Clinical trials: Deglutition Disorder
Stroke
Guideline - Based Nursing Plan for Dysphagia After Stroke
Research purposes:1, investigate the nursing management is the head nurse for swallowing disorder after stroke care management status; Compared with the existing research, the difference between guidelines and evidence-based…
- Trial name
- NCT04956471
- Testing
- interview
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Peking University Third Hospital
Gastroesophageal Reflux, Laryngopharyngeal Reflux
Precision Approach to PPI Therapy in Gastroesophageal Reflux Disease
This study plans to learn more about reflux associated laryngeal symptoms, and more efficient ways to diagnose and treat this condition.
- Trial name
- NCT03619811
- Testing
- Reflux Band® Upper Esophageal Sphincter (UES) Assist Device
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8
Swallowing Outcomes and Circulating Tumor DNA in Patients With HPV Related Oropharyngeal Cancer Treated With Transoral Surgery and Reduced Intensity Adjuvant Therapy
This is a non-randomized, open-label phase II clinical trial that studies the effect of reduced dose radiation therapy and chemotherapy after surgery in treating patients with human papillomavirus (HPV) caused throat cancer.
- Conditions
- Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Oropharyngeal Human Papillomavirus-Positive Squamous Cell Carcinoma
- Trial name
- NCT04920344
- Testing
- Transoral Surgery, External Beam Radiation Therapy, Cisplatin
- Where
- 3 sites in United States
- Volunteers
- 15 people
- Sponsor
- Rutgers, The State University of New Jersey
GERD
A Study to Compare PK, PD and Safety of UI058 and UIC202004 in Healthy Subjects
A Study to compare pharmacokinetics, pharmacodynamics and safety of UI058 and UIC202004 in healthy subjects
- Trial name
- NCT05282914
- Testing
- administration of UI058, administration of UIC202004
- Where
- South Korea
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Korea United Pharm. Inc.
GERD
to Assess the Efficacy and Safety of the Probiotic E. Coli Strain M17 on Patients With GERD
The study is an Open Label, Prospective, Non Comparative, Pilot, clinical trial design. Patients with inadequate relief in GI symptoms associated with GERD despite PPI treatment will be screened and those who meet the inclusion…
- Trial name
- NCT00324532
- Testing
- ProBactrix
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- BioBalance Corporation
Cough
Validation of Peptest™ for the Detection of Reflux in Cough
Chronic cough is a common presenting problem which has a significant impact on quality of life. Gastro-oesophageal reflux (GOR) is a common cause of chronic cough and reflux of stomach contents into the airways has been…
- Trial name
- NCT03851393
- Testing
- Induction of cough with inhaled citric acid, Peptest™ analysis of saliva pepsin, Peptest™
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Achalasia
POEM- Peroral Endoscopic Myotomy for Esophageal Motility Disorders
POEM has recently described as an alternative treatment for achalasia in humans. In this procedure the esophageal sphincter is incised through a submucosal tunnel in the esophagus.
- Trial name
- POEM (NCT01512719)
- Testing
- POEM
- Where
- 3 sites in Israel
- Volunteers
- 100 people
- Sponsor
- Hadassah Medical Organization
Obesity, Morbid, Metabolic Syndrome
Non-randomized Prospective Comparison Between SASI Bipartition and RYGB
The main aim of this project is to assess the safety and efficiency of the SASI Bipartition.
- Conditions
- Obesity, Morbid, Metabolic Syndrome, Bariatric Surgery Candidate, Postoperative Complications
- Trial name
- NCT04469712
- Testing
- SASI Bipartition, Gastric bypass
- Where
- Norway
- Volunteers
- 280 people
- Sponsor
- Aleris Hospital
Gastroesophageal Reflux Disease
The Efficacy of Neiguan (P6 Point) Acupressure in Patients With Gastroesophageal Reflux Disease (GERD)
In recent years, there is an increasing trend in the number of patients with Gastroesophageal reflux disease (GERD). The poor response to medicine was noticed in patients with non-erosive reflux disease.
- Trial name
- NCT02255071
- Testing
- Acupressure wristband
- Where
- Taiwan
- Volunteers
- 64 people
- Sponsor
- China Medical University Hospital
GERD
EndoStim Patient Registry
To provide a research tool enabling physicians to monitor long term clinical outcomes for patients undergoing gastroesophageal reflux disease (GERD) treatment with EndoStim LES Stimulation System.
- Trial name
- RESTORE (NCT02441400)
- Testing
- EndoStim LES Stimulation System
- Where
- 30 sites in Argentina, Austria and 5 more
- Volunteers
- 350 people
- Sponsor
- EndoStim Inc.
Minimally Conscious State, Vegetative State
The Initiation of Swallowing Can Indicate the Prognosis of DOC
This study is aimed to detect the initiation of swallowing act in DOC patients, to find if it is a good item as a stimulus and to detect the relationship between the initiation of swallowing act and the prognosis of DOC patients.
- Trial name
- NCT03508336
- Testing
- Coma Recovery Scale-Revised
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Hangzhou Normal University
Gastroesophageal Reflux
Effect of Vecam 40/300 and Vecam 20/300 Compared to Omeprazole 20 mg on Gastric pH
The study is designed to assess and compare the effect of Vecam 40/300, Vecam 20/300 and Omeprazole 20 mg (a standard FDA approved GERD treatment) on the control of gastric pH.
- Trial name
- NCT00818870
- Testing
- Omeprazole, Vecam
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Vecta Ltd.
Esophageal Achalasia
Comparison Study of Conventional POEM and Hybrid POEM for Esophageal Achalasia
Peroral endoscopic myotomy (POEM) has recently been introduced as promising alternative to laparoscopic Heller myotomy for patients with idiopathic achalasia.
- Trial name
- NCT01742494
- Testing
- Water-jet POEM, Conventional POEM
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shanghai Zhongshan Hospital
Parkinson Disease
Impact of Myofascial Release on Dysphagia in Parkinson's Disease Patients
The goal of this clinical trial is to explore Clinical Effect of Myofascial Release Therapy in Dysphagic Parkinson's Patients. The main question it aims to answer is: Can Myofascial Release Therapy improve swallowing function in…
- Trial name
- NCT06328296
- Testing
- Rehabilitation treatment, Myofascial Release Therapy
- Volunteers
- 80 people
- Sponsor
- Copka Sonpashan
Laryngopharyngeal Reflux
Twice Daily Prevacid for the Treatment of Laryngopharyngeal Reflux
The purpose of this study is to determine whether treatment with twice-daily Lansoprazole 30mg (Prevacid 30mg) and behavioral modifications for reflux is superior to treatment with behavioral modifications for reflux alone in the…
- Trial name
- NCT00864396
- Testing
- Prevacid
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- University of California, Davis
Gastroesophageal Reflux
Esomeprazole (NEXIUM) vs. Surgery
The study investigates the efficacy of long-term treatment of esomeprazole compared to anti-reflux surgery in the control of gastroesophageal reflux disease by assessing time to treatment failure.
- Trial name
- LOTUS (NCT00251927)
- Testing
- esomeprazole, Laparoscopic fundoplication (surgery)
- Where
- 59 sites in Austria, Belgium and 10 more
- Volunteers
- 626 people
- Sponsor
- AstraZeneca
Sleeve Gastrectomy, Pre-cardial Fat Pad
Preserving the Pre-cardial Fat Pad During Sleeve Gastrectomy on Postoperative Gastroesophageal Reflux
Gastroesophageal reflux disease (GERD) is one of the most common chronic conditions that can affect one's quality of life. Laparoscopic sleeve gastrectomy (LSG) has become a popular technique and currently is the most frequently…
- Conditions
- Sleeve Gastrectomy, Pre-cardial Fat Pad, Excessive Weight Loss, Total Weight Loss
- Trial name
- Pad and SG (NCT06732661)
- Testing
- Preserve pre-cardial fat pad, Dissect pre-cardial fat pad
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Beijing Chao Yang Hospital
Gastroesophageal Reflux
Which Supraesophageal Reflux Symptoms Reliably Respond to Proton-Pump-Inhibitor (PPI) Therapy
The investigators hypothesize that persons with the particular cluster of symptoms that are due to supraesophageal reflux (SER) will have complete resolution of those symptoms with adequate acid suppression when a PPI is…
- Trial name
- NCT00170001
- Testing
- Nexium, Sugar Pill
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Gastroesophageal Reflux
Is Laparoscopic Fundoplication Better Than Open Fundoplication in Children ?
The aim of the study was to compare short- and longterm outcomes after laparoscopic and open Nissen fundoplication in children.
- Trial name
- NCT01551134
- Testing
- Fundoplication
- Where
- Norway
- Volunteers
- 88 people
- Sponsor
- Oslo University Hospital
Inflammation, Gastroesophageal Reflux
Trial to Assess the Effectiveness of Educational Outreach in Prescription Guidelines
Background: The Portuguese National Health Directorate has issued clinical practice guidelines on prescription of anti-inflammatory drugs and COX-2 inhibitors, acid suppressive therapy and proton pump inhibitors, and…
- Conditions
- Inflammation, Gastroesophageal Reflux, Gastrointestinal Diseases, Cardiovascular Diseases
- Trial name
- TEP (NCT01984034)
- Testing
- Educational Outreach Visits, Passive Dissemination
- Where
- Portugal
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Universidade Nova de Lisboa
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