Clinical trials: Degenerative Joint Disease
Osteoarthritis, Rheumatoid Arthritis
Persona TM Tibia Clinical Outcomes Study
The primary objective of this study is to evaluate clinical performance for the commercially available Persona TM Tibia used in primary cementless tibia total knee arthroplasty.
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Traumatic Arthritis, Polyarthritis
- Trial name
- NCT03589300
- Testing
- Persona TM Tibia
- Where
- 7 sites in United States
- Volunteers
- 148 people
- Sponsor
- Zimmer Biomet
Osteoarthritis
Evaluation of the Safety of LipiodolⓇ Embolization in Symptomatic Digital Osteoarthritis Refractory to Conventional Treatment
The goal of this clinical trial is to evaluate the safety of arterial embolization using Lipiodol® in patients with symptomatic hand osteoarthritis refractory to conventional treatment.
- Trial name
- EMBARDI (NCT06611007)
- Testing
- embolization therapy
- Where
- France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Grenoble
Knee Osteoarthritis
A Parallel-group Active Comparator, Double-blind, Multicenter, Randomized, Double-blind, Phase III Clinical Study
A multicenter, randomized, double-blind, parallel-group, placebo-controlled, and active-drug, 12-week, multicenter clinical study.
- Trial name
- SAVE (NCT03936192)
- Testing
- glucosamine sulphate 1500mg and meloxicam 15mg, Glucosamine sulfate 1500mg and chondroitin sulfate 1200mg
- Sponsor
- Eurofarma Laboratorios S.A.
Hip Osteoarthritis, Primary Total Hip Arthroplasty
Suprainguinal Fascia Iliaca (SIFI) Block Improves Analgesia Following Total Hip Arthroplasty
The purpose of this study is to learn if using a suprainguinal fascia iliaca (SIFI) injection technique (also called a "nerve block") that numbs the nerves going to the side and front of the upper leg will improve pain control…
- Conditions
- Hip Osteoarthritis, Primary Total Hip Arthroplasty, Pain
- Trial name
- NCT02933671
- Testing
- Suprainguinal fascia iliaca (SIFI) block, Ropivacaine, Saline
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Duke University
To Evaluate a Linear Positive Correlation Between Plasma HbA1c and Synovial IL-6 in Diabetic Patients
Correlation Between Altered Glycometabolic Status and Joint Inflammation in Diabetic Patients With Osteoarthritis Undergoing Knee Arthroplasty
Evaluate the correlation between altered glycometabolic status and joint inflammation in diabetic patients with osteoarthritis undergoing knee replacement surgery
- Trial name
- GLICO PG (NCT05150119)
- Testing
- Evaluation of Synovial IL-6 in diabetic patients with gonarthrosis
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Non-inflammatory Degenerative Joint Disease
36 mm Ceramic-on-Ceramic Acetabular Cup Total Hip Replacement
This study is a supplement to the 28 mm Ceramic-on-Ceramic study which was designed to evaluate artificial hips with a 28 mm ceramic head and liner to determine whether they perform as well as artificial hips with a 28 mm ceramic…
- Trial name
- NCT00953719
- Testing
- 36 mm ceramic head on a ceramic acetabular liner, 28 mm ceramic head on a polyethylene acetabular liner
- Where
- 5 sites in United States
- Volunteers
- 243 people
- Sponsor
- DePuy Orthopaedics
MRI, Osteoarthrosis
Osteoarthrosis on 7.0T Magnetic Resonance Imaging
This clinical trial studies the use of 7-Tesla (7T)and 3T magnetic resonance imaging (MRI) in detecting osteoarthrosis. 7T MRI has increased detection sensitivity, including more accurate lesion delineation, higher inter-rater…
- Trial name
- NCT05343104
- Testing
- Magnetic resonance imaging
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Unilateral Primary Osteoarthritis of Knee
An Efficacy and Safety Study of Periarticular Parecoxib Sodium for Pain Management in Total Knee Arthroplasty
Primary Research Objective: The primary objective of this study is to determine efficacy of periarticular parecoxib sodium in a multimodal cocktail versus intravenous parecoxib injections for pain management in total knee…
- Trial name
- NCT01311804
- Testing
- parecoxib sodium
- Where
- Malaysia
- Volunteers
- 125 people
- Sponsor
- Ministry of Health, Malaysia
Osteoarthritis of Knee
Clinical Trial to Evaluate Safety and Efficacy of MesoCellA-Ortho Tissue-Engineered Advanced Therapy Product in Patients With Osteoarthrosis and Civilisation Diseases
The aim of the study is to evaluate safety, tolerability and clinical efficacy of a newly developed MesoCellA-Ortho tissue-engineered advanced therapy medicinal product in adult patients suffering with osteoarthritis and…
- Trial name
- BioMiStem-CT (NCT05081921)
- Testing
- MesoCellA-Ortho administration, HA administration
- Where
- Poland
- Volunteers
- 192 people
- Sponsor
- Jagiellonian University
Osteoarthritis, Knee
Validate a Pharmacodynamic Model of Oxytocin for Peripheral Analgesic Effects
The goal of this study is to validate the pharmacodynamic model for pain relief from oxytocin at a peripheral site by intravenous infusion targeted at different levels of the drug.
- Trial name
- NCT04435704
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Postsurgical Pain
Multiprofen-CC™ to Reduce Pain After Total Knee Arthroplasty
Total knee arthroplasty is a surgical treatment which involves replacing the damaged articular cartilage of the knee joint with an artificial prosthetic in end-stage knee osteoarthritis.
- Trial name
- MP-TKA (NCT06202989)
- Testing
- Multiprofen-CC™ plus standard treatment
- Where
- Canada
- Volunteers
- 306 people
- Sponsor
- KAZM Pharmaceuticals Inc.
Osteoarthritis, Knee
The Effect of Spironolactone on Pain in Older People With Osteoarthritis
This pilot study will obtain preliminary evidence on which to base sample size calculations for a future trial of whether spironolactone (an aldosterone blocker) reduces knee pain in older people with symptomatic OA knee when…
- Trial name
- SPIR-OA (NCT02046668)
- Testing
- spironolactone
- Where
- 2 sites in United Kingdom
- Volunteers
- 86 people
- Sponsor
- University of Dundee
Thermal Radiofrequency Neurolysis, Alcoholic Neurolysis
Thermal Radiofrequency Neurolysis Versus Alcoholic Neurolysis of the Genicular Nerves for Treatment of Chronic Knee Pain in Advanced Knee Osteoarthritis
This study aimed to compare the strength and duration of pain relief, quality of life and analgesic consumption between patients who undergo conventional thermal radiofrequency vs patients who undergo chemical neurolysis on…
- Conditions
- Thermal Radiofrequency Neurolysis, Alcoholic Neurolysis, Genicular Nerves, Treatment
- Trial name
- NCT07125768
- Testing
- Thermal Radiofrequency Neurolysis, Alcoholic Neurolysis
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Tanta University
Osteoarthritis
Medico-economic Study of Patient Matched Cutting Blocks (Ancillary) MyKnee ® LBS During Knee Arthroplasty GMK ®.
Total knee arthroplasty represents over 70 000 surgical procedures per year in France, increasing about 10% each year since the early 1990s.
- Trial name
- NCT01814384
- Testing
- prosthesis GMK ® without the ancillary MyKnee ® LBS, Matched patient cutting blocks MyKnee ® LBS
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Nantes University Hospital
Osteoarthritis, Knee
Blood Levels of Local Anaesthetic in Knee Arthroplasty Using a Continuous Infusion Device
The primary goal is to evaluate ropivacaine blood concentrations during and after local anaesthetic (ropivacaine) infiltration - the Caledonian technique - for total knee replacement surgery.
- Trial name
- BLOCKS-II (NCT01935648)
- Testing
- Ropivacaine
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Golden Jubilee National Hospital
Osteoarthritis, Arthritis
Periprosthetic Bone Mineral Density After Total Hip Arthroplasty Performed Through a Minimally Invasive Anterior Approach (AMIS) With Either an AMIStem or a Quadra Femoral Component
This is a monocentric, prospective, randomized clinical survey to verify if the periprosthetic remodelling brought about either the AMIStem or the Quadra femoral component is equivalent.
- Conditions
- Osteoarthritis, Arthritis, Avascular Necrosis, Fracture of the Femoral Neck or Head
- Trial name
- NCT01285843
- Testing
- Anterior Minimally Invasive Approach (AMIS)
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Medacta International SA
Osteoarthritis, Hand Osteoarthritis
Balneotherapy and Peloid Therapy Impact Small Joint Diseases
This clinical trial investigates the effects of natural healing factors (mineral water and mud procedures) in combination with regular rehabilitation of patients with degenerative small joint disease.
- Conditions
- Osteoarthritis, Hand Osteoarthritis, Foot Osteoarthritis
- Trial name
- NCT06477393
- Testing
- Regular rehababilitation, Heat procedures, Healing mud application
- Where
- 2 sites in Lithuania
- Volunteers
- 130 people
- Sponsor
- Lithuanian University of Health Sciences
Post Operative Pain, Knee Osteoarthritis
Cryoneurolysis Prior to Total Knee Arthroplasty
Knee osteoarthritis is a major issue worldwide with limited treatment options. Many patients receive knee joint replacement surgery which is considered effective and safe.
- Conditions
- Post Operative Pain, Knee Osteoarthritis, Opioid-Related Disorders
- Trial name
- NCT05840276
- Testing
- Cryoneurolysis
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Esbjerg Hospital - University Hospital of Southern Denmark
Osteoarthritis, Pain
Femoral Nerve Block Compared to Exparel in Total Knee Replacement
The main objective of the study is to determine if intrarticular injection with liposomal bupivicaine (Exparel) provides better postoperative pain relief and functional outcome following total knee replacement (TKR) than the…
- Trial name
- NCT02473198
- Testing
- Exparel, Femoral Nerve Block Bupivacaine, Toradol
- Where
- United States
- Volunteers
- 312 people
- Sponsor
- The New England Baptist Hospital
Osteoarthritis, Knee
All Polyethylene Versus Metal Backed Tibial Components in Knee Replacement
Total knee arthroplasty (TKA) is one of the most commonly performed orthopaedic procedures. Approximately 84,000 knee replacement procedures were recorded in the UK in 2012.
- Trial name
- NCT02482493
- Testing
- Sigma PFC
- Where
- United Kingdom
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Maidstone & Tunbridge Wells NHS Trust
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