Clinical trials: Degenerative Osteoarthritis
Psoriatic Arthritis, Hand Osteoarthritis
CBD Treatment in Hand Osteoarthritis and Psoriatic Arthritis.
A randomized, placebo-controlled trial with blinded outcome assessments will be conducted to evaluate the efficacy and safety of CBD in patients with Hand-OA and PsA during a 12-week treatment period.
- Trial name
- NordCAN (NCT03693833)
- Testing
- Cannabidiol
- Where
- Denmark
- Volunteers
- 136 people
- Sponsor
- Aalborg University Hospital
Knee Osteoarthritis, Replacement, Knee
Exploration of Appropriate BIS Range and Propofol Effect-site Concentration During Total Intravenous Anesthesia With Concomitant Adjuvants.
The goal of this clinical trial is to determine the appropriate Bispectral Index (BIS) range and propofol effect-site concentration required to maintain adequate anesthesia depth during total intravenous anesthesia (TIVA)…
- Conditions
- Knee Osteoarthritis, Replacement, Knee, Elective Surgical Patients, ASA Class I/II Patients
- Trial name
- NCT07736352
- Testing
- Propofol + Remifentanil +Midazolam, Propofol + Remifentanil + Dexmedetomidine, Propofol + Remifentanil + Esketamine
- Where
- China
- Volunteers
- 100 people
- Sponsor
- China-Japan Friendship Hospital
Peptic Ulcer
Efficacy and Safety Study of HZT-501 in Reducing the Risk of Ibuprofen-associated Ulcers
The purpose of this study is to evaluate whether HZT-501 is effective in reducing the rate of development of ibuprofen-associated ulcers in patients who require long-term daily use of ibuprofen.
- Trial name
- NCT00450658
- Testing
- HZT-501, Ibuprofen
- Volunteers
- 627 people
- Sponsor
- Amgen
Knee Osteoarthritis
Intra-articular PVA Hydrogel in Knee Osteoarthritis
This multicentre, prospective, randomized, double-blind, active-controlled, parallel group clinical investigation is aimed to assess the safety and the clinical performance over 6 months of a single intra-articular injection of…
- Trial name
- NCT04693104
- Testing
- PVA Hydrogel, Synvisk-One®
- Where
- Poland
- Volunteers
- 43 people
- Sponsor
- Rottapharm Biotech
Osteoarthritis, Knee, Osteoarthritis, Hip
Improve Osteoarthritis Care
The purpose of The Improve Osteoarthritis Care study is to improve the quality of osteoarthritis care in Norwegian primary care, by increasing the use of recommended treatment modalities and improving patient access to…
- Trial name
- NCT04670549
- Testing
- Implementation of treatment guidelines
- Where
- Norway
- Volunteers
- 1,541 people
- Sponsor
- Diakonhjemmet Hospital
Total Knee Arthroplasty, Osteoarthritis, Knee
Medial Peel Release Technique TKA Randomized Clinical Trial
Medial subperiosteal release is a commonly performed technique to improve surgical exposure and aid in joint balancing. This is a routine step during primary total knee arthroplasty that will be conducted on every enrolled…
- Trial name
- NCT05154058
- Testing
- Medial Subperiosteal Release with Sharp Dissection, Medial Subperiosteal Release with Electrocautery
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Emory University
Osteoarthritis, Knee, Osteoarthritis, Hip
A Study to Determine the Safety and the Efficacy of Fasinumab Compared to Placebo and Naproxen for Treatment of Adults With Pain From Osteoarthritis of the Knee or Hip
The primary objective of the study is to evaluate the efficacy of fasinumab compared with placebo, when administered for up to 16 weeks in patients with pain due to osteoarthritis (OA) of the knee or hip.
- Trial name
- FACT OA1 (NCT03161093)
- Testing
- Fasinumab, Naproxen
- Where
- 139 sites in United States, Denmark and 10 more
- Volunteers
- 3,307 people
- Sponsor
- Regeneron Pharmaceuticals
Knee Osteoarthritis
Chatbot-based Pain Management for People With Knee Osteoarthritis
Knee osteoarthritis (OA) is a prevalent degenerative joint disease that causes chronic pain, stiffness, impaired physical function, and associated psychosocial issues such as depression, insomnia, and loneliness.
- Trial name
- C-MPPM (NCT07843784)
- Testing
- The C-MPPM intervention, Online education
- Where
- Hong Kong
- Volunteers
- 36 people
- Sponsor
- The Hong Kong Polytechnic University
Hip Osteoarthritis, Knee Osteoarthritis
Determining the Impact of a Physiotherapist-Led Primary Care Model for Hip and Knee Pain - A Pilot Trial
This is a pilot cluster randomized controlled trial to to evaluate the individual and health system impacts of implementing a new physiotherapist-led primary care model for hip and knee pain in Canada.
- Trial name
- NCT05736133
- Testing
- Physiotherapist-led primary care model for hip and knee pain, Usual physician-led primary care model for hip and knee pain
- Where
- Canada
- Volunteers
- 205 people, healthy volunteers welcome
- Sponsor
- Jordan Miller, PT, PhD
Osteoarthritis, Physical Inactivity
Activating SilverSneakers Benefits for Seniors With Osteoarthritis
The aim of this pragmatic randomized controlled trial is to test the effects of a brief proactive care intervention involving mailed material and two phone calls on: (1) increasing participation in SilverSneakers exercise…
- Trial name
- NCT06782347
- Testing
- Proactive Care
- Where
- United States
- Volunteers
- 1,454 people
- Sponsor
- Milton S. Hershey Medical Center
Knee Osteoarthritis
Clinial Application of Park et al.(The Knee 27 (2020) 1577-1584)'s Study
The goal of this study was to perform pulsed radiofrequency ablation with a modified target suggested in the cadaver study by Park et al.
- Trial name
- NCT05202847
- Testing
- pulsed radiofrequency ablation to modifined points group, pulsed radiofrequency ablation to conventional points group
- Sponsor
- Gangnam Severance Hospital
Osteoarthritis
Allograft Transplantation in the Treatment of Osteoarthritis of the Metatarsophalangeal (MTP) Joint of the Great Toe
Using the concept of an implant acting as a spacer and stabilizer, the proposed study will evaluate the use of allograft knee meniscus in the treatment of MTP joint osteoarthritis of the great toe.
- Trial name
- MTP (NCT01673347)
- Testing
- Meniscal Allograft
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Paul Fortin, MD
Knee Osteoarthritis, Total Knee Arthroplasty
Hemoglobin Drop and Need for Blood Transfusion in Primary Knee Arthroplasty With or Without Drain Insertion
Total knee arthroplasty is a common operation performed to relieve pain and improve movement in patients with severe knee joint disease, such as osteoarthritis, rheumatoid arthritis, post-traumatic arthritis, or osteonecrosis.
- Trial name
- NCT07494708
- Testing
- Closed Suction Drain Insertion, No Drain Placement
- Where
- Pakistan
- Volunteers
- 102 people
- Sponsor
- Shifa International Hospital
Osteoarthritis, Hip
Dry Needling Versus Stretching for Muscle Extensibility
Hip osteoarthritis (OA) is one of the most prevalent chronic disease in the world. Currently several authors have shown the presence of active myofascial trigger points (MTrP) in the muscles surrounding the hip joint that…
- Trial name
- NCT04400825
- Testing
- Dry needling
- Where
- Spain
- Volunteers
- 38 people
- Sponsor
- Universidad de Zaragoza
Knee Osteoarthritis, Limitation, Mobility
The Effect of Graded Motor Imagery on Pain and Function in Individuals With Knee Osteoarthritis
The aim of this study is to investigate whether Graded Motor Imagery (GMI) application is as effective as Transcutaneous Electrical Nerve Stimulation (TENS) in individuals with knee osteoarthritis (OA).
- Trial name
- NCT05925517
- Testing
- Graded Motor Imagery (GMI), Transcutaneous Electrical Nerve Stimulation (TENS), Conventional Physiotherapy Program
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Artvin Coruh University
Knee Osteoarthritis
Early Progressive Strength Training to Patients With Unicompartmental Knee Replacement
The purpose and Study hypotheses: The purpose of the study is to investigate the effect of progressive resistance training in the early postoperative phase on patients who has had unicompartmental knee replacement.
- Trial name
- NCT01345825
- Testing
- Resistance training
- Where
- Denmark
- Volunteers
- 57 people
- Sponsor
- University of Aarhus
Knee Osteoarthritis
The Effect of Mobilization on Inflammatory Biomarkers in Patients With Knee Osteoarthritis.
This study is designed to investigate whether a hands-on therapy called Mobilization with Movement (MWM) can reduce pain and inflammation in individuals with knee osteoarthritis (OA).
- Trial name
- NCT07166068
- Testing
- Manual Therapy (Mobilization with Movement), Exercise
- Where
- Saudi Arabia
- Volunteers
- 40 people
- Sponsor
- University of Jazan
Osteoarthritis, Knee, Healthy Subjects
Predictors for Analgesic Effect to Standardized Exercise Therapy for Osteoarthritic Pain
Pain sensitization has been associated with pain severity in people with knee osteoarthritis (KOA) and a neuropathic pain component has been identified in up to 30% of KOA patients.
- Trial name
- NCT03718663
- Testing
- Physiotherapy-guided Evidence-based Exercise Therapy, Part 2: Military training
- Where
- Denmark
- Volunteers
- 28 people
- Sponsor
- Kristian Kjær Petersen
Osteoarthritis of the Knee
Structured Treatment of Osteoarthritis of the Knee With or Without Total Knee Replacement
The purpose of this study is to test whether surgical insertion of total knee replacement provides further improvement in quality of life, pain and function in addition to an algorithm for systematic non-surgical treatment…
- Trial name
- MEDIC (NCT01410409)
- Testing
- Neuromuscular training (NEMEX-TJR), Paracetamol, Burana
- Where
- 3 sites in Denmark
- Volunteers
- 100 people
- Sponsor
- Northern Orthopaedic Division, Denmark
Knee Osteoarthritis
Pivotal Clinical Trial to Evaluate the Efficacy and Safety After NPNP-001 Application in Patients with Knee Osteoarthritis.
This study was designed to demonstrate non-inferiority and safety in pain reduction after NPNP-001 application in patients with knee osteoarthritis.
- Trial name
- NCT06779071
- Testing
- NPNP-001, Conjuran
- Where
- South Korea
- Volunteers
- 260 people
- Sponsor
- PharmaResearch Co.,Ltd
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