Clinical trials: Degenerative Osteoarthritis
Knee Osteoarthritis, Post-traumatic Osteoarthritis
Establish Implant Accuracy With X-PSI Knee System
The goal of this study is to establish the accuracy of the new X-PSI Knee System guides by analyzing early postoperative (4-6 weeks) imaging data with regards to the mechanical alignment and compare them with preoperative…
- Trial name
- X-PSI (NCT03275246)
- Testing
- X-PSI Knee System
- Where
- 4 sites in Germany, Netherlands and 1 more
- Volunteers
- 8 people
- Sponsor
- Zimmer, GmbH
Thumb Osteoarthritis, Hand Osteoarthritis
Evaluation of the Effects of High Intensity Laser Therapy and Exercise in Hand Thumb Osteoarthritis
One of the standard treatment methods in individuals with thumb osteoarthritis (OA) is exercise. Combination therapy options involving these exercises can be applied to patients.
- Trial name
- NCT07112742
- Testing
- High-Intensity Laser Therapy and Exercise, High-Intensity Laser Therapy at a Non-Therapeutic Dose Combined With Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- TC Erciyes University
Unilateral Primary Osteoarthritis of Knee, Primary Osteoarthritis of Knee Nos
Effect of TENS for Pain and Function After Total Knee Replacement
Our primary hypothesis is that TENS decreases pain with movement by reducing hyperalgesia. Minimizing the severe pain experienced during required activities in the immediate postoperative period will promote functional recovery…
- Trial name
- TANK (NCT01364870)
- Testing
- Active TENS
- Where
- United States
- Volunteers
- 317 people
- Sponsor
- Barbara A Rakel
Knee Osteoarthritis
Assessment of Efficacy of a Single Intra-articular Injection of HYALUBRIX 60 in Knee Osteoarthritis
The purpose of this study is to evaluate the effect of one single intra-articular (IA) injection of HYALUBRIX 60® plus physical exercise program (PEP) in terms of pain reduction, compared to PEP alone, in patients with knee…
- Trial name
- NCT06113783
- Testing
- HYALUBRIX 60
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Fidia Farmaceutici s.p.a.
Coxarthrosis
Clinical Trial to Evaluate the Use of Platelet Rich Plasma in Front Hyaluronic Acid in Coxarthrosis
To evaluate the efficacy and safety of platelet rich plasma (PRP) in patients with coxarthrosis who don´t respond to treatment with NSAIDs, compared to treatment with hyaluronic acid (Hylan G-F 20).
- Trial name
- COX (NCT02694146)
- Testing
- Platelet rich plasma, Hylan G-F 20
- Where
- 2 sites in Spain
- Volunteers
- 74 people
- Sponsor
- Fundación Pública Andaluza Progreso y Salud
Hip Osteoarthritis, Avascular Necrosis of Hip
THA With and Without Computer Navigation
The goal of this observational study is to compare postoperative results between patients who had total hip arthroplasty (THA) with and without the use of a computer navigation program.
- Trial name
- NCT05871827
- Testing
- Intraoperative Fluoroscopic Computer Navigation
- Where
- United States
- Volunteers
- 234 people
- Sponsor
- Southeast Orthopedic Specialists
Gonarthrosis, Total Knee Arthroplasty
Infiltration or Nerve Blocks in Addition to Adductor Canal Block
The aim of this study is to evaluate the analgesic efficacy of this quadruple sensory block compared with the currently recommended procedure (adductor canal block + infiltration).
- Trial name
- INCA (NCT06920186)
- Testing
- Analgesia
- Where
- 2 sites in France
- Volunteers
- 100 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Knee Osteoarthritis
Study Comparing Traditional and Gender-specific Total Knee Replacement Designs
The purpose of this study is to compare results obtained with gender-specific and traditional knee replacement systems design among women undergoing total knee replacement surgery.
- Trial name
- NCT00937170
- Testing
- Zimmer LPS flex Gender Specific Implant (Total knee replacement), Zimmer High Flex LPS Implant (Total knee replacement), Stryker Triathlon Implant (Total knee replacement)
- Sponsor
- UConn Health
Osteoarthritis, Care Model
The Effect of Continuous Care Counseling Based on the Roy Adaptation Model on Comfort and Quality of Life in Patients Undergoing Total Knee Arthroplasty
Osteoarthritis is a common joint disease that leads to problems such as pain, restricted mobility, and decreased quality of life in the knee joint, especially among elderly individuals.
- Conditions
- Osteoarthritis, Care Model, Quality of Life, Nursing Interventions
- Trial name
- RAM-TKA (NCT07015879)
- Testing
- Continuous Care Counseling Based on the Roy Adaptation Model
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Cyprus International University
Knee Arthritis, Osteoarthritis
Platelet-Rich Plasma Composition and Clinical Effects in Knee Osteoarthritis
This is a prospective, observational cohort study involving 40 patients with primary knee osteoarthritis hospitalized in a rehabilitation hospital in Cluj-Napoca.
- Trial name
- NCT07558980
- Testing
- intra-articular administration of plasma rich in platelets (PRP)
- Where
- Romania
- Volunteers
- 40 people
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
Osteoarthritis, Knee, Pain
St. John's Wort Oil on Osteoarthritis
This study investigated the effect of St. John's Wort oil on pain intensity and physical functions in people with knee osteoarthritis. This study adopted a randomized, placebo-controlled, and qualitative mixed design.
- Trial name
- NCT05663996
- Testing
- locally applied to the skin
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- TC Erciyes University
Osteoarthritis of the Lumbar Spine, Pain, Back
A Study to Evaluate the Efficacy and Safety of X0002 Spray in Subjects With Osteoarthritis of the Lumbar Spine
This is a Phase 3, Multicenter, Randomized, 22 Week, Double-Blind, Placebo Controlled and 3-Week, Open-Label Study to Evaluate the Efficacy and Safety of X0002 Spray in relief of the signs and symptoms of Subjects with…
- Trial name
- NCT03110523
- Testing
- X0002
- Sponsor
- Techfields Pharma Co. Ltd
Knee Osteoarthritis
Intraarticular Xylitol Injections for Knee Osteoarthritis
Hypothesis: Intraarticular injections of isotonic Xylitol solution will improve pain in patients with knee osteoarthritis (OA).
- Trial name
- NCT02104596
- Testing
- Xylitol
- Where
- Israel
- Volunteers
- 96 people
- Sponsor
- Hadassah Medical Organization
Osteoarthritis
Mesenchymal Stromal Cells and Osteoarthritis
Osteoarthritis (OA) is one of the most frequent musculoskeletal disorders and represents the main indication for total joint arthroplasty.
- Trial name
- NCT01038596
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Technische Universität Dresden
Osteoarthritis, Knee, Arthroplasty, Replacement, Knee
Comparison of CoCr Alloy and TiN Coating in TKA
In the current prospective, randomized study, two different materials of the same total knee arthroplasty (TKA) system - cobalt-chromium (CoCr) and titanium-nitride (TiN) - are going to be compared with regards to postoperative…
- Trial name
- NCT04701359
- Testing
- TiN-alloy based total knee arthroplasty, CoCr-coating based total knee arthroplasty
- Where
- Austria
- Sponsor
- Medical University of Graz
Knee Osteoarthritis
Lysyl Oxidase and Lysyl Hydroxylase Levels in Knee Osteoarthritis
The aim of this study is to investigate the serum levels of lysyl hydroxylase, lysyl oxidase, and the lysyl oxidase-like enzymes in patients with different stages of knee osteoarthritis and to compare these findings with those of…
- Trial name
- KNEELOX (NCT07875296)
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Afyonkarahisar Health Sciences University
Osteoarthritis of Hip, Regional Anesthesia
Continuous Lumbar Plexus Block With and Without Parasacral Block in Patients Undergoing Total Hip Replacement
The purpose of this research study is to evaluate the analgesic efficacy of adding a single shot parasacral (sciatic) nerve block to a continuous lumbar plexus block in patients undergoing total hip replacement.
- Conditions
- Osteoarthritis of Hip, Regional Anesthesia, Other Acute Postoperative Pain, Total Hip Arthroplasty
- Trial name
- NCT02161484
- Testing
- Continuous Lumbar Plexus Block, Parasacral Nerve Block, Ropivacine 0.2%
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Rita Merman
Osteoarthritis
StepRite Evaluation
The purpose of this study is to compare the short-term changes in gait parameters and functional outcomes after total knee arthroplasty between those who use the StepRite device and those who follow a standard therapy program…
- Trial name
- NCT02270684
- Testing
- StepRite
- Volunteers
- 4 people
- Sponsor
- University of Southern California
Osteoarthritis, Knee
Role of Bone in Knee Osteoarthritis (OA)
The purpose of the study is to investigate protein and gene expression among damaged knee tissues. We will perform MRI's on subjects prior to total knee replacement to identify the location of bone marrow lesions.
- Trial name
- NCT00850538
- Testing
- MRI, Primary Total Knee Replacement
- Where
- Australia
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- The New England Baptist Hospital
Osteoarthritis
Vancomycin Powder and Dilute Povidone Iodine Lavage for Infection Prophylaxis in High Risk Total Joint Arthroplasty
This is a prospective, randomized, controlled, open label, parallel four-arm design, multi-center study to compare different intraoperative interventions in the prevention of acute PJI development.
- Trial name
- NCT04075526
- Testing
- Povidone iodine, Vancomycin powder, Conventional
- Where
- 14 sites in United States
- Volunteers
- 2,129 people
- Sponsor
- NYU Langone Health
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