Clinical trials: Deglutition Disorder
Non-erosive Reflux Disease
Clinical Trial to Assess the Efficacy and Safety of YYD601 in NERD Patients
Clinical Trial to Assess the Efficacy and Safety of YYD601 in NERD Patients
- Trial name
- NCT03967886
- Testing
- YYD601 20mg, Nexium 20mg
- Where
- South Korea
- Volunteers
- 170 people
- Sponsor
- Yooyoung Pharmaceutical Co., Ltd.
Stroke, Dysphagia
Tongue Pressure Resistance Training for Swallowing Impairment Post-Stroke
For patients who have suffered a stroke, tongue strength may be decreased compared to healthy individuals. Research on strengthening the tongue in the stroke population has shown positive effects of a tongue resistance training…
- Trial name
- TPRT-SIPS (NCT03969095)
- Testing
- Tongue Pressure Resistance Training
- Where
- 2 sites in United States, Canada
- Volunteers
- 1 people
- Sponsor
- University Health Network, Toronto
Swallowing Function
Detecting the Changes of Swallowing Function in Oral Cancer Patients
The evidence of swallowing changes in oral cancer patients is still limited. This study aimed to investigated the swallowing changes in these patients by using the videofluoroscopy (VFSS) and high resolution impedance manometry…
- Trial name
- NCT04862637
- Where
- Taiwan
- Volunteers
- 48 people
- Sponsor
- National Taiwan University Hospital
Acid Reflux Disease, Heartburn
Confocal Laser Microscopy in Non Erosive Reflux Disease
Heartburn or reflux disease affects about 20% of Americans. 50 - 70% of people who have endoscopy for reflux disease have a normal appearing esophagus.
- Trial name
- NCT00588939
- Testing
- Cell~vizio (Laser connfocal microscopy)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Mayo Clinic
Parkinson Disease, Deglutition Disorders
Describe to Better Understand, the Mealtime of People With Parkinson's Disease Dependent on Food Intake
The main objective is to describe strategies (verbal, non-verbal (gesture, intonation), and environmental), designed and used by the assisting/aided dyad to feed a dysphagic dependent person by articulating the safe and hedonic…
- Trial name
- AideAlimPark (NCT05898139)
- Where
- France
- Volunteers
- 22 people
- Sponsor
- University Hospital, Toulouse
Gastroesophageal Reflux Disease
Minimal Change Esophagitis by i-Scan Endoscopy in Dyspeptic Patients
The purpose of this study to assess efficacy of SE endoscopy in the detection of MCE in dyspeptic patients with or without GERD diagnosed by GerdQ or by endoscopy + PHM and in normal volunteers.
- Trial name
- MCE (NCT01742377)
- Testing
- Patients with GerdQ positive, Patients with GerdQ negative, Normal volunteers
- Where
- Thailand
- Volunteers
- 174 people
- Sponsor
- Prince of Songkla University
Gastroesophageal Reflux Disease (GERD)
Efficacy and Safety of DLBS2411 in the Management of GERD
This is a 2-arm, prospective, double-blind double-dummy, randomized-controlled study comparing DLBS2411 at a dose of 250 mg twice daily with omeprazole at a dose of 20 mg twice daily, given before morning and evening meals, for…
- Trial name
- NCT03367195
- Testing
- Omeprazole, DLBS2411
- Where
- 5 sites in Indonesia
- Volunteers
- 32 people
- Sponsor
- Dexa Medica Group
Dysphagia Rehabilitation
Dysphagia Digital Therapy: A Pilot Study
Dysphagia is a swallowing disorder characterized by impaired transfer of food or liquid from the oral cavity through the pharynx and esophagus, leading to significant nutritional, respiratory, and quality-of-life consequences.
- Trial name
- NCT07311161
- Testing
- "Pallow", mobile-based digital therapeutic (DTx)
- Where
- South Korea
- Volunteers
- 10 people
- Sponsor
- Dongtan Sacred Heart Hospital
Gastroesophageal Reflux Disease, Severity
Association Between Gastroesophageal Reflux Disease (GERD) Severity and Dental Caries
This study aimed to assess the relationship between gastroesophageal reflux disease (GERD) severity (based on upper gastrointestinal endoscopy) and dental caries severity.
- Conditions
- Gastroesophageal Reflux Disease, Severity, Dental Caries
- Trial name
- NCT07108751
- Testing
- Endoscopy
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Tanta University
Achalasia
Comprehensive Esophageal Diagnostics Study
The prospective clinical trial will study muscle fibrosis in relation to lower esophageal sphincter (LES) measurements on Functional Lumen Imaging Probe (FLIP) Topography (the novel technology that utilizes impedance planimetry)…
- Trial name
- NCT04641702
- Testing
- Atropine challenge, Esophageal muscle biopsy
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Emory University
Head and Neck Cancer, Dysphagia
Training Swallowing Initiation During Expiration
Head and neck cancers have escalated to epidemic levels in the United States, and survivors are suffering from life-long, devastating swallowing disorders with limited therapeutic options.
- Conditions
- Head and Neck Cancer, Dysphagia, Oropharyngeal Dysphagia, Oropharynx Squamous Cell Carcinoma
- Trial name
- NCT05278039
- Testing
- Respiratory-Swallow Phase Training, Swallow Practice
- Where
- 2 sites in United States
- Volunteers
- 88 people
- Sponsor
- Northwestern University
Dysphagia
How Active Breathing Training Improves Dysphagia in Elderly People
The goal of this clinical trial is to explore the impact of Active Breathing Exercises on swallowing function and quality of life in community-dwelling elderly individuals (≥60 year old) with swallowing disorders.
- Trial name
- NCT06303856
- Testing
- Active Breathing Exercises
- Volunteers
- 300 people
- Sponsor
- Muhammad
Oropharyngeal Dysphagia
Investigation of a Free Water Protocol
Hypothesis: Use of a Free Water Protocol (FWP) will improve patient satisfaction scores (Dysphagia Handicap Index), will not increase the risk of aspiration pneumonia/pneumonitis, and will result in improved oral hygiene (as…
- Trial name
- NCT06309602
- Testing
- Free Water Protocol, Control / Standard Care
- Where
- 2 sites in United States
- Volunteers
- 136 people
- Sponsor
- Poudre Valley Health System
GERD
Self-Propelled Percutaneous Endoscopic GastroJejunostomy (PEG-J)
This research is being done to study the safety of an investigational percutaneous endoscopic gastrojejunostomy (PEGJ) tube and whether the addition of a balloon on the end of the J tube prevents it from slipping back into the…
- Trial name
- NCT01551095
- Testing
- PEGJ tube
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Johns Hopkins University
Esophageal Achalasia
Study on the Relationship Between Pathological Features of Achalasia and Prognosis of Per-oral Endoscopic Myotomy
Achalasia is the most common motility disorder of esophagus, characterized by disorders of the lower esophageal sphincter (LES).
- Trial name
- NCT05113173
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Fandong Meng
Dysphagia
Percutaneous Endoscopic Gastrostomy Tube Placement by Otorhinolaryngologist
The investigators main endpoint was focused on the analysis of the type, rate and the impact of different clinical parameters on the complications of the PEG tube placements performed at the Department of Otorhinolaryngology …
- Trial name
- NCT01476241
- Testing
- PEG tube placement
- Where
- Finland
- Volunteers
- 292 people
- Sponsor
- University of Helsinki
Dysphagia
Pharyngocise Dose Response Study
In this study supported by an American Cancer Society grant, the investigators are evaluating two levels of swallowing exercise intensity on the maintenance of swallowing muscles and their function in Head/Neck cancer patients…
- Trial name
- NCT01279837
- Testing
- Pharyngocise
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- University of Florida
Esophageal Motility Disorders
Changes in Esophageal Motility and Swallowing Symptoms After Thyroid Surgery
The pronounced effect of goiter on the esophagus needs further exploration, as the mechanisms by which goiter leads to swallowing difficulties are unknown.
- Trial name
- NCT03100357
- Testing
- Thyroidectomy
- Volunteers
- 39 people
- Sponsor
- University of Southern Denmark
Deglutition Disorders
Wearable Monitoring Systems for Swallowing Function and Disorders
Wearable tele-rehabilitation technology allows for the efficient provision of rehabilitation services from a distance, facilitating tele-management of many disorders.
- Trial name
- NCT04243577
- Testing
- Tele-EaT Sensors, Conventional Sensors
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Purdue University
Gastroesophageal Reflux Disease (GERD)
Anthropometry in Gastroesophageal Reflux Disease and Esophageal Injury
Is waist to hip ratio (WHR), waist circumference (WC), (as markers of visceral adiposity) associated with an increase in acidic and non acidic reflux as well as systemic inflammation involving esophageal mucosa, thereby…
- Trial name
- NCT01570842
- Testing
- Anthropometric measurements, Tissue samples
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Mayo Clinic
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