Clinical trials: Degenerative Disc Disease, Lumbar
Intervertebral Disc Degeneration, Chronic Low-back Pain
Efficacy of Intradiscal Injection of Autologous BM-MSC in Subjects With Chronic LBP Due to Multilevel Lumbar IDD
DREAM is a phase II B efficacy monocentric, prospective, randomized, controlled double blinded trial, comparing intra-discal autologous adult bone marrow mesenchymal stem cells (BM-MSC) therapy and sham treated controls in…
- Trial name
- DREAM (NCT05066334)
- Testing
- Autologous BM-MSC
- Where
- Italy
- Volunteers
- 52 people
- Sponsor
- Fondazione Policlinico Universitario Campus Bio-Medico
Degenerative Disc Disease
CHARITE™ vs. ALIF 5-Year Follow-up
To assess the clinical and radiographic outcomes through 5-years following treatment with CHARITÉ™ Artificial Disc vs. the BAK Cage for treatment of degenerative disc disease at one level (L4-S1).
- Trial name
- NCT00215332
- Testing
- CHARITE
- Where
- 10 sites in United States
- Volunteers
- 367 people
- Sponsor
- DePuy Spine
Lumbar Degenerative Disease, Lumbar Spondylolisthesis
Perioperative Nutrition Management in Patients Undergoing Open Posterior Lumbar Surgery
Patients undergoing open posterior lumbar fusion surgery often experience postoperative gastrointestinal problems, such as bloating, constipation, and delayed passage of gas and stool, and may be at nutritional risk.
- Conditions
- Lumbar Degenerative Disease, Lumbar Spondylolisthesis, Lumbar Disc Herniation
- Trial name
- NCT07893938
- Testing
- Oral nutritional supplements (ONS), Carbohydrate loading (OCL), 'Probiotics (Bifidobacterium and Lactobacillus triple live capsules)'
- Where
- China
- Volunteers
- 90 people
- Sponsor
- First Affiliated Hospital of Kunming Medical University
Degenerative Disc Disease, Degenerative Scoliosis
A Comparison of Stryker's Tritanium Posterior Lumbar Cage and PEEK Implant
The purpose of this study is to compare outcomes of patients with degenerative disc disease undergo lumbar spinal fusion with Stryker's Tritanium® Posterior Lumbar Cage or the UniLIF PEEK implant.
- Trial name
- NCT03817606
- Testing
- Tritanium Posterior Lumbar Cage, AVS UniLIF PEEK Posterior Lumbar Cage
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Riverside Medical Center
Degenerative Disc Disease
AMG0103 in Subjects With Chronic Discogenic Lumbar Back Pain
This clinical trial evaluate the safety, tolerability and exploratory efficacy of targeted single injection of AMG0103 in subject with chronic discogenic lumbar back pain
- Trial name
- NCT03263611
- Testing
- AMG0103
- Where
- 6 sites in United States
- Volunteers
- 25 people
- Sponsor
- AnGes, Inc.
Stenosis, Spondylolisthesis
Evaluation of Radiographic and Patient Outcomes Following Lumbar Spine Fusion Using Demineralized Bone Matrix (DBM) Mixed With Autograft
The purpose of this study is to compare Optecure™ as an autograft extender (treatment) to autograft alone (control) in patients undergoing 1 or 2 level fusion of the lumbar spine(one level is defined as two adjacent vertebrae)…
- Conditions
- Stenosis, Spondylolisthesis, Degenerative Disc Disease
- Trial name
- NCT00254852
- Testing
- Posterior Lateral Fusion (PLF), Anterior Lumbar Interbody Fusion (ALIF), Transforaminal lumbar interbody fusion (TLIF)
- Where
- 6 sites in United States
- Volunteers
- 94 people
- Sponsor
- Exactech
Degenerative Disc Disease, Spondylolisthesis, Grade 1
AccuLIF® PROSPECTIVE PATIENT OUTCOMES STUDY
This is a post-market clinical study of the AccuLIF expandable transforaminal lumbar interbody fusion (TLIF) cage in patients requiring surgery for degenerative disc disease (DDD) with up to Grade I spondylolisthesis or…
- Conditions
- Degenerative Disc Disease, Spondylolisthesis, Grade 1, Retrolisthesis
- Trial name
- APROPOS (NCT02704689)
- Testing
- AccuLIF expandable TLIF cage
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- VB Spine, LLC
Degeneration of Lumbar Intervertebral Disc
Qualitative Pain Measurement at Patients With Degenerative Low Back Pain
The purpose of the study is: to measure sensitization of the nociceptive system at patients with low back pain in order to carry out a necessary surgical procedure to examine a possible association between low back pain and…
- Trial name
- NCT01980576
- Where
- Denmark
- Volunteers
- 1 people
- Sponsor
- Northern Orthopaedic Division, Denmark
Intervertebral Disk Degeneration
Patient Positioning in Lumbar Fusion Surgery and Its Impact on Spinal Sagittal Balance and Surgeon Satisfaction
This is a parallel, randomized controlled trial comparing two types of patient positioning and their effect on radiologic measures (pre-surgery visit, in the operating room prior to surgery, at the conclusion of surgery, and at 3…
- Trial name
- NCT01326091
- Testing
- Hyperlordotic Positioning
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Duke University
Lumbar Degenerative Disc Disease
Moderate - Severe Degenerative Disc Disease Evaluation of the Lumbar Spine
The purpose of the study is to confirm the safety and effectiveness of SB-01 For Injection in adult patients with chronic low back pain and related disability due to Lumbar Degenerative Disc Disease.
- Trial name
- MODEL (NCT05516992)
- Testing
- SB-01 For Injection
- Where
- 30 sites in United States
- Volunteers
- 417 people
- Sponsor
- Spine BioPharma, Inc
Degenerative Disc Disease
A Phase 3 Study of AGA111 in Patients With Degenerative Disc Disease Undergoing Lumbar Interbody Fusion
The primary objective of the study is to assess the overall efficacy of a single intervertebral local administration of AGA111 in patients with degenerative disc disease undergoing lumbar interbody fusion.
- Trial name
- NCT06115512
- Testing
- AGA111
- Where
- 35 sites in China
- Volunteers
- 412 people
- Sponsor
- Angitia Biopharmaceuticals
Spondylosis, Spondylolisthesis
Comparison of Radiographic Fusion Rate and Clinical Outcome of ALIF and XLIF Performed With Either Recombinant Human Bone Morphogenetic Protein-2 or ViviGen®
The aim of this study is to prospectively investigate the potential for bony fusion of ViviGen® bone graft substitute in comparison to rhBMP-2 in monosegmental ALIF procedure L5/S1 and in monosegmental XLIF procedure L4/5
- Conditions
- Spondylosis, Spondylolisthesis, Degenerative Disc Disease
- Trial name
- NCT05238740
- Testing
- ViviGen®, rhBMP-2
- Where
- Switzerland
- Volunteers
- 168 people
- Sponsor
- Lindenhofgruppe AG
Spinal Lumbar Stenosis, Claudication, Intermittent
Evaluation of Safety and Effectiveness of Lobster Dynamic Interspinous Spacer in Lumbar Spinal Stenosis
The aim of this study is to demonstrate the safety and effectiveness of the Lobster interspinous spacer device for the treatment of Lumbar Spinal Stenosis in comparison to an SSED-based performance goal.
- Trial name
- LB2CT01 (NCT05587465)
- Testing
- Lobster Device
- Where
- Italy
- Volunteers
- 210 people
- Sponsor
- Diametros Medical srl
Degenerative Disc Disease
Long-term Assessment of BDyn Dynamic Stabilization Device in Patients With Lumbar Degenerative Disc Disease
The goal of this clinical trial is to estimate the cumulative reoperation rate at upper adjacent segment level in patients treated with BDyn dynamix stabilization for lumbar degenerative disc diseases over long-term follow-up.
- Trial name
- MOBIDYN (NCT07580664)
- Testing
- Dynamic Lumbar Stabilization Device
- Volunteers
- 150 people
- Sponsor
- Cousin Biotech
Lumbar Disc Herniation, Lumbar Spinal Stenosis
Effect of Irrigation Pressure on Postoperative Complications and Surgical Field Clarity in Unilateral Biportal Endoscopic Surgery
This study is being done to find out if the height of the fluid bag and the direction of the surgical cut affect the pressure of the fluid used during unilateral biportal endoscopic (UBE) spine surgery.
- Conditions
- Lumbar Disc Herniation, Lumbar Spinal Stenosis, Lumbar Degenerative Disease
- Trial name
- NCT07837427
- Testing
- Unilateral Biportal Endoscopic Surgery
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Fan Zhang
Degenerative Disc Disease, Spinal Fusion
KUR-113 Bone Graft Versus Local Autograft for the Treatment of Single-level Transforaminal Lumbar Interbody Fusion
The purpose of this study is to evaluate the safety and efficacy of KUR-113 Bone Graft (TGplPTH1-34 in fibrin) compared to local autograft for the treatment of Degenerative Disk Disease (DDD).
- Trial name
- STRUCTURE (NCT04294004)
- Testing
- TGplPTH1-34 in fibrin, Autologous Bone Graft
- Where
- 15 sites in United States
- Volunteers
- 50 people
- Sponsor
- Kuros Biosurgery AG
Spine Health, Spine Injuries and Disorders
Occupational Exposure to Whole Body Vibration Among U.S. Military Veterans: Acute and Chronic Contributions to Musculoskeletal Disorders and Spine-Area Pain
Significance to VA: There is a lack of prospective longitudinal studies investigating the relationship between risk factors to Veterans and development and progression of musculoskeletal (MSK) spine injury and pain.
- Conditions
- Spine Health, Spine Injuries and Disorders, Spine Degeneration, Whole Body Vibration
- Trial name
- NCT07367139
- Testing
- Water
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Milwaukee VA Medical Center
Degenerative Disc Disease
Trinity Evolution in Posterior or Transforaminal Lumbar Interbody Fusion (PLIF/TLIF)
The purpose of this study is to utilize Trinity Evolution in conjunction with an interbody spacer and supplemental posterior fixation of the surgeon's choice and to follow the patients to measure the clinical outcomes and rate of…
- Trial name
- TLF (NCT00965380)
- Where
- 15 sites in United States
- Volunteers
- 207 people
- Sponsor
- Orthofix Inc.
Lumbar Disc Disease
Intra-operatory Neurophysiological Monitoring Changes as a Predictive Clinical Outcome Measure in Lumbar Radiculopathy.
The purpose of this study is to determine the relation among: (1) changes in voltage and amplitude of trans-operatory records obtained through the use of Intra-operative Neurophysiological Monitoring (IONM), and (2) clinical…
- Trial name
- NCT02185508
- Where
- Mexico
- Volunteers
- 200 people
- Sponsor
- American British Cowdray Medical Center
Degenerative Disc Disease, Spondylolisthesis, Lumbar Region
Clinical Effectiveness of Pre-operative Methadone in Single Level Lateral Transpsoas Interbody Fusions
Spinal operations including lumbar fusions for degenerative disorders are becoming more prevalent as the population ages. Inadequate or excessive postoperative analgesia can result in medical comorbidities and prolonged hospital…
- Trial name
- NCT04112550
- Testing
- Methadone Hydrochloride, Oxycodone-Acetaminophen
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- The Methodist Hospital Research Institute