Clinical trials: Deglutition Disorder
EoE, Eosinophilic Esophagitis
Mepo for Eosinophilic Esophagitis (EoE) Study
Multi-center, randomized, double blind, parallel-arm, placebo controlled trial to determine whether mepolizumab is more effective than placebo for improving symptoms of dysphagia and decreasing esophageal eosinophil counts in…
- Trial name
- NCT03656380
- Testing
- Mepolizumab 300 mg, Mepolizumab 100 mg
- Where
- 4 sites in United States
- Volunteers
- 66 people
- Sponsor
- University of North Carolina, Chapel Hill
Neurogenic Dysphagia, Rehabilitation
Action Observation Therapy Program in Patients With Neurogenic Dysphagia
Swallowing is the delivery of food taken from the mouth to the stomach at an appropriate rate with the sequential movements of the structures in the oral, pharyngeal, and esophageal regions.
- Conditions
- Neurogenic Dysphagia, Rehabilitation, Deglutition Disorders
- Trial name
- NCT05782790
- Testing
- Action Observation Theraphy Group, Classic Swallowing Exercise Group
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Zonguldak Bulent Ecevit University
Gastro Esophageal Reflux
Antireflux Mucosectomy (ARMS) for Treatment of Gastroesophageal Reflux
This is a phase II clinical study to investigate the safety and efficacy of endoscopic antireflux mucosectomy (ARMS) for treatment of GERD.
- Trial name
- ARMS (NCT04194723)
- Testing
- Antireflux Mucosectomy
- Where
- Hong Kong
- Volunteers
- 30 people
- Sponsor
- Chinese University of Hong Kong
Quality of Life, Dysphagia
Evaluation of the Functional Status of Jejunoplasty and Coloplasty and Its Impact on Quality of Life (CEREC)
The goal of this prospective population-based cohort study is to assess: The evolution of the functional status of patients undergoing complex esophageal reconstruction Its impact on quality of life, depending on the type of…
- Trial name
- CEREC (NCT05802459)
- Testing
- EORTC QLQ-C30, EORTC QLQ-OG25, GIQLI
- Where
- Spain
- Volunteers
- 36 people
- Sponsor
- Hospital Universitari de Bellvitge
Laryngopharyngeal Reflux
Predictive Value of Subjective and Objective Measurement Tools for Extraesophageal Reflux
Acid reflux can cause many symptoms in the throat, including discomfort or pain, and difficulty with breathing and voice problems.
- Trial name
- NCT01829074
- Volunteers
- 150 people
- Sponsor
- Respiratory Technology Corporation
Dysphagia
Consequences of an Initial Treatment for Head and Neck Cancer on Swallowing Function: Impact on Nutritional Status
The aim of the present prospective study was to assess dysphagia (occurrence, severity, length) in head and neck cancer (HNC), from diagnosis to 18 months after their first line treatment regardless of the treatment.
- Trial name
- DYSPHAGIA (NCT03068559)
- Volunteers
- 240 people
- Sponsor
- Centre Antoine Lacassagne
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Esophagogastric Cancer, Moderate to Severe Dysphagia
A Trial of a New Type of Photodynamic Therapy (VTP) in the Treatment of Patients With Cancer of the Esophagus Who Have Trouble Swallowing
The purpose of this study is to establish the highest dose of laser light for WST-11 VTP to treat obstruction from esophageal cancer that can be safely given.
- Trial name
- NCT03133650
- Testing
- WST 11-mediated VTP therapy
- Where
- 3 sites in United States, Israel
- Volunteers
- 12 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Gastroesophageal Reflux, Heartburn
HEARD (Long Term) Study - Histology of the Esophagus in Acid-Related Disease
Determine if different levels of acid-suppression with esomeprazole for 6 months on chosen histological markers of esophageal epithelial acid-related disease in patients with upper GI symptoms.
- Conditions
- Gastroesophageal Reflux, Heartburn, Dyspepsia
- Trial name
- NCT00243724
- Testing
- Esomeprazole
- Where
- 10 sites in Canada
- Volunteers
- 350 people
- Sponsor
- AstraZeneca
Erosive Esophagitis
Impact of Timing on the Efficacy of Zegerid 40 mg in Healing Reflux Esophagitis: A Pilot Study
The purpose of this study was to determine the effect of morning versus bedtime administration of omeprazole/sodium bicarbonate (Zegerid) on endoscopic healing for patients with moderate or severe reflux esophagitis.
- Trial name
- NCT00693225
- Testing
- Omeprazole/sodium bicarbonate
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- Yvonne Romero
Gastroesophageal Reflux Disease
The Use of Lansoprazole to Treat Infants With Symptoms of Gastroesophageal Reflux
The purpose of this study is to assess the safety and efficacy of lansoprazole microgranules oral suspension, once daily (QD), in infants with gastroesophageal reflux symptoms during a 4-week treatment period.
- Trial name
- NCT00324974
- Testing
- Lansoprazole microgranules suspension
- Where
- 17 sites in United States, Poland
- Volunteers
- 162 people
- Sponsor
- Takeda
Pulmonary Aspiration of Gastric Contents
Prophylaxis for Aspiration of Gastric Contents.
Effect of orally administered two equal and consecutive doses of proton pump inhibitors, omeprazole, lansoprazole, esomeprazole , rabeprazole and pantoprazole and Histamine 2 receptor antagonists cimetidine…
- Trial name
- NCT02703896
- Testing
- Drug either PPIS or H2RA and prokinetics, orogastric intubation
- Volunteers
- 1,920 people, healthy volunteers welcome
- Sponsor
- King Saud University
Gastroesophageal Reflux
Effect of a Nickel Free Diet and Nickel Sensitization on GERD Patients.
There is little evidence on the effect of a nickel-free diet on gastroesophageal reflux disease (GERD). We hope to determine if a nickel-free diet improves GERD symptoms in patients with a nickel allergy by having patients…
- Trial name
- NCT03720756
- Testing
- Nickel-free diet
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- West Virginia University
Dysphagia, Oropharyngeal, Deglutition Disorders
Ultrasound Study of the Submentonian Musculature and Its Relationship in Dysphagia
Acquired dysphagia is one of the most frequent complications suffered by patients in intensive care units (ICU) after orotracheal extubation.
- Conditions
- Dysphagia, Oropharyngeal, Deglutition Disorders, Mechanical Ventilation Complication
- Trial name
- NCT06369337
- Testing
- Ultrasound
- Volunteers
- 150 people
- Sponsor
- Universidad Europea de Madrid
Gastro Esophageal Reflux Disease, Barrett Esophagus
Patient Preferences for Barrett's Esophagus and Esophageal Cancer Screening Tests
This study plans to learn more about what patients think about screening for esophageal cancer (EAC) and Barrett's esophagus (BE); a pre-cancerous condition associated with esophageal cancer.
- Trial name
- NCT06693622
- Testing
- Patient survey
- Where
- United States
- Volunteers
- 556 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Achalasia
Peroral Endoscopic Myotomy for the Treatment of Achalasia
There will be a retrospective chart review for patients who underwent endoscopic procedures and POEM from 06/2016 - 01/2019 \& a prospective chart review will be performed for patients who will undergo endoscopic procedures and…
- Trial name
- NCT04640753
- Testing
- Endoscopic procedure for achalasia
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Methodist Health System
Dysphagia
Aspiration in Acute Respiratory Failure Survivors
The purpose of this study is to learn more about problems with swallowing that could develop in patients who are very sick and need a machine to help them breathe.
- Trial name
- NCT02363686
- Testing
- FEES, BSE
- Where
- 3 sites in United States
- Volunteers
- 248 people
- Sponsor
- University of Colorado, Denver
Deglutition Disorder, High Risk Pregnancy
Study of Fetal Swallowing
This study will establish a database of fetal movements associated with feeding. It will use information obtained from standard fetal ultrasound procedures to identify and measure the growth of the baby's face, lips, tongue, jaw…
- Trial name
- NCT00004566
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Dysphagia of Newborn
Development of Dysphagia Evaluation Via Video Analysis Based on Deep Learning Method in Neonates and Infants and Correlation Between the Evaluation and the Development
The purpose of this study is to develop an evaluation of dysphagia through deep learning-based video analysis in newborns and infants, and to report the correlation with future development.
- Trial name
- NCT05204966
- Testing
- AI analysis
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Asan Medical Center
Eosinophilic Esophagitis, Dysphagia
EoE(Eosinophilic Esophagitis)
To evaluate quantitative magnetic resonance imaging(MRI) as a potential non-invasive, radiation-free diagnostic tool for evaluating esophageal wall remodeling (thickness and stiffness) and response to treatment in children and…
- Trial name
- NCT01999439
- Testing
- Eosinophilic Esophagitis with Dysphagia
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Michigan
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.