Clinical trials: Degenerative Conditions, Neurologic
Generalized Myasthenia Gravis, Anti-AChR Antibody Positive
Early Ravulizumab Treatment Of Anti- AChR Antibody-Positive Generalized Myasthenia Gravis
The primary objective of the study is to evaluate the effectiveness of Ravulizumab in improving MG-ADL in an early-stage AChR+ gMG population.
- Trial name
- NCT06967480
- Testing
- Ravulizumab
- Where
- 23 sites in Italy
- Volunteers
- 40 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Parkinson's Disease (PD)
COmedication Study Assessing Mono- and cOmbination Therapy With Levodopa-carbidopa inteStinal Gel
The purpose of this study is to evaluate treatment of advanced Parkinson's Disease (PD) patients on levodopa-carbidopa intestinal gel (LCIG) monotherapy in a routine clinical setting.
- Trial name
- COSMOS (NCT03362879)
- Where
- 30 sites in Austria, Canada and 9 more
- Volunteers
- 412 people
- Sponsor
- AbbVie
Parkinson Disease
Cueing-assisted Gamified Augmented-reality Gait-and-balance Rehabilitation at Home for People With Parkinson's Disease
Background: Physiotherapy in the clinic is highly recommended for improving gait, balance and falls risk in people with Parkinson's disease. In addition, technology may help boost unsupervised exercise hours at home.
- Trial name
- CAPARE (NCT06590987)
- Testing
- Strolll AR
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- VU University of Amsterdam
Aging, Emotions
Emotion Study/Substudy: Flexible Brain Study
The proposed research applies the highly innovative technology of real-time functional Magnetic Resonance Imaging (rtfMRI) to examine plasticity of brain-regulatory mechanisms related to cognitive and affective processing and to…
- Conditions
- Aging, Emotions, Parkinson Disease
- Trial name
- NCT03872414
- Testing
- Anterior cingulate cortex activation, Primary auditory cortex activation
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of Florida
Parkinson' Disease
Parkinson's Improvement Activated by Hula Understanding (PAHU) - Part 2
if hula can help quality of life, well being, balance and overall motor symptoms for individuals with Parkinson's disease.
- Trial name
- PAHU2 (NCT07808606)
- Testing
- hula
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Hawaii
Amyotrophic Lateral Sclerosis
Derivation of Induced Pluripotent Stem Cells From an Existing Collection of Human Somatic Cells
Induced pluripotent stem cells potentially may be useful in the future as an unlimited source of cells for transplantation. The major goal of the project is to develop human iPS cells from various types of cell cultures or lines…
- Trial name
- NCT00801333
- Where
- 2 sites in Israel
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Psychotic Disorders, Alzheimer Disease
A Study to Assess the Efficacy and Safety of ITI-1284 in the Treatment of Psychosis Associated With Alzheimer's Disease
This is a multicenter, randomized, double-blind, parallel-group, placebo-controlled, flexible-dose study evaluating the efficacy, safety, and tolerability of ITI-1284 compared with placebo in the treatment of psychosis in…
- Trial name
- NCT06540833
- Testing
- ITI-1284
- Where
- 69 sites in United States, Bulgaria and 8 more
- Volunteers
- 370 people
- Sponsor
- Intra-Cellular Therapies, Inc.
Insomnia
A Dual Orexin Receptor Antagonist to Reduce Biomarkers of Neurodegeneration in Adults With Insomnia.
The goal of this clinical trial is to explore the potential neuroprotective benefits of a dual orexin receptor antagonist (DORA) in adults with insomnia.
- Trial name
- Neuro-DORA (NCT06823752)
- Testing
- Lemborexant 10 MG
- Where
- Australia
- Volunteers
- 20 people
- Sponsor
- Woolcock Institute of Medical Research
Falls, Alzheimer's Disease
Wii-fit for Activity, Balance and Gait in Assisted Living
Falls in Alzheimer's Disease (AD) are common and lead to fractures, acute hospitalizations and increased rate of institutionalization. Poor balance and gait abnormalities, commonly associated with AD, are risk factors.
- Trial name
- NCT01000038
- Testing
- Wii-Fit intervention, Walking
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Nebraska
Parkinson Disease
PSA Versus STN DBS for TD-PD
The aim of this study is to compare the effectiveness of the deep brain stimulation in the posterior subthalamic area (PSA) versus the subthalamic nucleus (STN) for the treatment of tremor-dominant Parkinson's disease (PD) in a…
- Trial name
- PSA-STN (NCT05382858)
- Testing
- Deep brain stimulation
- Where
- China
- Volunteers
- 27 people
- Sponsor
- Ruijin Hospital
Amyotrophic Lateral Sclerosis
Biomarkers in Different Types of Amyotrophic Lateral Sclerosis (ALS) Patients Being Treated With Edaravone
This study is being conducted to help the investigators better understand how the new FDA approved medication Edaravone (also known as Radicava) works in subsets of patients with ALS.
- Trial name
- NCT04097158
- Testing
- Sample Collection
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Loma Linda University
Dyskinesia, Drug-Induced, Parkinson Disease
Investigating the Causal Role of preSMA in Levodopa-induced Dyskinesia in Parkinson's Disease
Using a within-subject cross-over design, we will include 20 patients with Parkinson disease (PD) and peak-of-dose dyskinesia. Patients will be studied after withdrawal from their normal dopaminergic medication.
- Trial name
- NCT03354455
- Testing
- Repetitive transcranial magnetic stimulation
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Danish Research Centre for Magnetic Resonance
Alzheimer Disease
Multicenter Trial of Prednisone in Alzheimer's Disease
This is a randomized placebo controlled, double blind study. Patients who meet eligibility criteria and decide to participate in the study will be randomly assigned to receive either drug treatment or a placebo.
- Trial name
- NCT00000178
- Testing
- Prednisone
- Where
- 19 sites in United States
- Sponsor
- National Institute on Aging (NIA)
Lewy Body Dementia, Parkinson Disease Dementia
Environmental and Reproductive Health Risk for Lewy Body Dementia
The goal of this survey study is to identify environmental, occupational and reproductive health risk factors for Lewy body dementia, which includes Parkinson's disease dementia and dementia with Lewy bodies.
- Conditions
- Lewy Body Dementia, Parkinson Disease Dementia, Dementia With Lewy Bodies
- Trial name
- LBD-TOROS (NCT06005935)
- Testing
- Survey
- Where
- United States
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Parkinson's Disease
Characterizing the Specificity and Stability of Local Field Potentials in the Globus Pallidus Internus of Patients Undergoing Deep Brain Stimulation for Parkinson's Disease
Deep brain stimulation for Parkinson's disease is a well established therapy. Current practice requires tedious adjustment of stimulation settings based on frequent patient assessments.
- Trial name
- NCT02438033
- Testing
- Medtronic Activa PC+S Sensing Deep Brain Stimulator Generator
- Sponsor
- Nader Pouratian
Alzheimer's Disease
Open-Label Extension Assessing Long-Term Safety Of Rosiglitazone In Subjects With Mild To Moderate Alzheimer's Disease
This is an open-label extension to study 49653/461, to assess the long-term safety of rosiglitazone (extended release tablets) in subjects with mild to moderate Alzheimer's Disease.
- Trial name
- NCT00381238
- Testing
- rosiglitazone
- Where
- 7 sites in United States, Canada
- Volunteers
- 33 people
- Sponsor
- GlaxoSmithKline
Charcot Marie Tooth Disease
Development of Charcot Marie Tooth Disease (CMT) Pediatric Scale for Children With CMT
The primary goal of this project is to develop and test a Charcot Marie Tooth disease (CMT) Pediatric Scale for use in evaluation in natural history CMT study.
- Trial name
- INC-6603 (NCT01203085)
- Where
- 14 sites in United States, Australia and 3 more
- Volunteers
- 1,201 people
- Sponsor
- University of Iowa
Parkinson Disease
Continuous Electrical Neuromodulation of the Globus Pallidus Intern in Parkinson's Disease by the Directional Electrode CARTESIA™
Many patients have benefited from the implantation of brain stimulation electrodes for the treatment of various motor signs of Parkinson's disease in the phase of motor fluctuations.
- Trial name
- NEC-Parkinson (NCT05626608)
- Testing
- Classical ring stimulation, Stimulation in directional mode
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Montpellier
Brain Damage, Chronic
The Effect of tDCS on Subcortical Brain Functioning
This research is being done to determine whether transcranial direct current stimulation (tDCS) can improve certain abilities related to cognition, emotion and/or physical functioning in individuals with subcortical brain damage.
- Trial name
- NCT01602276
- Testing
- Transcranial Direct Current Stimulation (tDCS)
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Mild Cognitive Impairment, Alzheimer Disease
Effects of Yeast Beta-glucan on Cognitive Function in Patients With Mild Cognitive Impairment
Patients with mild cognitive impairment aged 50-80 years old were recruited in Shiyan City, Hubei Province, and divided into intervention group and placebo group.
- Trial name
- NCT06083350
- Testing
- Yeast beta-glucan, Starch
- Where
- 2 sites in China
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Xiaofan Xu