Clinical trials: Deglutition
Caregiver Burden, Alzheimer Disease
Reducing Burden in Care Partners of Community-Dwelling Persons With Dementia and Oropharyngeal Dysphagia
The goal of this clinical trial is to learn if a newly-created website tool, called WeCareToFeedDysphagia, helps to reduce feelings of burden in care partners of patients with Alzheimer's disease and related dementias (AD/ADRD)…
- Conditions
- Caregiver Burden, Alzheimer Disease, Dementia, Oropharyngeal Dysphagia
- Trial name
- NCT06557863
- Testing
- WeCareToFeedDysphagia web tool
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Northwell Health
Gastroesophageal Reflux
Phase III Study Comparing Zegerid® With Losec® for the Relief of Heartburn Associated With Gastroesophageal Reflux Disease
Heartburn is the main symptom of Gastroesophageal Reflux Disease (GERD), which, accompanied by acid regurgitation and other symptoms, has a substantial negative impact on a patients' quality of life.
- Trial name
- NCT01493089
- Testing
- Zegerid, Losec
- Where
- Poland
- Volunteers
- 239 people
- Sponsor
- Norgine
Gastro-esophageal Reflux
Safety Study of Airway Clearance Techniques in Infants.
The purpose of this study is to determine whether three airway clearance techniques ( Bouncing, Assisted Autogenic Drainage ( AAD) and bouncing and AAD) provoke or aggravate gastro-esophageal reflux in infants under the age of 1…
- Trial name
- NCT02128867
- Testing
- Assisted Autogenic Drainage (AAD), bouncing and AAD, bouncing
- Where
- Belgium
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Barrett's Esophagus
Prospective Study to Compare the Efficacy of E.G.Scan to Detect Barrett's Esophagus Compared With Standard Endoscopy
The purpose of this study was to evaluate whether a disposable nasal endoscope called "E.G. Scan II" will visualize the esophagus as well as the standard test, sedated endoscopy.
- Trial name
- NCT02066233
- Testing
- EG Scan II (transnasal endoscopy), Standard Endoscopy
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Gastroesophageal Reflux Disease
Feasibility of Placing Bravo PH Capsule in Proximal Esophagus
Assessing the feasibility and patient tolerance to placement of Bravo PH capsule in proximal esophagus. There will be no difference in patient-perception of a proximally-placed Bravo esophageal pH monitor compared with a distal…
- Trial name
- bravo (NCT00378898)
- Testing
- BRAVO capsule, Fluoroscopy
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Vanderbilt University Medical Center
Gastro-oesophageal Reflux
Influence of IPV on GOR in Infants From 0 to 12 Months.
The purpose of this study is to determine whether Intrapulmonary Percussive Ventilation ( airway clearance technique) provokes or aggravates gastro-oesophageal reflux in infants from 0 to 12 months.
- Trial name
- NCT02124863
- Testing
- Intrapulmonary Percussive Ventilation
- Where
- Belgium
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Gastroesophageal Reflux Disease
An Explorative Trial to Evaluate the Pharmacodynamic Effect of SPD557 on Reflux Parameters in Refractory GERD Patients
The purpose of this trial is to investigate the pharmacodynamic effect on reflux parameters of SPD557 tablets (0.5 mg t.i.d., on top of PPI treatment) in patients with Gastroesophageal Reflux Disease (GERD) with persistent…
- Trial name
- NCT01370863
- Testing
- SPD557
- Where
- 15 sites in Belgium, France and 4 more
- Volunteers
- 67 people
- Sponsor
- Shire
Dysphagia
Dysphagia Following Anterior Cervical Spine Surgery; Single Dose Steroid vs Saline (DysDexVSSal)
This prospective, randomized, double blind, controlled study evaluates the effect of a single dose of perioperative IV steroid versus saline on swallowing after anterior cervical spine surgery
- Trial name
- NCT03711474
- Testing
- Dexamethasone, Saline
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- West Virginia University
Barrett Esophagus, GERD
Patient Acceptance and Preference Among Screening Modalities for Detection of Barrett's Esophagus
To assess patient acceptance and preference among screening modalities, Esophagogastroduodenoscopy (EGD), Transnasal Esophagoscopy (TNE), and Cytosponge for Barrett's esophagus (BE).
- Trial name
- NCT04301986
- Testing
- Cytosponge, Transnasal Endoscopy (TNE), Esophagogastroduodenoscopy
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of North Carolina, Chapel Hill
Gastroesophageal Reflux Disease
Safety and Quality of Life Study of Dexlansoprazole Modified Release Formulation to Treat Heartburn
The purpose of this study is to determine the long-term safety profile of daily treatment with dexlansoprazole MR in subjects with gastroesophageal reflux disease.
- Trial name
- NCT00255190
- Testing
- Dexlansoprazole MR
- Where
- 181 sites in United States
- Volunteers
- 591 people
- Sponsor
- Takeda
Gastroesophageal Reflux Disease
PREA, PK And Safety PASS Study Of IV Pantoprazole In Pediatric Subjects
The purpose of this study is to characterize the pharmacokinetics (PK) and safety of intravenous (IV) pantoprazole in patients 1 to 16 years old who are candidates for acid suppression therapy.
- Trial name
- NCT02401035
- Testing
- IV pantoprazole
- Where
- 19 sites in United States, Argentina and 7 more
- Volunteers
- 19 people
- Sponsor
- Pfizer
Mitral Valve (MV) Regurgitation
ACCESS-Europe A Two-Phase Observational Study of the MitraClip® System in Europe
The MitraClip System enables the European physicians an alternative therapeutic option for patients with mitral regurgitation (MR).
- Trial name
- ACCESS-EU (NCT01288976)
- Testing
- MitraClip, Medical Management, Mitral Valve Surgery
- Where
- Germany
- Volunteers
- 721 people
- Sponsor
- Abbott Medical Devices
Stroke, Parkinson Disease
Videofluoroscopic Swallowing Study (VFSS)
The study procedure of simultaneous VFSS and DDS measurement will be completed in one day and the subject will be followed within 2 business days after the study procedure to monitor for adverse events.
- Conditions
- Stroke, Parkinson Disease, Multiple Sclerosis, Oropharyngeal Dysphagia
- Trial name
- PORSCHE (NCT03387267)
- Testing
- Dysphagia Detection System
- Where
- 13 sites in United States, Finland
- Volunteers
- 452 people
- Sponsor
- Société des Produits Nestlé (SPN)
Feeding Tube
Self-Propelled Versus Standard Percutaneous Endoscopic Gastrojejunostomy(PEG-J); RCT
Our main hypothesis is that self-propelled Percutaneous Endoscopic Gastrojejunostomy tube (PEG-J) that has a balloon on it's tip is associated with lower J-tube retrograde migration rate, and lower rates of short- and long-term…
- Trial name
- NCT01892267
- Testing
- PEG-J placement
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Johns Hopkins University
Stroke, Dysphagia
Treatment of Dysphagia Using the Mendelsohn Maneuver
The primary goal of the investigation is to determine the effects of the Mendelsohn maneuver on the physiology of the swallow in individuals who have suffered a stroke and exhibit signs of pharyngeal dysphagia.
- Trial name
- NCT00592761
- Testing
- Mendelsohn Maneuver
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Arkansas
Swallowing Disorder, Respiratory Insufficiency
The Impact of High-Flow Nasal Cannula on Swallow Function
Background: High-flow nasal cannula (HFNC) is a non-invasive heated and humidified oxygen delivery device that is capable of delivering high-flow rates.
- Trial name
- NCT03590457
- Testing
- Airvo 2; High-Flow nasal cannula system
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Nasal Polyps, Gastroesophageal Reflux
Investigation of the Association Between Nasal Polyposis and Extraesophageal Reflux Disease
Although nasal polyposis has been recognized as an inflammatory process for many years, the true etiology of nasal polyposis mainly unknown.
- Trial name
- NCT00215787
- Testing
- lansoprazole
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Head and Neck Surgery Associates
Parkinson's Disease, Multiple Sclerosis
Expiratory Muscle Training for Persons With Neurodegenerative Disease
Respiratory difficulty is one of the primary factors leading to death in patients with Parkinson's Disease (PD) and Multiple Sclerosis.
- Trial name
- EMST (NCT00856518)
- Testing
- EMST
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- VA Office of Research and Development
Venous Insufficiency, Venous Reflux
Effects of Non Contact Low Frequency Ultrasound in Healing Venous Leg Ulcers
This trial is a prospective, randomized, controlled, multi-center study of subjects presenting with chronic lower extremity venous ulcers.
- Conditions
- Venous Insufficiency, Venous Reflux, Lower Extremity Ulcer
- Trial name
- NCT01549860
- Testing
- MIST Therapy
- Where
- United States
- Volunteers
- 156 people
- Sponsor
- Celleration, Inc.
Dysphagia, Pneumonia
Oropharyngeal Dysphagia in Patients With Community Acquired Pneumonia
This study investigates relationship between community acquired pneumonia and oropharyngeal dysphagia in patients admitted to a department of respiratory medicine in Northern Denmark.
- Trial name
- NCT01974089
- Testing
- Dysphagia
- Where
- Denmark
- Volunteers
- 154 people
- Sponsor
- Regionshospital Nordjylland