Clinical trials: Degenerative Lumbar Diseases
Spinal Stenosis Lumbar, Spinal Canal Stenosis
Degenerative Lumbar Stenosis Conservative Treatment
The trial aims to compare the effectiveness of three methods of conservative treatment of degenerative lumbar spine stenosis (DLSS): GOLDIC autologous serum epidural injections, steroid epidural injections and manual therapy.
- Trial name
- GOLDSTEN (NCT04492774)
- Testing
- Goldic serum, Steroid injections, Manual therapy
- Where
- Poland
- Volunteers
- 90 people
- Sponsor
- Sutherland Medical Center
Lumbar Disc Disease
Intra-operatory Neurophysiological Monitoring Changes as a Predictive Clinical Outcome Measure in Lumbar Radiculopathy.
The purpose of this study is to determine the relation among: (1) changes in voltage and amplitude of trans-operatory records obtained through the use of Intra-operative Neurophysiological Monitoring (IONM), and (2) clinical…
- Trial name
- NCT02185508
- Where
- Mexico
- Volunteers
- 200 people
- Sponsor
- American British Cowdray Medical Center
Other Intervertebral Disc Degeneration, Lumbar Region
Trunk Muscles and Lumbar Intervertebral Disc Degeneration in Combat Sports
This study examined whether there is an association between the presence of lumbar intervertebral disc degeneration (LDD) and the size and symmetry of the cross-sectional areas (CSAs) of the trunk muscles in combat sports…
- Trial name
- NCT02744781
- Testing
- Lumbar disc degeneration; LDD
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- National Institute of Technology, Hiroshima College
Degenerative Disc Disease (DDD)
Freedom Lumbar Disc in the Treatment of Lumbar Degenerative Disc Disease
This study will look at the result of using the FLD device as an artificial lumbar disc. The study will compare the safety and effectiveness of the FLD artificial lumbar disc to an already approved artificial lumbar disc.
- Trial name
- FLD (NCT00775801)
- Testing
- FLD, Control
- Where
- 14 sites in United States, Germany
- Volunteers
- 300 people
- Sponsor
- AxioMed Spine Corporation
Degenerative Disc Disease
TXA in Spinal Fusion
Tranexamic acid and placebo will be given during surgery to patients who have elected to undergo lumber interbody fusion on 2 or more levels.
- Trial name
- NCT04272606
- Testing
- Tranexamic Acid, Saline Solution, Visual Acuity Exam
- Where
- United States
- Volunteers
- 123 people
- Sponsor
- Catherine R. Olinger
Degeneration Spine
Primary Sacroiliac Fusion Versus Fusion to the Sacrum for Degenerative Disease of the Lumbar Spine
To prove that the use of additional S2alar-iliac screws for pure lumbar fusions due to degenerative lumbar disease provides superior outcome compared to the standard procedure of fusion to S1.
- Trial name
- PSEUDOLUSE (NCT04308018)
- Testing
- S2alar-iliac screws, S1 screws
- Volunteers
- 148 people
- Sponsor
- Technical University of Munich
Degenerative Disc Disease
Placebo-controlled Study to Evaluate Rexlemestrocel-L Alone or Combined With Hyaluronic Acid in Participants With Chronic Low Back Pain
This is a prospective, multicenter, randomized, double-blind, placebo-controlled Phase 3 study designed to evaluate the safety and efficacy of Mesoblast's rexlemestrocel-L alone or combined with hyaluronic acid (HA) in…
- Trial name
- MSB-DR003 (NCT02412735)
- Testing
- Rexlemestrocel-L, Rexlemestrocel-L + HA Mixture
- Where
- 48 sites in United States, Australia
- Volunteers
- 404 people
- Sponsor
- Mesoblast, Ltd.
Spondylolisthesis
XLIF® vs. MAS®TLIF for the Treatment of Symptomatic Lumbar Degenerative Spondylolisthesis With or Without Central Stenosis.
The purpose of this study is to determine differences in the XLIF and TLIF procedures with respect to perioperative variables in adult patients with low-grade symptomatic spondylolisthesis.
- Trial name
- NCT01024699
- Where
- 9 sites in United States
- Volunteers
- 55 people
- Sponsor
- NuVasive
Low Back Pain, Lumbar Degenerative Disease
Effects of Health Education for Patients Received Minimally Invasive Lumbar Spinal Surgery
Lumbar degenerative disease surgery has been a routine clinical operation, and has good treatment effects. Although the patient's neurological symptoms improve after surgery, many patients still have postoperative muscle…
- Trial name
- NCT04120532
- Testing
- Perioperative Rehabilitation
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Taipei Medical University Shuang Ho Hospital
Lumbar Spondylosis
Effect of Chewing Gum on Abdominal Distension in Patients After Lumbar Spine Surgery
According to chewing gum can promote the recovery of gastrointestinal function, it is used as an intervention measure for patients after lumbar surgery to evaluate the effect of chewing gum on improving abdominal distension of…
- Trial name
- NCT04970732
- Testing
- Gum chewing
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Peking University Third Hospital
Osteopenia, Lumbar Spondylolisthesis
Denosumab vs Zoledronate After Lumbar Fusion
The aim of the study was to compare denosumab and zoledronate efficacy in bone mass, bone turnover markers (BTMs), Visual Analogue Scale (VAS) for leg and back, EuroQol Five-Dimension (EQ-5D) scores, Quality of Life Questionnaire…
- Trial name
- NCT05638399
- Testing
- Denosumab 60 mg/ml [Prolia], Zoledronate
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shenzhen People's Hospital
Degenerative Disc Disease, Chronic Low-back Pain
Lumbar Operatively Inserted PerQdisc Artificial Implant Following Nuclectomy
This study will be a prospective, open-label, multi-center study that will collect safety data for the minimally invasive PerQdisc Nucleus Replacement Device deployed to reduce chronic low back pain.
- Trial name
- LOPAIN1 (NCT04141098)
- Testing
- All patients that meet the inclusion/exclusion criteria will receive the PerQdisc® Nucleus Replacement Device.
- Where
- Paraguay
- Volunteers
- 9 people
- Sponsor
- Spinal Stabilization Technologies
Degenerative Disc Disease, Facet Joint Syndrome
Intradiscal and Intra-articular Injection of Autologous Platelet-Rich-Plasma (PRP) in Patients With Lumbar Degenerative Disc Disease and Facet Joint Syndrome
Autologous Platelet-Rich-Plasma (PRP) represents a regenerative therapy that has gained remarkable ground in the field of orthopaedics in recent years.
- Trial name
- NCT04816747
- Testing
- Autologous PRP
- Volunteers
- 50 people
- Sponsor
- Stylianos Kapetanakis
Spondylolisthesis Degenerative, Spinal Fusion
The Effect of Lordosis on Clinical Outcome After Spinal Fusion for One-level Degenerative Spondylolysthesis
Degenerative spondylolisthesis is a common spinal degenerative disease. It is defined as the slippage of one vertebrae on the vertebrae bellow.
- Trial name
- NCT04174144
- Testing
- Single-level TLIF
- Where
- Slovenia
- Volunteers
- 32 people
- Sponsor
- University Medical Centre Ljubljana
Degenerative Changes, Stenosis
Accell Evo3™ Demineralized Bone Matrix in Instrumented Lumbar Spine Fusion
The objective of this study is to prospectively evaluate the performance of Integra Accell Evo3 Demineralized Bone Matrix as an adjunct for instrumented posterolateral spine fusion, as compared to local autograft.
- Conditions
- Degenerative Changes, Stenosis, Spondylosis
- Trial name
- NCT02018445
- Testing
- Posterolateral Fusion
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- SeaSpine, Inc.
Degenerative Disc Disease
CHARITE™ vs. ALIF 5-Year Follow-up
To assess the clinical and radiographic outcomes through 5-years following treatment with CHARITÉ™ Artificial Disc vs. the BAK Cage for treatment of degenerative disc disease at one level (L4-S1).
- Trial name
- NCT00215332
- Testing
- CHARITE
- Where
- 10 sites in United States
- Volunteers
- 367 people
- Sponsor
- DePuy Spine
Degenerative Disc Disease, Spine Fusion
Post Marketing Study of MagnetOs Putty Compared to Local Autograft in Patients Undergoing Posterolateral Lumbar Fusion
This is a phase IV post-marketing study for MagnetOs Putty. MagnetOs Putty is a synthetic bone graft extender product that is routinely used by surgeons as a treatment for patients with leg pain and/or back pain and undergoing…
- Trial name
- PARTNER (NCT04679896)
- Testing
- MagnetOs Putty
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Kuros Biosurgery AG
Chronic Back Pain, Degenerative Disc Disease Lumbar
CELZ-201-DDT for the Treatment of Chronic Lower Back Pain
CELZ-201-DDT is an investigational (experimental) cell therapy currently being studied for people with degenerative disc disease who have chronic lower back pain.
- Trial name
- ADAPT (NCT07137559)
- Testing
- CELZ-201-DDT
- Sponsor
- Creative Medical Technology Holdings Inc
Degenerative Disc Disease
Clinical Study of rhBMP-2/BCP With the TSRH® Spinal System for Posterolateral Lumbar Fusion in Patients With Degenerative Disc Disease
This study is designed to assess the safety and effectiveness of the rhBMP/BCP/TRSH Spinal System in treatment of the patients with degenerative disc disease.
- Trial name
- NCT01494454
- Testing
- rhBMP-2/BCP/TSRH® or rhBMP-2/BCP/CD HORIZON® Spinal System, Autograft/TSRH® or autograft/CD HORIZON® Spinal System.
- Volunteers
- 197 people
- Sponsor
- Medtronic Spinal and Biologics
Spinal Fusion, Spinal Stenosis
Vancomycin Powder Combined With Autogenous Bone Graft as a Prevention for Post-operative Infection for Spine Surgery
Deep surgical site infection (DSSI) is one of the most challenging complications for spinal surgeons and can lead to a poor clinical outcome.
- Conditions
- Spinal Fusion, Spinal Stenosis, Spondylolisthesis
- Trial name
- NCT03883022
- Testing
- with U-VANCO (vancomycin hydrochloride), without U-VANCO (vancomycin hydrochloride)
- Where
- Taiwan
- Volunteers
- 400 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan