Clinical trials: Degenerative Joint Disease
Osteoarthritis, Knee, Knee Arthritis
Isokinetic Performance After Cruciate-substituting Ultra-congruent and Posterior Stabilized Total Knee Arthroplasties
The choice between ultra-congruent (UC) insert or posterior cruciate ligament-stabilized (PS) insert in posterior cruciate ligament (PCL) sacrificing total knee arthroplasty (TKA) remains debatable.
- Trial name
- NCT04419311
- Testing
- Vanguard® Knee System
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Aksaray University Training and Research Hospital
Hip Osteoarthritis, Hip Pain Chronic
Dexamethasone With Ropivacaine for PENG Block in Total Hip Arthroplasty
Does adding Dexamethasone to the Periarticular Nerve Group Block in Patients undergoing Total Hip Arthroplasty reduce the dose of ropivacaine?
- Conditions
- Hip Osteoarthritis, Hip Pain Chronic, Hip Arthritis
- Trial name
- NCT06470334
- Testing
- Ropivacaine, Ropivacaine+Dexamethasone
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- Poznan University of Medical Sciences
Osteoarthritis, Hip Osteoarthritis
MRgFUS in the Treatment of Hand and Hip Osteoarthritic Pain
This project aims at performing a pilot study to provide data on safety and potential efficacy of Magnetic Resonance guided Focused Ultrasound Surgery (MRgFUS) in the treatment of pain caused by trapeziometacarpal osteoarthritis…
- Conditions
- Osteoarthritis, Hip Osteoarthritis, Hand Osteoarthritis
- Trial name
- NCT03467165
- Testing
- MRgFUS treatment
- Where
- Italy
- Volunteers
- 14 people
- Sponsor
- Istituto Ortopedico Rizzoli
Osteoarthrosis
Efficacy Study of Condrosulf in the Treatment of Symptomatic OA of the Hand
The goal of the present study is to investigate the effectiveness of Condrosulf® 800 mg tablets vs. placebo once a day for 6 months in the symptomatic treatment of finger joint osteoarthritis.
- Trial name
- NCT00291499
- Testing
- Chondroitin 4&6 sulfate (Condrosulf)
- Volunteers
- 163 people
- Sponsor
- IBSA Institut Biochimique SA
Osteoarthritis, Knee, Postoperative Edema
Effect of Tergase Injection on Reducing Edema After Bilateral Total Knee Arthroplasty
This clinical trial is conducted to compare and evaluate the efficacy and safety of Tergase injection (4,500 IU) in reducing postoperative edema between treated and untreated knees in patients undergoing bilateral total knee…
- Conditions
- Osteoarthritis, Knee, Postoperative Edema, Bilateral Total Knee Arthroplasty
- Trial name
- ALT-TKA (NCT07705165)
- Testing
- Berahyaluronidase alfa
- Volunteers
- 30 people
- Sponsor
- Man Soo Kim
Knee Osteoarthritis, Obesity
A Study of Econoglutide Injection in Obese Participants With Knee Osteoarthritis (KOA)
The main purpose of the study is to evaluate the efficacy and safety of ecnoglutide injections versus placebo in obese participants with KOA.
- Trial name
- NCT07734311
- Testing
- Ecnoglutide Injection
- Where
- China
- Volunteers
- 360 people
- Sponsor
- Hangzhou Sciwind Biosciences Co., Ltd.
Knee Osteoarthritis (Knee OA), Knee Pain Chronic
Advanced Brain Imaging-TKA (fMRI-TKA)
Knee replacement surgery is a common and effective treatment for pain and mobility loss, yet up to 1 in 5 patients remain dissatisfied after surgery due to ongoing pain or difficulty with daily activities.
- Conditions
- Knee Osteoarthritis (Knee OA), Knee Pain Chronic, Brain Network Connectivity, Patient Satisfaction
- Trial name
- fMRI-TKA (NCT07464080)
- Testing
- fMRI Brain Scan
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Ottawa Hospital Research Institute
Osteoarthritis
Subject Insights to Understand the Hand Osteoarthritis (HOA)
Osteoarthritis (OA) is a degenerative joint disease which causes joints to become painful and stiff. HOA is the second most common form of OA and is characterized by stiffness, joint pain and inflammation and tenderness in the…
- Trial name
- NCT03271203
- Testing
- Michigan Hand Outcomes Questionnaire, Real-time data capture app
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- GlaxoSmithKline
Knee Arthritis Osteoarthritis
Comparing Pain Science Education to Biomedical Education for People With Knee Osteoarthritis: A Randomized Controlled Trial
Knee osteoarthritis (OA) is a common cause of pain and disability in older adults. Many people with knee OA believe that pain is primarily caused by joint damage or "wear and tear." These beliefs may contribute to fear of…
- Trial name
- NCT07823673
- Testing
- Pain Science Education, Biomedical Education
- Volunteers
- 82 people
- Sponsor
- McMaster University
Osteoarthritis
An Efficacy and Safety Study of Transdermal Therapeutic System (TTS)-Fentanyl in Participants With Osteoarthritis
The purpose of this study is to evaluate the efficacy and safety of Transdermal Therapeutic System (TTS)-fentanyl patch (transdermal patch containing a drug that is put on the skin so the drug will enter the body through the…
- Trial name
- NCT01774929
- Testing
- TTS-fentanyl
- Where
- Thailand
- Volunteers
- 35 people
- Sponsor
- Janssen-Cilag Ltd.,Thailand
Shoulder Arthritis
Study on Shoulder Arthritis Treatment With Intra-articular Injections of Autologous Bone Marrow Aspirate.
Treatment of isolated osteoarthritis of the glenohumeral joint at the initial stages involves the use of numerous conservative or arthroscopic treatments with uncertain results and, upon their failure, the current solution for…
- Trial name
- Stemshoulder (NCT04308213)
- Testing
- Marrow Cellution System
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Istituto Clinico Humanitas
Osteoarthritis, Knee
Oxford Partial Knee Replacement. A Randomized Clinical Trial of Three Implant Types
The purpose of this scientific study is to clarify whether there is a relationship between the appearance of radiolucent lines in bone-cement interphase of the tibial component of the different models of the Oxford Uni Knee…
- Trial name
- NCT00679120
- Testing
- Oxford Uni Knee
- Where
- Denmark
- Volunteers
- 75 people
- Sponsor
- University of Aarhus
Osteoarthritis, Knee
Reaching Exercise Goals: Comparison of Exercise Means in Patients With Knee Osteoarthritis
The primary objective is to evaluate water based treadmill exercise, land based treadmill exercise, and upright cycling in meeting American College of Sports Medicine exercise goals for moderate exercise.
- Trial name
- NCT01359124
- Testing
- Exercise Cycle, Land-based Treadmill, Water-based Treadmill
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Milton S. Hershey Medical Center
Osteoarthritis, Rheumatoid Arthritis
The Standard Care Versus Celecoxib Outcome Trial
The Standard Care versus Celecoxib Outcome Trial (SCOT) is a large streamline safety study designed to compare the cardiovascular safety of celecoxib versus traditional non-selective Non Steroidal Anti-Inflammatory Drug (NSAID)…
- Trial name
- SCOTLSSS (NCT00447759)
- Testing
- Celecoxib, Diclofenac
- Where
- 10 sites in Denmark, Netherlands and 1 more
- Volunteers
- 7,297 people
- Sponsor
- University of Dundee
Hand Osteoarthritis
Efficacy Study of an Anti-Tumor Necrosis Factor (TNF) Alpha Agent in Patients With Hand Osteoarthritis
Digital osteoarthritis (DO) which affects the interphalangeal joints and the Metacarpophalangeal (MCP) of the thumb is a common disease, the prevalence of which increases with age (36% of the population aged over 70).
- Trial name
- DORA (NCT00597623)
- Testing
- Adalimumab (Humira®)
- Where
- France
- Volunteers
- 84 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Osteoarthritis With Controlled Hypertension
Effects of Lumiracoxib and Ibuprofen on Blood Pressure and Urinary Eicosanoid Excretion in Osteoarthritis Patients With Controlled Hypertension
This randomized study will compare the effect of lumiracoxib, ibuprofen and placebo on 24-hour blood pressure profile and on urinary excretions of eicosanoids in controlled hypertensive patients who have osteoarthritis.
- Trial name
- NCT00419796
- Testing
- Lumiracoxib
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Novartis
Knee Osteoarthritis
Patient-Reported Outcomes in Evaluating Lorecivivint (SM04690) for Moderate to Severe Knee Osteoarthritis (STRIDES-1)
This phase 3 study is a multicenter, randomized, double-blind, placebo-controlled study of lorecivivint injected intraarticularly (IA) into the target knee (most painful) joint of moderately to severely symptomatic osteoarthritis…
- Trial name
- STRIDES-1 (NCT04385303)
- Testing
- Lorecivivint
- Where
- 76 sites in United States
- Volunteers
- 496 people
- Sponsor
- Biosplice Therapeutics, Inc.
Osteoarthritis
First-in-human Study With Ascending Single Intra-articular Doses of GZ389988 in Patients With Painful Osteoarthritis of the Knee
Primary Objective: To assess the safety and tolerability of ascending single intraarticular doses of GZ389988 in patients with painful osteoarthritis (OA) of the knee.
- Trial name
- NCT02424942
- Testing
- GZ389988
- Where
- Germany
- Volunteers
- 28 people
- Sponsor
- Genzyme, a Sanofi Company
Osteoarthritis of the Shoulder, Adhesive Capsulitis
Amnion-Based Injections in the Shoulder
Osteoarthritis (OA) of the shoulder is a common debilitating condition affecting up to 5% of the general population and as much as 32% of patients over 60 years of age.
- Trial name
- NCT03770546
- Testing
- Amnion Injection, Betamethasone injection
- Where
- United States
- Sponsor
- University of Alabama at Birmingham
Knee Osteoarthritis
Virtual Reality and Older Adult Knee OA
At the Brigham and Women's Hospital (BWH) Pain Management Center (PMC), knee OA is one of the most common conditions causing older adults to experience chronic pain.
- Trial name
- NCT04951661
- Testing
- Virtual Reality
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Tufts University
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