Clinical trials: Degenerative Joint Disease
Coxarthrosis
Compaction Total Hip Arthroplasty (THA) Bilateral
This is a prospective, randomized study comparing two different bone preparation techniques for insertion of a porous coated titanium cementless femoral stem.
- Trial name
- NCT00317889
- Testing
- Bone preparation technique: compaction, Bone preparation technique: broaching
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Northern Orthopaedic Division, Denmark
Osteoarthritis, Knee
Role of Bone in Knee Osteoarthritis (OA)
The purpose of the study is to investigate protein and gene expression among damaged knee tissues. We will perform MRI's on subjects prior to total knee replacement to identify the location of bone marrow lesions.
- Trial name
- NCT00850538
- Testing
- MRI, Primary Total Knee Replacement
- Where
- Australia
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- The New England Baptist Hospital
Spine Osteoarthritis, Spa Resorts
Effectiveness of Spa Treatment, Outpatient Physiotherapy and no Physiotherapy in Spine Osteoarthritis
In the first study group will participate patients with spine osteoarthritis who will be treated in polish spas in Subcarpathian Region. Complex physiotherapy including balneotherapy will be applied in study group participants.
- Trial name
- NCT03974308
- Testing
- Comprehensive physiotherapy including balneotherapy and filling questionaire, Comprehensive physiotherapy without balneotherapy and filling questionaire, No intervention, only filling questionaire
- Where
- Poland
- Volunteers
- 300 people
- Sponsor
- University of Rzeszow
Osteo Arthritis Knee
Effects of Anti-gravity Treadmill Training on Knee Osteoarthritis in Geriatric Population.
Knee osteoarthritis is a very common disorder affecting majority of elderly population. There is considerable functional disability associated with this disorder. The financial burden associated with this disease is quite high.
- Trial name
- NCT04299568
- Testing
- Anti gravity treadmill training, Physical Therapy
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- Foundation University Islamabad
Diabetes Mellitus Type 2, Breast Neoplasms
AI-Based Phenome Data Analysis for Predicting the Onset of Major Diseases
This study aims to develop and validate an artificial intelligence (AI)-based predictive model to estimate the risk of incident onset of five major diseases or conditions: cardiovascular disease, type 2 diabetes mellitus, breast…
- Conditions
- Diabetes Mellitus Type 2, Breast Neoplasms, Low Back Pain, Osteoarthritis
- Trial name
- NCT07595718
- Where
- South Korea
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Jae Yong Jeon, MD
Obesity, Knee Osteoarthritis
Subcutaneous Tirzepatide Once-weekly in Patients With Obesity and Knee Osteoarthritis (STOP KNEE-OA)
This is a trial of tirzepatide in people with obesity and knee osteoarthritis. The main purpose of this study is to see if tirzepatide can reduce number of these participants who require a knee replacement.
- Conditions
- Obesity, Knee Osteoarthritis, Osteoarthritis, Knee
- Trial name
- STOP KNEE-OA (NCT06191848)
- Testing
- Tirzepatide
- Where
- 4 sites in Australia
- Volunteers
- 352 people
- Sponsor
- University of Melbourne
Vulvar Cancer
Groin Sentinel Node Biopsy and 18FDG-PET/CT in cN0 Vulvar Cancer Patients Candidate to Standard Lymphadenectomy
The study aim is to verify the accuracy of SNB combined with 18F-FDG PET/CT in cN0 invasive vulvar cancer (IVC) patients currently not candidate to SNB according to standard guidelines.
- Trial name
- GroSNaPET (NCT02969278)
- Testing
- 18FDG-PET/TC, Sentinel node biopsy
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Catholic University of the Sacred Heart
Total Knee Arthroplasty, Knee Replacement
Investigating Patient Satisfaction With Smart Knee Implants
The main goal of this study is to see if there is a connection between the social and economic resources available in a patient's neighborhood (measured by the Area Deprivation Index, ADI) and their recovery after knee…
- Conditions
- Total Knee Arthroplasty, Knee Replacement, Knee Replacement Arthroplasty, Knee Osteoarthritis
- Trial name
- NCT06968143
- Testing
- Smart Knee Implant
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Osteoarthritis (OA) of the Knee
Investigation of Biopsychosocial Characteristics of Individuals with Knee Osteoarthritis
Since pain and depression are observed together in rheumatic diseases, the concept of limitation caused by the disease and health-related quality of life becomes more determinant than radiological joint damage.
- Trial name
- NCT06591715
- Testing
- Home exercise program
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Aysima Barlak
Osteoarthritis
Study of FLEXISEQ® for Treatment of Osteoarthritis of the Knee in NSAID-compromised Patients
Primary Objective To substantiate the efficacy of 2.2 g FLEXISEQ® for the treatment of pain related to osteoarthritis (OA) of the knee in patients contraindicated for or with clinical intolerance to NSAIDs.
- Trial name
- OANIT (NCT02594176)
- Testing
- FLEXISEQ®
- Where
- Germany
- Volunteers
- 600 people
- Sponsor
- Pro Bono Bio
Hip Osteoarthritis
Project Arthritis Recovering Quality of Life Through Education - Hip
Introduction: One in four people are at risk of developing symptomatic hip OAH. Perhaps the greatest potential for improvement in OAH treatment is to approach the early stages of pathology, since total hip arthroplasty was…
- Trial name
- NCT04018690
- Testing
- Patients will be submitted to needle lavage, followed by the injection of 3mL of hylan and 1 mL of ropivacaine, Patients will be submitted to needle lavage, followed by the injection of 0,5mL triamcinolone (10mg) and 1 mL of ropivacaine,
- Where
- Brazil
- Volunteers
- 48 people
- Sponsor
- University of Sao Paulo General Hospital
Arthrocentesis
Injection of Tenoxicam Versus Arthrocentesis Alone in the Treatment of Temporomandibular Joint Osteoarthritis
The aim of the study is to examine the effectiveness of arthrocentesis plus tenoxicam injection and to compare it with arthrocentesis alone in patients with TMJ-OA.
- Trial name
- NCT05497570
- Testing
- Tenoxicam Injectable Product
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Arthritis Multiple Joint
Botulism Toxin Injection as a Treatment for Arthritis of the Basal Thumb Joint
Basal arthritis of the thumb is a common condition with increased prevalence in post-menopausal women, obese persons, and the elderly. Surgical options are varied and efficacious, but not all patients are candidates for surgery.
- Trial name
- NCT01045694
- Testing
- Botulinum Toxin Type A, Steroid - Triamcinolone Acetonide, Lidocaine
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Missouri-Columbia
Osteoarthritis, Knee
Comparative Outcomes Between Imageless Robotic-assisted and Conventional Total Knee Arthroplasty
The purpose of this study is to compare post-operative mechanical alignment (Hip-Knee-Ankle angle; HKA) between imageless robotic-assisted (Navio™ Robotics-assisted Surgical System) and Conventional Total Knee Arthroplasty
- Trial name
- NCT04307251
- Testing
- Navio™ Robotics-assisted Surgical System, LEGION Total Knee System, Conventional, LEGION Total Knee System
- Where
- Thailand
- Volunteers
- 168 people
- Sponsor
- Navamindradhiraj University
Unilateral Primary Osteoarthritis, Unspecified Hip
A Clinical Trial Comparing Monocryl and Dermabond Closure Versus Staple Closure in Total Hip Arthroplasty
Patients undergoing primary hip arthroplasty will be randomized to receive either monocryl closure of fascial and dermal layers with dermabond and tegaderm covering versus standard vicryl closure of fascia layer and staple…
- Trial name
- NCT02519829
- Testing
- Monocryl closure, Vicryl and Staple closure, Tegaderm dressing
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Knee Osteoarthritis
Kinematics of Contemporary Knee Arthroplasty
Total joint replacement is an efficacious treatment for osteoarthritis of hips and knees. Both total knee replacement (TKR) and total hip replacements (THR) have excellent implant survivorship.
- Trial name
- NCT02965690
- Testing
- Zimmer Biomet NexGen CR, Medacta International GMK Sphere
- Where
- Norway
- Volunteers
- 26 people
- Sponsor
- Oslo University Hospital
Osteoarthritis, Hip, Arthroplasty Complications
Incidence of 30 Day Return to Hospital Following Same Day Discharge Total Hip Arthroplasty
Amongst patients who are discharged home from hospital on the same day as their elective Primary Total Hip Arthroplasty, the Investigators seek to quantify the incidence of return to hospital within 30 days of surgery for…
- Conditions
- Osteoarthritis, Hip, Arthroplasty Complications, Complication of Surgical Procedure, Perioperative Complication
- Trial name
- NCT04120324
- Testing
- Eligible for Same Day Discharge, Primary Single Joint Total Hip Arthroplasty, Discharge Same Day
- Where
- Canada
- Volunteers
- 109 people
- Sponsor
- University of British Columbia
Osteoarthritis
A Trial of a Single Delivery of SB-061 in Osteoarthritis of the Knee
This study evaluates a novel agent, SB-061, for the treatment of osteoarthritis of the knee. Half of the patients will receive the agent via intra-articular injection and half will receive a placebo injection.
- Trial name
- MODIFY2 (NCT03231280)
- Testing
- SB-061
- Where
- 2 sites in Estonia
- Volunteers
- 60 people
- Sponsor
- Symic OA Co.
Osteoarthritis, Osteoarthritis, Hip
Pericapsular Nerve Group Block Chemical Neurolysis in Advanced Hip Osteoarthritis
PENG neurolysis in advanced osteoarthritis of the hip joint.
- Trial name
- PENG (NCT06087588)
- Testing
- 0.9%sodium chloride, 95% ethanol
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Poznan University of Medical Sciences
Osteoarthritis
Evaluation of Biomarkers in Human Synovial Fluid
Osteoarthritis is a condition that causes joints in the human body to deteriorate over time. This condition affects more than 250 million people around the globe.
- Trial name
- NCT02664870
- Testing
- Arthroscopy, Arthroplasty
- Where
- United States
- Volunteers
- 149 people
- Sponsor
- Duke University
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