Clinical trials: Deglutition Disorder
Dysphagia
Clinical Trial for Clinical Excellence and Safety Evaluation of 4-channel Functional Electric Stimulator
This study is a pilot study to prepare clinical trials to evaluate the safety and effectiveness of 4-channel electric stimulation therapy devices as a newly developed function for the treatment of dysphagia disorders.
- Trial name
- NCT05483582
- Testing
- 4-channel Electrical Stimulation Device, 2-channel Electrical Stimulation Device
- Where
- South Korea
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Acute Stroke, Dysphagia
Prediction of Functional Health Status and Aspiration Using Multiple Dysphagia Scales Over 6 Months After Acute Stroke
In order to discover dysphagia scales, which shows meaningful predictability of aspiration and functional health status in patients with acute stroke, authors plan to find out more predictable indicators than existing…
- Trial name
- NCT03787524
- Where
- South Korea
- Volunteers
- 68 people
- Sponsor
- Ulsan University Hospital
Tongue Cancer, Jaw Cancer
Quality of Life in Patients Treated for Tongue and/or Jaw Neoplasia Before and After Speech Therapy
This study aims to verify the impact of four speech therapy sessions on the Quality of Life of patients treated for malignant tongue and/or jaw cancer, using as measure specific questionnaires of speech and swallowing.
- Conditions
- Tongue Cancer, Jaw Cancer, Oral Cancer, Intelligibility, Speech
- Trial name
- NCT04126226
- Testing
- Speech-language guidance, Speech therapy exercises for swallowing, Speech therapy exercises for speech
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
GERD (Gastroesophageal Reflux Disease)
Normal Values of Ambulatory 24-hour Oesophageal pH-impedance Monitoring in an Indian Cohort of Participants
This study aims to determine normal 24-hour pH-impedance monitoring values, including acid exposure time (AET), in healthy Indian adults. It will help improve GERD diagnosis in India by providing population-specific data.
- Trial name
- NCT06928350
- Where
- India
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Asian Institute of Gastroenterology, India
ALS, Respiratory Insufficiency
Combined Respiratory Training in Persons With ALS
The goal of this interventional trial is to learn about lung volume recruitment (LVR) and expiratory muscle strength training (EMST) in a total of up to 39 patients diagnosed with ALS. The following aims will be addressed: 1.
- Conditions
- ALS, Respiratory Insufficiency, Dysphagia
- Trial name
- NCT05913882
- Testing
- Respiratory Muscle Strength Training (LVR+EMST)
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Nova Southeastern University
Dysphagia, Cervical Spinal Cord Injury
Dysphagia After Anterior Cervical Spine Surgery
The purpose of this research project is to investigate the incidence of impaired swallowing (dysphagia) after anterior cervical spine surgery (ACSS) and to study the long-term effect of dysphagia on nutritional status 12 ± 3…
- Trial name
- NCT04855838
- Testing
- Oral neuromuscular training
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Umeå University
Non-erosive Reflux Disease, Gastroesophageal Reflux
Confocal Endomicroscopy for Non-Erosive Reflux Disease Detection
Primary Objective: Evaluate response to NERD treatment between patients with normal endomicroscopy findings compared with patients with abnormal endomicroscopy findings.
- Trial name
- CENERDD (NCT02788591)
- Testing
- Proton Pump Inhibitor (PPI) Therapy, Sucralfate
- Where
- 2 sites in United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- LCMC Health
Dysphagia of Newborn
The Effects of Pacifier-Activated Lullaby on Oral Feeding Among Preterm Infants
Preterm infants often have difficulty learning how to feed by mouth because the coordination of sucking, swallowing, and breathing develops later in pregnancy.
- Trial name
- Music therapy (NCT07819734)
- Testing
- Pacifier-Activated Lullaby (PAL) Therapy
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Nemours Children's Clinic
Deglutition Disorders, Dysphagia
Brief and Intensive Therapy for Dysphagia in Patients With Head and Neck Cancer
According to data in the literature, patients with head and neck cancer, who undergo combined treatment of radio-chemotherapy, have, to a greater or lesser extent, swallowing changes.
- Conditions
- Deglutition Disorders, Dysphagia, Head and Neck Cancer, Radiotherapy; Complications
- Trial name
- dysphagia (NCT03755921)
- Testing
- bried and intensive therapy
- Volunteers
- 20 people
- Sponsor
- Federal University of Health Science of Porto Alegre
GERD
Electrical Stimulation Therapy (EST) of the Lower Esophageal Sphincter (GERD)
The investigational device that will be used in this trial is the EndoStim® Lower Esophageal Sphincter (LES) Stimulation System.
- Trial name
- EST-SHAM-EUR (NCT02514616)
- Testing
- Laparoscopic IPG and lead implant procedure, Active Electric Stimulation Therapy, Delayed Electric Stimulation Therapy
- Where
- 2 sites in Belgium, France
- Volunteers
- 1 people
- Sponsor
- Erasme University Hospital
Eosinophilic Esophagitis
Swallowing Characteristics of Pediatric Patients With Eosinophilic Esophagitis
Eosinophilic Esophagitis (EoE) can affect patients all age group and clinical symptoms of the disease varies depending on the patient's ages.
- Trial name
- NCT04704752
- Testing
- Swallowing Evaluation
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Gazi University
Stroke, Acute, Dysphagia
Post Stroke Dysphagia: Effect of Adding rTMS to Conventional Therapy on the Prevalence of Pneumonia.
BACKGROUND: Dysphagia is one of the most life-threatening stroke complications. Dysphagic stroke patients are at increased risk of aspiration pneumonia.
- Conditions
- Stroke, Acute, Dysphagia, Pneumonia
- Trial name
- NCT06123650
- Testing
- Repetitve transcranial magnetic stimulation
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Cairo University
Gastro Oesophageal Reflux Disease
Study Comparing Fexuprazan and Esomeprazole in Patients With Gastroesophageal Reflux Disease
The goal of this clinical trial was to evaluate the effectiveness and safety of fexuprazan 40 mg for relieving symptoms of gastroesophageal reflux disease (GERD) in adults.
- Trial name
- NCT07326904
- Testing
- Fexuprazan, Esomeprazole
- Where
- 3 sites in Indonesia
- Volunteers
- 145 people
- Sponsor
- Universitas Indonesia
Swallowing Disorder, Dysphagia
Validation of a Screening Tool for Swallowing Disorders for the Elderly
Swallowing disorder, or dysphagia, is a lack of protection of the airways during the passage of the food bolus towards the esophagus.
- Trial name
- DéGluT'G (NCT06163118)
- Testing
- Deglut'G test, SLP swallowing test, ENT doctor swallowing test
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital Center of Martinique
Gut-Brain Disorders, GERD Without Erosive Esophagitis
Cognitive-behavioral Therapy for the Diseases Associated With Esophageal-brain-gut Axis Communication Abnormalities.
Gastroesophageal reflux disease (GERD) is a challenging gastrointestinal disorder, and proton pump inhibitors (PPIs) are typically the first line of treatment.
- Trial name
- NCT06939465
- Testing
- Cognitive Behavioral Therapy (CBT)
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Hualien Tzu Chi General Hospital
GERD
Anti-Reflux Endoscopic Therapy Using Argon Plasma Coagulation (AREA) in Gastroesophageal Reflux Disease (GERD) Patients: A Single Center, Randomized, Sham, Controlled Trial (The AREA Study)
Background and Rationale: Gastroesophageal reflux disease is affecting 1 in 3 US adults with half experiencing daily symptoms. Per recent data, more than 50% continue to experience daily symptoms despite taking medical therapy…
- Trial name
- AREA (NCT06641375)
- Testing
- Anti reflux endoscopic theraphy, Endoscopy
- Where
- India
- Volunteers
- 18 people
- Sponsor
- Asian Institute of Gastroenterology, India
Gastro Esophageal Reflux
Endoscopic Classification of Fundoplication Integrity Predicts Pathologic Reflux
This single-center, two-phase cohort study aimed to develop and validate a simple endoscopic classification of fundoplication integrity after anti-reflux surgery (ARS - Nissen or Toupet fundoplication).
- Trial name
- NCT07722663
- Where
- Italy
- Volunteers
- 153 people
- Sponsor
- IRCCS Policlinico S. Donato
Dysphagia, Oropharyngeal
Reference Values for Videofluoroscopic Measures of Swallowing
Dysphagia (swallowing impairment) is a serious health condition seen in many age-related disease and injury processes. Although videofluoroscopy (VF) is an international "gold standard" dysphagia diagnostic exam, there is a…
- Trial name
- NIA_RV (NCT05497219)
- Testing
- Videofluoroscopic Swallowing Study (VF)
- Where
- 5 sites in United States, Canada
- Volunteers
- 580 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Dysphagia, Stroke
Digital Intelligent Tongue-Pressure Biofeedback Resistance Training for Post-Stroke Dysphagia: A Randomized Controlled Trial
Post-stroke dysphagia is a common complication of stroke and may lead to impaired oral intake, malnutrition, aspiration, and pneumonia.
- Trial name
- NCT07798401
- Testing
- Digital Intelligent Tongue-Pressure Biofeedback Resistance Training, Conventional Tongue-Pressure Resistance Training
- Where
- China
- Volunteers
- 80 people
- Sponsor
- First People's Hospital of Foshan
Neurological Diseases or Conditions, Healthy Participants
GEL & MEDication Dysphagia
This research project examines the prevalence of medication-related dysphagia in patients with dysphagia-associated diseases. Its primary aim is to assess how frequently swallowing difficulties occur during medication intake and…
- Trial name
- GELMED (NCT07254663)
- Testing
- medication swallowing
- Where
- 3 sites in Germany
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Heinrich-Heine University, Duesseldorf