Clinical trials: Degenerative Joint Disease
Pain
Study to Evaluate the Efficacy, Safety, Tolerability and Pharmacokinetics of AZD1386 in Patients With Osteoarthritis (OA) of the Knee
The primary aim of this study is to investigate if AZD1386 is efficacious as an analgesic in patients with osteoarthritis of the knee and at what dose.
- Trial name
- OA19 (NCT00878501)
- Testing
- AZD1386
- Where
- 41 sites in Bulgaria, Canada and 5 more
- Volunteers
- 241 people
- Sponsor
- AstraZeneca
Knee Osteoarthritis
Combination of PRP and XLHA Prepared With RegenMatrix Medical Device To Treat Moderate to Severe Knee Osteoarthritis
In this clinical trial the investigator assess the safety and efficacy of a single injection of a combination of cross-linked hyaluronic acid (HA) with autologous platelet-rich plasma (PRP) obtained with the RegenMatrix medical…
- Trial name
- NCT05727371
- Testing
- Regen Matrix-PRP-XLHA, Hylan G-F 20
- Where
- 13 sites in France
- Volunteers
- 280 people
- Sponsor
- RegenLab France SAS
Osteoarthritis
Safety & Effectiveness of Autologous Regenerative Cell Therapy on Pain & Inflammation of Osteoarthritis of the Shoulder
This is a prospective open-label clinical study of 50 patients to determine safety and treatment potential of autologous cell therapy for pain and inflammation associated with Osteoarthritis of the shoulder.
- Trial name
- NCT02844738
- Testing
- [StroMed + platelet rich plasma (PRP)]
- Where
- United States
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- VivaTech International, Inc.
Arthrosis, Arthritis
The Effect of Subsartorial Saphenous Block on Postoperative Pain Following Major Ankle and Hind Foot Surgery
The study investigates the effect of a ultrasound-guided subsartorial saphenous block on postoperative pain following major ankle and hind foot surgery.
- Trial name
- NCT02697955
- Testing
- Bupivacaine-epinephrine
- Where
- Denmark
- Volunteers
- 18 people
- Sponsor
- University of Aarhus
Cartilage Diseases
Molecular Biomarkers Associated With Degenerative Joint Disease in the Knee
This investigation describes a novel complex of structural degradation proteins that is associated with pain in individuals with meniscal pathology undergoing arthroscopic partial meniscectomy.
- Trial name
- NCT01006278
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Scuderi, Gaetano J., M.D.
Osteoarthritis of Knee
Effect of Video-based Game and Aerobic Exercise on Knee Osteoarthritis
This randomized controlled trial was conducted by the CONSORT guidelines for non-pharmacological treatments. Participants were randomly assigned to control, gaming, or aerobic groups using the closed-envelope randomization…
- Trial name
- NCT06885008
- Testing
- Active video game, Aerobic exercise, Conventional treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people
- Sponsor
- Hasan Kalyoncu University
Osteoarthritis, Knee
Muscle Property, Alignment and Joint Loading in People With Knee Osteoarthritis
Knee osteoarthritis (KOA) is a common chronic painful musculoskeletal condition among older adults. It poses great challenge to the health care system due to its inability to be cured.
- Trial name
- NCT03628508
- Testing
- Exercise
- Where
- Hong Kong
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Pain, Back, Pain, Neck
Preliminary Muscle Contraction in the Rehabilitation and Prevention of Degenerative Pain in the Locomotor System
RESEARCH OBJECTIVE: To investigate the effect of muscle preliminary contraction in the rehabilitation and prevention of degenerative pain in the spine, hip, knee, ankle, shoulder, elbow, and ankle joints, as well as after hip and…
- Conditions
- Pain, Back, Pain, Neck, Pain, Hip Burning, Pain, Shoulder
- Trial name
- PMQRPDP (NCT06415825)
- Testing
- Standard advice and Preliminary muscle contraction, Standard advice
- Volunteers
- 216 people
- Sponsor
- Medical University of Sofia
Osteo Arthritis Knee
An Effectiveness and Safety 6 Months Study of 3 Injections One Week Apart of SYNOLIS VA 40/80 in the Treatment of Symptomatic Knee Osteoarthritis
Multicentre, independent assessment study on SYNOLIS VA 40/80 over a period of 24 weeks
- Trial name
- NCT05829850
- Testing
- SYNOLIS VA 40/80
- Where
- 3 sites in Poland
- Volunteers
- 51 people
- Sponsor
- Aptissen SA
Osteoarthritis, Osteoarthritis Knee Pain
Clinical Trial of Type II Collagen vs. Sodium Hyaluronate Intra-articular Injection in Knee Osteoarthritis
The purpose of this clinical trial is to evaluate the efficacy and safety of CartiSave compared with sodium hyaluronate in patients with knee pain.
- Conditions
- Osteoarthritis, Osteoarthritis Knee Pain, Knee Arthritis
- Trial name
- CartiSave (NCT07907926)
- Testing
- CartiSave, Hyalforte Injection
- Where
- 4 sites in South Korea
- Volunteers
- 117 people
- Sponsor
- ATEMs
Osteoarthritis, Knee
GMK-UNI Anatomical UKA: Fixation of Cemented vs Cementless Designs
Unicompartmental knee arthroplasty (UKA) is the principal surgical alternative to the total knee arthroplasty (TKA) in patients with end-stage unicompartmental tibiofemoral osteoarthritis (OA) of the knee.
- Trial name
- NCT03522025
- Testing
- Unicompartmental Knee Arthroplasty (UKA)
- Where
- 5 sites in France, Switzerland
- Volunteers
- 70 people
- Sponsor
- Medacta International SA
Osteoarthritis, Rheumatoid Arthritis
Clinical Study Comparing Two Implant Surface Finishes in Patients Undergoing Cementless Total Hip Replacement
Prospective, randomized study of Summit Porocoat versus Summit DuoFix HA in total hip arthroplasty
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Post-traumatic Arthritis, Avascular Necrosis
- Trial name
- SPD (NCT00306917)
- Testing
- non-coated femoral hip stem, coated femoral hip stem
- Where
- United States
- Volunteers
- 245 people
- Sponsor
- DePuy Orthopaedics
Osteoarthritis
An RSA and DEXA Study on Migration of Proximal Interphalangeal (PIP) Joint Prostheses of the Hand
The purpose of this study is to compare the early migration and the periprosthetic bone changes of cemented versus non-cemented interphalangeal implants using Roentgen stereophotogrammetric analysis and dual energy x-ray…
- Trial name
- NCT00175188
- Testing
- Avanta (PIP joint implant with a titanium porous coating)
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- University of Aarhus
Osteoarthritis, Fibromyalgia
Efficacy & Safety Study of Natural Eggshell Membrane (NEM) for the Treatment of Joint & Connective Tissue Disorders
The purpose of this study was to evaluate the use of the dietary supplement Natural Eggshell Membrane (NEM) for the treatment of joint and connective tissue discomfort \& pain.
- Trial name
- NCT00750854
- Testing
- NEM Formulation X, NEM Formulation Y
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- ESM Technologies, LLC
Polyarthritis
Erosive Osteoarthritis of the Hands: Treatment by Methotrexate Versus Placebo
Interest of methotrexate in inflammatory rheumatisms was demonstrated since several years. At present time,there is no effective treatment against digital arthritis.
- Trial name
- ADEM (NCT01068405)
- Testing
- Methotrexate
- Where
- France
- Volunteers
- 64 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Anterior Cruciate Ligament Reconstruction
The Effects of Tranexamic Acid on Joint Inflammation and Cartilage Health in Anterior Cruciate Ligament Injured Patients
Patients who tear their ACL are at high risk for developing arthritis (post-traumatic osteoarthritis-PTOA) just 10 years later. Joint bleeding and inflammation contribute to deterioration of joint health.
- Trial name
- NCT03552705
- Testing
- Tranexamic Acid
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Stanford University
Osteoarthritis
Surgery Versus no Surgery for OA of the Knee
The purpose of this trial is to evaluate the effectiveness of arthroscopy (lavage and debridement) in conjunction with the best available non-surgical treatment versus the best available non-surgical treatment alone (medication…
- Trial name
- NCT00158431
- Testing
- Arthroscopy plus Medical Management, Medical Management
- Where
- Canada
- Volunteers
- 186 people
- Sponsor
- Fowler Kennedy Sport Medicine Clinic
Knee Pain Chronic, Rheumatoid Arthritis
Cemented vs Cementless Persona Keel RCT
The main objective of this study is to evaluate the safety, performance, and clinical benefits of the Persona Keel cementless and cemented knee.
- Conditions
- Knee Pain Chronic, Rheumatoid Arthritis, Osteoarthritis, Traumatic Arthritis
- Trial name
- NCT05630053
- Testing
- Cementless Persona Knee System, Cemented Persona Knee System
- Where
- 7 sites in United States
- Volunteers
- 300 people
- Sponsor
- Zimmer Biomet
Osteoarthritis, Knee, Osteoarthritis
The Three-dimensional Gait Analysis of Medial Knee Osteoarthritis
Static imaging has been commonly and clinically accepted to assess the severity of medial knee osteoarthritis (KOA), especially the radiography.
- Trial name
- NCT02878239
- Testing
- Steps 1, Steps 2
- Where
- China
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
Osteoarthritis
Methotrexate in Symptomatic Knee Osteoarthritis
Osteoarthritis (OA) is a common disabling condition, for which no effective therapy currently exists.Synovitis is commonly demonstrated in knee OA imaging.
- Trial name
- NCT01654575
- Testing
- Methotrexate
- Where
- Egypt
- Volunteers
- 88 people
- Sponsor
- University of Alexandria
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