Clinical trials: Degenerative Joint Disease
Osteoarthritis
Sahastara Remedy Extract Capsule in Primary Osteoarthritis of Clinical Trial Phase II
To study efficacy and safety of Sahastara 95% ethanolic extract capsules compared to treatment Primary osteoarthritis for primary osteoarthritis, it was compared with diclofenac (Phase II).
- Trial name
- NCT04591795
- Testing
- Sahastara remedy extract, Diclofenac
- Where
- Thailand
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Mr NARIN KAKATUM
Osteoarthritis
Analgesia After Total Hip Arthroplasty: Peri-Articular Injection Versus Epidural Patient Controlled Analgesia (PCA)
The best way to provide analgesia after total hip arthroplasty is hotly debated. There are two protocols in use at Hospital for Special Surgery(HSS).
- Trial name
- PAI Hip (NCT01658072)
- Testing
- Peri-Articular Injection, Epidural Patient Controlled Analgesia (Epidural PCA)
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Hospital for Special Surgery, New York
Osteoarthritis
Adalimumab for Inflammatory Osteoarthritis
We will conduct a pilot study of the effectiveness of adalimumab for inflammatory osteoarthritis.
- Trial name
- NCT00686439
- Testing
- adalimumab
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Alberta
Knee Osteoarthritis, Symptomatic Knee Osteoarthritis
Assessment of Efficacy of Low Intensity Resistance Training in Women at Risk for Symptomatic Knee Osteoarthritis
The purpose of this study is to asses the efficacy of a 4 week low-intensity resistance training program with concurrent application of partial blood flow restriction (PBFR) to the exercising limbs to improve quadriceps strength…
- Trial name
- PBFR2 (NCT01440972)
- Testing
- partial blood flow restriction (PBFR), low intensity resistance training
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Osteoarthritis, Knee
Vanguard TKA With KneeAlign 2 and Without KneeAlign 2
Purpose of this study is to determine the effectiveness of the KneeAlign 2 system in terms of precise implant alignment by demonstrating that KneeAlign 2 provides better tibial alignment compared to conventional instruments
- Trial name
- NCT02695329
- Testing
- KneeAlign 2
- Where
- Japan
- Volunteers
- 100 people
- Sponsor
- Zimmer Biomet
Osteoarthritis of Knee, Knee Pain Chronic
Computer-guided Action Planning to Support Physical Activity (CAPPA) for Employees With Chronic Knee Symptoms
The goal of this clinical trial is to learn if a brief health coaching intervention based on an approach known as brief action planning + Fitbit can increase physical activity in employees with chronic knee symptoms who work for…
- Trial name
- CAPPA (NCT06734052)
- Testing
- CAPPA, Health education
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Marquette University
Knee Osteoarthritis
Effectiveness of Manual Therapy and Neuromuscular Training in the Management of Knee Osteoarthritis
The purpose of the study is to compare the short-term effectiveness of manual therapy with neuromuscular training and conventional physical therapy with neuromuscular training in patients with knee osteoarthritis.
- Trial name
- NCT05659849
- Testing
- Manual therapy techniques, Transcutaneous Electrical Nerve Stimulation (TENS)
- Where
- Saudi Arabia
- Volunteers
- 60 people
- Sponsor
- University of Tabuk
Osteo Arthritis of the Knee
Home-Based Leg Dexterity Trainer for Management of Knee Osteoarthritis
Rationale: Roughly 14 million adults aged 60 or older (10% male/13% female) in the United States experience symptoms of knee osteoarthritis (OA).
- Trial name
- NCT07397806
- Testing
- Lex Dexterity Trainer, Wobble Board
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- Steadman Philippon Research Institute
Arthrosis of First Carpometacarpal Joint
Short-term Recovery After Trapeziectomy and TMC Prosthesis: a Diary Study
Rationale: The trapeziometacarpal (TMC) joint is one of the most common areas in the hand and wrist to develop osteoarthritis (OA).
- Trial name
- THUMB Diary (NCT06654349)
- Where
- Netherlands
- Volunteers
- 200 people
- Sponsor
- Reinier Haga Orthopedisch Centrum
Osteoarthritis
The Effect of Mobilization With Movement on Pain and Function Among Patients With Knee Osteoarthritis
Osteoarthritis (OA) is the most prevalent form of arthritis and is reported to be the most important reason behind functional disability and musculoskeletal disorders among aged individuals.
- Trial name
- NCT02865252
- Testing
- MWM Treatment
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Imam Abdulrahman Bin Faisal University
Primary Osteoarthritis, Secondary Osteoarthritis
Clinical and Radiological Outcomes of Medacta Shoulder System
This is a post-marketing surveillance on Medacta Shoulder System
- Conditions
- Primary Osteoarthritis, Secondary Osteoarthritis, Rotator Cuff Tear Arthropathy, Rheumatoid Arthritis Shoulder
- Trial name
- NCT03547947
- Testing
- Medacta Shoulder System
- Where
- 6 sites in France, Germany and 1 more
- Volunteers
- 200 people
- Sponsor
- Medacta International SA
Coxarthrosis, Muscle Weakness
Does Capsulectomy, Performed in Total Hip Arthroplasty With a Direct Anterior Approach Cause Knee Extension Strength Loss?
Total hip arthroplasty (THA) has been successful in relieving pain and restoring function in patients with advanced arthritis of the hip joint.
- Trial name
- NCT04500093
- Testing
- Capsulotomy with Repair, Capsuloectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Bezmialem Vakif University
Osteoarthritis of Glenohumeral Joint
Columbia Shoulder Study (CSS)
This prospective study will evaluate the Bigliani/Flatow prosthesis. The aims of this study are to establish the safety, effectiveness, and value of the prosthetic system, and to collect information from expert shoulder surgeons…
- Trial name
- CSS (NCT01488006)
- Testing
- Bigliani/Flatow Shoulder System
- Where
- United States
- Volunteers
- 207 people
- Sponsor
- Columbia University
Osteoarthritis, Knee, Pain, Knee
Study of Resiniferatoxin for Knee Pain in Moderate to Severe Osteoarthritis
This study evaluates the safety of resiniferatoxin in patients with moderate to severe knee pain due to osteoarthritis.
- Trial name
- NCT03542838
- Testing
- Resiniferatoxin, Saline
- Where
- 4 sites in United States
- Volunteers
- 94 people
- Sponsor
- Sorrento Therapeutics, Inc.
Knee Osteoarthritis, Deformity Knee
Long Term Evaluation of Clinical and Radiologic Results on Femoro-patellar Joint After High Tibial Osteotomy
Osteotomies are among the oldest orthopedic treatments, in use for over 2000 years and still commonly employed. The basic principle involves making a bone cut to allow the realignment of the limb segment affected by deformity.
- Trial name
- NCT06251752
- Testing
- X-rays: load bearing inferior limbs, lateral knee, axial patella
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Istituto Ortopedico Rizzoli
Knee Osteoarthritis, Physical Activity Behaviour
Person-Centred Digital Rehabilitation for Knee Osteoarthritis
This study aims to improve our understanding of how people with knee osteoarthritis think about, regulate, and adapt their physical activity while participating in Joint Academy's digital osteoarthritis programme for knee…
- Trial name
- NCT07875647
- Where
- Sweden
- Volunteers
- 500 people
- Sponsor
- Mälardalen University
Hip Osteoarthritis
Clinical Pilates in Hip Osteoarthritis: A Randomised Controlled Trial
The aim of this study is to investigate the effect of a clinical Pilates exercise program on reducing symptoms in individuals with hip osteoarthritis.
- Trial name
- NCT06783452
- Testing
- Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Izmir Katip Celebi University
Osteoarthritis, Hip, Osteoarthritis, Knee
A Study to Evaluate Long-Term Safety of Multiple Doses of Tapentadol (CG5503) Prolonged-Release (PR) and Oxycodone Controlled-Release (CR) in Patients With Chronic Pain
The purpose of this study is to evaluate the safety profile of tapentadol (CG5503) PR at doses of 100 mg - 250 mg administered twice daily over a maximum one year period to patients with at least a 3-month history of low back…
- Conditions
- Osteoarthritis, Hip, Osteoarthritis, Knee, Lower Back Pain, Pain
- Trial name
- NCT00361504
- Testing
- Oxycodone CR, Tapentadol (CG5503) ER
- Where
- 52 sites in United States, Canada
- Volunteers
- 1,123 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Osteoarthritis
A Study of Two Approved Drugs in Patients With Osteoarthritis (0966-219)
The purpose of this study is to compare the safety and effectiveness of two approved drugs in the treatment of osteoarthritis of the knee.
- Trial name
- NCT00092352
- Testing
- MK0966, rofecoxib
- Volunteers
- 395 people
- Sponsor
- Merck Sharp & Dohme LLC
Knee Osteoarthritis, Pain
The Effect of Adding Instrumented Hip Concentric Abductor Strengthening Exercise in Knee Osteoarthritis
The aim of this study was to investigate the effectiveness of adding hip device-assisted concentric abductor strengthening (HDACAS) program to knee device-assisted concentric flexor-extensor strengthening (KDACFES) program on…
- Conditions
- Knee Osteoarthritis, Pain, Physical Disability
- Trial name
- NCT06331858
- Testing
- hip device-assisted concentric abductor strengthening (HDACAS), knee device-assisted concentric flexor-extensor strengthening (KDACFES)
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Kutahya Health Sciences University
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