Clinical trials: Degenerative Spine Disease
Degenerative Disc Disease, Spinal Fusion
KUR-113 Bone Graft Versus Local Autograft for the Treatment of Single-level Transforaminal Lumbar Interbody Fusion
The purpose of this study is to evaluate the safety and efficacy of KUR-113 Bone Graft (TGplPTH1-34 in fibrin) compared to local autograft for the treatment of Degenerative Disk Disease (DDD).
- Trial name
- STRUCTURE (NCT04294004)
- Testing
- TGplPTH1-34 in fibrin, Autologous Bone Graft
- Where
- 15 sites in United States
- Volunteers
- 50 people
- Sponsor
- Kuros Biosurgery AG
Intervertebral Disc Degeneration, Lumbar Spinal Stenosis
Minimally Invasive Surgery Versus Traditional Open Surgery In The Treatment Of Single Level Lumbar Stenosis
The purpose of this study is to determine the effectiveness of minimally invasive surgical technique over the traditional open surgical procedure in patients with degenerative lumbar stenosis
- Trial name
- NCT04408846
- Testing
- Lumbar fusion
- Where
- Russia
- Sponsor
- Novosibirsk Research Institute of Traumatology and Orthopaedics n.a. Ya.L. Tsivyan
Cervical Stenosis, Myelopathy
Assessing Microbiome in Primary Anterior Cervical Fusion Patients
Patients who are about to undergo cervical fusion surgery at Hospital for Special Surgery (HSS) are being asked to take part in this research study.
- Conditions
- Cervical Stenosis, Myelopathy, Cervical Spondylosis With Myelopathy, Degenerative Disc Disease
- Trial name
- NCT07877766
- Testing
- Primary Anterior Cervical Discectomy Procedures
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Hospital for Special Surgery, New York
Degenerative Disc Disease, Spondylolisthesis
Advanced Materials Science in XLIF Study
This study is being conducted to evaluate the clinical and radiographic outcomes of three different interbody implant types when used with cancellous allograft chips with BMA or cellular allograft in patients undergoing XLIF…
- Trial name
- AMS in XLIF (NCT03649490)
- Where
- 15 sites in United States
- Volunteers
- 300 people
- Sponsor
- NuVasive
Degenerative Spondylolisthesis, Lumbar Spinal Stenosis
Effect of Degenerative Spondylolisthesis on the Clinical Outcome of Unilateral Biportal Endoscopy for Lumbar Spinal Stenosis: Study Protocol
A single-center, prospective cohort trial aims to provide stronger evidence regarding the impact of degenerative spondylolisthesis on the clinical outcome of unilateral biportal endoscopy for lumbar spinal stenosis
- Trial name
- NCT06394089
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Beijing Friendship Hospital
Spinal Stenosis
A Study of the In-Space Device for Treatment of Moderate Spinal Stenosis
The purpose of this study is to evaluate the safety and effectiveness of the In-Space compared to the X STOP Interspinous Process Distraction (IPD) device ("X STOP") for the treatment of patients experiencing intermittent…
- Trial name
- In-Space (NCT00697827)
- Testing
- Interspinous Spacer device, Interspinous Process Distraction Device
- Where
- 10 sites in United States
- Volunteers
- 44 people
- Sponsor
- Synthes USA HQ, Inc.
Degenerative Disc Disease, Spondylolisthesis
Rate of Bony Fusion Using NanoBone® Synthetic Bone Graft Versus Local Autologous Bone Graft.
The objectives of this longitudinal study are to assess and measure fusion status (fused or not fused) and rate of bony fusion using NanoBone® Synthetic Bone Graft in patients requiring one to two level lumbar posterolateral…
- Trial name
- BONE (NCT04615260)
- Testing
- NanoBone
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Artoss Inc.
Degenerative Arthropathy of Lumbar Spinal Facet Joint
Prognostic Factors in Zygapophyseal Osteoarthritis Infiltration: a Prospective Cohort Study
Magnet Resonance Image findings of facet osteoarthritis and patient characteristics are prognostic factors for improving or worsening the clinical outcome after treatment with facet infiltration.
- Trial name
- NCT03304730
- Where
- Brazil
- Volunteers
- 147 people
- Sponsor
- Hospital Israelita Albert Einstein
Disc Degenerative Disease, Spine Degeneration
Physiotherapy and Osteopathic Treatment for Pain in the Cervical and Lumbar Spine and Temporomandibular Joints
Study Summary: Effectiveness of Physiotherapy and Osteopathy in Treating Spinal and Temporomandibular Joint Pain About the Study and Its Objective This study is conducted by Artur Hołodniuk, MSc, a physiotherapist and academic…
- Conditions
- Disc Degenerative Disease, Spine Degeneration, Back Ache, Temporomandibular Disorder (TMD)
- Trial name
- NCT07830836
- Testing
- General Osteopathic Treatment, Visceral Therapy, Magnetic field therapy
- Where
- Poland
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Poznan University of Physical Education
Degenerative Spine Disease, Spinal Deformity
Prospective, Observational Registry of Renaissance-guided Spine Surgeries
To establish an observational registry for systematic collection of clinical data from Renaissance-guided spine surgeries.
- Trial name
- NCT02212899
- Where
- 4 sites in United States
- Volunteers
- 93 people
- Sponsor
- Mazor Robotics
Lumbar Degenerative Spinal Disease
Robotic-assisted Pedicule Screw Placement
The main objective of the study is to evaluate the feasibility of using the robotic assisted device ROSA™ for pedicle screws placement.
- Trial name
- ARASS (NCT01944553)
- Testing
- The ROSA™ robot
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Montpellier
Degenerative Disc Disease, Spondylolisthesis
Pilot Study to Assess Safety/Preliminary Effectiveness of Prefix in Subjects With Degenerative Disc Disease (DDD) Undergoing Spine Fusion Surgery
This is a pilot study to evaulate the safety and prelimary effectiveness of Prefix as compared to autogenous bone for spinal fusion procedures in skeletally mature subjects with degenerative disc disease (DDD) at one level from…
- Trial name
- NCT00798902
- Testing
- Prefix (AMPLEX) B2A Peptide Enhanced Ceramic Granules, Iliac crest autograft
- Where
- 6 sites in United States
- Volunteers
- 22 people
- Sponsor
- BioSurface Engineering Technologies, Inc
Spinal Disease
ROMEO®2 PAD. 2 YEARS PROSPECTIVE FOLLOW-UP
This study is designed as a post-marketing observational, controlled, prospective, non-inferiority study where the efficacy and safety of the Degenerative Disc Disease treatment by arthrodesis using…
- Trial name
- ROMEO 2 PAD FR (NCT04174534)
- Where
- 3 sites in France
- Volunteers
- 3 people
- Sponsor
- Spineart SA
Degenerative Disc Disease
Prospective Study To Assess The Safety and Efficacy of the PROW LIF Procedure
This is a prospective, single-arm, open-label, non-randomized study. The aim of the study is to assess the safety and efficacy of the Prow LIF procedure in Transforaminal Lumbar Interbody Fusion (TLIF) procedures for the…
- Trial name
- NCT01850537
- Testing
- treatment of degenerative disc disease using the PROW LIF
- Where
- Israel
- Volunteers
- 15 people
- Sponsor
- NLT Spine
Degenerative Disc Disease
Comparative Analysis of Virtuos and Autograft in Lumbar Fusion
Compare the lumbar fusion rates at 12 and 24 months when lumbar arthrodesis is performed using Virtuos or Autograft Bone Graft. Surgical approach is limited to TLIF (MIS or Open) with posterior fixation and supplemental…
- Trial name
- NCT05614284
- Testing
- Virtuos
- Where
- 3 sites in United States
- Volunteers
- 6 people
- Sponsor
- Orthofix Inc.
Spinal Disease, Spinal Radiculopathy
This Study is to Determine if Degenerative Spinal Pain and Disorders Cause the Levels of Substance P to Change in a Patients Saliva, Blood and/or Cerebrospinal Fluid.
The objective of this pilot study is to determine if degenerative spinal disorders such as acute radiculopathy, myelopathy, stenosis, or disc and facet disease cause detectable alterations in Substance P levels in saliva, serum…
- Conditions
- Spinal Disease, Spinal Radiculopathy, Myelopathy, Neurogenic Claudication
- Trial name
- Substance P (NCT01458938)
- Testing
- treatment plan
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Carolina Neurosurgery & Spine Associates
Degenerative Disc Disease
Virtuos Bone Graft in Lumbar Fusion
A post-market open label study to assess the efficacy of a cellular based allograft bone graft in lumbar spinal fusion at one or two levels
- Trial name
- NCT06686017
- Where
- 9 sites in United States
- Volunteers
- 150 people
- Sponsor
- Orthofix Inc.
Degenerative Disc Disease, Intervertebral Disc Disease
Treatment of Degenerative Disc Disease With Allogenic Mesenchymal Stem Cells (MSV)
In this study we want to evaluate the clinical use of allogenic mesenchymal stem cells (MSC), obtained from bone marrow of healthy donors, for treatment of Degenerative Disc Disease (DDD).
- Conditions
- Degenerative Disc Disease, Intervertebral Disc Disease, Low Back Pain
- Trial name
- Disc_allo (NCT01860417)
- Testing
- Allogenic Mesenchymal Stromal Cells, Mepivacaine
- Where
- 2 sites in Spain
- Volunteers
- 24 people
- Sponsor
- Red de Terapia Celular
Degenerative Disc Disease
ArcadiusXP L Post Market Clinical Follow-Up
The purpose of this study is to collect clinical and radiological mid-term (2 years) data on the ArcadiusXP L® lumbar stand-alone cage in a post-market clinical follow-up study (PMCF) limited to 32 patients.
- Trial name
- ArcadiusXPLPMS (NCT01895426)
- Where
- 2 sites in Germany
- Volunteers
- 32 people
- Sponsor
- Aesculap AG
Paraspinal Muscles, Degenerative Lumbar Diseases
The Impact of Paraspinal Muscle Atrophy in Spine Surgeries
The goal of this observational study is to learn about the role of pre-operative paraspinal muscle atrophy in outcomes of lumbar spine fusion surgeries in patients with degenerative lumbar spine diseases.
- Trial name
- NCT07002918
- Where
- Egypt
- Volunteers
- 55 people
- Sponsor
- Assiut University