Clinical trials: Degenerative Osteoarthritis
Osteoarthritis in the Knee
Effects of Therapeutic Touch on Osteoarthritis of the Knee
This study is to evaluate the efficacy of the Kreiger/Kunz method of Therapeutic Touch on function, pain perception and quality of life in persons with Osteoarthritis in the knee.
- Trial name
- NCT00759512
- Testing
- Therapeutic Touch
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Toledo Health Science Campus
Degenerative Osteoarthritis
Continuous Distal Adductor Canal Block With Periarticular Local Anesthetic Infiltration Versus Continuous Distal Adductor Canal Block Alone for Analgesia After Total Knee Arthroplasty
Continuous administration of local anesthetics to the distal adductor canal could spread into the popliteal fossa and contribute to analgesic effects on posterior knee pain.
- Trial name
- NCT05427019
- Testing
- Distal adductor canal block, Distal adductor canal block and Periarticular block
- Where
- South Korea
- Volunteers
- 66 people
- Sponsor
- Yonsei University
Osteoarthritis, OA
Autologous Alpha-2 Macroglobulin Rich Plasma, Safety and Efficacy in Symptomatic Moderate Knee Osteoarthritis
The purpose of this study is to determine the effectiveness and safety of autologous alpha-2 macroglobulin rich plasma (A2MRP) injections in the treatment of knee osteoarthritis (OA).
- Conditions
- Osteoarthritis, OA, Knee Osteoarthritis
- Trial name
- A2MRP (NCT06329492)
- Testing
- Autologous Alpha-2 Macroglobulin Rich Plasma (A2MRP)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Knee Osteoarthritis
Comparison of Proprioception for HTO (High Tibial Osteotomy) and UKA (Unicompartmantal Knee Arthroplasty)
Osteoarthritis of the knee (KOA), a common degenerative joint disease, affects a significant part of the world's population. Although it can hold all the compartments in the knee joint, isolated medial compartment involvement has…
- Trial name
- NCT05993637
- Testing
- Examination of propriception
- Volunteers
- 50 people
- Sponsor
- Istanbul University - Cerrahpasa
Rheumatoid Arthritis, Osteoarthritis
A Single Centre Study to Assess the Long-term Performance of the Pinnacle™ Cup With a Ceramic-on-ceramic Bearing in Primary Total Hip Replacement
The purpose of this study is to monitor the performance of the Pinnacle™ Cup with a ceramic-on-ceramic bearing combination in the treatment of patients with hip joint disease requiring a total hip replacement.
- Conditions
- Rheumatoid Arthritis, Osteoarthritis, Post-traumatic Arthritis, Collagen Disorders
- Trial name
- NCT00872222
- Testing
- Pinnacle™ Acetabular System
- Where
- Czechia
- Volunteers
- 98 people
- Sponsor
- DePuy International
Arthroplasty, Replacement, Knee, Osteoarthritis, Knee
Electrochemical Behavior of Biomedical Alloys Exposed to Human Synovial Fluid
Biomedical implant metals are reactive when in contact with body fluids. Some reactions may adverse the biocompatibility character of the material and should be studied.
- Trial name
- NCT04027231
- Testing
- analysis of the synovial fluid
- Where
- Switzerland
- Volunteers
- 150 people
- Sponsor
- Brigitte Jolles, MD
Hip Osteoarthritis, Knee Osteoarthritis
Comparative Effectiveness of Decision Support Strategies for Joint Replacement Surgery
This study is a 2X2 factorial randomized trial that will the examine the comparative effectiveness of two patient decision aids for hip and knee osteoarthritis (OA) as well as the impact of a surgeon-focused intervention.
- Trial name
- NCT02729831
- Testing
- Interactive decision aid, Video decision aid, Provider Report
- Where
- 3 sites in United States
- Volunteers
- 1,220 people
- Sponsor
- Massachusetts General Hospital
Knee Osteoarthritis, Post-traumatic Osteoarthritis
Clinical Evaluation of Vanguard DD RP
This is a single cohort, prospective study of performance and safety of the Vanguard Deep Dish Rotating Platform (DD RP) cementless fixation with the goal to acquire clinical outcomes data and evaluate the performance of the…
- Conditions
- Knee Osteoarthritis, Post-traumatic Osteoarthritis, Rheumatoid Arthritis
- Trial name
- NCT04076202
- Testing
- Cementless Vanguard DD RP
- Where
- Austria
- Volunteers
- 113 people
- Sponsor
- Zimmer Biomet
Osteoarthritis
Evaluation of the Latella Knee Implant System for Medial Osteoarthritis Pain Reduction (Latella-2 Study)
The objective of the Latella-2 study is to demonstrate the safety and efficacy of the Latella Knee Implant System for the reduction of medial osteoarthritis knee pain.
- Trial name
- NCT02343705
- Testing
- Latella Knee Implant System
- Where
- 12 sites in Netherlands, Spain and 1 more
- Volunteers
- 67 people
- Sponsor
- Cotera, Inc.
Knee Osteoarthritis
Comparison of Aquatic and Land-Based Mulligan Mobilization With Movement in Knee Osteoarthritis
This study aims to compare the effects of aquatic and land-based Mulligan mobilization with movement in individuals with knee osteoarthritis, with particular focus on their impact on pain and functional outcomes.
- Trial name
- NCT07484529
- Testing
- Aquatic Mobilization with Movement, Land Mobilization with Movement
- Where
- Pakistan
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Osteoarthritis
Multicenter Trial of Stem Cell Therapy for Osteoarthritis (MILES)
The study is a multicenter trial conducted to compare the effectiveness of an injection of a corticosteroid control to mesenchymal stem cell (MSC) preparations from autologous bone marrow concentrate (BMAC), adipose derived stem…
- Trial name
- MILES (NCT03818737)
- Testing
- Bone Marrow Derived MSCs, Adipose-derived MSCs, Umbilical Cord Tissue (UCT) MSCs
- Where
- 5 sites in United States
- Volunteers
- 475 people
- Sponsor
- Emory University
Osteoarthritis, Knee
fMRI Study of Expectancy on Acupuncture Treatment Outcomes in Knee OA
The results of the proposed experiments will directly inform clinicians who treat patients with osteoarthritis of the knee about how to maximize the benefits of acupuncture treatments.
- Trial name
- KOA (NCT01040754)
- Testing
- Acupuncture
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- Massachusetts General Hospital
Osteoarthritis, Knee
Efficacy and Safety of PG-530742 in the Treatment of Mild to Moderate Knee Osteoarthritis
Matrix metalloproteinases (MMPs) have been implicated in the cartilage degradation. PG-530742 inhibits some MMPs, potentially limiting cartilage degradation and disease progression.
- Trial name
- NCT00041756
- Testing
- PG-530742, 50 mg PG-530742, 100 mg PG-530742
- Where
- 23 sites in Hungary, United Kingdom
- Volunteers
- 395 people
- Sponsor
- Procter and Gamble
Osteoarthritis Knees
Adipose-tissue-derived Total-Stromal-cells (TOST) Therapy in Knee Osteoarthritis
In this phase II Randomized Clinical Trial (RCT), impacts of a single Intra-articular injection of autologous adipose tissue derive total-stromal-cells (TOST) on knee pain, physical function, stiffness, and cartilage thickness…
- Trial name
- NCT05280002
- Testing
- Adipose Tissue derived Total-Stromal-Cells (TOST)
- Where
- Bangladesh
- Volunteers
- 30 people
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Osteoarthritis
The Phosphodiesterase 3 Inhibitor Cilostazol as an Adjunct to Conventional Therapy in Patients With Osteoarthritis
Cilostazol is able to suppress the degradation of type II collagen in human chondrocytes induced by IL-1b. Cilostazol add-on for celecoxib therapy has synergistic anti-arthritic potential by inhibiting proinflammatory cytokine…
- Trial name
- NCT04789837
- Testing
- Cilostazol 50 MG
- Where
- Egypt
- Sponsor
- Sadat City University
Osteoarthritis
Study Evaluating rhMBP-2/CPM in Open Wedge Osteotomies
To assess the feasibility of using rhBMP-2/CPM in OWO as a surgical model for pharmacodynamic studies, with assessment of the following parameters: Injecting the desired volume of rhBMP-2/CPM within the defect Conducting…
- Trial name
- NCT00243295
- Testing
- rhBMP-2/CPM
- Volunteers
- 6 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Osteoarthitis
Clinical Trial to Assess the Safety and Efficacy of Intra-articular Injection Collagen Versus Hyaluronic Acid on Knee Osteoarthritis
This study was designed to assess the efficacy for pain relief, functional improvement, and safety of intra-articular collagen injections compared to hyaluronic acid injections for knee osteoarthritis.
- Trial name
- NCT07511777
- Testing
- CartiZol, Synovian inj.
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Cellontech Co., Ltd.
Osteoarthritis
To Determine the Safety, Tolerability, Pharmacokinetics and Effect on Pain of a Single Intra-articular Administration of Canakinumab in Patients With Osteoarthritis in the Knee
The purpose of this study was to determine whether, in patients with mild to moderate knee osteoarthritis, canakinumab is safe and tolerable when injected intra-articularly.
- Trial name
- NCT01160822
- Testing
- Canakinumab, Naproxen
- Where
- 13 sites in United States, Finland and 2 more
- Volunteers
- 169 people
- Sponsor
- Novartis Pharmaceuticals
Osteoarthritis, Knee
Zero Degree Knee Positioner for Improved Earley Knee Extension Following Total Knee Arthroplasty
Studies have demonstrated that early rehabilitation interventions following knee arthroplasty (TKA) can shorten the time needed to regain baseline extension/full extension and gait mechanics.
- Trial name
- NCT05678231
- Testing
- Zero Degree Knee Positioner
- Where
- United States
- Volunteers
- 154 people
- Sponsor
- Prisma Health-Midlands
Knee Osteoarthritis
Implementation of Tele-Exercise for Management of Knee Osteoarthritis in Older Rural Primary Care Patients
Knee osteoarthritis (OA) is highly prevalent and a leading cause of pain that limits physical functioning in older adults. Clinical practice guidelines recommend physical exercise for managing symptoms of knee OA.
- Trial name
- NCT04706702
- Testing
- Tele-EnhanceFitness
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Washington
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