Clinical trials: Degenerative Joint Disease
Early Stage Osteoarthritis of the CMC-1 Joint
Clinical Evaluation of the Articulinx InterCarpoMetacarpal Cushion (ICMC)for Osteoarthritis of the First CarpoMetacarpal Joint
This study is to evaluate the performance of the Articulinx ICMC (InterCarpoMetacarpalCushion)in the carpometacarpal joint (CMC joint) and to describe the clinical results in patients who have been treated with this device.
- Trial name
- NCT01961570
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Articulinx
Osteoarthritis
Muscle Regrowth During Physical Rehabilitation and Amino Acid Supplementation
The general hypothesis is that in older adults muscle regrowth after an acute musculoskeletal stress will be positively influenced by traditional physical rehabilitation, and further enhanced by nutritional supplementation.
- Trial name
- NCT00760383
- Testing
- Essential amino acids, Alanine
- Where
- 2 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Oregon
Knee Osteoarthritis
Efficacy and Safety of a New Formulation of Chondroitin Sulfate and Glucosamine Sulfate to Treat Knee Osteoarthritis
The main objective is to assess the efficacy of a new formulation containing chondroitin sulfate and glucosamine sulfate (CS+GS) compared with placebo in patients with primary osteoarthritis of the knee.
- Trial name
- NCT01893905
- Testing
- CS+SG
- Where
- Spain
- Volunteers
- 158 people
- Sponsor
- Tedec-Meiji Farma, S.A.
Osteoarthritis, Knee, Pain
A Phase 2 Clinical Trial Examining the Effects on Osteoarthritic Knee Pain of CGS-200-1, CGS-200-5 and Vehicle Control
This is a multi-center, randomized, double-blind clinical trial to examine the comparative effects on OAKP of CGS-200-1 (1% Capsaicin content) (N=40), CGS-200-5 (5% Capsaicin content) (N=40), and CGS-200 Vehicle (no Capsaicin)…
- Trial name
- NCT03528369
- Testing
- CGS-200-1, CGS-200-5, CGS-200 Vehicle
- Where
- 6 sites in United States
- Volunteers
- 122 people
- Sponsor
- Propella Therapeutics
Osteoarthritis, Injury
Predicting Osteoarthritis Risk Following Knee Injury.
This observational study seeks to identify and validate novel soluble biomarkers (within blood, synovial fluid, urine) which contribute to the prognostic assessment of an individual with an acute knee injury, a group of…
- Trial name
- KICK (NCT02667756)
- Testing
- Non-interventional
- Where
- United Kingdom
- Volunteers
- 150 people
- Sponsor
- University of Oxford
Post-operative Pain, Osteoarthritis
Evaluation of the Use of Spinal Epimorph in Total Knee Arthroplasty
The purpose of this study is to determine the contribution of spinal epimorph to patient's perioperative pain management in Total Knee Arthroplasty (TKA).
- Trial name
- NCT01667445
- Testing
- Epimorph, Spinal analgesia
- Where
- Canada
- Volunteers
- 113 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Lumbar Spondylolisthesis, Arthrosis; Spine
Analysis of the Clinical Efficacy of Intravenous Application of Hemostatic Drugs in Improving the Clarity of Vision Under Endoscope, Perioperative Bleeding Volume and Anti-inflammatory Effect of Spinal Endoscopic Lumbar Fusion
To study the clinical efficacy of carosodiumsulfonate and desmopressin in improving the clarity of vision under endoscope, perioperative bleeding volume and anti-inflammatory effect in endoscopic lumbar fusion
- Trial name
- NCT06255366
- Testing
- Caroxime sodium sulfonate, Desmopressin, 0.9% Sodium Chloride Injection
- Volunteers
- 126 people
- Sponsor
- Chengdu University of Traditional Chinese Medicine
Total Hip Arthroplasty, Osteoarthritis, Hip
Migration in Total Hip Arthroplasty with a Cemented BiMobile Cup: Better Stability with More Cement?
Objective: The main objective of this study is to compare the (early) migration of the cemented BiMobile cup at two year post-surgery between two different cup sizes after standard optimal reaming, and consequently adjusting the…
- Trial name
- Be-Mobile (NCT04049279)
- Testing
- BiMobile standard cement, BiMobile larger cement, Avantage standard cement
- Where
- Netherlands
- Volunteers
- 75 people
- Sponsor
- JointResearch
Degenerative Arthritis
Combined Administration of Intravenous and Topical Tranexamic Acid in Total Knee Arthroplasty
This prospective randomized controlled trial was conducted To compare the efficacy of TNA in terms of total blood loss and the allogenic transfusion rate among the three study groups; intravenous alone, combined intravenous and…
- Trial name
- NCT02286973
- Testing
- Tranexamic Acid
- Volunteers
- 264 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Osteoarthritis of the Knee
Structured Non-operative Treatment of Knee Osteoarthritis
The purpose of this study is to test whether an algorithm for systematic non-surgical treatment consisting of corrective insoles, neuromuscular training, weight loss, patient education and pharmacological treatment with…
- Trial name
- NCT01535001
- Testing
- Neuromuscular training (NEMEX-TJR), Information, Paracetamol
- Where
- 3 sites in Denmark
- Volunteers
- 100 people
- Sponsor
- Northern Orthopaedic Division, Denmark
Osteo Arthritis Knee
Comparison Between Intra-articular Infiltrations of PRP, MFAT, and PRP-MFAT in the Treatment of Symptomatic Knee Osteoarthritis.
This research protocol evaluate the efficacity of intra-articular injections of autologous microfat associated with a preparation of autologous PRP, in symptomatic, resistant to first-line medical treatment, degenerative or…
- Trial name
- MICROPREP3 (NCT06084637)
- Testing
- Intra-articular injection of autologous microfat, Intra-articular injection of autologous platelet-rich plasma, Intra-articular injection of autologous microfat and platelet-rich plasma
- Volunteers
- 180 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Osteoarthritis, Knee, Meniscus; Degeneration
High Tibial Osteotomy With/Without Arthroscopy.
This study will compare Hight Tibial Osteotomy with or without arthroscopically repair intra-articular knee lesions in patients with early stages of Osteoarthritis.The purpose of this study is evaluate if addition of arthroscopy…
- Trial name
- NCT05128851
- Testing
- HTO, Arthroscopy treatment, Micro fractures
- Where
- Poland
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Centre of Postgraduate Medical Education
Knee Osteoarthrosis
Use of Adipose Tissue Derived Mesenchymal Stem Cells for Knee Osteoarthrosis
Adipose tissue derived Mesenchymal Stem cells (ATMSC) will be injected in patients diagnosed with Knee osteoarthrosis
- Trial name
- NCT02966951
- Testing
- Adipose tissue derived mesenchymal stem cell
- Where
- Jordan
- Volunteers
- 10 people
- Sponsor
- Hanan Jafar
Hemi Knee Arthroplasty, Patello-femoral Osteoarthritis
Evaluation of Orthopedic Knee Measurement Using Lunar iDXA
This study is to compare scans of the knee performed using new software designed specifically to look at the knee joint with those performed using approved software designed for scans of the hip.
- Trial name
- NCT01348958
- Testing
- iDXA knee software
- Where
- New Zealand
- Volunteers
- 36 people
- Sponsor
- GE Healthcare
Arthritis
Staying Positive With Arthritis Study
Arthritis is a painful, disabling condition that disproportionately affects African Americans. Existing arthritis treatments yield only small to moderate improvements in pain and are not effective at reducing racial disparities…
- Trial name
- SPA (NCT02223858)
- Testing
- Positive Activities (PA) Program, Attention Control (AC) Program
- Where
- 2 sites in United States
- Volunteers
- 360 people
- Sponsor
- VA Office of Research and Development
Knee Osteoarthritis
GAE Using Embosphere Microspheres vs Corticosteroid Injections for Treatment of Symptomatic Knee OA (MOTION)
This multicenter, prospective, interventional trial is designed to assess the outcome of subjects with symptomatic knee osteoarthritis (OA) that are randomized to treatment with either genicular artery embolization (GAE) using…
- Trial name
- MOTION (NCT05818150)
- Testing
- Embosphere Microspheres, Corticosteroid injection
- Where
- 27 sites in United States, Australia and 4 more
- Volunteers
- 264 people
- Sponsor
- Merit Medical Systems, Inc.
Knee Osteoarthritis
Gait Analysis in Patients Underwent Total Knee Arthroplasty With a Medial Pivot Design.
The purpose of the present pilot study is to evaluate, through gait analysis and rating scales, the functional outcome during the execution of motor tasks with high functional demand such as walking on an unstable surface, stair…
- Trial name
- NCT04244838
- Testing
- Gait Analysis
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- Istituto Ortopedico Rizzoli
Knee Osteoarthritis
Trial Evaluating multimOdal toPical Cream In CompArison to pLacebo (TOPICAL)
Randomized controlled trial regarding the efficacy of a multimodal topical analgesic, Multiprofen, in comparison to placebo cream treatment on knee pain and function in patients with knee osteoarthritis.
- Trial name
- TOPICAL (NCT03199417)
- Testing
- Multiprofen
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Osteoarthritis
Safety and Clinical Effectiveness of A3 SVF in Osteoarthritis
To purpose of this study is to determine if treatment with SVF (Stromal Vascular Fraction) has an effect on pain and inflammation associated with Osteoarthritis.
- Trial name
- NCT01947348
- Testing
- treatment with A3 SVF
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Institute of Regenerative and Cellular Medicine
Temporomandibular Joint Osteoarthritis
Efficacy of Autologous Conditioned Serum in Temporomandibular Joint Disorder
Temporomandibular joint (TMJ) disorders are health conditions that can occur at any age and are recognized as the most common cause of chronic pain, affecting 5-12% of the population.
- Trial name
- NCT06839326
- Testing
- Autologous Conditioned Serum, Genesis Biyomedikal, Sanakin®-Acrs produce, Platelet Rich Plasma, Control Group/ Only Arthrocentesis
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Batman University
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