Clinical trials: Degenerative Joint Disease of Knee
Knee Osteoarthritis
Effect of Antigravity Treadmill in Knee Osteoarthritis (AGTreadmill)
To date, the anti-gravity treadmill, as a representative method of lower body positive pressure treadmills, has been rarely reported for knee osteoarthritis rehabilitation.
- Trial name
- AGTreadmill (NCT06347692)
- Testing
- antigravity treadmill, physical therapy exercise program
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Prince Sattam Bin Abdulaziz University
Pain, Knee Osteoarthritis
A Study to Evaluate the Efficacy and Safety of CG5503 Prolonged Release (PR) in Subjects With Moderate to Severe Chronic Pain Due to Osteoarthritis of the Knee
The purpose of this study is to evaluate whether tapentadol (CG5503) prolonged-release (PR) tablets at doses of 100-250 mg twice daily provide a better pain relief in patients with moderate to severe chronic pain due to…
- Trial name
- NCT00486811
- Testing
- Tapentadol ER (100 to 250 mg twice daily), Oxycodone CR (20 to 50 mg twice daily)
- Where
- 100 sites in Austria, Croatia and 11 more
- Volunteers
- 990 people
- Sponsor
- Grünenthal GmbH
Osteoarthritis of the Knee
A Study to Evaluate the Efficacy and Safety of X0002 Spray in Subjects With Osteoarthritis
This is a phase 2, multicenter, randomized, double blind (with dose), placebo controlled, parallel group, proof of concept, and dose range finding study to evaluate the efficacy, safety, and PK of X0002 spray in adult subjects…
- Trial name
- NCT02067611
- Testing
- X0002
- Where
- 20 sites in United States
- Volunteers
- 216 people
- Sponsor
- Lina Xu
Knee Osteoarthritis
Phase Ib Trial of Injectable RAB001 for Knee Osteoarthritis
This is a randomized, double-blind, placebo-controlled dose-escalation study designed to evaluate the safety, tolerability, pharmacokinetics (PK), and preliminary efficacy of intra-articular injection of RAB001 in participants…
- Trial name
- LBRC_RAB001_OA (NCT07652372)
- Testing
- RAB001 medium dose
- Where
- 2 sites in China
- Volunteers
- 60 people
- Sponsor
- ZhongShan LaiBo RuiChen BioMedicine Co.,Ltd.
Knee Osteoarthritis
The Effect of Training With Custom-Made Biomechanical Perturbation Platform on Kinetics, Kinematics and Electromyography in Knee Osteoarthritis Patients
The aim of this study is to evaluate the outcome of specific repetitive biomechanical perturbation training on motor patterns. The first hypothesis of this project is that footwear derived biomechanical challenges will convey…
- Trial name
- NCT00724139
- Testing
- : APOS biomechanical gait system, Apos - Sports and Medical Technologies Ltd. Hertzlia, Israel
- Where
- Israel
- Volunteers
- 15 people
- Sponsor
- HaEmek Medical Center, Israel
Knee Osteoarthritis
Based on the Ultrasound Evaluating the Effect of Xiaozhong Fang Particles for Knee Osteoarthritic With Synovial Fluid
This study is a randomized, single blind, controlled trial. Aim to compare the effectiveness (especially the absorption degree of the synovial effusion measured by B ultrasonic) of the treatment group with the control group.
- Trial name
- NCT03586700
- Testing
- Xiao zhong fang granules, Short wave infrared radiation
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Beijing University of Chinese Medicine
Osteoarthritis
Leukocyte-rich PRP vs Leukocyte-poor PRP for the Treatment of Knee Cartilage Degeneration: a Randomized Controlled Trial
Platelet-rich Plasma (PRP) is the most exploited biologic agents currently used for the treatment of osteoarthritis (OA) of different joints, in particular knee OA.
- Trial name
- PRP014 (NCT02923700)
- Testing
- Leukocyte-rich PRP intra-articular injections, Leukocyte-poor PRP intra-articular injections
- Where
- Italy
- Volunteers
- 192 people
- Sponsor
- Istituto Ortopedico Rizzoli
Osteoarthritis
Meloxicam SoluMatrix® Capsules vs Meloxicam Tablets to Treat Osteoarthritis Pain
The purpose of this study is to evaluate the safety and efficacy of a low dose and a high dose of Meloxicam SoluMatrix® Capsules versus Meloxicam Tablets for the treatment of pain due to osteoarthritis of the knee or hip.
- Trial name
- NCT02405793
- Testing
- Meloxicam Test Capsules, Meloxicam Tablets
- Sponsor
- Iroko Pharmaceuticals, LLC
Knee Arthritis Osteoarthritis
Condylar Offset and Outcomes in Primary Total Knee Arthroplasty
This prospective cohort study aims to evaluate the effect of posterior condylar offset (PCO) and anterior condylar offset (ACO) changes on functional outcomes after primary total knee arthroplasty (TKA).
- Trial name
- OFFSET-TKA (NCT07517614)
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- SB Istanbul Education and Research Hospital
Pain Management, Osteoarthritis
Efficacy and Safety of Etoricoxib+Diacerein in Osteoarthritis.
The goal of this clinical trial is to learn if fixed-dose combination etoricoxib 90 mg + diacerein 50 mg capsule works to treat knee/hip osteoarthritis-associated pain in adults. It will also learn about the safety of the drug.
- Trial name
- NCT07549386
- Testing
- Etoricoxib 90 mg + diacerein 50 mg, Meloxicam 15 mg + diacerein 50 mg
- Where
- 4 sites in Mexico
- Volunteers
- 123 people
- Sponsor
- Laboratorios Liomont
Osteoarthritis, Knee
P.F.C. Sigma Fixed Versus P.F.C. RP Mobile Bearing Total Knee Systems
This post-market clinical follow-up study was designed to compile long-term knee replacement outcomes of the PFC Sigma fixed and PFC Sigma mobile Rotating Platform (RP) knee systems.
- Trial name
- NCT00208286
- Testing
- PFC Sigma Fixed Bearing, PFC Sigma Mobile Bearing
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- DePuy International
Osteoarthritis
The Press Fit Condylar (P.F.C.) Sigma Rotating Platform (RP) TC3 Revision Knee in Revision Knee Arthroplasty
The purpose of this study is to evaluate the long-term clinical and functional performance of the P.F.C. Sigma Rotating Platform TC3 knee system in revision knee surgery and to determine whether the implant design results in a…
- Trial name
- TC3 (NCT00733681)
- Testing
- PFC Sigma RP TC3 Revision knee system
- Where
- 9 sites in France, Germany and 2 more
- Volunteers
- 181 people
- Sponsor
- DePuy International
Osteoarthritis
Use of Synvisc® in Knee Osteoarthritis - Survey on Practice
Study of prescription methods in everyday medical practice, tolerance profile and effect of Synvisc® until six months of follow-up.
- Trial name
- NCT02195544
- Testing
- Synvisc®
- Volunteers
- 70 people
- Sponsor
- Boehringer Ingelheim
Osteoarthritis
"Score Infectivity" During Reoperation on Total Hip or Knee Prosthesis
The hip or knee is a validated treatment of end-stage osteoarthritis, and these interventions commonly make a significant improvement in the quality of life of patients. Infection can occur in 1-5% of cases.
- Trial name
- NCT02467764
- Testing
- Retrospective study
- Volunteers
- 200 people
- Sponsor
- University Hospital, Strasbourg, France
Knee Osteoarthritis, Knee Osteoarthritis (Knee OA)
Creation of a Prospective Data Collecting Registry for Genicular Artery Embolization for Arthritis
The goal of this study is to create a prospective registry (<100 patients) to show the effectiveness of the genicular artery embolization procedure overtime in reducing bilateral or unilateral osteoarthritic knee pain as measured…
- Conditions
- Knee Osteoarthritis, Knee Osteoarthritis (Knee OA), Knee Osteoarthritis (OA)
- Trial name
- GAE (NCT06781463)
- Testing
- Registry (N/A)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Chicago
Osteoarthritis
Efficacy of Eccentric Resistance Training in Persons With Knee Osteoarthritis
The purpose of this study is to determine if there are differences in balance, strength, functional performance and self-reported outcomes for subjects with knee osteoarthritis who complete a low intensity, long duration…
- Trial name
- NCT02350387
- Testing
- High Intensity Short Duration Exercise, Low intensity Long Duration Exercise
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Regis University
Treatment, Osteoarthritis
Evaluate Safety & Efficacy of Condroflex in Subjects With OA
Primary Objective: To compare, after 12 weeks of double-blind treatment, the evolution of the improvement of pain (at rest and during / after exercise) in the questionnaire WOMAC (Western Ontario and McMaster Universities…
- Conditions
- Treatment, Osteoarthritis, Elderly
- Trial name
- ZD20108 (NCT00838487)
- Testing
- condroflex and exercise, sugar pill and exercise
- Where
- Brazil
- Volunteers
- 240 people
- Sponsor
- Zodiac Produtos Farmaceuticos S.A.
Osteoarthritis, Total Knee Arthroplasty
Use of Cold and Compression Therapy With Total Knee Replacement Patients
The purpose of the study is to evaluate the effectiveness of a device that delivers cold and intermittent compression as compared to ice and compressive wraps on patients who have undergone knee replacement.
- Trial name
- NCT00712816
- Testing
- Game Ready Injury Treatment System (CoolSystems Inc.), Ice with compressive bandages
- Where
- 11 sites in United States, Australia
- Volunteers
- 224 people
- Sponsor
- CoolSystems, Inc.
Gonarthritis, Degenerative Disease
Clinical Performance and Safety of the Unicompartmental Univation® XF Pro Implant
The study is designed as a prospective, observational, mid-term, multi-center follow-up study. It is planned to include 150 patients from 4 different study centres in Germany.
- Trial name
- UNI_XF_PRO (NCT06657248)
- Testing
- univation® XF Pro
- Where
- 4 sites in Germany
- Volunteers
- 150 people
- Sponsor
- Aesculap AG
Anterior Cruciate Ligament Injuries, Exercise
Preventing Posttraumatic Osteoarthritis With Physical Activity Promotion
Osteoarthritis (OA) is a leading cause of disability worldwide that affects millions of Americans each year. Posttraumatic OA (PTOA) significantly impacts patients after anterior cruciate ligament (ACL) injury and ACL…
- Conditions
- Anterior Cruciate Ligament Injuries, Exercise, Cartilage, Articular, Knee Injuries
- Trial name
- NCT04906499
- Testing
- Physical Activity Promotion
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of North Carolina, Chapel Hill
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.