Clinical trials: Degenerative Osteoarthritis
Knee Osteoarthritis
Wearable Sensor-based Balance Training for Patients With Knee Osteoarthritis
Knee osteoarthritis (KOA) is one of the leading causes of lower limb disability among the elderly and can cause loss of knee joint proprioception that contributes towards deterioration of postural balance.
- Trial name
- NCT02620462
- Testing
- Wearable sensor-based exercise training
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Arizona
Osteoarthritis, Knee
Multiple Ascending Doses (MAD) of Anti-A Disintegrin and Metalloproteinase With Thrombospondin Motifs-5 (Anti-ADAMTS-5) Nanobody in Participants With Knee Osteoarthritis (OA)
The study will be conducted in participants with symptomatic knee OA to explore the safety, tolerability, immunogenicity, pharmacokinetics (PK), and pharmacodynamics (PD) of MAD of M6495.
- Trial name
- NCT03583346
- Testing
- M6495
- Where
- Denmark
- Volunteers
- 32 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Osteoarthritis
Chronic Muscle Disuse in the Elderly
The purpose of this study is to define the effects of chronic disuse on skeletal muscle structure and function in elderly individuals at the cellular and molecular level by examining elderly characterized by chronic muscle disuse…
- Trial name
- NCT01190046
- Testing
- Resistance exercise training
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Knee Osteoarthritis, Umbilical Cord Bleeding
The Maximum Tolerated Dose of Mesenchymal Stem Cells From Umbilical Cord
The aim of this study was to evaluate the maximum tolerated dose of Mesenchymal Stem Cells (MSCs) from umbilical cord in the treatment of human knee OA
- Trial name
- NCT03357770
- Testing
- mesenchymal stem cells
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Peking University People's Hospital
Anterior Cruciate Ligament Reconstruction
The Effects of Tranexamic Acid on Joint Inflammation and Cartilage Health in Anterior Cruciate Ligament Injured Patients
Patients who tear their ACL are at high risk for developing arthritis (post-traumatic osteoarthritis-PTOA) just 10 years later. Joint bleeding and inflammation contribute to deterioration of joint health.
- Trial name
- NCT03552705
- Testing
- Tranexamic Acid
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Stanford University
Osteoarthritis, Knee, Fractures, Ununited
Modern Methods of Treatment and Diagnosis of Patients With Injuries and Diseases of the Musculoskeletal System
Brief Summary This clinical study investigates the safety and effectiveness of combining advanced regenerative therapies with personalized surgical technology for patients with delayed fracture healing (non-unions), knee…
- Conditions
- Osteoarthritis, Knee, Fractures, Ununited, Arthroplasty, Replacement, Knee
- Trial name
- MTDMS (NCT07628010)
- Testing
- Autologous Mesenchymal Stromal Cells Combined with Platelet-Rich Plasma, Patient-Specific 3D-Printed Surgical Instruments
- Where
- Ukraine
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Zaporizhzhiya State Medical University
Hip Osteoarthritis
Platelet Rich Plasma Versus Corticosteroids in Hip Osteoarthritis Pain
Prospective, single-center that may go on to being multicenter, randomized trial comparing platelet rich plasma (PRP) versus corticosteroid injection for the treatment of symptoms of Hip osteoarthritis.
- Trial name
- NCT06793982
- Testing
- Platelet Rich Plasma Joint Injection, Corticosteroid Injection
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- LifeBridge Health
Osteoarthritis, Joint Diseases
Knee Stability Training for Knee Osteoarthritis (OA)
People with knee osteoarthritis (OA) frequently complain of knee instability. This study will test whether certain exercises can improve knee stability, reduce pain, and improve physical function in people with knee OA.
- Trial name
- NCT00078624
- Testing
- Traditional exercise therapy for knee osteoarthritis, Knee stability training
- Where
- United States
- Volunteers
- 231 people
- Sponsor
- University of Pittsburgh
Osteoarthritis
Effects of Osteoarthritis Pain, Morphine, and Placebo on Neuroendocrine Function in Men
This study will examine the effects of morphine on leuteinizing hormone, testosterone, adrenocorticotropic hormone and cortisol in men.
- Trial name
- NCT00088296
- Testing
- Blood Draw
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Osteoarthritis, Hip, Hip Osteoarthritis
Intravenous Dexamethasone (0 vs 4 vs 8 mg) as an Adjunct to PENG Block for Postoperative Analgesia in Total Hip Arthroplasty
his study will test whether giving dexamethasone through a vein can improve pain control after total hip replacement surgery. Dexamethasone is commonly used to reduce nausea and may also help with pain, but it is not clear which…
- Trial name
- NCT07581470
- Testing
- Dexamethasone 4mg, Dexamethasone 8mg
- Where
- Poland
- Volunteers
- 198 people
- Sponsor
- Poznan University of Medical Sciences
Osteoarthritis Shoulder, Avascular Necrosis of the Head of Humerus
Catalyst CSR Shoulder System for Semi or Total Shoulder Arthroplasty
Evaluation of the performance and safety of the Catalyst CSR Shoulder System with clinical and radiographic results at multiple time points through 24 months postoperatively This study will be a prospective multi-center study…
- Conditions
- Osteoarthritis Shoulder, Avascular Necrosis of the Head of Humerus, Rheumatoid Arthritis Shoulder
- Trial name
- NCT04968405
- Testing
- Catalyst CSR Total Shoulder System
- Where
- 3 sites in United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Catalyst OrthoScience
Osteoarthritis Shoulder
Diaphragm-Sparing Regional Anesthesia Techniques for Shoulder Surgery
This study will compare two regional anesthesia techniques for shoulder surgery and evaluate their effects on diaphragmatic function.
- Trial name
- NCT07474896
- Testing
- Ropivacaine 0.2% for Interscalene Block, Ropivacaine 0.2% for Infraclavicular and Suprascapular Nerve Blocks
- Where
- Poland
- Volunteers
- 70 people
- Sponsor
- Poznan University of Medical Sciences
Knee Osteoarthritis
Pharmacokinetics of Imrecoxib in Subjects With Hepatic Insufficiency
This clinical research study will assess pharmacokinetics and the safety of Imrecoxib in patients with impaired hepatic function as compared to healthy volunteers.
- Trial name
- NCT02456688
- Testing
- Imrecoxib
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Localized, Primary Osteoarthritis, Post-traumatic Arthrosis of Other Joints, Shoulder Region
Clinical Outcomes in Shoulder Hemi-arthroplasty Using a PyC Spherical Interpositional Implant
The INSPYRE implant is a new range of shoulder hemi-arthroplasty device. It consists of a Pyrocarbon spherical interpositional implant and is indicated in primary surgery to relieve severe pain or significant disability caused by…
- Conditions
- Localized, Primary Osteoarthritis, Post-traumatic Arthrosis of Other Joints, Shoulder Region, Avascular Necrosis of the Head of Humerus
- Trial name
- NCT02424760
- Testing
- Shoulder hemi-arthroplasty
- Volunteers
- 67 people
- Sponsor
- Stryker Trauma and Extremities
Knee Osteoarthritis (Knee OA)
Exercise-induced Irisin in Individuals With Knee Osteoarthritis.
The goal of this prospective randomised controled study is to investigate the effect of 8-weeks brisk walking exercise on irisin levels, physical and psychosocial parameters in individuals with knee osteoarthritis, and the…
- Trial name
- Osteoarthritis (NCT06758388)
- Testing
- home exercise program, home exercise program + brisk walking exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people
- Sponsor
- Ümmahani Kuş
Knee Osteoarthritis, Knee Arthritis
Pain Management After Adductor Canal Block for Total Knee Arthroplasty
This randomized, double-blinded, placebo-controlled trial sought to evaluate the efficacy of the iPACK block with Adductor Canal Block on postoperative pain, functional recovery and NLR and PLR levels.
- Conditions
- Knee Osteoarthritis, Knee Arthritis, Knee Arthropathy, Knee Pain Chronic
- Trial name
- NCT06086483
- Testing
- Ropivacaine 0.2% Injectable Solution, 0.9%sodium chloride
- Where
- Poland
- Volunteers
- 361 people
- Sponsor
- Poznan University of Medical Sciences
Knee Osteoarthritis
Impact of Sensor Technology in Knee OA
OBJECTIVES: Physical activity has been established as an important component of rehabilitation for knee osteoarthritis (OA), and is often guided by a physical therapist.(1) Physical therapy for knee OA typically involves 1-3…
- Trial name
- NCT05222503
- Testing
- Knee Brace + OPUM Digital Knee, Knee Brace
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- OPUM Technologies US LTD
Osteoarthritis
Determination of Adipocytokine in Synovial Fluid of Osteoarthritis Patients
The purpose of this study is to determine the concentration of different adipocytokine (adiponectin, leptin, resistin, visfatin, osteopontin) and an inflammation classic markers as Interleukine 1 beta, tumor necrosis alfa…
- Trial name
- NCT01993342
- Testing
- arthrocentesis, ultrasonography of the knee
- Where
- Spain
- Volunteers
- 35 people
- Sponsor
- Parc Taulí Hospital Universitari
Osteoarthritis Thumb, Thumb Carpometacarpal Joint Osteoarthritis
TOUCH® CMC 1 New Enrollment US Study
The purpose of this study is to meet a PMA (P240020) condition of approval of the TOUCH® CMC 1 Prosthesis to evaluate the effectiveness and safety of the prosthesis in the United States (US) population.
- Trial name
- PAS002 (NCT07405983)
- Testing
- TOUCH® CMC 1 Prosthesis
- Where
- 4 sites in United States
- Volunteers
- 163 people
- Sponsor
- Keri Medical SA
Health-related Quality of Life, Pain
Outcomes During Digitally Delivered Osteoarthritis Treatment
Objectives: To examine changes in health-related quality of life (HRQL), pain and function among patients with knee or hip osteoarthritis (OA) participating in digitally delivered exercise and education treatment for up to 12 or…
- Conditions
- Health-related Quality of Life, Pain, Function, Osteoarthritis, Knee
- Trial name
- NCT05026580
- Testing
- Joint Academy exercise and education smart phone application
- Where
- Sweden
- Sponsor
- Joint Academy
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