Clinical trials: Degenerative Arthritis
Osteoarthritis, Hip
Evaluation of a Short Femoral Stem in Total Hip Arthroplasty
In recent years, short femoral stems have been introduced. Short stems are designed based on traditional stems with good clinical results.
- Trial name
- NCT02743208
- Testing
- Short stem hip arthroplasty (SHA), Total hip arthroplasty (THA)
- Sponsor
- St. Olavs Hospital
Osteoarthritis
Low Level Laser Therapy and Interferential Current in Osteoarthritis
This study aims to evaluate the effectiveness of the low level laser therapy and interferential current in 168 patients with knee osteoarthritis
- Trial name
- NCT02898025
- Testing
- Active Interferential Current, Active Laser
- Where
- Brazil
- Volunteers
- 168 people
- Sponsor
- Universidade Cidade de Sao Paulo
Osteoarthritis of the Knee, Avascular Necrosis of the Femoral Condyle
Multicentre GMK UNI Anatomical Cementless Study - FR
Unicompartmental Knee Arthroplasty (UKA) is the principal surgical alternative to Total Knee Arthroplasty (TKA) in patients with end-stage unicompartmental tibiofemoral osteoarthritis (OA) of the knee.
- Conditions
- Osteoarthritis of the Knee, Avascular Necrosis of the Femoral Condyle, Revision Surgery
- Trial name
- NCT06715917
- Where
- 5 sites in France, Switzerland
- Volunteers
- 249 people
- Sponsor
- Medacta International SA
Knee Osteoarthritis, Knee Osteoarthritis (Knee OA)
Reflexology and Mulligan Mobilization for Knee Osteoarthritis
to investigate the effect of adding Reflexlogy to mulligan mobilization and the conventional treatment for patients with Osteoarthritis knees
- Trial name
- NCT06815016
- Testing
- Reflexology ,mulligan mobilization and conventional, reflexology and conventional, mulligan mobilization and conventional
- Where
- Egypt
- Volunteers
- 84 people
- Sponsor
- Cairo University
Osteoarthritis of Knee
Temporary Clamping of Drains Combined With Tranexamic Acid Reduce Blood Loss After TKA: A Prospective RCT
Total knee arthroplasty (TKA) may be associated with significant blood loss, and transfusion carries substantial risk of immunologic reaction and disease transmission.
- Trial name
- NCT01449552
- Testing
- Tranexamic acid, Drain clamping, Drain clamping and tranexamic acid
- Volunteers
- 240 people
- Sponsor
- Mahidol University
Osteo Arthritis Knee
Safety and Efficacy of JointAlive™ on the Knee-joint Function in Adults With Knee Arthritis
Osteoarthritis (OA) is a joint disorder caused by wear and tear on the joint over time; as a result, the protective cartilage of the bone in the joint gradually wears down.
- Trial name
- NCT04395547
- Testing
- JointAlive™
- Where
- Canada
- Volunteers
- 72 people
- Sponsor
- Chenland Nutritionals Inc.
Osteoarthritis, Knee, Pain
Diagnostic Genicular Nerve Block Prior to Radiofrequency Ablation for Knee Osteoarthritis Pain
Chronic painful knee OA is a major cause of disability in older adults. In patients whose symptoms are refractory to conservative management but who do not wish to undergo TKA or, alternatively, are not operative candidates…
- Conditions
- Osteoarthritis, Knee, Pain, Nerve; Lesion
- Trial name
- NCT02578108
- Testing
- genicular nerve diagnostic block with lidocaine (local anesthetic), genicular nerve radiofrequency ablation
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Northwestern University
Osteoarthritis, Hip, Rheumatoid Arthritis
Acetabular Shell Positioning Using Patient Specific Instruments
The proposed study is a double-blinded randomized controlled trial comparing patient specific instruments with solely standardized instruments and pre-operative planning used for the placement of the acetabular cup prosthesis…
- Conditions
- Osteoarthritis, Hip, Rheumatoid Arthritis, Avascular Necrosis
- Trial name
- NCT01791738
- Testing
- Acetabular positioning system
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- The Cleveland Clinic
Osteoarthrosis
Early Stability of the Delta-TT Cup With Polyethylene Insert Versus a Ceramic Insert. A RSA Study.
The goal of this study is to study the stability of the Delta-TT cup with polyethylene insert and the Delta-TT cup with ceramic insert both combined with the H-MAX femoral stem by means of RSA to assess whether the differences in…
- Trial name
- RSA-DELTA-TT (NCT03093038)
- Testing
- H-MAX stem & Delta-TT cup + polyethylene, H-MAX stem & Delta-TT cup + ceramic, C2 stem & Delta-TT cup + ceramic
- Where
- Netherlands
- Volunteers
- 70 people
- Sponsor
- JointResearch
Hip Osteoarthritis
Isokinetic Performance and Function After Total Hip Arthroplasty
There are ongoing debates on the effects of the surgical approach on outcome after total hip arthroplasty. It was hypothesized that with the anterolateral approach, trauma to the abductor arm can be occured and related…
- Trial name
- NCT04640740
- Testing
- hip arthroplasty
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Gulhane Training and Research Hospital
Osteoarthritis, Post-traumatic Arthritis
A Randomised Multi-centre Study to Compare the Long-term Performance of the Future Hip to 3 Other Implants in Primary Total Hip Replacement
This post-market clinical follow-up study was designed to compare hip replacement outcomes of the European Hip against 3 controls (Omniflex, Zweymuller, and Spotorno), however Omniflex did not end up being used.
- Conditions
- Osteoarthritis, Post-traumatic Arthritis, Collagen Disorders, Avascular Necrosis
- Trial name
- NCT00208468
- Testing
- European Hip, Zweymüller, CLS Spotorno
- Where
- 3 sites in Austria, Germany and 1 more
- Volunteers
- 317 people
- Sponsor
- DePuy International
Osteoarthritis, Pain
Study to Assess MEDI -578 in Patients With Osteoarthritis (OA) of the Knee
The purpose of this study is to evaluate the safety and tolerability of a single intravenous dose of MEDI-578, a monoclonal antibody, in patients with osteoarthritis of the knee.
- Trial name
- NCT01072591
- Testing
- MEDI-578
- Where
- United Kingdom
- Volunteers
- 108 people
- Sponsor
- AstraZeneca
Knee Osteoarthritis, Knee Osteoarthritis (Knee OA)
Home-Based Strategies for Knee Osteoarthritis
Knee osteoarthritis (KOA) is a common chronic joint condition leading to pain, functional limitations, and reduced quality of life.
- Trial name
- NCT07212647
- Testing
- Home Exercise Group, Topical Therapy Group
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 83 people
- Sponsor
- Istanbul University - Cerrahpasa
Osteoarthritis of the Knee
Bone Marrow Aspirate Concentrate (BMAC) vs Corticosteroid Injection
Prospective single-masked (study participant will be masked), randomized controlled trial to examine the influence of BMAC on patient-reported outcomes (PROs) in patients with primary knee osteoarthritis.
- Trial name
- BMAC (NCT05985785)
- Testing
- Autologous bone marrow aspirate concentrate (BMAC), Corticosteroid injections, Crossover Autologous bone marrow aspirate concentrate (BMAC)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Rush University Medical Center
Knee Osteoarthritis
Safety of Use of Pandora for Patients Suffering From Gonarthrosis
The knee osteoarthritis is a frequent degenerative condition that mainly affects subjects over 60, population often weakened by numerous comorbidities and concomitant treatments, justifying the development of new therapies.
- Trial name
- PANDORA1 (NCT05414617)
- Testing
- Intra-articular single injection, Intra-articular three injections
- Where
- 2 sites in France
- Volunteers
- 20 people
- Sponsor
- Labrha
Knee Osteoarthritis
Assessment of Efficacy of Low Intensity Resistance Training in Men at Risk for Symptomatic Knee Osteoarthritis
The purpose of this research study is to determine whether low intensity resistance training with concurrent application of a peripheral blood flow restriction device to the exercising limb will elicit increased quadriceps…
- Trial name
- PBFR3 (NCT01487525)
- Testing
- Double leg press with partial blood flow restriction, Double leg press without partial blood flow restriction
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Osteoarthritis, Rheumatoid Arthritis
Randomized Controlled Clinical Outcomes of the Vanguard XP Bicruciate Knee System
Randomized Controlled Study to determine if preservation of ligaments provides increased functional ability post-operatively in comparison to traditional TKA which sacrifices soft tissue.
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Traumatic Arthritis, Lower Limb Deformity
- Trial name
- GK9B (NCT02175576)
- Testing
- Vanguard XP Bicruciate Knee System, Vanguard CR Knee System
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Zimmer Biomet
Knee Osteoarthritis
Ketorolac Versus Triamcinolone Knee Injections for Osteoarthritis
Osteoarthritis is a disabling disease of the joint spaces and has a high impact on society due to the amount of people who are affected by the disease. Nonoperative management is a mainstay of therapy in most patients.
- Trial name
- NCT02295189
- Testing
- Ketorolac Tromethamine, Triamcinolone Acetonide
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- San Antonio Military Medical Center
Knee Osteoarthritis
Patient-Reported and Radiographic Outcomes in Evaluating Lorecivivint (SM04690) for the Treatment of Knee Osteoarthritis
This phase 3 study is a multicenter, randomized, double-blind, placebo-controlled study of lorecivivint injected intra-articularly (IA) into the target knee (most painful) joint of moderately to severely symptomatic…
- Trial name
- STRIDES-Xray (NCT03928184)
- Testing
- Lorecivivint
- Where
- 99 sites in United States
- Volunteers
- 501 people
- Sponsor
- Biosplice Therapeutics, Inc.
Rheumatoid Arthritis of Knee, Osteoarthritis of the Knee
Exploratory Study on Safety of PEEK Knee Prosthesis
In this study, 10 subjects will be underwent total knee arthroplasty with PEEK knee prosthesis and be followed up 3, 6, and 12 months after surgery.
- Trial name
- NCT04927104
- Testing
- PEEK Knee Prosthesis
- Where
- China
- Volunteers
- 10 people
- Sponsor
- RenJi Hospital