Clinical trials: Degenerative Neurologic Disease
Amyotrophic Lateral Sclerosis
Frequency of SOD1 and C9orf72 Gene Mutations in French ALS
The purpose of the study is to determine the frequency of mutations in the C9orf72 and SOD1 genes in the incident population of ALS patients followed in the FILSLAN centres
- Trial name
- GENIALS (NCT04819555)
- Testing
- Blood
- Where
- 20 sites in France
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Tours
Amyotrophic Lateral Sclerosis
Study to Investigate the Long-term Safety of FAB122 in Patients With Amyotrophic Lateral Sclerosis
A multicenter, open-label extension study to investigate the long-term safety of FAB122 in patients with Amyotrophic Lateral Sclerosis
- Trial name
- ADOREXT (NCT05866926)
- Testing
- FAB122
- Where
- Spain
- Volunteers
- 201 people
- Sponsor
- Ferrer Internacional S.A.
Aging, Alzheimer's Disease
Effects of Exercise and Cognitive Training on Cognitive Function in Older Adults
The purpose of this study is to gain a better understanding of the effects of exercise and cognitive training on improving brain function in healthy older adults who may be at risk for developing Alzheimer's Disease.
- Trial name
- NCT01038726
- Testing
- Exercise Training, Cognitive Training, Flexibility Training
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Hereditary Spastic Paraparesis
Evaluation of an Intensive Training Program for Patients with Hereditary Spastic Paraparesis SPG4/Spast
Hereditary spastic paraparesis is a group of inherited neurological diseases. Only symptomatic treatments exist for the moment. The Modifspa study (cf citation) carried out by the team showed that patients perceived a feeling of…
- Trial name
- WALK-up (NCT06229626)
- Testing
- intensive reeducation
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Alzheimer Disease
Correlation of P-glycoprotein Polymorphisms With Microbial Metabolites in Patients With Alzheimer's Disease on Medication
The importance of the proposed study concerns the understanding of the way in which each drug acts in each organism separately, both at the genome level and at the microbiome level.
- Trial name
- NCT05532644
- Testing
- AD drugs
- Where
- Greece
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Dementia With Lewy Bodies, Degeneration Nerves
Visualising Cerebral and Peripheral Cholinergic Nerves in Patients With Dementia Lewy Bodies.
Lewy Body Dementia (DLB) is the second most common type of neurodegenerative dementia and characterized by loss of cholinergic neurons in the cerebrum and possibly also internal organs.
- Conditions
- Dementia With Lewy Bodies, Degeneration Nerves, Positron-Emission Tomography, Acetylcholine
- Trial name
- NCT04291144
- Testing
- PET-CT using FEOBV, MRI-scan, Cognitive assessment
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Alzheimer Disease
Identification of Diagnosis Biomarkers in the Tears of Alzheimer's Disease Patients: The COG-EYE Pilot Study
The diagnosis of Alzheimer's disease (AD) relies on the detection of protein biomarkers, particularly in cerebrospinal fluid (e.g., Aβ and phosphorylated Tau) or through brain imaging.
- Trial name
- COG-EYE (NCT06661564)
- Testing
- Basal tear collection for the analysis of metabo-lipidomic profiles and concentrations of protein biomarkers (Tau, phosphorylated Tau, Aβ 1-40, and Aβ 1-42), Collection of a blood sample (5 mL) for blood biomarkers analysis
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Alzheimer's Disease (AD), Lewy Body Dementia (LBD)
Social-cognitive Functioning: Validation of a New Neuropsychological Test
It is now established that disturbances in social cognition are frequent in neurology and that they contribute to the development of social conduct disorders.
- Conditions
- Alzheimer's Disease (AD), Lewy Body Dementia (LBD), Frontotemporal Degeneration (FTD)
- Trial name
- REALSOCOG (NCT05558709)
- Testing
- REALSOCOG, BCS, Hetero-questionnaires
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Tuberous Sclerosis Complex
Roll-over Study to Collect and Assess Long-term Safety of Everolimus in Patients With TSC and Refractory Seizures Who Have Completed the EXIST-3 Study [CRAD001M2304] and Who Are Benefitting From Continued Treatment
The purpose of this study is to evaluate the long-term safety in patients with TSC and refractory seizures who are currently receiving everolimus treatment in the Novartis-sponsored EXIST-3 study and who are determined to be…
- Trial name
- NCT02962414
- Testing
- everolimus
- Where
- 67 sites in United States, Australia and 16 more
- Volunteers
- 206 people
- Sponsor
- Novartis Pharmaceuticals
Parkinson Disease
Investigation of Effects of Delayed Feedback on Non-motor Symptoms in Individuals With Parkinson's Disease
Learning deficits are frequent in individuals with Parkinson's Disease. Clear feedback is integral because through feedback individuals know whether they should stick with an action that they have been doing (if the feedback is…
- Trial name
- NCT06217484
- Testing
- delayed feedback
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Kessler Foundation
Amyotrophic Lateral Sclerosis
Clinical Trial of Ezogabine (Retigabine) in ALS Subjects
This study evaluates the effect of retigabine (600 mg/day, 900 mg/day, or placebo) on motor neuron activity in people with Amyotrophic Lateral Sclerosis (ALS). The total study duration is approximately 14 weeks.
- Trial name
- NCT02450552
- Testing
- Ezogabine
- Where
- 12 sites in United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Brian Wainger
Parkinson Disease, Cognitive Impairment
Istradefylline for Parkinson Disease With Cognitive Impairment
The purpose of this research study is to determine whether istradefylline improves cognition in individuals with Parkinson disease with cognitive impairment.
- Trial name
- NCT05333549
- Testing
- Istradefylline medication
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Virginia Commonwealth University
Progressive Supranuclear Palsy, Parkinson's Disease
Deep TMS for the Treatment of Patients With Parkinson's Disease and Progressive Supranuclear Palsy
Background: Progressive supranuclear palsy (PSP) is a rare neuro-degenerative disease, counted among atypical parkinsonism (AP).
- Trial name
- DeepTMSPARK (NCT02734485)
- Testing
- active Deep TMS
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- IRCCS San Raffaele Roma
NEUROFIBROMATOSIS 1
Photodynamic Therapy for Benign Dermal Neurofibromas- Phase II
The investigators wish to determine the time to disease progression for benign neurofibromas treated with Levulan Kerastick topical photosensitizer and red light photodynamic therapy (PDT) in patients with neurofibromatosis type…
- Trial name
- NCT02728388
- Testing
- aminolevulinic acid
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Donald Basel
Alzheimer's Disease
Relative Bioavailability Study in Healthy Subjects to Evaluate the Pharmacokinetics of HTL0009936 After One Dose of Prototype Formulation
The purpose of this study is to find a modified release oral tablet formulation for this drug, which will be safe and well tolerated.
- Trial name
- NCT02710188
- Testing
- HTL0009936 modified release, HTL0009936 immediate release
- Where
- United Kingdom
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Nxera Pharma UK Limited
Parkinson s Disease
Comparison of Immersive and Non-Immersive Virtual Reality Rehabilitation in Parkinson's Disease
Parkinson's disease commonly affects walking ability, balance, mobility, and cognitive function, increasing the risk of falls and reducing independence.
- Trial name
- VR-PD (NCT07659288)
- Testing
- Immersive Virtual Reality, Non-Immersive Virtual Reality
- Where
- Chile
- Volunteers
- 16 people
- Sponsor
- Neuro Group XR Inc.
Parkinson Disease, Anesthesia
UPDRS-III Comparisons of DBS for PD Between Patients Receiving MAC and AAA Anesthesia
Compares the patients' scores of UPDRS-III before and six-month after receiving deep brain stimulation for Parkinson's disease under MAC or AAA anesthesia.
- Trial name
- NCT04361188
- Testing
- MAC anesthesia, AAA anesthesia
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shenzhen Second People's Hospital
Parkinson Disease, Dementia
Using Gait Robotics to Improve Symptoms of Parkinson's Disease
This study evaluates the benefits of exoskeleton-based exercise for improving mood and cognition in people with Parkinson's disease (PD).
- Conditions
- Parkinson Disease, Dementia, Mild Cognitive Impairment
- Trial name
- NCT03583879
- Testing
- Exoskeleton exercise, Standard exercise, No treatment
- Where
- 2 sites in Canada
- Volunteers
- 41 people
- Sponsor
- University of New Brunswick
Idiopathic Parkinson's Disease
Comparison of Balance, Activity-specific Balance Confidence and Quality of Life in Parkinson's Patients
Parkinson's disease is characterized by cardinal motor signs and motor freezing, gait, posture and balance disorder. About 80% of the causes of falls in Parkinson's patients are due to postural instability and motor freezing, and…
- Trial name
- NCT05671341
- Testing
- Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 61 people
- Sponsor
- Nigde Omer Halisdemir University
Alzheimer Disease, Dementia
Harmony at Home: A Pilot Telehealth Program for Rural ADRD Caregivers
There is a need for caregiver-initiated and -implemented non-pharmacological interventions directly to and for the person with dementia, including environmental assessment and modification, as first-line treatments for behavioral…
- Conditions
- Alzheimer Disease, Dementia, Brain Diseases, Central Nervous System Diseases
- Trial name
- NCT05202223
- Testing
- Harmony at HOME (H@H)
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Elizabeth K Rhodus
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.