Clinical trials: Degenerative Osteoarthritis
Osteoarthritis, Avascular Necrosis
Metal Ions in Ceramic on Metal Total Hip Arthroplasty
The investigators aim to measure the blood levels of certain metals in a group of patients all of whom have had a ceramic on metal total hip replacement.
- Conditions
- Osteoarthritis, Avascular Necrosis, Rheumatoid Arthritis, Developmental Dysplasia of the Hip
- Trial name
- COM (NCT01437124)
- Where
- United Kingdom
- Volunteers
- 83 people
- Sponsor
- Hussain Kazi
Knee Osteoarthritis
Phase I Clinical Trial of UC-MSCs in the Treatment of Knee Osteoarthritis
In recent years, the incidence rate and disability rate of osteoarthritis have continued to grow, and it has become a common chronic disease of elderly patients, second only to the "three highs", and poses a continuous threat to…
- Trial name
- NCT06463847
- Testing
- UC-MSCs
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Osteoarthritis, Knee
Influence of Osteoarthritis Information on Treatment Beliefs
The aim of this study is to evaluate the effect of educational information, with and without a general practitioner recommendation to exercise, on willingness to undertake exercise/physical activity for knee osteoarthritis.
- Trial name
- NCT04698655
- Testing
- Information on treatment options, Recommendation from general practitioner, Information on osteoarthritis
- Where
- Australia
- Volunteers
- 735 people, healthy volunteers welcome
- Sponsor
- University of Melbourne
Osteoarthritis, Knee
Simple Home-Based Exercise for Knee Osteoarthritis
1. Simple home-based standing balance training and isometric knee extension exercise for 4 weeks would improve functional ability and knee muscle strength of patients with knee osteoarthritis. 2.
- Trial name
- NCT00687726
- Testing
- Standing balance exercise, Isometric knee extension exercise
- Where
- Thailand
- Volunteers
- 48 people
- Sponsor
- Srinakharinwirot University
Knee Osteoarthritis, Osteoarthritis
Intra-Articular Polyacrylamide Hydrogel Injections Improve Pain and Function in Knee Osteoarthritis
This study is designed to evaluate the effects of intra-articular injections of polyacrylamide hydrogel (Arthrosamid®) in patients with knee osteoarthritis.
- Conditions
- Knee Osteoarthritis, Osteoarthritis, Osteoarthritis of the Knee, Degenerative Joint Disease of the Knee
- Trial name
- HYDRO-KNEE (NCT07193368)
- Testing
- Polyacrylamide hydrogel 2.5% intra-articular injection
- Where
- Turkey (Türkiye)
- Volunteers
- 387 people
- Sponsor
- Feza Korkusuz MD
Knee Osteoarthritis
Effects of Gait Retraining on Lower Extremity Biomechanics
The purpose of this proposed study is to investigate both the acute and chronic response of frontal plane knee moment after gait retraining and to assess the effects on the biomechanics of the contralateral side.
- Trial name
- NCT03663790
- Testing
- Foot Progression, Trunk Lean
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- George Mason University
Osteoarthritis, Knee
An Effectiveness and Safety Study of IDEA-033 in Comparison to Oral Naproxen and Placebo for the Treatment of Osteoarthritis of the Knee
The purpose of this study is to identify the dose(s) of IDEA-033 that will provide a meaningful effect for treating osteoarthritis of the knee.
- Trial name
- NCT00211549
- Testing
- IDEA-033
- Where
- 100 sites in United States
- Volunteers
- 875 people
- Sponsor
- IDEA AG
OsteoArthritis Knee
A Comparison of 2-octyl Cyanoacrylate Skin Adhesive and Polyester Mesh for Wound Closure in Total Knee Arthroplasty, A Randomized Controlled Study
The goal of this randomized controlled study is to investigate the Efficacy of Using skin adhesive (Dermabond) and skin adhesive with polyester mesh (Dermabond Prineo )for Wound Closure in Total Knee Arthroplasty, The main…
- Trial name
- NCT06232018
- Testing
- Skin adhesive (Dermabond), skin adhesive + polyester mesh (Dermabond prineo)
- Where
- Thailand
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Pooriwat Lertsurawat
Osteoarthritis
Local Infiltration Analgesia or Intrathecal Morphine in Total Knee Arthroplasty
The purpose of this study is to determine whether local infiltration analgesia is more effective than intrathecal morphine in reducing postoperative pain in total knee arthroplasty.
- Trial name
- NCT00992082
- Testing
- ropivacaine, ketorolac and epinephrine, morphine
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Region Örebro County
Knee Osteoarthritis
Porous Baseplate in Total Knee Replacement
This is a multi-centre single cohort trial of patients undergoing cruciate-retaining total knee arthroplasty with the Advance Porous fixed bearing tibial baseplate and compatible femoral, patellar, and bearing components.
- Trial name
- NCT05226689
- Testing
- POROUS TIBIA BASEPLATE W/ JRNY LOCK
- Where
- 2 sites in Canada
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Canadian Radiostereometric Analysis Network
Knee Osteoarthritis, Osteoarthritis
"Bimodal vs Unimodal High-Intensity Pulsed Electromagnetic Field Therapy in Older Adults With Knee Osteoarthritis"
This randomized, double-blind clinical trial aims to evaluate the effect of high-intensity pulsed electromagnetic field therapy (HI-PEMF) applied either exclusively on the knee joint or bimodally on the knee and quadriceps, in…
- Conditions
- Knee Osteoarthritis, Osteoarthritis, Osteo Arthritis of the Knee, Gonarthrosis
- Trial name
- HIPEMF-OAK (NCT07198750)
- Testing
- HI-PEMF - Knee (Chronic Pain Protocol), HI-PEMF - Quadriceps (Muscle Strengthening Protocol), Home-Based Exercise Program
- Where
- Mexico
- Volunteers
- 64 people
- Sponsor
- Hospital Civil de Guadalajara
Knee Osteoarthritis, Persistent Postsurgical Pain
Comparison of Conventional and Cooled Radiofrequency of the Genicular Nerves in Patients With Chronic Knee Pain
Chronic knee pain remains a disabling disease despite current treatment strategies. There is an increase in the prevalence of osteoarthritis (OA) of the knee in the general population, presently affecting approximately 450,000…
- Conditions
- Knee Osteoarthritis, Persistent Postsurgical Pain, Chronic Knee Pain
- Trial name
- COGENIUS (NCT05407610)
- Testing
- Conventional Radiofrequency ablation of the genicular nerves, Cooled Radiofrequency ablation of the genicular nerves
- Where
- 15 sites in Belgium, Netherlands
- Volunteers
- 400 people
- Sponsor
- Ziekenhuis Oost-Limburg
Lower Back Pain, Facets Joints Osteoarthritis
Safety and Efficacy of MRgFUS for the Treatment of Low Back Pain
Chronic pain affects an estimated 50 to 65 million individuals in the US, and its incidence and prevalence is steadily on the rise in correspondence with the increasing longevity of the population.
- Trial name
- NCT01232582
- Testing
- Exablate treatment
- Where
- 2 sites in Israel, United Kingdom
- Volunteers
- 50 people
- Sponsor
- InSightec
Knee Osteoarthritis
ESCAPE-pain Programme in Malaysia
The overall aim of this study is to develop an evidence based exercise programme for the management of knee osteoarthritis which is feasible and acceptable to patients and healthcare professionals in Malaysia.
- Trial name
- NCT03379623
- Testing
- ESCAPE-pain Programme
- Where
- 2 sites in Malaysia
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Muhammad Kamil Che Hasan
Knee Osteoarthritis
Combined Effect of Laser Acupuncture and Electroacupuncture in Knee Osteoarthritis Patients
Background: Knee osteoarthritis (KOA) is a common degenerative joint disorder affected 250 million people globally. It can not only result in disability, but also associated with cardiovascular disease and mortality.
- Trial name
- NCT04188925
- Testing
- Laser Acupuncture
- Where
- Taiwan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Osteoarthritis, Hip
Changes in Postural Stability Following THA for OA
Total hip arthroplasty (THA) is a common surgery that eases pain, restores functional movement, and improves the overall quality of life in people with severe hip osteoarthritis (OA).
- Trial name
- CPS (NCT06088160)
- Testing
- Total Hip Arthroplasty
- Where
- Canada
- Volunteers
- 90 people
- Sponsor
- Western University, Canada
Patellofemoral Osteoarthritis
Proximal and Distal Therapeutic Approach in Pain and Lower Limb Kinematic in People With Patellofemoral Osteoarthritis
This is a crossover study that will investigate the immediate effects of a proximal therapeutic approach (SERF strap) and a distal one (foot orthoses) on knee pain intensity, global change, symptoms, ease of performance and…
- Trial name
- NCT04332900
- Testing
- Elastic hip strap, Insole
- Volunteers
- 30 people
- Sponsor
- Universidade Federal de Sao Carlos
Osteoarthritis
Hand Ultrasonography: Clinical and Functional Correlation in Symptomatic Osteoarthritis (OA)
Objective: To evaluate the correlation / association between inflammatory ultrasonography findings and clinical /functional assessment in symptomatic hand OA interphalangeal joints (IP).
- Trial name
- NCT02324192
- Testing
- Ultrasonography
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Federal University of São Paulo
Osteoarthritis Hip, Joint Disease
Mobilization With Movement in Patients With Osteoarthritis of the Hip
The concept of mobilization with movement, also referred to as a Mulligan mobilization, has not been studied in patients with hip osteoarthritis, subsisting questions about the possible effects in this population.
- Conditions
- Osteoarthritis Hip, Joint Disease, Musculoskeletal Diseases, Pathologic Processes
- Trial name
- MWM (NCT02390336)
- Testing
- Real mobilization-with-movement (MWM)
- Volunteers
- 40 people
- Sponsor
- Natália Maria Oliveira Campelo
Knee Osteoarthritis
Effectiveness of the ARTH-e Application for Exercise Adherence in People With Knee Osteoarthritis : RCT
The aim of this study is to investigate the effectiveness of a smartphone-based e-health application (intervention group) compared with standard care (control group) in terms of changes in adherence in patients with knee…
- Trial name
- ARTH-e3 (NCT06359171)
- Testing
- Application ARTH-e
- Where
- 4 sites in France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Clermont-Ferrand
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