Clinical trials: Degenerative Disc Disease, Lumbar
Degenerative Disc Disease, Isthmic-lytic Spondylolisthesis
Efficacy of Using Solum IV and BMC With GFC in TLIF
The purpose of this study is to examine the efficacy of using Solum IV and bone marrow concentrate with general fluid concentrate in Transforaminal Lumbar Interbody Fusion (TLIF).
- Conditions
- Degenerative Disc Disease, Isthmic-lytic Spondylolisthesis, Degenerative Spondylolisthesis, Spinal Stenosis
- Trial name
- NCT03223701
- Testing
- Solum IV, Bone Marrow Concentrate with general fluid concentrate (GFC) in Transforaminal Lumbar Interbody Fusion
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Seton Healthcare Family
Degenerative Disc Disease
Study to Assess the Performance of MagnEtOs Flex Matrix Compared to Cellular Allograft
The purpose of this study is to demonstrate the performance of MagnetOs Flex Matrix in patients with leg pain and/or back pain.
- Trial name
- NCT06415123
- Testing
- MagnetOs Flex Matrix
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Research Source
Disc Degeneration
Mesenchymal Stem Cells for Lumbar Degenerative Disc Disease
This study seeks to bridge these technologies and obtain data regarding the safety and efficacy of image guided percutaneous needle injection of expanded autologous bone marrow derived mesenchymal stem cells to symptomatic…
- Trial name
- NCT03692221
- Testing
- MSC Treatment group 1 (low dose), MSC Treatment group 2 (high dose), Healthy Control (no treatment)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Low Back Pain, Lumbosacral Radiculopathy
A Prospective Study to Compare Bupivacaine and Exparel Versus Bupivacaine or Exparel Alone for Postoperative Pain Relief
The purpose of this study is to collect information about how patients feel when doctors manage their pain after lumbar spine surgery using a combination of EXPAREL® and bupivacaine injected into the lumbar spine at the end of…
- Conditions
- Low Back Pain, Lumbosacral Radiculopathy, Lumbar Disc Degeneration, Lumbar Disc Herniation
- Trial name
- NCT03514277
- Testing
- Exparel, Bupivacaine
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Virtua Health, Inc.
Degenerative Disc Disease Lumbar, Spinal Stenosis
Multimodal Analgesia Versus Routine Care Pain Management
Most patients undergoing surgery experience significant post-operative pain. Inadequate peri-operative pain management may decrease post-operative mobilization and increase length of hospitalization.
- Conditions
- Degenerative Disc Disease Lumbar, Spinal Stenosis, Lumbar Spondylolisthesis
- Trial name
- MMA (NCT01861743)
- Testing
- Multimodal Analgesia, Patient controlled analgesia
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Spinal Stenosis Lumbar, Disc Degeneration
Efficacy and Safety of Preemptive Intravenous Dexamethasone in MIS-TLIF
Researchers are considering Dexamethasone as preemptive medication before minimally invasive spine fusion surgery to minimize postoperative back pain with minimal side effects, aiming to enhance the effectiveness of surgery and…
- Conditions
- Spinal Stenosis Lumbar, Disc Degeneration, Disc Disease, Fusion of Spine
- Trial name
- MIS-TLIF (NCT06367855)
- Testing
- Dexamethasone, Normal saline
- Where
- Thailand
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Potsawat Surabotsopon
Lumbar Disc Degeneration, Low Back Pain
Interleukin-1β (rs 1143627 T/C) Gene Polymorphism May Increase the Risk of Developing LDD in Turkish Population
This study aims to show the association between the Interleukin-1β (rs 1143627 T/C) gene polymorphism and the patient's pain level, radiological features, functional disability, and spinal flexibility.
- Conditions
- Lumbar Disc Degeneration, Low Back Pain, Inflammation
- Trial name
- NCT05601739
- Where
- Turkey (Türkiye)
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Yeditepe University
Other Intervertebral Disc Degeneration, Lumbar Region
Trunk Muscles and Lumbar Intervertebral Disc Degeneration in Combat Sports
This study examined whether there is an association between the presence of lumbar intervertebral disc degeneration (LDD) and the size and symmetry of the cross-sectional areas (CSAs) of the trunk muscles in combat sports…
- Trial name
- NCT02744781
- Testing
- Lumbar disc degeneration; LDD
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- National Institute of Technology, Hiroshima College
Degenerative Lumbar Spinal Stenosis, Degenerative Disc Disease
Effect of RECK in Posterior Spinal Fusion
"RECK" is a combination of local anesthesia medications, used for the purpose of pain control. RECK is an acronym which stands for Ropivacaine, Epinephrine, Clonidine, and Ketorolac.
- Conditions
- Degenerative Lumbar Spinal Stenosis, Degenerative Disc Disease, Degenerative Spondylolisthesis, Degenerative Disease
- Trial name
- NCT06447194
- Testing
- Ropivacaine, Epinephrine, Clonidine, and Ketorolac Injection Cocktail
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Spine Health, Spine Injuries and Disorders
Occupational Exposure to Whole Body Vibration Among U.S. Military Veterans: Acute and Chronic Contributions to Musculoskeletal Disorders and Spine-Area Pain
Significance to VA: There is a lack of prospective longitudinal studies investigating the relationship between risk factors to Veterans and development and progression of musculoskeletal (MSK) spine injury and pain.
- Conditions
- Spine Health, Spine Injuries and Disorders, Spine Degeneration, Whole Body Vibration
- Trial name
- NCT07367139
- Testing
- Water
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Milwaukee VA Medical Center
Neuropathic Pain
Balance and Gait on Neuropathic Pain Due to Lumbar Disc Degeneration
Chronic lumbar neuropathic pain, characterized by pain, numbness, tingling and muscle weakness in the lower extremities, is one of the most common neuropathic pain syndromes.
- Trial name
- NCT05223439
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Degenerative Disc Disease
Viable Allograft Supplemented Disc Regeneration in the Treatment of Patients With Low Back Pain
The objective of this study is to evaluate the safety and efficacy of viable allograft transplantation for the treatment of patients with symptomatic disc degeneration and tissue loss.
- Trial name
- VAST (NCT03709901)
- Testing
- Active Allograft
- Where
- 13 sites in United States
- Volunteers
- 218 people, healthy volunteers welcome
- Sponsor
- VIVEX Biologics, Inc.
Degenerative Disc Disease, Spondylolisthesis
Prospective, Multi-center Study to Assess Posterolateral Fusion Using FIBERGRAFT
This is a prospective, non-randomized (single arm), multi-center, post-market clinical study designed to evaluate FIBERGRAFT® BG Matrix mixed with autograft and bone marrow aspirate in up to 150 subjects with degenerative disc…
- Conditions
- Degenerative Disc Disease, Spondylolisthesis, Spinal Stenosis Lumbar
- Trial name
- NCT03884283
- Testing
- FIBERGRAFT BG Matrix
- Where
- 9 sites in United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Prosidyan, Inc.
Degenerative Lumbar Spinal Stenosis, Degenerative Disc Disease
Clinical Decision-Making and Virtual Reality Exercise
Degenerative lumbar spine disease (DLSD) is common in elderly individuals and can result in pain, muscle weakness, and paresthesia.
- Conditions
- Degenerative Lumbar Spinal Stenosis, Degenerative Disc Disease, Degenerative Spondylolisthesis, Degenerative Intervertebral Discs
- Trial name
- NCT05375201
- Testing
- VR skateboarding training
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Low Back Pain, Low Back Pain, Mechanical
Effects of Mechanical Versus Manual Traction in the Management of Low Back Pain.
This study compared the effects of mechanical and manual traction on pain, disability and lumbar spinal curvature in patients with discogenic low back pain
- Conditions
- Low Back Pain, Low Back Pain, Mechanical, Disc Degeneration, Disc Prolapse
- Trial name
- NCT05059249
- Testing
- Hot Pack, Manual Traction, Mechanical Traction
- Where
- Pakistan
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Foundation University Islamabad
Spinal Stenosis Lumbar, Lumbar Disc Herniation
Cortical Bone Trajectory Screws vs. Traditional Pedicle Screws Fixation
Transforaminal lumbar interbody fusion (TLIF) had been favorable for effectively decrease pain and disability in specific spinal disorders; however, there has been concern regarding pedicle screw placement during TLIF surgery.
- Conditions
- Spinal Stenosis Lumbar, Lumbar Disc Herniation, Intervertebral Disc Degeneration
- Trial name
- NCT03105167
- Testing
- cortical bone trajectory screws, pedicle screws
- Where
- China
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Lumbar Degenerative Disease, Lumbar Degenerative Disc Disease
ISOVUE Comparative Trial
This study aimed to investigate a novel technique for intraoperative quantitative and qualitative feedback during discectomy and endplate preparation in TLIF.
- Conditions
- Lumbar Degenerative Disease, Lumbar Degenerative Disc Disease, Degenerative Spine
- Trial name
- ISOVUE (NCT07363759)
- Testing
- ISOVUE 300 Observation, ISOVUE 300 Feedback
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Stenosis, Herniated Nucleus Pulposus
Impact of Local Steroid Application in Extreme Lateral Lumbar Interbody Fusion
Neural injury is a well-known complication following extreme lateral lumbar interbody fusion (XLIF). It has been found that up to 9.4% of patients will have either temporary or persistent neurologic deficit.
- Conditions
- Stenosis, Herniated Nucleus Pulposus, Degenerative Disc Disease, Spondylosis
- Trial name
- NCT03327272
- Testing
- Methylprednisolone, Saline
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Sciatica, Lumbar Radiculopathy
Brain Mechanisms Supporting Cannabis-induced Pain Relief
Chronic low back pain is a common and disabling condition that affects millions of people in the United States. Many people with chronic low back pain do not get enough relief from current treatments.
- Conditions
- Sciatica, Lumbar Radiculopathy, Lower Back Pain, Degenerative Disc Disease
- Trial name
- NCT04982965
- Testing
- Active Cannabis
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Degenerative Disc Disease, Spondylolisthesis, Lumbar Region
Clinical Effectiveness of Pre-operative Methadone in Single Level Lateral Transpsoas Interbody Fusions
Spinal operations including lumbar fusions for degenerative disorders are becoming more prevalent as the population ages. Inadequate or excessive postoperative analgesia can result in medical comorbidities and prolonged hospital…
- Trial name
- NCT04112550
- Testing
- Methadone Hydrochloride, Oxycodone-Acetaminophen
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- The Methodist Hospital Research Institute