Clinical trials: Degenerative Lumbar Disease
Intervertebral Disc Degeneration, Spinal Fusion
Minimally Invasive Surgery Techniques for One-level Degenerative Lumbar Deformities Correction
This study will be conducted at Research Institute of Traumatology and Orthopedics (NRITO) n.a. Ya.L.Tsivyan, Novosibirsk, Russia.
- Trial name
- NCT03908203
- Testing
- Minimally invasive one-level lumbar deformity correction
- Where
- Russia
- Sponsor
- Novosibirsk Research Institute of Traumatology and Orthopaedics n.a. Ya.L. Tsivyan
Spinal Fusion
Bone Marrow Clot for Posterior Lumbar Fusion
Bone marrow aspirate (BMA) in association to graft substitutes has long been introduced as a promising alternative to iliac crest bone graft in spinal fusion.
- Trial name
- NCT05936047
- Testing
- Vertebral bone marrow clot
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- Istituto Ortopedico Rizzoli
Degenerative Disc Disease, Chronic Low-back Pain
Lumbar Operatively Inserted PerQdisc Artificial Implant Following Nuclectomy
This study will be a prospective, open-label, multi-center study that will collect safety data for the minimally invasive PerQdisc Nucleus Replacement Device deployed to reduce chronic low back pain.
- Trial name
- LOPAIN1 (NCT04141098)
- Testing
- All patients that meet the inclusion/exclusion criteria will receive the PerQdisc® Nucleus Replacement Device.
- Where
- Paraguay
- Volunteers
- 9 people
- Sponsor
- Spinal Stabilization Technologies
Degenerative Lumbar Disease
Decision Making in Degenerative Lumbar Spine : CT vs. MRI
To identify the optimal imaging modality involved in decision making in patients with degenerative lumbar spine using CT vs. MRI.
- Trial name
- NCT04130035
- Volunteers
- 30 people
- Sponsor
- Assiut University
Lumbar Spinal Stenosis, Degenerative Spondylolisthesis
A Pivotal Study of the Premia Spine TOPS™ System
The purpose of this trial is to assess whether the Total Posterior Spine System (TOPS System) is more effective than transforaminal lumbar interbody fusion (TLIF) when used to stabilize a single lumbar level (L2 - L5) following…
- Trial name
- NCT03012776
- Testing
- Total Posterior Spine System (TOPS), Transforaminal Lumbar Interbody Fusion (TLIF)
- Where
- 36 sites in United States
- Volunteers
- 305 people
- Sponsor
- Premia Spine
Low Back Pain, Degeneration of Lumbosacral Intervertebral Disc
The Underlying Mechanism of Spinal Manipulative Therapy and the Effect of Pain on Physical Outcome Measures
The purpose of this study is to compare changes in spinal stiffness and back muscle activity between spinal manipulative therapy (SMT) responders, non-responders and asymptomatic participants.
- Conditions
- Low Back Pain, Degeneration of Lumbosacral Intervertebral Disc, Muscle Weakness, Spine Stiffness
- Trial name
- NCT01761838
- Testing
- SMT for low back pain patients, Pain induction (optional), Low back pain participants without SMT
- Where
- Canada
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Degenerative Disc Disease Lumbar
FLXfit Post Market Outcome Study Protocol
This investigation will provide safety and effectiveness information on the use of the FLXfit™ Cage. Data will be used for Post Market follow-up of the FLXfit™ system by evaluating: Safety as measured by the rate of serious…
- Trial name
- TLIF (NCT02882243)
- Testing
- FLXfit Cage for fusion
- Volunteers
- 40 people
- Sponsor
- Foundation for Orthopaedic Research and Education
Degenerative Disc Disease
rhBMP-2/CRM/CD HORIZON® Spinal System Pilot Study (2-Level)
The purpose of this study is to evaluate the feasibility of using the investigational implant (rhBMP-2/CRM with the CD HORIZON® Spinal System) as a method of facilitating posterolateral lumbar spinal fusion at two adjacent…
- Trial name
- NCT01491568
- Testing
- rhBMP-2/CRM/CD HORIZON® Spinal System
- Volunteers
- 29 people
- Sponsor
- Medtronic Spinal and Biologics
Degenerative Disc Disease
A Pivotal Study of rhBMP-2/ACS/LT-CAGE® Device for Anterior Lumbar Interbody Fusion in Patients With Degenerative Disc Disease
This study is designed to assess the safety and effectiveness of the rhBMP-2/ACS/LT-CAGE® Device using laparoscopic surgical technique as compared to an historical control group treated with Autogenous Bone/LT-CAGE® Device using…
- Trial name
- NCT01491425
- Testing
- rhBMP-2/ACS//LT-CAGE® Device, Autogenous Bone//LT-CAGE® Device
- Volunteers
- 134 people
- Sponsor
- Medtronic Spinal and Biologics
Scoliosis
Perspective Analysis of Coronal Imbalance in Degenerative Scoliosis
Currently there is paucity of information on the prevalence of pre-operative coronal imbalance in patients with degenerative lumbar scoliosis (DLS) and its influence on surgical outcomes.
- Trial name
- NCT02388555
- Testing
- Posterior osteotomy correction
- Volunteers
- 284 people
- Sponsor
- Nanjing University School of Medicine
Degenerative Disc Disease
Pivotal Study of rhBMP-2/ACS/LT-CAGE® Device for Anterior Lumbar Interbody Fusion in Patients With Symptomatic Degenerative Disc Disease
This study is designed to assess the safety and effectiveness of the rhBMP-2/ACS/LT-CAGE® device as compared to the LT-CAGE® device with autogenous bone in patients with symptomatic degenerative disc disease using an open…
- Trial name
- NCT01491386
- Testing
- rhBMP-2/ACS/LT-CAGE® Device, Autogenous Bone/LT-CAGE® Device
- Volunteers
- 279 people
- Sponsor
- Medtronic Spinal and Biologics
Degenerative Spondylolisthesis, Chronic Low Back Pain
Lumbar Stabilization Exercises vs Flexor Exercises in Degenerative Spondylolisthesis
The purpose of this study is to compare the effectiveness of pain control and functional improvement in patients with degenerative spondylolisthesis treated with "lumbar stabilization exercises" vs "flexor exercises (williams…
- Trial name
- NCT02664688
- Testing
- Lumbar stabilization exercises, Flexor exercises
- Where
- Mexico
- Volunteers
- 92 people
- Sponsor
- Instituto Nacional de Rehabilitacion
Spondylolisthesis
Validation of Appropriateness Criteria for the Surgical Treatment of Lumbar Degenerative Spondylolisthesis
The main objective of this study is the external validation of the appropriateness criteria for the surgical treatment of Lumbar Degenerative Spondylolisthesis.
- Trial name
- NCT02966639
- Where
- United States
- Volunteers
- 171 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Lumbar Spine Instability, Lumbar Spinal Stenosis
Modified-Thoracolumbar Interfascial Plane Block and Erector Spinae Plane Block Following Lumbar Instrumentation Surgery
Ultrasound (US)-guided peripheral nerve blocks have been used increasily due to the advantages of ultrasound in anesthesia practice. TLIP block is one of these nerve blocks performed under US guidance.
- Conditions
- Lumbar Spine Instability, Lumbar Spinal Stenosis, Lumbar Disc Disease, Lumbar Spine Degeneration
- Trial name
- NCT04189341
- Testing
- Erector spinae plane block (Group E), Modified-thoracolumbar interfascial plane block
- Where
- Turkey (Türkiye)
- Sponsor
- Medipol University
Intervertebral Disk Degeneration
Efficacy and Safety of K-rod Dynamic Stabilization System in the Repair of Lumbar Degenerative Diseases
To conduct a prospective, single-center, self-controlled, clinical trial to verify the efficacy and safety of K-Rod dynamic stability system in the repair of lumbar degenerative diseases following 2 years follow-up, aiming to…
- Trial name
- NCT03214042
- Testing
- K-rod dynamic stabilization system
- Volunteers
- 67 people
- Sponsor
- Shenyang Orthopedic Hospital
Lumbar Disc Degeneration
Application of Internet Plus Nursing Intervention in Postoperative Rehabilitation of Patients With Lumbar Disc Herniation
The purpose of this observational study is to understand the influence of rehabilitation guidance through Internet plus mini program on the compliance of patients at home rehabilitation exercise who have undergone lumbar…
- Trial name
- NCT07547410
- Testing
- Internet plus applet
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Lumbar Degenerative Diseases, Gene Product Sequence Variation
Correlation Between Microbial Infection and Lumbar Degenerative Disease Based on High-throughput Gene Sequencing
Lumbar degenerative disease is one of the most common diseases in orthopedic and spinal surgery. The pathogenesis of lumbar degenerative disease is still unclear, mainly including aging degeneration and biomechanical hypothesis.
- Trial name
- NCT06075979
- Testing
- Lumbar disc herniation, Lumbar spinal stenosis
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- HaoxuanZhang
Constriction, Pathologic, Spine Degeneration
Strategic Use of Big Data in Spine Surgery - Testing Digital Prediction of Outcome in Clinical Praxis
The goal of this prospective, multicenter clinical trial is to determine if the use of the postoperative outcome prediction model the Dialogue Support tool can alter postoperative patient-reported outcome and satisfaction…
- Conditions
- Constriction, Pathologic, Spine Degeneration, Surgery, Radiculopathy
- Trial name
- NCT05817747
- Testing
- Dialogue support tool
- Where
- 10 sites in Sweden
- Volunteers
- 900 people
- Sponsor
- Sahlgrenska University Hospital
Lumbar Degenerative Disc Disease
Moderate - Severe Degenerative Disc Disease Evaluation of the Lumbar Spine
The purpose of the study is to confirm the safety and effectiveness of SB-01 For Injection in adult patients with chronic low back pain and related disability due to Lumbar Degenerative Disc Disease.
- Trial name
- MODEL (NCT05516992)
- Testing
- SB-01 For Injection
- Where
- 30 sites in United States
- Volunteers
- 417 people
- Sponsor
- Spine BioPharma, Inc
Disc Degeneration
Comparaison of Interbody Bone Fusion Between Two Osteoinductive Bioactive Bone Substitutes After Anterior Lumbar Interbody Arthrodesis in Degenerative Lumbar Disc Surgery in Adults
Disc degeneration is a progressive deterioration process of the intervertebral disc, which can manifest as significant low back pain and a loss of mobility that interferes with daily activities.
- Trial name
- FUSALIF (NCT07044206)
- Testing
- Use of bone substitute during intervertebral fusion surgery
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Montpellier