Clinical trials: Degenerative Joint Disease
Cartilage Diseases
Molecular Biomarkers Associated With Degenerative Joint Disease in the Knee
This investigation describes a novel complex of structural degradation proteins that is associated with pain in individuals with meniscal pathology undergoing arthroscopic partial meniscectomy.
- Trial name
- NCT01006278
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Scuderi, Gaetano J., M.D.
Knee Osteoarthritis
Evaluation of Functional Improvement After Spa Therapy in Fontcaude Center
Evaluation of functional improvement after spa therapy in Fontcaude center, for knee osteoarthritis Background. Knee osteoarthritis is the first indication of spa therapy in rheumatology.
- Trial name
- FONTCAUDE (NCT03289078)
- Testing
- Spa Treatment
- Sponsor
- University Hospital, Montpellier
Osteoarthritis, Osteoarthritis, Knee
A Study to Evaluate the Efficacy, Safety and Tolerability of EVI-01 Intra-Articular Injection in Osteoarthritis of the Knee
Objective: Identifying the dose of EVI-01 with the best clinical response, balancing the efficacy, safety, and tolerability of the investigational product.
- Trial name
- NCT05337540
- Testing
- EVI-01, Active comparator Synvisc-One
- Where
- 2 sites in Brazil
- Volunteers
- 120 people
- Sponsor
- Aptissen SA
Knee Osteoarthritis
Effects Of Native Collagen Type 2 Treatment
The aim of this study was to evaluate symptomatic efficacy of native collagen type 2 on joint pain and function and its effects on urinary biological markers related to cartilage degeneration in patients with knee osteoarthritis.
- Trial name
- NCT02237989
- Testing
- paracetamol, paracetamol+native collagen type 2
- Volunteers
- 39 people
- Sponsor
- Eskisehir Osmangazi University
Knee Osteoarthritis
Radio-frequency Ablation in Knee Osteoarthritis by Three Needles Technique
The study is designed to evaluate and compare the efficacy of three needles approach as a new technique in radiofrequency neurotomy of genicular nerve versus the traditional single needle approach as a treatment of advanced knee…
- Trial name
- NCT03613610
- Testing
- Radio-frequency ablation of genicular nerves
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Alaa Fouli Gaber Ebrahim
Prehabilitation, Knee Osteoarthritis
Effectiveness of a Prehabilitation Program for Hip or Knee Arthroplasty Surgery.
We live in an increasingly aging society in which the incidence of osteoarticular diseases increases, among which osteoarthritis (OA) stands out.
- Conditions
- Prehabilitation, Knee Osteoarthritis, Hip Osteoarthritis, Physical Therapy Modalities
- Trial name
- Preoperative (NCT06721897)
- Testing
- Prehabilitation Program, Non prehabilitation Program
- Where
- Spain
- Volunteers
- 44 people
- Sponsor
- University of Jaén
Aortic Diseases, Osteoarthritis, Hip
Pro-inflammatory Cytokines in Blood From Orthopedic Surgery Compared to Abdominal Aneurysm Repair
The purpose of this study is to investigate the contents in blood sampled from surgery site during hip replacement compared with blood sampled from abdominal aortic surgery.
- Trial name
- KEEP-HB (NCT00851149)
- Testing
- Sangvia blood sampling system
- Where
- Norway
- Volunteers
- 20 people
- Sponsor
- Sykehuset i Vestfold HF
Osteoarthritis, Knee
Effects of Corrective Exercise Training for Improving Neuropathic Pain and Function in Knee Osteoarthritis
Patients with neuropathic pain had longer duration of symptoms increased severity of pain, functional limitation and disability as compare to the patient with general knee osteoarthritis.
- Trial name
- NCT04995250
- Testing
- corrective exercise training for knee
- Where
- Pakistan
- Volunteers
- 16 people
- Sponsor
- Riphah International University
Knee Osteoarthristis
Efficacy of Virtual Reality Based Exercise Regimes on Kinesiophobia, Pain and Functional Disability in Patients With Knee Osteoarthritis
Knee Osteoarthritis is one of the most prevalent degenerative conditions in Pakistan. Although a variety of Physical therapy treatments have been proven to be beneficial in patients with early stages of knee Osteoarthritis.
- Trial name
- NCT05777421
- Testing
- Conventional Physical Therapy for Knee Osteoarthriths, Virtual Reality-Based Therapeutic Exercise regimes
- Where
- Pakistan
- Volunteers
- 24 people
- Sponsor
- Foundation University Islamabad
Osteoarthritis of the Knee
Serum and Synovium Protease Inhibitor Levels in Primary and Secondary Osteoarthritic Joints
Osteoarthritis (OA) is the irreversible degeneration of articular cartilage and underlying bone. It poses a major healthcare problem as it is the leading cause of joint disease and disability in the United States.
- Trial name
- NCT01613833
- Testing
- Blood Draw, Joint Aspirate Harvest
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Scuderi, Gaetano J., M.D.
Osteoarthritis, Gait Disorders, Neurologic
Effect of Flamingo Exercises on Balance
The aim of this study is to determine the effect of flamingo exercise on balance in patients with balance impairment due to senil osteoarthritis
- Trial name
- NCT03361449
- Testing
- Flamingo exercise, training with kinesthetic ability trainer
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ufuk University
Knee Osteoarthritis
The Bone Cement Penetration in Medial Fixed-bearing Unicompartmental Knee Arthroplasty
During Medial Fixed-bearing Unicompartmental Knee Arthroplasty, pulsed lavage combined with moderate pressurization achieves deeper cement penetration into cancellous bone than manual rinsing, optimizing the bone-cement-implant…
- Trial name
- NCT07866378
- Testing
- unicompartmental knee arthroplasty
- Where
- China
- Volunteers
- 88 people
- Sponsor
- Tianjin Union Medical Center
Hip Osteoarthritis, Osteoarthritis
Development and Evaluation of a Web Based Decision Aid for Patients With Hip Osteoarthritis
The main goal of this study is assess the effectiveness of a PtDA for patients with hip osteoarthritis
- Trial name
- NCT04241978
- Testing
- Patient Decision Aid (PtDA), Brochure with general information about osteoarthritis
- Where
- Spain
- Volunteers
- 130 people
- Sponsor
- Servicio Canario de Salud
Knee Osteoarthritis (Knee OA)
Comparison of SVF Injection With and Without Microfracture in Moderate Knee Osteoarthritis
This prospective, randomized controlled clinical trial aims to evaluate the clinical and radiological effects of combining stromal vascular fraction (SVF) therapy with arthroscopic microfracture in patients with knee…
- Trial name
- NCT07112885
- Testing
- Arthroscopic Microfracture Combined with Autologous SVF Injection, Arthroscopic Debridement Followed by Autologous SVF Injection
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Istanbul University
Hand Osteoarthritis
An Integrated Self Management Programme to Improve Outcomes in Patients With Hand Osteoarthritis
The goal of this trial is to evaluate the efficacy of an integrated self-management programme in improving clinical outcomes in patients with hand osteoarthritis (OA).
- Trial name
- OASIS-H (NCT06264908)
- Testing
- Integrated self-management programme
- Volunteers
- 90 people
- Sponsor
- Dr Iris Tang Yan Ki
Osteoarthritis, Knee, Psychological Disorder
Total Knee Arthroplasty Combined With Psychological Intervention for Patients With Psychological Disorders
Objective To evaluate the incidence of psychological problems in total knee arthroplasty (TKA) patients and examine whether perioperative psychological intervention can improve the outcomes of and patient satisfaction with TKA.
- Conditions
- Osteoarthritis, Knee, Psychological Disorder, Psychological Intervention, Satisfaction
- Trial name
- NCT03715608
- Testing
- Psychological Intervention
- Volunteers
- 60 people
- Sponsor
- Peking University Third Hospital
Osteoarthritis, Knee
The Effect of Exercise on Serum Levels of Collagen and Proteoglycan in Patients With Knee Osteoarthritis
The aim of EFEX-OA-02 is to explore how running, cycling, exercise simulation and resting acutely influence collagen and proteoglycan homeostasis in OA, as reflected by changes in collagen and proteoglycan levels in urine and…
- Trial name
- EFEX-OA-02 (NCT04542668)
- Testing
- Cycling then running, Running then cycling, Inotropy
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Nordic Bioscience A/S
Knee Osteoarthritis, Effusion Synovial
Methotrexate in the Treatment of Advanced Knee Osteoarthritis With Effusion-synovitis
This multicentre randomized placebo-controlled clinical trial aims to evaluate whether methotrexate (MTX) has effects of relieving symptoms and reducing inflammation on advanced knee osteoarthritis (OA) with inflammatory…
- Conditions
- Knee Osteoarthritis, Effusion Synovial, Knee Pain
- Trial name
- NCT03815448
- Testing
- Methotrexate
- Where
- 11 sites in China
- Volunteers
- 215 people
- Sponsor
- Zhujiang Hospital
Osteoarthritis Ankle
MONOVISC for Ankle Joint Pain Relief Due to Osteoarthritis
The goal of this study is to demonstrate the clinical improvement and safety in patients treated with MONOVISC for ankle osteoarthritis.
- Trial name
- NCT04204278
- Testing
- Monovisc
- Where
- 4 sites in Czechia, Poland
- Volunteers
- 25 people
- Sponsor
- Anika Therapeutics, Inc.
Total Knee Arthroplasty, Osteoarthritis
Kinematic and Mechanical Alignment Randomized Trial
Knee replacement surgery is the second most common surgery in Canada. People who have very painful knee arthritis usually receive a knee replacement where the surgeon aims to make everyone's knee as straight as possible (called…
- Trial name
- KMART (NCT06787417)
- Testing
- Restricted Kinematically-aligned Arthroplasty, Mechanically-Aligned Arthroplasty
- Where
- Canada
- Volunteers
- 260 people
- Sponsor
- McMaster University
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