Clinical trials: Degenerative Joint Disease
Early Knee Osteoarthritis
Validity and Reliability Study of the Turkish Version of the Early Osteoarthritis Questionnaire
The symptoms of early osteoarthritis (OA) are quite similar to established knee OA, they differ, particularly in frequency, intensity, and severity.
- Trial name
- NCT06388811
- Testing
- Early Osteoarthritis Questionnaire
- Where
- Turkey (Türkiye)
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Gonarthrosis; Primary, Gonarthrosis
Comparison of Multiradius and Singleradius Total Knee Arthroplasty
The Investigators would like to compare multiradius and single-radius total knee arthroplasty using with association between sagittal patellar offset and anterior knee pain in subjects having undergone bilateral total knee…
- Conditions
- Gonarthrosis; Primary, Gonarthrosis, Gonarthrosis; Primary, Bilateral, Knee Osteoarthritis
- Trial name
- NCT04364971
- Testing
- singleradius and multiradius total knee arthroplasty
- Where
- Turkey (Türkiye)
- Volunteers
- 494 people
- Sponsor
- Bezmialem Vakif University
Osteoarthritis, Knee, Physical Therapy Modalities
Incorporation of Photobiomodulation Therapy in an Exercise Program With Blood Flow Restriction for Knee Osteoarthritis
Knee osteoarthritis (OA) is one of the most common musculoskeletal disorders in the world. The aim of this project is to evaluate the additional effect of photobiomodulation therapy on the quadriceps muscle and knee joint in a…
- Trial name
- NCT04247893
- Testing
- blood flow restriction, Photobiomodulation
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Nove de Julho
Knee Osteoarthritis
Perineural Dextrose Versus Local Anesthetic Injections in Knee Osteoarthritis
This prospective observational study aims to compare the clinical effectiveness of perineural 5% dextrose injections and perineural local anesthetic injections in patients with symptomatic knee osteoarthritis.
- Trial name
- NCT07381621
- Testing
- Perineural 5% Dextrose Injection, Perineural Local Anesthetic Injection
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 86 people
- Sponsor
- Ankara Training and Research Hospital
Osteoarthritis, Knee
Validate a Pharmacodynamic Model of Oxytocin for Peripheral Analgesic Effects
The goal of this study is to validate the pharmacodynamic model for pain relief from oxytocin at a peripheral site by intravenous infusion targeted at different levels of the drug.
- Trial name
- NCT04435704
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Osteoarthritis, Knee, Self Stimulation
Exercise and Muscle Stimulation in Patients With Knee Osteoarthritis
Objective: To evaluate the effectiveness of neuromuscular electrical stimulation (NMES) combined with closed kinetic chain (CKC) exercises in patients with knee OA.
- Conditions
- Osteoarthritis, Knee, Self Stimulation, Exercise Addiction
- Trial name
- NCT01320904
- Testing
- NMES, Closed Kinetic Chain
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Universidade Luterana do Brasil
Knee Osteoarthritis, Postoperative Pain
Ultrasound-Guided PASC Block vs Femoral-Sciatic Nerve Block for Postoperative Analgesia After Total Knee Arthroplasty
This randomized, double-blind comparative study evaluates postoperative analgesic efficacy and motor effects of ultrasound-guided para-sartorial compartments (PASC) block versus ultrasound-guided combined femoral-sciatic nerve…
- Conditions
- Knee Osteoarthritis, Postoperative Pain, Total Knee Arthroplasty
- Trial name
- NCT07320833
- Testing
- Ultrasound-Guided Femoral Nerve Block plus Sciatic Nerve Block, Ultrasound-Guided Para-sartorial Compartments Block
- Where
- Egypt
- Volunteers
- 62 people
- Sponsor
- Ain Shams University
Osteoarthritis, Knee
Open Ended Trocar vs. Fenestrated Blunt Trocar in Bone Marrow Aspirate for Osteoarthritis
Osteoarthritis (OA) is a leading cause of disability around the world. The aging population is only further increasing its prevalence.
- Trial name
- NCT03579407
- Testing
- BMA cell therapy injection
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Advanced Orthopaedic Specialists
Osteoarthritis, Knee
RSA Restoris MultiCompartmental Knee
Patients with isolated medial compartment arthritis of the knee are commonly treated with unicompartmental knee arthroplasty (UKA).
- Trial name
- NCT05417984
- Testing
- Restoris MCK
- Volunteers
- 33 people
- Sponsor
- Reinier Haga Orthopedisch Centrum
Osteoarthritis, Knee
Mobilizing Hispanics With Knee Osteoarthritis
The objective is to conduct an early-stage clinical trial in order to provide data required to support a future clinical trial to demonstrate the effectiveness of a culturally acceptable treatment program to increase exercise and…
- Trial name
- NCT06522906
- Testing
- Muscle Strengthening, General Physical Activity, Education
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Knee Osteoarthritis
Effects of ITB Myofascial Release on Symptoms Associated With Knee OA.
The aim of this randomized controlled trial is to determine the effects of ITB myofascial release with graston technique on symptoms associated with knee Osteoarthritis for reducing pain, enhancing knee range of motion and…
- Trial name
- NCT06109038
- Testing
- Conventional PT + ITB release with graston technique, Conventional PT
- Where
- Pakistan
- Volunteers
- 28 people
- Sponsor
- Riphah International University
Osteoarthritis Thumb, Immobilization
Effects of Motor Imagery on Trapeziometacarpal Osteoarthritis in Women During the Postoperative Immobilization Period
The aim of this study is to verify whether after trapeziometacarpal osteoarthrosis surgery and during the period of immobilization immediately after it, applying motor imagery, improvements are achieved on pain, strength, edema…
- Trial name
- NCT03815734
- Testing
- motor imagery
- Where
- Spain
- Volunteers
- 44 people
- Sponsor
- Eva Prado Robles
Osteoarthritis of the Knee, Degenerative Osteoarthritis
Platelet-Rich Plasma and the Effects of NSAIDs on Pain and Functional Scores in Knee Osteoarthritis
The primary research purpose is to determine if the use of a drug therapy intervention (each study participant will be randomly assigned to receive one of 3 study medications which will be blinded from everyone, including the…
- Conditions
- Osteoarthritis of the Knee, Degenerative Osteoarthritis, Knee Pain Chronic
- Trial name
- PRPNSAIDsKOA (NCT05742763)
- Testing
- Ibuprofen and PRP, Acetaminophen and PRP
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- QC Kinetix LLC
Chronic Pain, Osteoarthritis
Effects of Transcranial Direct Current Stimulation (tDCS) and Transcranial Ultrasound on Osteoarthritis Pain of the Knee
The purpose of this study is to see the effects of transcranial direct current stimulation (tDCS) on the pain associated with osteoarthritis of the knee.
- Trial name
- NCT01404052
- Testing
- Transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Spaulding Rehabilitation Hospital
Knee Osteoarthritis
Home Based Hip Strengthening for Knee OA Patients
In knee osteoarthritis patients, weakness of hip abductor muscles is considered an important contributing factor leading to the progression of the disease.
- Trial name
- NCT05131048
- Testing
- conventional group, experimental group
- Volunteers
- 90 people
- Sponsor
- University of Lahore
Knee Osteoarthritis
Prospective Multi-centre Outcomes Study of Persona Knee System in Total Knee Arthroplasty
This is a prospective, multi-centre, non comparative, post market clinical follow-up study involving orthopaedic surgeons skilled in TKA and experienced implanting the devices included in this study.
- Trial name
- NCT04461626
- Testing
- Persona fixed bearing knee system (All patients will receive Persona fixed bearing knee system)
- Where
- 18 sites in Australia, India and 4 more
- Volunteers
- 1,017 people
- Sponsor
- Zimmer Biomet
Osteoarthritis, Knee
Intra-articular Tenoxicam Versus Triamcinolone Acetonide in Knee Osteoarthritis Management
Knee osteoarthritis is a very common joint condition that leads to pain, stiffness, and difficulty with daily activities, particularly in middle-aged and older adults.
- Trial name
- NCT07194135
- Testing
- Tenoxicam, Triamcinolone Acetonide
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Benha University
Bilateral Knee Osteoarthritis, Autologous Adipose Tissue
Bilateral Knee Osteoarthritis: Intra-articular Injection of Filtered Autologous Adipose Tissue Versus Placebo
The purpose of the study is to assess the radiological and clinical outcomes comparing two different treatments (Filtered Autologous Adipose Tissue versus Placebo) in patients affecting bilateral knee osteoarthritis.
- Trial name
- NCT04567732
- Testing
- injection of Filtered Autologous Adipose Tissue
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Istituto Ortopedico Rizzoli
Osteoarthritis, Knee
The Effects of a Tourniquet in Total Knee Arthroplasty.
About 5000 total knee arthroplasties (TKA) are performed annually in Norway. Pain and reduced physical function is present in patients operated with TKA up to a year after surgery and about one of five patients are not satisfied…
- Trial name
- NCT03666598
- Testing
- Tourniquet
- Where
- Norway
- Volunteers
- 80 people
- Sponsor
- Norwegian University of Science and Technology
Gonarthrosis; Primary
Efficacy of Ultrasound-Guided Genicular Nerve Block in Patients With Gonarthrosis: A Randomized, Placebo-Controlled, Double-Blind Study
This study planned to enroll a minimum of 30 patients aged 50 years and older, with a diagnosis of gonarthrosis classified as stage 2 or higher according to the Kellgren-Lawrence grading system, and who report complaints of knee…
- Trial name
- NCT07326098
- Testing
- genicular nerve block
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Ege University
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