where
- South Korea
- Volunteers
- 120 people
- Sponsor
- Ensol Bioscience
Knee Osteoarthritis
Total Knee Arthroplasty With Vitamin E Polyethylene
The aim of this observational study is to investigate if there is any difference in survival rate, clinical and radiological results after total knee replacement with vitamin E-blended polyethylene in comparison to conventional…
- Trial name
- NCT05810285
- Testing
- GKS Prime Flex Mobile knee
- Where
- Italy
- Volunteers
- 186 people
- Sponsor
- Permedica spa
Osteoarthritis
A Prospective Observational Study on Discontinuation of Medication of Shinbaro Capsule
This study investigates how gastrointestinal toxicity affects discontinuation of medication given to patients with osteoarthritis in routine clinical practice.
- Trial name
- NCT02064634
- Where
- South Korea
- Volunteers
- 6,700 people
- Sponsor
- Green Cross Corporation
Arthritis Shoulder, Post-traumatic Arthrosis of Other Joints, Upper Arm
Mirror Medacta Shoulder System Pivotal Trial
The purpose of this study is to demonstrate safety and efficacy of the Mirror Medacta Shoulder System in total shoulder arthroplasty.
- Trial name
- NCT05062252
- Testing
- Mirror Medacta Shoulder System, Medacta Shoulder System
- Where
- 2 sites in Switzerland
- Volunteers
- 100 people
- Sponsor
- Medacta International SA
Knee Osteoarthritis
AposTherapy for Singaporean Patients With Knee Osteoarthritis (OA)
Osteoarthritis (OA) is the most prevalent form of arthritis in the elderly. It is estimated that 7% of men and 11% of women over the age of 65 have KOA.
- Trial name
- NCT01562652
- Testing
- AposTherapy (All Phases of Step-cycle {APOS} system, APOS-Medical and Sports Technologies Ltd. Herzliya, Israel)
- Where
- Singapore
- Volunteers
- 60 people
- Sponsor
- Apos Medical and Sports Technology Ltd.
Arthritis, Degenerative
Pilot Study Evaluating the Safety and Efficacy of a New Hard-on-Hard Total Hip Replacement System
The purpose of this study is to assess the early and long term safety and efficacy of the hard-on-hard total hip replacement system (R3 ODH-ODH utilization) in patients with non-inflammatory arthritis.
- Trial name
- NCT02154516
- Testing
- ODH Hip System
- Where
- 2 sites in South Africa
- Volunteers
- 26 people
- Sponsor
- Smith & Nephew, Inc.
Osteoarthritis
Efficacy of Proprietary Cherry Juice Blend in Osteoarthritis of the Knee
The primary purpose of this research study is to test the ability of a proprietary cherry juice blend to be helpful in the treatment of osteoarthritis (OA) of the knee.
- Trial name
- NCT00443092
- Testing
- proprietary cherry juice blend (food), control juice (kool aid blend)
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- CherryPharm
Osteoarthritis (OA), Rheumatoid Arthritis (RA)
Prevalence Study of Gastrointestinal Risk Factors in Patients With Osteoarthritis (OA), Rheumatoid Arthritis (RA) and Ankylosing Spondylitis (AS).
RATIONAL is a multinational, multicentre, observational, cross sectional study of adult patients in treatment with NSAID therapy for OA, RA or AS during for at least 2 weeks before study visit (at least one dose).
- Conditions
- Osteoarthritis (OA), Rheumatoid Arthritis (RA), Ankylosing Spondylitis (AS)
- Trial name
- RATIONAL (NCT01577563)
- Where
- 85 sites in Argentina, Colombia and 8 more
- Volunteers
- 5,383 people
- Sponsor
- AstraZeneca
Non-inflammatory Degenerative Joint Disease, Rhematoid Arthritis
Tornier Perform™ Reversed Monopost Study
This study is a Multi-center, Prospective Follow-up, Non-significant risk, Post-Market Clinical Follow-Up (PMCF) study to Evaluate the Safety and Effectiveness of the Tornier Perform™ Reversed MonoPost System.
- Conditions
- Non-inflammatory Degenerative Joint Disease, Rhematoid Arthritis, Correction of Functional Deformity, Fracture of the Humeral Head
- Trial name
- Monarch (NCT07764614)
- Testing
- Tornier Perform™ Reversed MonoPost
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- Stryker Trauma and Extremities
Osteoarthritis
Tanezumab in Osteoarthritis of the Hip or Knee (2)
Test the efficacy and safety of 2 doses of tanezumab compared with naproxen and placebo in patients with osteoarthritis
- Trial name
- NCT00863304
- Testing
- tanezumab 10 mg, tanezumab 5 mg, naproxen
- Where
- 95 sites in United States
- Volunteers
- 849 people
- Sponsor
- Pfizer
Pain Associated With Osteoarthritis of the Knee
A Study to Evaluate the Efficacy and Safety of X0002 Spray in Subjects With Osteoarthritis Knee Pain
This is a Phase 3, Multicenter, 22-Week, double-blind and 30-Week open label Study to Evaluate the Efficacy and Safety of X0002 Spray in relief of pain of subjects with Osteoarthritis of the Knee.
- Trial name
- NCT03081806
- Testing
- X0002
- Where
- 33 sites in United States
- Volunteers
- 399 people
- Sponsor
- Techfields Pharma Co. Ltd
Osteoarthritis
Safety and Efficacy of Dose Conversion From Vicodin® to Buprenorphine Transdermal System (Butrans™) in Subjects With OA Pain
The objective of this study is to evaluate the safety and efficacy of dose conversion from hydrocodone/ acetaminophen (Vicodin®) to the buprenorphine transdermal system (Butrans™) in subjects with osteoarthritis pain of the hip…
- Trial name
- NCT00312572
- Testing
- Buprenorphine transdermal patch
- Where
- 36 sites in United States
- Volunteers
- 204 people
- Sponsor
- Purdue Pharma LP
Osteoarthritis
A Study to Evaluate the Effect of Analgesics on a Walking Model of Knee Pain (0000-105)(COMPLETED)
This study will evaluate a walking model of osteoarthritis for use in testing of new therapeutic agents. The primary hypothesis is that participants treated with Naproxen or Ultracet will have lower Pain Intensity (PI) than those…
- Trial name
- NCT00772967
- Testing
- Naproxen, Ultracet
- Volunteers
- 22 people
- Sponsor
- Merck Sharp & Dohme LLC
Osteoarthritis, Knee
A Phase 1/2A, Single Dose Study Of PF-04383119 In Japanese Patients With Moderate To Severe Pain From Osteoarthritis Of The Knee
To evaluate the safety and tolerability of single IV doses of PF-04383119 in Japanese patients with moderate to severe pain from OA of the knee (Part I).
- Trial name
- NCT00669409
- Testing
- PF-04383119 (tanezumab)
- Where
- 12 sites in Japan
- Volunteers
- 83 people
- Sponsor
- Pfizer
Mild to Moderate Knee OA
A Prospective Observational Study to Evaluate Long-term Changes in Cartilage Morphology in Subjects Who Previously Received TPX-100 or Placebo in Study TPX-100-1 for Patellar Osteoarthritis Involving Both Knees
To evaluate the long-term changes in patellar cartilage thickness in TPX-100 versus placebo-treated knees in subjects who participated in Study TPX-100-1 or TPX-100-2.
- Trial name
- NCT03125499
- Testing
- Previous treated with TPX-100
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- OrthoTrophix, Inc
Osteoarthritis
Efficacy of ThermoProfen in Patients With Mild to Moderate Pain Associated With Osteoarthritis of the Knee
ThermoProfen is a transdermal ketoprofen patch that is integrated with a long-lasting CHADD (Controlled Heat-Assisted Drug Delivery) unit for the treatment of chronic pain associated with osteoarthritis.
- Trial name
- NCT00488267
- Testing
- ThermoProfen™ (Matrix Transdermal Ketoprofen/CHADD™ System)
- Where
- 36 sites in United States
- Volunteers
- 679 people
- Sponsor
- ZARS Pharma Inc.